DE3226687C2 - - Google Patents

Info

Publication number
DE3226687C2
DE3226687C2 DE3226687A DE3226687A DE3226687C2 DE 3226687 C2 DE3226687 C2 DE 3226687C2 DE 3226687 A DE3226687 A DE 3226687A DE 3226687 A DE3226687 A DE 3226687A DE 3226687 C2 DE3226687 C2 DE 3226687C2
Authority
DE
Germany
Prior art keywords
compound
general formula
methyl
lower alkyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3226687A
Other languages
German (de)
English (en)
Other versions
DE3226687A1 (de
Inventor
Isao Yamatsu
Shinya Ibaragi Jp Abe
Yuichi Tokio/Tokyo Jp Inai
Takeshi Ibaragi Jp Suzuki
Kensaku Abiko Chiba Jp Kinoshita
Mannen Ibaragi Jp Mishima
Yoshinori Misato Saitama Jp Katoh
Seiichi Tsuchiura Jp Kobayashi
Manabu Ibaragi Jp Murakami
Kouzi Toride Ibaragi Jp Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of DE3226687A1 publication Critical patent/DE3226687A1/de
Application granted granted Critical
Publication of DE3226687C2 publication Critical patent/DE3226687C2/de
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
    • C07C67/11—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond being mineral ester groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
DE19823226687 1981-07-23 1982-07-16 Polyprenylverbindungen, verfahren zu deren herstellung und arzneimittel, welche diese enthalten Granted DE3226687A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56114371A JPS5815940A (ja) 1981-07-23 1981-07-23 ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬

Publications (2)

Publication Number Publication Date
DE3226687A1 DE3226687A1 (de) 1983-02-10
DE3226687C2 true DE3226687C2 (en, 2012) 1993-04-08

Family

ID=14636023

Family Applications (3)

Application Number Title Priority Date Filing Date
DE19823226687 Granted DE3226687A1 (de) 1981-07-23 1982-07-16 Polyprenylverbindungen, verfahren zu deren herstellung und arzneimittel, welche diese enthalten
DE3250048A Expired - Fee Related DE3250048C2 (en, 2012) 1981-07-23 1982-07-16
DE3250046A Expired - Fee Related DE3250046C2 (en, 2012) 1981-07-23 1982-07-16

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE3250048A Expired - Fee Related DE3250048C2 (en, 2012) 1981-07-23 1982-07-16
DE3250046A Expired - Fee Related DE3250046C2 (en, 2012) 1981-07-23 1982-07-16

Country Status (12)

Country Link
US (3) US4455316A (en, 2012)
JP (1) JPS5815940A (en, 2012)
KR (1) KR880001027B1 (en, 2012)
CA (1) CA1189855A (en, 2012)
CH (1) CH654574A5 (en, 2012)
DE (3) DE3226687A1 (en, 2012)
ES (1) ES514213A0 (en, 2012)
FR (1) FR2510107A1 (en, 2012)
GB (1) GB2104513B (en, 2012)
NL (1) NL193023C (en, 2012)
PH (1) PH18679A (en, 2012)
SE (2) SE452461B (en, 2012)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI901046A7 (fi) * 1989-03-17 1990-09-18 Eisai Co Ltd Polyprenyyliyhdisteen stabiloiminen
FI96169C (fi) * 1989-07-10 1996-05-27 Eisai Co Ltd Menetelmä polyprenyyliyhdistettä sisältävän farmaseuttisen koostumuksen valmistamiseksi
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
GB9403857D0 (en) * 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
US7054969B1 (en) * 1998-09-18 2006-05-30 Clearspeed Technology Plc Apparatus for use in a computer system
CN113880717B (zh) * 2021-10-29 2022-09-13 中国农业大学 一类双酯基取代的水杨酸甲酯类似物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3798260A (en) * 1970-12-30 1974-03-19 Mitsubishi Chem Ind Process for producing acyloxydodecatrienes
JPS51113842A (en) 1975-03-31 1976-10-07 Ikeda Mohandou:Kk Process for preparing o-(2,6-dichloroanilino)phenyl acetic acid
US4192953A (en) * 1975-11-18 1980-03-11 Sankyo Company Limited Polyprenyl derivatives
US4059641A (en) * 1975-11-18 1977-11-22 Sankyo Company Limited Polyprenyl derivatives
US4260551A (en) * 1975-11-18 1981-04-07 Sankyo Company Limited Polyprenyl derivatives
JPS52131507A (en) * 1976-04-24 1977-11-04 Sankyo Co Ltd Polyprenyl derivatives
DE2940373A1 (de) * 1979-10-05 1981-04-23 Troponwerke GmbH & Co KG, 5000 Köln Lysin-(1-(p-chlorbenzoyl)-5-methoxy-2-methyl-3-indol) -acetoxy-acetate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS56113718A (en) * 1980-01-12 1981-09-07 Agency Of Ind Science & Technol Bifunctional terpenoid, its preparation, and ulcer preventive agent comprising it
DE3006024C2 (de) * 1980-02-18 1983-08-04 Solvon Arzneimittel-Vertriebs- Und Lizenzgesellschaft Mbh, 85011 Burgthann Topisches, Indomethacin enthaltendes Arzneimittel in Salbenform
JPS5731615A (en) * 1980-07-31 1982-02-20 Eisai Co Ltd Remedy for skin disease with keratinization

Also Published As

Publication number Publication date
DE3226687A1 (de) 1983-02-10
SE468812B (sv) 1993-03-22
FR2510107A1 (fr) 1983-01-28
GB2104513A (en) 1983-03-09
DE3250048C2 (en, 2012) 1993-08-05
SE8204367L (sv) 1983-01-24
NL193023C (nl) 1998-08-04
SE8204367D0 (sv) 1982-07-16
KR840000237A (ko) 1984-02-18
CA1189855A (en) 1985-07-02
DE3250046C2 (en, 2012) 1992-01-02
US4709079A (en) 1987-11-24
CH654574A5 (fr) 1986-02-28
SE452461B (sv) 1987-11-30
SE8602138D0 (sv) 1986-05-12
US4455316A (en) 1984-06-19
PH18679A (en) 1985-08-29
KR880001027B1 (ko) 1988-06-15
NL193023B (nl) 1998-04-01
NL8202876A (nl) 1983-02-16
SE8602138L (sv) 1986-05-12
JPH0247463B2 (en, 2012) 1990-10-19
US4576963A (en) 1986-03-18
ES8308827A1 (es) 1983-08-01
ES514213A0 (es) 1983-08-01
JPS5815940A (ja) 1983-01-29
FR2510107B1 (en, 2012) 1985-01-25
GB2104513B (en) 1984-12-19

Similar Documents

Publication Publication Date Title
DE2549783C3 (de) Triglyceride mit entzündungshemmender Wirkung
DE2414680C2 (de) Substituierte 2-Furancarbonsäuren und 2-Furancarbonsäureester, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen enthalten
DE1793591C3 (en, 2012)
DE3226687C2 (en, 2012)
DE69430383T2 (de) Chroman-derivate
DE2818351C2 (de) N-[2-(α-Naphthoxy)-isobutyryl]-aminosäuren, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel
EP0009777B1 (de) Retinsäure- und 7,8-Dehydro-retinsäure-N-(carboxy)-phenyl-amide, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
EP0033075B1 (de) Substituierte 1,8-Dihydroxy-9-(10H)anthracenone, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2748291A1 (de) Triglyceride, verfahren zu ihrer herstellung und ihre verwendung zur behandlung von entzuendungen
DE69023045T2 (de) Carboxamidderivate.
DE2618936C3 (de) N-Acyl-glutamine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
DE2038628C3 (de) N,N'-Di(carboxyalkyI)-p-phenylendiamine, deren Salze und Diäthylester, Verfahren zu ihrer Herstellung und ihre Verwendung
DE3204854A1 (de) 2-amino-3-(halogenbenzoyl)-methylphenylessigsaeuren, deren ester und salze, pharmazeutische zubereitungen, welche diese verbindungen enthalten, und ihre verwendung
EP0496274A1 (de) Tricyclisches Pyridonderivat
DE3407507A1 (de) Neue o-(2,6-dichloranilino)-phenylessigsaeureester, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE69108580T2 (de) Optisch aktives Derivat der d-2-(6-Methoxy-2-naphthyl)-propionsäure und es enthaltende pharmazeutische Zusammensetzungen.
DE2520483A1 (de) Phenoxy-isobuttersaeurederivate und diese verbindungen enthaltende arzneimittel
DE2061181C3 (de) Antiarthritisch wirkendes Arzneimittel auf der Basis einer Goldverbindung
DE3320544A1 (de) Polyprenylverbindungen, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE2842495C2 (de) 4-Cyclohexyl-α-niederalkyl-1-naphthalinessigsäure, deren pharmakologisch verträgliche Salze und Derivate, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
JPH0196158A (ja) 抗炎症剤
DE2834911C2 (de) Antihypertonikum
DE2808203C2 (de) Arzneimittel, enthaltend p-Chlorphenoxyisobuttersäure-p-chlorphenolester
DE2505813C3 (de) 2-(4-Isobutylphenyl)-buttersäure, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
DE2141357C3 (de) Bis-(4-chlorphenoxy)-essigsäureester, Verfahren zu ihrer Herstellung diese Verbindungen enthaltende Arzneimittel

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07D209/26

8172 Supplementary division/partition in:

Ref country code: DE

Ref document number: 3250046

Format of ref document f/p: P

Q171 Divided out to:

Ref country code: DE

Ref document number: 3250046

8172 Supplementary division/partition in:

Ref country code: DE

Ref document number: 3250047

Format of ref document f/p: P

Ref country code: DE

Ref document number: 3250048

Format of ref document f/p: P

Q171 Divided out to:

Ref country code: DE

Ref document number: 3250048

Ref country code: DE

Ref document number: 3250047

AH Division in

Ref country code: DE

Ref document number: 3250046

Format of ref document f/p: P

AH Division in

Ref country code: DE

Ref document number: 3250047

Format of ref document f/p: P

Ref country code: DE

Ref document number: 3250048

Format of ref document f/p: P

Ref country code: DE

Ref document number: 3250046

Format of ref document f/p: P

D2 Grant after examination
AH Division in

Ref country code: DE

Ref document number: 3250048

Format of ref document f/p: P

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee