DE3431058A1 - Gereinigtes, entgiftetes endotoxin - Google Patents

Gereinigtes, entgiftetes endotoxin

Info

Publication number
DE3431058A1
DE3431058A1 DE19843431058 DE3431058A DE3431058A1 DE 3431058 A1 DE3431058 A1 DE 3431058A1 DE 19843431058 DE19843431058 DE 19843431058 DE 3431058 A DE3431058 A DE 3431058A DE 3431058 A1 DE3431058 A1 DE 3431058A1
Authority
DE
Germany
Prior art keywords
endotoxin
rde
purified
composition according
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19843431058
Other languages
German (de)
English (en)
Other versions
DE3431058C2 (fi
Inventor
Edgar Ernst Hamilton Mont. Ribi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ribi Immunochem Research Inc
Original Assignee
Ribi Immunochem Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribi Immunochem Research Inc filed Critical Ribi Immunochem Research Inc
Publication of DE3431058A1 publication Critical patent/DE3431058A1/de
Application granted granted Critical
Publication of DE3431058C2 publication Critical patent/DE3431058C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/05—Immunological preparations stimulating the reticulo-endothelial system, e.g. against cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19843431058 1983-08-26 1984-08-23 Gereinigtes, entgiftetes endotoxin Granted DE3431058A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52696783A 1983-08-26 1983-08-26

Publications (2)

Publication Number Publication Date
DE3431058A1 true DE3431058A1 (de) 1985-03-07
DE3431058C2 DE3431058C2 (fi) 1987-06-11

Family

ID=24099553

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3448164A Expired DE3448164C2 (fi) 1983-08-26 1984-08-23
DE19843431058 Granted DE3431058A1 (de) 1983-08-26 1984-08-23 Gereinigtes, entgiftetes endotoxin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3448164A Expired DE3448164C2 (fi) 1983-08-26 1984-08-23

Country Status (22)

Country Link
JP (1) JPS6072825A (fi)
KR (1) KR880002223B1 (fi)
AT (1) AT389228B (fi)
AU (1) AU554039B2 (fi)
BE (1) BE900377A (fi)
CA (1) CA1225592A (fi)
CH (1) CH660125A5 (fi)
DE (2) DE3448164C2 (fi)
DK (1) DK389384A (fi)
ES (1) ES8606883A1 (fi)
FI (1) FI843204A (fi)
FR (1) FR2550945B1 (fi)
GB (1) GB2147806B (fi)
HU (1) HU191713B (fi)
IL (1) IL72675A (fi)
IN (1) IN157910B (fi)
IT (1) IT1177974B (fi)
NL (1) NL192326C (fi)
NO (1) NO843243L (fi)
NZ (1) NZ209233A (fi)
SE (1) SE8404090L (fi)
ZA (1) ZA846309B (fi)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3524992A1 (de) * 1984-07-12 1986-01-16 Ribi Immunochem Research, Inc., Hamilton, Mont. Zusammensetzung zur inhibierung der ausloesung von akutem strahlungssyndrom an warmbluetern
DE3712767A1 (de) * 1986-04-15 1987-10-22 Ribi Immunochem Research Inc Immunologisches adjuvans
DE3712768A1 (de) * 1986-04-15 1987-10-22 Ribi Immunochem Research Inc Immunologisches adjuvans fuer polysaccharid-impfstoffe

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10115310A1 (de) * 2001-03-28 2002-10-10 Nodar A Daniela Bakteriophagen-Präparation
KR100868443B1 (ko) * 2002-05-27 2008-11-11 주식회사 포스코 폭과 길이가 가변 조정되는 런치박스 제작장치

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3318568A1 (de) * 1982-05-26 1984-01-12 Ribi Immunochem Research, Inc.,, 59840 Hamilton, Mont. Therapeutische zusammensetzung enthaltend gereinigtes, entgiftetes endotoxin, trehalosedimycolat und ein mit azeton ausgefaelltes nebenprodukt von mit chloroform-methanol extrahierten endotoxischen glykolipiden
DE3318567A1 (de) * 1982-05-26 1984-01-12 Ribi Immunochem Research, Inc.,, 59840 Hamilton, Mont. Therapeutische zusammensetzung enthaltend gereinigtes, entgiftetes endotoxin, zellwandgeruest und trehalosedimycolat

