DE3662689D1 - Thiazolidinedione derivatives, their production and use - Google Patents
Thiazolidinedione derivatives, their production and useInfo
- Publication number
- DE3662689D1 DE3662689D1 DE8686300220T DE3662689T DE3662689D1 DE 3662689 D1 DE3662689 D1 DE 3662689D1 DE 8686300220 T DE8686300220 T DE 8686300220T DE 3662689 T DE3662689 T DE 3662689T DE 3662689 D1 DE3662689 D1 DE 3662689D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- thiazolidinedione derivatives
- thiazolidinedione
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001467 thiazolidinediones Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP808585 | 1985-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3662689D1 true DE3662689D1 (en) | 1989-05-11 |
Family
ID=11683488
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686300220T Expired DE3662689D1 (en) | 1985-01-19 | 1986-01-15 | Thiazolidinedione derivatives, their production and use |
| DE2001199018 Active DE10199018I2 (de) | 1985-01-19 | 1986-01-15 | Thiazolidindion-Derivate, deren Herstellung und Anwendung. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2001199018 Active DE10199018I2 (de) | 1985-01-19 | 1986-01-15 | Thiazolidindion-Derivate, deren Herstellung und Anwendung. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4687777A (enExample) |
| EP (1) | EP0193256B1 (enExample) |
| JP (1) | JPS61267580A (enExample) |
| KR (1) | KR920010046B1 (enExample) |
| CN (1) | CN1003934B (enExample) |
| AR (1) | AR240698A1 (enExample) |
| AT (1) | ATE41931T1 (enExample) |
| AU (1) | AU572719B2 (enExample) |
| BR (1) | BR1100325A (enExample) |
| CA (1) | CA1277323C (enExample) |
| CS (1) | CS407991A3 (enExample) |
| DE (2) | DE3662689D1 (enExample) |
| DK (2) | DK171614B1 (enExample) |
| ES (1) | ES8705886A1 (enExample) |
| FI (1) | FI81098C (enExample) |
| GR (1) | GR860124B (enExample) |
| HK (1) | HK3692A (enExample) |
| HU (1) | HU196795B (enExample) |
| IE (1) | IE58928B1 (enExample) |
| LU (1) | LU90719I2 (enExample) |
| LV (1) | LV5779B4 (enExample) |
| MX (1) | MX9202933A (enExample) |
| MY (1) | MY102016A (enExample) |
| NL (1) | NL300038I2 (enExample) |
| NO (1) | NO163857C (enExample) |
| PT (1) | PT81859B (enExample) |
| SG (1) | SG105691G (enExample) |
| ZA (1) | ZA86203B (enExample) |
Families Citing this family (276)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK305884A (da) * | 1983-06-24 | 1984-12-25 | Yamanouchi Pharma Co Ltd | Phenoxyderivat, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
| US4812570A (en) * | 1986-07-24 | 1989-03-14 | Takeda Chemical Industries, Ltd. | Method for producing thiazolidinedione derivatives |
| FI91869C (fi) * | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
| HU203330B (en) * | 1987-06-10 | 1991-07-29 | Pfizer | Process for producing oxazolidin-2-one derivatives and hypoglychemic pharmaceutical compositions containing them |
| GB8713861D0 (en) * | 1987-06-13 | 1987-07-15 | Beecham Group Plc | Compounds |
| EP0295828A1 (en) * | 1987-06-13 | 1988-12-21 | Beecham Group Plc | Novel compounds |
| US4791125A (en) * | 1987-12-02 | 1988-12-13 | Pfizer Inc. | Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents |
| US4798835A (en) * | 1987-12-02 | 1989-01-17 | Pfizer Inc. | dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidine-2,4-dione as an anti-atherosclerosis agent |
| GB8820389D0 (en) * | 1988-08-26 | 1988-09-28 | Beecham Group Plc | Novel compounds |
| GB8919417D0 (en) | 1989-08-25 | 1989-10-11 | Beecham Group Plc | Novel compounds |
| US4997948A (en) * | 1989-10-27 | 1991-03-05 | American Home Products | 5-[(1- and 2-naphthalenyl) sulfonyl]-2,4-thiazolidinediones and derivatives thereof |
| US5356913A (en) * | 1990-02-09 | 1994-10-18 | The Upjohn Company | Use of insulin sensitizing agents to treat hypertension |
| DE69100282T3 (de) * | 1990-02-09 | 2001-01-11 | Pharmacia & Upjohn Co., Kalamazoo | Verwendung insulin-sensiblisierender wirkstoffe zur behandlung von hypertonie. |
| DE69132713D1 (de) * | 1990-04-27 | 2001-10-11 | Sankyo Co | Benzylidenthiazolidinderivate, ihre Herstellung und ihre Anwendung als Lipidperoxid-Inhibitoren |
| GB9023584D0 (en) * | 1990-10-30 | 1990-12-12 | Beecham Group Plc | Novel compounds |
| US5158966A (en) * | 1991-02-22 | 1992-10-27 | The University Of Colorado Foundation, Inc. | Method of treating type i diabetes |
| KR100249988B1 (ko) * | 1991-04-11 | 2000-04-01 | 로렌스 티. 마이젠헬더 | 티아졸리딘디온 유도체, 그의 제조방법 및 용도 |
| US5441971A (en) * | 1991-04-11 | 1995-08-15 | The Upjohn Company | Thiazolidinedione derivatives, production and use thereof |
| US5183823A (en) * | 1991-04-11 | 1993-02-02 | Takeda Chemical Industries, Ltd. | Pyridine n-oxide compounds which are useful as hypoglycemic and hypolipidemic agents |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| GB9124513D0 (en) * | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
| US5741803A (en) * | 1992-09-05 | 1998-04-21 | Smithkline Beecham Plc | Substituted thiazolidinedionle derivatives |
| GB9218830D0 (en) * | 1992-09-05 | 1992-10-21 | Smithkline Beecham Plc | Novel compounds |
| NZ248573A (en) * | 1992-09-10 | 1996-02-27 | Lilly Co Eli | 5-arylmethyl (and methylidene) thiazolidin-4-one derivatives; their preparation and pharmaceutical compositions |
| US5594016A (en) * | 1992-12-28 | 1997-01-14 | Mitsubishi Chemical Corporation | Naphthalene derivatives |
| JP2845743B2 (ja) * | 1992-12-28 | 1999-01-13 | 三菱化学株式会社 | 新規なナフタレン誘導体 |
| USRE39384E1 (en) | 1993-09-01 | 2006-11-07 | Smithkline Beecham P.L.C. | Substituted thiazolidinedione derivatives |
| US6046222A (en) * | 1993-09-15 | 2000-04-04 | Warner-Lambert Company | Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| US5457109A (en) * | 1993-09-15 | 1995-10-10 | Warner-Lambert Company | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| JP3081245B2 (ja) * | 1993-09-15 | 2000-08-28 | 三共株式会社 | Niddmの発症を阻止又は遅延するためのチアゾリジンジオン類の用途 |
| US5874454A (en) * | 1993-09-15 | 1999-02-23 | Warner-Lambert Company | Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
| ES2135711T4 (es) * | 1994-03-08 | 2000-01-01 | American Home Prod | Derivados de tiazolidindiona como agentes antihiperglucemicos. |
| US6251928B1 (en) * | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
| ATE238297T1 (de) * | 1994-10-20 | 2003-05-15 | Nippon Chemiphar Co | Chinolinderivat |
| US5708012A (en) * | 1995-04-28 | 1998-01-13 | Sankyo Company, Limited | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus |
| WO1996035688A1 (en) * | 1995-05-08 | 1996-11-14 | Nippon Chemiphar Co., Ltd. | 2,4-thiazolidinedione or oxazolidinedione derivatives and hypoglycemic agent |
| TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| CA2180296C (en) * | 1995-07-03 | 2007-01-09 | Yoshio Tsujita | Treatment of arteriosclerosis and xanthoma |
| EP0783888A1 (en) | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis |
| NZ314406A (en) * | 1996-03-18 | 2000-12-22 | Sankyo Co | Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles |
| US5958957A (en) * | 1996-04-19 | 1999-09-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| JP2000511883A (ja) * | 1996-04-19 | 2000-09-12 | ノボ ノルディスク アクティーゼルスカブ | ホスホチロシン認識ユニットを有する分子のモジュレーター |
| CA2257284C (en) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remedy for autoimmune diseases |
| US5952509A (en) * | 1996-06-27 | 1999-09-14 | Takeda Chemical Industries, Ltd. | Production of benzaldehyde compounds |
| ATE399545T1 (de) * | 1996-11-08 | 2008-07-15 | Nippon Chemiphar Co | Mittel zur verringerung der eigeweidefette |
| JP2001514663A (ja) * | 1997-03-12 | 2001-09-11 | エスモンド,ロバート ダブリュー. | アルツハイマー病を処置または予防するための方法 |
| US5908859A (en) * | 1997-08-11 | 1999-06-01 | Eli Lilly And Company | Benzothiophenes for inhibiting hyperlipidemia |
| HUP9902721A2 (hu) | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület |
| WO1999030739A1 (en) * | 1997-12-16 | 1999-06-24 | Sankyo Company, Limited | Leukemia remedy |
| GB9726568D0 (en) * | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Novel pharmaceutical |
