DE3334937A1 - Carbapenem-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel - Google Patents

Carbapenem-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel

Info

Publication number
DE3334937A1
DE3334937A1 DE19833334937 DE3334937A DE3334937A1 DE 3334937 A1 DE3334937 A1 DE 3334937A1 DE 19833334937 DE19833334937 DE 19833334937 DE 3334937 A DE3334937 A DE 3334937A DE 3334937 A1 DE3334937 A1 DE 3334937A1
Authority
DE
Germany
Prior art keywords
alkyl
substituted
phenyl
alkylamino
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19833334937
Other languages
German (de)
English (en)
Other versions
DE3334937C2 (enrdf_load_stackoverflow
Inventor
Choung Un 13104 Manlius N.Y. Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DE3334937A1 publication Critical patent/DE3334937A1/de
Application granted granted Critical
Publication of DE3334937C2 publication Critical patent/DE3334937C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
DE19833334937 1982-09-28 1983-09-27 Carbapenem-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel Granted DE3334937A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42575582A 1982-09-28 1982-09-28
US53001183A 1983-09-09 1983-09-09

Publications (2)

Publication Number Publication Date
DE3334937A1 true DE3334937A1 (de) 1984-04-05
DE3334937C2 DE3334937C2 (enrdf_load_stackoverflow) 1991-05-02

Family

ID=27026797

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19833334937 Granted DE3334937A1 (de) 1982-09-28 1983-09-27 Carbapenem-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel

Country Status (29)

Country Link
KR (1) KR890002228B1 (enrdf_load_stackoverflow)
AR (1) AR241785A1 (enrdf_load_stackoverflow)
AT (1) AT382621B (enrdf_load_stackoverflow)
AU (1) AU575541B2 (enrdf_load_stackoverflow)
CA (1) CA1269978A (enrdf_load_stackoverflow)
CH (1) CH656130A5 (enrdf_load_stackoverflow)
CS (1) CS247168B2 (enrdf_load_stackoverflow)
DD (1) DD212255A5 (enrdf_load_stackoverflow)
DE (1) DE3334937A1 (enrdf_load_stackoverflow)
DK (1) DK442383A (enrdf_load_stackoverflow)
ES (1) ES8503354A1 (enrdf_load_stackoverflow)
FI (1) FI78094C (enrdf_load_stackoverflow)
FR (1) FR2533568B1 (enrdf_load_stackoverflow)
GB (1) GB2128187B (enrdf_load_stackoverflow)
GR (1) GR78696B (enrdf_load_stackoverflow)
HU (1) HU191066B (enrdf_load_stackoverflow)
IE (1) IE55947B1 (enrdf_load_stackoverflow)
IL (1) IL69824A (enrdf_load_stackoverflow)
IT (1) IT1163944B (enrdf_load_stackoverflow)
LU (1) LU85021A1 (enrdf_load_stackoverflow)
NL (1) NL8303310A (enrdf_load_stackoverflow)
NO (1) NO163284C (enrdf_load_stackoverflow)
NZ (1) NZ205626A (enrdf_load_stackoverflow)
OA (1) OA07548A (enrdf_load_stackoverflow)
PT (1) PT77404B (enrdf_load_stackoverflow)
SE (1) SE461734B (enrdf_load_stackoverflow)
SU (1) SU1493108A3 (enrdf_load_stackoverflow)
YU (1) YU43196B (enrdf_load_stackoverflow)
ZW (1) ZW20783A1 (enrdf_load_stackoverflow)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0167139A1 (en) * 1984-07-02 1986-01-08 Merck & Co. Inc. Carbapenems having an externally alkylated 2-quaternary pyridiniumalkylthio substituent
EP0170073A1 (en) * 1984-07-02 1986-02-05 Merck & Co. Inc. 1-Methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
AT396472B (de) * 1985-09-11 1993-09-27 Bristol Myers Squibb Co Verfahren zur herstellung neuer carbapenem-antibiotika
AT397090B (de) * 1985-11-22 1994-01-25 Bristol Myers Squibb Co Verfahren zur herstellung von neuen carbapenemderivaten

