YU190683A - Process for obtaining carbapenem antibiotics - Google Patents

Process for obtaining carbapenem antibiotics

Info

Publication number
YU190683A
YU190683A YU01906/83A YU190683A YU190683A YU 190683 A YU190683 A YU 190683A YU 01906/83 A YU01906/83 A YU 01906/83A YU 190683 A YU190683 A YU 190683A YU 190683 A YU190683 A YU 190683A
Authority
YU
Yugoslavia
Prior art keywords
obtaining
carbapenem antibiotics
carbapenem
antibiotics
obtaining carbapenem
Prior art date
Application number
YU01906/83A
Other versions
YU43196B (en
Inventor
C J Kim
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of YU190683A publication Critical patent/YU190683A/en
Publication of YU43196B publication Critical patent/YU43196B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65611—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. penicillins and analogs
YU1906/83A 1982-09-28 1983-09-22 Process for obtaining carbapenem derivatives YU43196B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42575582A 1982-09-28 1982-09-28
US53001183A 1983-09-09 1983-09-09

Publications (2)

Publication Number Publication Date
YU190683A true YU190683A (en) 1985-10-31
YU43196B YU43196B (en) 1989-04-30

Family

ID=27026797

Family Applications (1)

Application Number Title Priority Date Filing Date
YU1906/83A YU43196B (en) 1982-09-28 1983-09-22 Process for obtaining carbapenem derivatives

Country Status (29)

Country Link
KR (1) KR890002228B1 (en)
AR (1) AR241785A1 (en)
AT (1) AT382621B (en)
AU (1) AU575541B2 (en)
CA (1) CA1269978A (en)
CH (1) CH656130A5 (en)
CS (1) CS247168B2 (en)
DD (1) DD212255A5 (en)
DE (1) DE3334937A1 (en)
DK (1) DK442383A (en)
ES (1) ES525983A0 (en)
FI (1) FI78094C (en)
FR (1) FR2533568B1 (en)
GB (1) GB2128187B (en)
GR (1) GR78696B (en)
HU (1) HU191066B (en)
IE (1) IE55947B1 (en)
IL (1) IL69824A (en)
IT (1) IT1163944B (en)
LU (1) LU85021A1 (en)
NL (1) NL8303310A (en)
NO (1) NO163284C (en)
NZ (1) NZ205626A (en)
OA (1) OA07548A (en)
PT (1) PT77404B (en)
SE (1) SE461734B (en)
SU (1) SU1493108A3 (en)
YU (1) YU43196B (en)
ZW (1) ZW20783A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683296A (en) * 1983-03-07 1987-07-28 Bristol-Myers Company Carbapenem intermediates
CA1273011A (en) * 1984-07-02 1990-08-21 Susan M. Schmitt Carbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkylthio substituent
CA1273012A (en) * 1984-07-02 1990-08-21 Burton G. Christensen 1-methylcarbapenems having an externally alkylated mono- of bicyclic 2-quarternary heteroarylalkylthio substituent
US4680292A (en) * 1984-12-13 1987-07-14 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having a 2-heteroaryliumaliphatic substituent
US4725594A (en) * 1984-12-13 1988-02-16 Merck & Co., Inc. Carbapenems having an internally or externally alkylated mono- or bicyclic 2-quaternary heteroarylalxyl heteromethyl substituent
US4729993A (en) * 1984-12-13 1988-03-08 Merck & Co., Inc. Carbapenems and 1-methylcarbapenems having an externally alkylated mono- or bicyclic 2-quaternary heteroarylalkyl substituent
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4880922A (en) * 1985-11-22 1989-11-14 Bristol-Myers Company Carbapenems with quaternized heterothioalkylthio substitution at position 2
NZ219892A (en) * 1986-04-15 1991-02-26 Merck & Co Inc N-amino quaternised heteroarylium carbapenem derivatives and pharmaceutical compositions thereof
DK168047B1 (en) * 1987-12-07 1994-01-24 Lederle Japan Ltd (1R, 5S, 6S) -2-SUBSTITUTED THIO-6-OE (R) -1-HYDROXYETHYLAA-1-METHYL-CARBAPENEM-3-CARBOXYLIC ACID DERIVATIVES, PROCEDURES FOR PREPARING THEREOF, MIXTURES AND PREPARATION
EP0876370A1 (en) 1996-01-12 1998-11-11 Takeda Chemical Industries, Ltd. Carbapenem compounds, their production and use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation
EP0038869A1 (en) * 1980-04-30 1981-11-04 Merck & Co. Inc. Process for the preparation of 1-carbapenems, and intermediates for their preparation
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids
GB2089340B (en) * 1980-10-25 1984-09-19 Beecham Group Ltd -lactam antibiotics their preparation and their use
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
EP0074599A1 (en) * 1981-09-09 1983-03-23 Takeda Chemical Industries, Ltd. 5,6-cis-Carbapenem derivatives, their production and use

Also Published As

Publication number Publication date
NZ205626A (en) 1986-12-05
LU85021A1 (en) 1984-04-24
DK442383D0 (en) 1983-09-27
SE8305217L (en) 1984-03-29
ZW20783A1 (en) 1984-11-28
IL69824A0 (en) 1983-12-30
DE3334937C2 (en) 1991-05-02
GB8325744D0 (en) 1983-10-26
DK442383A (en) 1984-03-29
ATA344983A (en) 1986-08-15
NO163284C (en) 1990-05-02
AT382621B (en) 1987-03-25
FI833417A0 (en) 1983-09-23
DD212255A5 (en) 1984-08-08
GR78696B (en) 1984-09-27
ES8503354A1 (en) 1985-02-16
IT1163944B (en) 1987-04-08
KR890002228B1 (en) 1989-06-24
FI833417A (en) 1984-03-29
HU191066B (en) 1987-01-28
IE55947B1 (en) 1991-02-27
FR2533568A1 (en) 1984-03-30
FI78094B (en) 1989-02-28
SU1493108A3 (en) 1989-07-07
OA07548A (en) 1985-03-31
IL69824A (en) 1991-04-15
NO833479L (en) 1984-03-29
CS247168B2 (en) 1986-12-18
SE461734B (en) 1990-03-19
GB2128187B (en) 1986-06-18
AU1934283A (en) 1984-04-05
YU43196B (en) 1989-04-30
SE8305217D0 (en) 1983-09-27
CA1269978A (en) 1990-06-05
DE3334937A1 (en) 1984-04-05
IE832266L (en) 1984-03-28
FI78094C (en) 1989-06-12
AR241785A1 (en) 1992-12-30
ES525983A0 (en) 1985-02-16
KR840006249A (en) 1984-11-22
GB2128187A (en) 1984-04-26
NL8303310A (en) 1984-04-16
CH656130A5 (en) 1986-06-13
IT8323022A0 (en) 1983-09-27
PT77404B (en) 1986-06-26
FR2533568B1 (en) 1990-01-26
AU575541B2 (en) 1988-08-04
NO163284B (en) 1990-01-22
PT77404A (en) 1983-10-01

Similar Documents

Publication Publication Date Title
YU31981A (en) Process for obtaining beta-lactamic antibiotics
PT76887A (en) Process for preparing carbapenem antibiotics
YU93580A (en) Process for prodicing antibiotics
GB2119371B (en) Carbapenem antibiotics
YU190683A (en) Process for obtaining carbapenem antibiotics
GB2136802B (en) Carbapenem process
PT76410B (en) Process for preparing a41030 antibiotics
HU201761B (en) Process for producing carbapenem derivatives
ZA836966B (en) Carbapenem antibiotics
PT76518A (en) Process for preparing new carbapenem antibiotics
YU173983A (en) Process for obtaining beta-lactame antibiotics
YU222781A (en) Process for obtaining 1-oxa-beta-lactam antibiotics
HUT37167A (en) Process for preparing antibiotic bbm-1644
YU222681A (en) Process for obtaining bis-tetrazolyl-methyl substituted cephalosporin antibiotics
ZA832412B (en) Carbapenem antibiotics
PT73684A (en) Process for preparing bis-tetrazolmethyl substituted beta- -lactam antibiotics
ZM1484A1 (en) Carbapenem process
HUT34979A (en) Process for producing carbapeneme antibiotics
PH18232A (en) Process for producing antibiotic x-14868a
YU149785A (en) Process for obtaining new cephalosporin derivatiaves