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2160326B1 (fi) * 1971-11-19 1975-02-07 Anvar
BE793260A (fr) * 1971-12-24 1973-06-22 Pasteur Institut Agent immunostimulant, medicaments le contenant et procede de fabrication de cet agent immunostimulant
JPS5132794A (en) * 1974-06-20 1976-03-19 Anvar Koshuyokoirusu oyobi ajubantokatsuseiojusuru maikobakuteriumufurakushonnoseiseiho
FR2393065A1 (fr) * 1977-05-31 1978-12-29 Merieux Inst Procede de separation de lipides d'endotoxines bacteriennes et notamment d'endotoxine de bordetella pertussis
US4436727A (en) * 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3318568A1 (de) * 1982-05-26 1984-01-12 Ribi Immunochem Research, Inc.,, 59840 Hamilton, Mont. Therapeutische zusammensetzung enthaltend gereinigtes, entgiftetes endotoxin, trehalosedimycolat und ein mit azeton ausgefaelltes nebenprodukt von mit chloroform-methanol extrahierten endotoxischen glykolipiden
DE3318567A1 (de) * 1982-05-26 1984-01-12 Ribi Immunochem Research, Inc.,, 59840 Hamilton, Mont. Therapeutische zusammensetzung enthaltend gereinigtes, entgiftetes endotoxin, zellwandgeruest und trehalosedimycolat

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3524992A1 (de) * 1984-07-12 1986-01-16 Ribi Immunochem Research, Inc., Hamilton, Mont. Zusammensetzung zur inhibierung der ausloesung von akutem strahlungssyndrom an warmbluetern
DE3546592C2 (fi) * 1984-07-12 1988-06-01 Ribi Immunochem Research, Inc., Hamilton, Mont., Us
DE3712767A1 (de) * 1986-04-15 1987-10-22 Ribi Immunochem Research Inc Immunologisches adjuvans
DE3712768A1 (de) * 1986-04-15 1987-10-22 Ribi Immunochem Research Inc Immunologisches adjuvans fuer polysaccharid-impfstoffe

Also Published As

Publication number Publication date
NL8402515A (nl) 1985-03-18
DK389384D0 (da) 1984-08-13
AU554039B2 (en) 1986-08-07
NL192326C (nl) 1997-06-04
FR2550945A1 (fr) 1985-03-01
IL72675A (en) 1988-04-29
FI843204A (fi) 1985-02-27
SE8404090L (sv) 1985-02-27
NO843243L (no) 1985-02-27
BE900377A (fr) 1985-02-18
DK389384A (da) 1985-02-27
DE3448164C2 (fi) 1987-06-25
IT1177974B (it) 1987-09-03
CA1225592A (en) 1987-08-18
GB2147806B (en) 1986-10-22
HU191713B (en) 1987-03-30
GB8420612D0 (en) 1984-09-19
FR2550945B1 (fr) 1988-09-16
IL72675A0 (en) 1984-11-30
IT8448757A0 (it) 1984-08-24
IT8448757A1 (it) 1986-02-24
HUT34887A (en) 1985-05-28
JPS6072825A (ja) 1985-04-24
CH660125A5 (de) 1987-03-31
NL192326B (nl) 1997-02-03
ZA846309B (en) 1985-03-27
KR880002223B1 (ko) 1988-10-20
IN157910B (fi) 1986-07-19
AU3221584A (en) 1985-02-28
NZ209233A (en) 1987-11-27
ATA273384A (de) 1989-04-15
FI843204A0 (fi) 1984-08-14
JPH0556326B2 (fi) 1993-08-19
DE3431058C2 (fi) 1987-06-11
ES8606883A1 (es) 1986-05-01
AT389228B (de) 1989-11-10
ES535124A0 (es) 1986-05-01
SE8404090D0 (sv) 1984-08-14
KR850001696A (ko) 1985-04-01
GB2147806A (en) 1985-05-22

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