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683296A (en) * 1983-03-07 1987-07-28 Bristol-Myers Company Carbapenem intermediates
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4729993A (en) * 1984-12-13 1988-03-08 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
US4725594A (en) * 1984-12-13 1988-02-16 Merck & Co., Inc. Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent
NZ219892A (en) * 1986-04-15 1991-02-26 Merck & Co Inc N-amino quaternised heteroarylium carbapenem derivatives and pharmaceutical compositions thereof
DK168047B1 (da) * 1987-12-07 1994-01-24 Lederle Japan Ltd (1r,5s,6s)-2-substitueret thio-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater, fremgangsmaade til remstilling deraf, midler og praeparater indeholdende den krystallinske forbindelse samt dens anvendelse.
CA2241321A1 (en) 1996-01-12 1997-07-17 Tetsuo Miwa Carbapenem compounds, their production and use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
EP0038869A1 (en) * 1980-04-30 1981-11-04 Merck & Co. Inc. Process for the preparation of 1-carbapenems, and intermediates for their preparation
EP0050334A1 (en) * 1980-10-17 1982-04-28 Merck & Co. Inc. 2-Carbamimidoyl-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, a process for preparing and an antibiotic composition comprising the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
EP0050927B1 (en) * 1980-10-25 1985-03-27 Beecham Group Plc The preparation of beta-lactam antibiotics
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
EP0074599A1 (en) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-cis-Carbapenem derivatives, their production and use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
EP0038869A1 (en) * 1980-04-30 1981-11-04 Merck & Co. Inc. Process for the preparation of 1-carbapenems, and intermediates for their preparation
EP0050334A1 (en) * 1980-10-17 1982-04-28 Merck & Co. Inc. 2-Carbamimidoyl-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, a process for preparing and an antibiotic composition comprising the same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0167139A1 (en) * 1984-07-02 1986-01-08 Merck & Co. Inc. Carbapenems having an externally alkylated 2-quaternary pyridiniumalkylthio substituent
EP0170073A1 (en) * 1984-07-02 1986-02-05 Merck & Co. Inc. 1-Methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
AT396472B (de) * 1985-09-11 1993-09-27 Bristol Myers Squibb Co Verfahren zur herstellung neuer carbapenem-antibiotika
AT397090B (de) * 1985-11-22 1994-01-25 Bristol Myers Squibb Co Verfahren zur herstellung von neuen carbapenemderivaten

Also Published As

Publication number Publication date
GB8325744D0 (en) 1983-10-26
CA1269978A (en) 1990-06-05
DE3334937C2 (enrdf_load_stackoverflow) 1991-05-02
FR2533568B1 (fr) 1990-01-26
YU43196B (en) 1989-04-30
OA07548A (fr) 1985-03-31
FI833417A7 (fi) 1984-03-29
YU190683A (en) 1985-10-31
FR2533568A1 (fr) 1984-03-30
ES525983A0 (es) 1985-02-16
IE55947B1 (en) 1991-02-27
AR241785A1 (es) 1992-12-30
ES8503354A1 (es) 1985-02-16
GR78696B (enrdf_load_stackoverflow) 1984-09-27
KR840006249A (ko) 1984-11-22
PT77404A (en) 1983-10-01
SU1493108A3 (ru) 1989-07-07
IL69824A0 (en) 1983-12-30
CH656130A5 (de) 1986-06-13
AT382621B (de) 1987-03-25
IT8323022A0 (it) 1983-09-27
HU191066B (en) 1987-01-28
ATA344983A (de) 1986-08-15
CS247168B2 (en) 1986-12-18
SE461734B (sv) 1990-03-19
DD212255A5 (de) 1984-08-08
LU85021A1 (fr) 1984-04-24
SE8305217L (sv) 1984-03-29
ZW20783A1 (en) 1984-11-28
DK442383A (da) 1984-03-29
FI78094B (fi) 1989-02-28
IT1163944B (it) 1987-04-08
FI833417A0 (fi) 1983-09-23
IL69824A (en) 1991-04-15
NO163284C (no) 1990-05-02
AU1934283A (en) 1984-04-05
NZ205626A (en) 1986-12-05
SE8305217D0 (sv) 1983-09-27
AU575541B2 (en) 1988-08-04
IE832266L (en) 1984-03-28
DK442383D0 (da) 1983-09-27
FI78094C (fi) 1989-06-12
KR890002228B1 (ko) 1989-06-24
NO833479L (no) 1984-03-29
NL8303310A (nl) 1984-04-16
GB2128187B (en) 1986-06-18
NO163284B (no) 1990-01-22
GB2128187A (en) 1984-04-26
PT77404B (en) 1986-06-26

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: BRISTOL-MYERS SQUIBB CO. (N.D.GES.D.STAATES DELAWA

8128 New person/name/address of the agent

Representative=s name: KINZEBACH, W., DIPL.-CHEM. DR.PHIL. RIEDL, P., DIP

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee