KR890002228B1 - 카르바페넴 유도체 및 그의 제조방법 - Google Patents

카르바페넴 유도체 및 그의 제조방법 Download PDF

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Publication number
KR890002228B1
KR890002228B1 KR1019830004574A KR830004574A KR890002228B1 KR 890002228 B1 KR890002228 B1 KR 890002228B1 KR 1019830004574 A KR1019830004574 A KR 1019830004574A KR 830004574 A KR830004574 A KR 830004574A KR 890002228 B1 KR890002228 B1 KR 890002228B1
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KR
South Korea
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alkyl
compound
pharmaceutically acceptable
nitrobenzyl
hydrogen
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Expired
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KR1019830004574A
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English (en)
Korean (ko)
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KR840006249A (ko
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김중운
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브리스톨-마이어스 컴페니
이삭 자코브스키
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Publication of KR840006249A publication Critical patent/KR840006249A/ko
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Publication of KR890002228B1 publication Critical patent/KR890002228B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
KR1019830004574A 1982-09-28 1983-09-28 카르바페넴 유도체 및 그의 제조방법 Expired KR890002228B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US42575582A 1982-09-28 1982-09-28
US425755 1982-09-28
US53001183A 1983-09-09 1983-09-09
US530011 1983-09-09

Publications (2)

Publication Number Publication Date
KR840006249A KR840006249A (ko) 1984-11-22
KR890002228B1 true KR890002228B1 (ko) 1989-06-24

Family

ID=27026797

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830004574A Expired KR890002228B1 (ko) 1982-09-28 1983-09-28 카르바페넴 유도체 및 그의 제조방법

Country Status (29)

Country Link
KR (1) KR890002228B1 (enrdf_load_stackoverflow)
AR (1) AR241785A1 (enrdf_load_stackoverflow)
AT (1) AT382621B (enrdf_load_stackoverflow)
AU (1) AU575541B2 (enrdf_load_stackoverflow)
CA (1) CA1269978A (enrdf_load_stackoverflow)
CH (1) CH656130A5 (enrdf_load_stackoverflow)
CS (1) CS247168B2 (enrdf_load_stackoverflow)
DD (1) DD212255A5 (enrdf_load_stackoverflow)
DE (1) DE3334937A1 (enrdf_load_stackoverflow)
DK (1) DK442383A (enrdf_load_stackoverflow)
ES (1) ES8503354A1 (enrdf_load_stackoverflow)
FI (1) FI78094C (enrdf_load_stackoverflow)
FR (1) FR2533568B1 (enrdf_load_stackoverflow)
GB (1) GB2128187B (enrdf_load_stackoverflow)
GR (1) GR78696B (enrdf_load_stackoverflow)
HU (1) HU191066B (enrdf_load_stackoverflow)
IE (1) IE55947B1 (enrdf_load_stackoverflow)
IL (1) IL69824A (enrdf_load_stackoverflow)
IT (1) IT1163944B (enrdf_load_stackoverflow)
LU (1) LU85021A1 (enrdf_load_stackoverflow)
NL (1) NL8303310A (enrdf_load_stackoverflow)
NO (1) NO163284C (enrdf_load_stackoverflow)
NZ (1) NZ205626A (enrdf_load_stackoverflow)
OA (1) OA07548A (enrdf_load_stackoverflow)
PT (1) PT77404B (enrdf_load_stackoverflow)
SE (1) SE461734B (enrdf_load_stackoverflow)
SU (1) SU1493108A3 (enrdf_load_stackoverflow)
YU (1) YU43196B (enrdf_load_stackoverflow)
ZW (1) ZW20783A1 (enrdf_load_stackoverflow)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683296A (en) * 1983-03-07 1987-07-28 Bristol-Myers Company Carbapenem intermediates
CA1273012A (en) * 1984-07-02 1990-08-21 Burton G. Christensen 1-methylcarbapenems having an externally alkylated mono- of bicyclic 2-quarternary heteroarylalkylthio substituent
CA1273011A (en) * 1984-07-02 1990-08-21 Susan M. Schmitt Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
US4725594A (en) * 1984-12-13 1988-02-16 Merck & Co., Inc. Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent
US4729993A (en) * 1984-12-13 1988-03-08 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4880922A (en) * 1985-11-22 1989-11-14 Bristol-Myers Company Carbapenems with quaternized heterothioalkylthio substitution at position 2
NZ219892A (en) * 1986-04-15 1991-02-26 Merck & Co Inc N-amino quaternised heteroarylium carbapenem derivatives and pharmaceutical compositions thereof
DK168047B1 (da) * 1987-12-07 1994-01-24 Lederle Japan Ltd (1r,5s,6s)-2-substitueret thio-6-oe(r)-1-hydroxyethylaa-1-methyl-carbapenem-3-carboxylsyrederivater, fremgangsmaade til remstilling deraf, midler og praeparater indeholdende den krystallinske forbindelse samt dens anvendelse.
EP0876370A1 (en) * 1996-01-12 1998-11-11 Takeda Chemical Industries, Ltd. Carbapenem compounds, their production and use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
EP0038869A1 (en) * 1980-04-30 1981-11-04 Merck & Co. Inc. Process for the preparation of 1-carbapenems, and intermediates for their preparation
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
GB2089340B (en) * 1980-10-25 1984-09-19 Beecham Group Ltd -lactam antibiotics their preparation and their use
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
EP0074599A1 (en) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-cis-Carbapenem derivatives, their production and use

Also Published As

Publication number Publication date
YU43196B (en) 1989-04-30
YU190683A (en) 1985-10-31
NZ205626A (en) 1986-12-05
ES525983A0 (es) 1985-02-16
IL69824A (en) 1991-04-15
ATA344983A (de) 1986-08-15
GB2128187B (en) 1986-06-18
SE8305217L (sv) 1984-03-29
FI833417A0 (fi) 1983-09-23
NO163284C (no) 1990-05-02
PT77404A (en) 1983-10-01
NL8303310A (nl) 1984-04-16
AT382621B (de) 1987-03-25
NO163284B (no) 1990-01-22
DE3334937A1 (de) 1984-04-05
IT1163944B (it) 1987-04-08
NO833479L (no) 1984-03-29
ES8503354A1 (es) 1985-02-16
CA1269978A (en) 1990-06-05
DE3334937C2 (enrdf_load_stackoverflow) 1991-05-02
CS247168B2 (en) 1986-12-18
PT77404B (en) 1986-06-26
IT8323022A0 (it) 1983-09-27
LU85021A1 (fr) 1984-04-24
AU575541B2 (en) 1988-08-04
GR78696B (enrdf_load_stackoverflow) 1984-09-27
FR2533568B1 (fr) 1990-01-26
IL69824A0 (en) 1983-12-30
CH656130A5 (de) 1986-06-13
GB2128187A (en) 1984-04-26
SU1493108A3 (ru) 1989-07-07
IE832266L (en) 1984-03-28
AU1934283A (en) 1984-04-05
GB8325744D0 (en) 1983-10-26
FR2533568A1 (fr) 1984-03-30
HU191066B (en) 1987-01-28
FI78094B (fi) 1989-02-28
SE8305217D0 (sv) 1983-09-27
DK442383A (da) 1984-03-29
FI78094C (fi) 1989-06-12
KR840006249A (ko) 1984-11-22
OA07548A (fr) 1985-03-31
DD212255A5 (de) 1984-08-08
SE461734B (sv) 1990-03-19
IE55947B1 (en) 1991-02-27
DK442383D0 (da) 1983-09-27
ZW20783A1 (en) 1984-11-28
FI833417A7 (fi) 1984-03-29
AR241785A1 (es) 1992-12-30

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