| US20040058873A1 (en) * | 1998-03-12 | 2004-03-25 | Esmond Robert W. | Method for treating or preventing Alzheimer's disease |
| AU1740900A (en) * | 1998-11-20 | 2000-06-13 | Genentech Inc. | Method of inhibiting angiogenesis |
| US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
| TWI249401B (en) * | 1999-04-14 | 2006-02-21 | Takeda Chemical Industries Ltd | Agent for improving ketosis |
| AU4314000A (en) | 1999-04-28 | 2000-11-17 | Institute Of Medicinal Molecular Design. Inc. | Heterocyclic carboxylic acid derivatives |
| HK1043113A1 (zh) * | 1999-07-01 | 2002-09-06 | Geron Corporation | 端粒酶抑制劑及其使用方法 |
| JP2001072592A (ja) | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
| US7390824B1 (en) * | 1999-09-07 | 2008-06-24 | Bristol-Myers Squibb Company | Method for treating diabetes employing an aP2 inhibitor and combination |
| US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| CO5200844A1 (es) | 1999-09-17 | 2002-09-27 | Novartis Ag | Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes |
| US6878749B2 (en) | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
| ES2156574B1 (es) * | 1999-11-18 | 2002-02-01 | Vita Invest Sa | Nuevos derivados de tiazolidindiona como agentes antidiabeticos |
| EP1236719A4 (en) | 1999-12-03 | 2003-06-25 | Kyoto Pharma Ind | NOVEL HETEROCYCLIC COMPOUNDS AND SALTS THEREOF, USE OF THESE COMPOUNDS IN MEDICINE |
| EP1741445B1 (en) | 2000-01-21 | 2013-08-14 | Novartis AG | Combinations comprising dipeptidylpeptidase-IV inhibitors and antidiabetic agents |
| US6680387B2 (en) * | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| US6958355B2 (en) * | 2000-04-24 | 2005-10-25 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| BR0110258A (pt) * | 2000-04-25 | 2003-01-07 | Kyorin Seiyaku Kk | Cristal estável de derivado de tiazolidinadiona e processo para sua produção |
| WO2002024689A1 (en) * | 2000-09-21 | 2002-03-28 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis |
| US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
| ATE341343T1 (de) * | 2000-12-26 | 2006-10-15 | Sankyo Co | Medizinische zusammensetzungen mit diuretischem und die insulinresistenz verbesserndem mittel |
| MXPA03006724A (es) * | 2001-01-26 | 2003-10-24 | Schering Corp | Combinaciones de inhibidor(es) de absorcion de esterol con agente(s) cardiovascular(es) para el tratamiento de condiciones vasculares. |
| NZ526532A (en) * | 2001-01-26 | 2005-01-28 | Schering Corp | The use of substituted azetidinone compounds for the treatment of sitosterolemia |
| US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| TW200840563A (en) * | 2001-01-26 | 2008-10-16 | Schering Corp | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(S) and treatments for vascular indications |
| DE60221798T2 (de) * | 2001-01-26 | 2008-06-05 | Schering Corp. | Kombinationen von gallensäure sequestriermitteln und hemmern der sterol absorption zur behandlung von kardiovaskulären indikationen |
| JP4777602B2 (ja) * | 2001-01-26 | 2011-09-21 | シェーリング コーポレイション | ペルオキシソーム増殖因子活性化レセプター(ppar)活性化剤およびステロール吸収阻害剤の組合せおよび血管症状の処置 |
| JP2004517920A (ja) * | 2001-01-26 | 2004-06-17 | シェーリング コーポレイション | 血管状態を治療するためのステロール吸収阻害剤と血液調整剤との組合せ |
| PT1757606E (pt) * | 2001-02-24 | 2009-05-26 | Boehringer Ingelheim Pharma | Utilização de derivados de xantina como produto farmacêutico, bem como seu processo de preparação |
| KR200249057Y1 (ko) * | 2001-03-22 | 2001-10-19 | 김진환 | 뚜껑, 받침대에 합체된 하수역류. 악취방지 장치 |
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| US20060047000A1 (en) * | 2001-04-24 | 2006-03-02 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
| EP1382336B1 (en) * | 2001-04-25 | 2010-09-08 | Takeda Pharmaceutical Company Limited | Use of the abc expression promotor pioglitazone for the treatment of arteriosclerosis obliterans |
| SK14452003A3 (sk) * | 2001-04-26 | 2004-04-06 | Liva, A. S. | Spôsob výroby pioglitazonu ako antidiabetika |
| MXPA03010811A (es) * | 2001-05-29 | 2004-02-27 | Kyoto Pharma Ind | Compuestos heterociclico y uso farmaceutico. |
| NZ530313A (en) * | 2001-05-29 | 2005-06-24 | Kyoto Pharma Ind | Heterocyclic derivatives and medicinal use thereof |
| WO2003013609A1 (fr) * | 2001-08-03 | 2003-02-20 | Takeda Chemical Industries, Ltd. | Medicaments a liberation continue |
| US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
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| US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
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| US20050101638A1 (en) * | 2002-11-08 | 2005-05-12 | Webb Randy L. | Combination of organic compounds |
| CA2470075A1 (en) * | 2001-12-20 | 2003-07-03 | Teva Pharmaceutical Industries Ltd. | Hydrogenation of precursors to thiazolidinedione antihyperglycemics |
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| ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| WO2003062427A1 (fr) * | 2002-01-23 | 2003-07-31 | Yamanouchi Pharmaceutical Co., Ltd. | Methode de criblage de medicaments ameliorant la resistance a l'insuline |
| US7015345B2 (en) * | 2002-02-21 | 2006-03-21 | Asahi Kasei Pharma Corporation | Propionic acid derivatives |
| KR100450700B1 (ko) * | 2002-03-22 | 2004-10-01 | 주식회사종근당 | 티아졸리딘디온 유도체 화합물 및 이를 함유하는 약제학적조성물 |
| US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
| PL376577A1 (pl) | 2002-06-17 | 2006-01-09 | Themis Laboratories Private Limited | Wielowarstwowe tabletki zawierające tiazolidinedion i biguanidy oraz metody ich wytwarzania |
| DE60316152D1 (de) | 2002-07-16 | 2007-10-18 | Cadila Healthcare Ltd | Prozess zur herstellung von pioglitazon via verschiedene zwischenstufen |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| US4582839A (en) * | 1984-03-21 | 1986-04-15 | Takeda Chemical Industries, Ltd. | 2,4-thiazolidinediones |
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
-
1986
- 1986-01-08 AR AR30280186A patent/AR240698A1/es active
- 1986-01-09 JP JP61003243A patent/JPS61267580A/ja active Granted
- 1986-01-10 ZA ZA86203A patent/ZA86203B/xx unknown
- 1986-01-14 IE IE10786A patent/IE58928B1/en not_active IP Right Cessation
- 1986-01-15 AT AT86300220T patent/ATE41931T1/de active
- 1986-01-15 DE DE8686300220T patent/DE3662689D1/de not_active Expired
- 1986-01-15 DE DE2001199018 patent/DE10199018I2/de active Active
- 1986-01-15 EP EP86300220A patent/EP0193256B1/en not_active Expired
- 1986-01-16 NO NO86860141A patent/NO163857C/no unknown
- 1986-01-17 ES ES550986A patent/ES8705886A1/es not_active Expired
- 1986-01-17 GR GR860124A patent/GR860124B/el active IP Right Revival
- 1986-01-17 DK DK021986D patent/DK171614B1/da not_active IP Right Cessation
- 1986-01-17 FI FI860232A patent/FI81098C/fi not_active IP Right Cessation
- 1986-01-17 PT PT81859A patent/PT81859B/pt unknown
- 1986-01-17 US US06/820,390 patent/US4687777A/en not_active Expired - Lifetime
- 1986-01-17 CA CA000499769A patent/CA1277323C/en not_active Expired - Lifetime
- 1986-01-17 DK DK21986A patent/DK21986A/da not_active IP Right Cessation
- 1986-01-17 AU AU52467/86A patent/AU572719B2/en not_active Expired
- 1986-01-17 HU HU86251A patent/HU196795B/hu unknown
- 1986-01-18 KR KR1019860000283A patent/KR920010046B1/ko not_active Expired
- 1986-01-18 CN CN86100411.6A patent/CN1003934B/zh not_active Expired
-
1987
- 1987-09-19 MY MYPI87001769A patent/MY102016A/en unknown
-
1991
- 1991-12-12 SG SG1056/91A patent/SG105691G/en unknown
- 1991-12-27 CS CS914079A patent/CS407991A3/cs unknown
-
1992
- 1992-01-09 HK HK36/92A patent/HK3692A/en not_active IP Right Cessation
- 1992-06-17 MX MX9202933A patent/MX9202933A/es unknown
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1996
- 1996-07-03 LV LV960211A patent/LV5779B4/xx unknown
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1997
- 1997-04-22 BR BR1100325-1A patent/BR1100325A/pt active IP Right Grant
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2001
- 2001-01-01 NL NL300038C patent/NL300038I2/nl unknown
- 2001-01-24 LU LU90719C patent/LU90719I2/fr unknown
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