DE3431058C2 - - Google Patents

Info

Publication number
DE3431058C2
DE3431058C2 DE3431058A DE3431058A DE3431058C2 DE 3431058 C2 DE3431058 C2 DE 3431058C2 DE 3431058 A DE3431058 A DE 3431058A DE 3431058 A DE3431058 A DE 3431058A DE 3431058 C2 DE3431058 C2 DE 3431058C2
Authority
DE
Germany
Prior art keywords
rde
endotoxin
spp
composition
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3431058A
Other languages
German (de)
English (en)
Other versions
DE3431058A1 (de
Inventor
Edgar Ernst Hamilton Mont. Us Ribi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ribi Immunochem Research Inc
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Publication of DE3431058A1 publication Critical patent/DE3431058A1/de
Application granted granted Critical
Publication of DE3431058C2 publication Critical patent/DE3431058C2/de
Granted legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/05Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55544Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19843431058 1983-08-26 1984-08-23 Gereinigtes, entgiftetes endotoxin Granted DE3431058A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52696783A 1983-08-26 1983-08-26

Publications (2)

Publication Number Publication Date
DE3431058A1 DE3431058A1 (de) 1985-03-07
DE3431058C2 true DE3431058C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-06-11

Family

ID=24099553

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3448164A Expired DE3448164C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1983-08-26 1984-08-23
DE19843431058 Granted DE3431058A1 (de) 1983-08-26 1984-08-23 Gereinigtes, entgiftetes endotoxin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3448164A Expired DE3448164C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1983-08-26 1984-08-23

Country Status (22)

Country Link
JP (1) JPS6072825A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR880002223B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT389228B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU554039B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE900377A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1225592A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH660125A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3448164C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK389384A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8606883A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI843204L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2550945B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB2147806B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU191713B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL72675A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN157910B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1177974B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL192326C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO843243L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ209233A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE8404090L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA846309B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629722A (en) * 1984-07-12 1986-12-16 Ribi Immunochem Research, Inc. Method of inhibiting the onset of acute radiation syndrome
US4803070A (en) * 1986-04-15 1989-02-07 Ribi Immunochem Research Inc. Immunological emulsion adjuvants for polysaccharide vaccines
US4806352A (en) * 1986-04-15 1989-02-21 Ribi Immunochem Research Inc. Immunological lipid emulsion adjuvant
DE10115310A1 (de) * 2001-03-28 2002-10-10 Nodar A Daniela Bakteriophagen-Präparation
KR100868443B1 (ko) * 2002-05-27 2008-11-11 주식회사 포스코 폭과 길이가 가변 조정되는 런치박스 제작장치

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2160326B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1971-11-19 1975-02-07 Anvar
BE793260A (fr) * 1971-12-24 1973-06-22 Pasteur Institut Agent immunostimulant, medicaments le contenant et procede de fabrication de cet agent immunostimulant
GB1516507A (en) * 1974-06-20 1978-07-05 Anvar Process for obtaining mycobacterial fractions with anti-tumor anti-viral and adjuvant activities and pharmaceutical compositions containing them
FR2393065A1 (fr) * 1977-05-31 1978-12-29 Merieux Inst Procede de separation de lipides d'endotoxines bacteriennes et notamment d'endotoxine de bordetella pertussis
US4435386A (en) * 1982-05-26 1984-03-06 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436728A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US4436727A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product

Also Published As

Publication number Publication date
NZ209233A (en) 1987-11-27
ZA846309B (en) 1985-03-27
ES8606883A1 (es) 1986-05-01
ATA273384A (de) 1989-04-15
HUT34887A (en) 1985-05-28
GB2147806A (en) 1985-05-22
FR2550945A1 (fr) 1985-03-01
GB8420612D0 (en) 1984-09-19
SE8404090D0 (sv) 1984-08-14
CA1225592A (en) 1987-08-18
IT8448757A1 (it) 1986-02-24
NL8402515A (nl) 1985-03-18
DE3431058A1 (de) 1985-03-07
AU3221584A (en) 1985-02-28
DK389384D0 (da) 1984-08-13
AT389228B (de) 1989-11-10
AU554039B2 (en) 1986-08-07
NO843243L (no) 1985-02-27
IT1177974B (it) 1987-09-03
DK389384A (da) 1985-02-27
IN157910B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-07-19
JPH0556326B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-08-19
GB2147806B (en) 1986-10-22
HU191713B (en) 1987-03-30
NL192326C (nl) 1997-06-04
FI843204A0 (fi) 1984-08-14
FR2550945B1 (fr) 1988-09-16
KR850001696A (ko) 1985-04-01
FI843204A7 (fi) 1985-02-27
DE3448164C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1987-06-25
ES535124A0 (es) 1986-05-01
IL72675A (en) 1988-04-29
IT8448757A0 (it) 1984-08-24
NL192326B (nl) 1997-02-03
KR880002223B1 (ko) 1988-10-20
JPS6072825A (ja) 1985-04-24
BE900377A (fr) 1985-02-18
FI843204L (fi) 1985-02-27
IL72675A0 (en) 1984-11-30
CH660125A5 (de) 1987-03-31
SE8404090L (sv) 1985-02-27

Similar Documents

Publication Publication Date Title
DE3921416C2 (de) Modifizierte Lipopolysaccharide, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung
DE3318569C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE3318567C2 (de) Therapeutisches Mittel, enthaltend gereinigtes, entgiftetes Endotoxin, Zellwandgerüst und Trehalosedimycolat
DE2954387C2 (de) Die tumorspezifische Immunität vergrößernder Bakterienzellenextrakt und Verfahren zu seiner Herstellung
DE3331003C2 (de) Verfahren zur Stabilisierung des Tumor-Nekrose-Faktors und diesen enthaltende wäßrige Lösung oder Pulversubstanz
DE69937343T2 (de) Adjuvanszusammensetzung und methoden zu deren verwendung
DE68929318T2 (de) Legionellosis-Impfstoffe und Verfahren zur deren Herstellung
DE3712768C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE3318568A1 (de) Therapeutische zusammensetzung enthaltend gereinigtes, entgiftetes endotoxin, trehalosedimycolat und ein mit azeton ausgefaelltes nebenprodukt von mit chloroform-methanol extrahierten endotoxischen glykolipiden
DE3407823C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE2331144A1 (de) Wasserloesliche extrakte von mycobacterien
DE3434766A1 (de) Einen pyridinloeslichen extrakt und gereinigtes entgiftetes endotoxin enthaltendes pharmazeutisches praeparat
DE2747379A1 (de) P-amino-phenyl-n-acetyl-muramyl-l- alanyl-d-isoglutamin, verfahren zu dessen herstellung und diese verbindung enthaltende arzneimittel
DE2519938A1 (de) Extrakte von corynebakterien, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen
DE2547105A1 (de) N-acetyl-muramyl-l-alanyl-d-isoglutamin enthaltende oelfreie adjuvanzien
DE3431058C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE2262427C3 (de) Immunostimulierendes Mittel
DE69810024T2 (de) Inhibitor der immunoglobulin e antikörpererzeugung zur behandlung von typ i allergie-verwandten krankheiten
DE69231724T2 (de) Fischimpfstoff gegen infektion mit aeromonas salmonicida
DE60213785T2 (de) Saponin inaktivierte mykoplasma impfstoffe
DE3323092C2 (de) Pharmazeutisches Präparat
DE3817762C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP0187286A1 (de) Öladjuvierte Vaccine und Verfahren zu ihrer Herstellung
DE3323093A1 (de) Pharmazeutisches praeparat
EP0271447B1 (de) Vorbeugende Massnahmen zur Verhinderung der "Komplexen Respiratorischen Erkrankung bei Rindern" durch Verabreichung von Interferon

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8172 Supplementary division/partition in:

Ref country code: DE

Ref document number: 3448164

Format of ref document f/p: P

Q171 Divided out to:

Ref country code: DE

Ref document number: 3448164

AH Division in

Ref country code: DE

Ref document number: 3448164

Format of ref document f/p: P

D2 Grant after examination
AH Division in

Ref country code: DE

Ref document number: 3448164

Format of ref document f/p: P

8364 No opposition during term of opposition