FR2510107A1 - Composes polyprenyliques, leur procede de preparation et medicaments contenant ces composes - Google Patents
Composes polyprenyliques, leur procede de preparation et medicaments contenant ces composes Download PDFInfo
- Publication number
- FR2510107A1 FR2510107A1 FR8212911A FR8212911A FR2510107A1 FR 2510107 A1 FR2510107 A1 FR 2510107A1 FR 8212911 A FR8212911 A FR 8212911A FR 8212911 A FR8212911 A FR 8212911A FR 2510107 A1 FR2510107 A1 FR 2510107A1
- Authority
- FR
- France
- Prior art keywords
- lower alkyl
- alkyl group
- group
- hydrogen atom
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000000034 method Methods 0.000 title claims description 17
- 238000002360 preparation method Methods 0.000 title claims description 10
- 239000003814 drug Substances 0.000 title abstract description 14
- -1 INDOLYL CARBOXYLIC ACIDS Chemical class 0.000 claims abstract description 55
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical class CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 50
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 40
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- 125000005843 halogen group Chemical group 0.000 claims description 19
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 11
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
- 125000001185 polyprenyl group Polymers 0.000 claims description 7
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims description 6
- 229920001550 polyprenyl Polymers 0.000 claims description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
- C07C67/11—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond being mineral ester groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/612—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a six-membered aromatic ring in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56114371A JPS5815940A (ja) | 1981-07-23 | 1981-07-23 | ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2510107A1 true FR2510107A1 (fr) | 1983-01-28 |
| FR2510107B1 FR2510107B1 (en, 2012) | 1985-01-25 |
Family
ID=14636023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8212911A Granted FR2510107A1 (fr) | 1981-07-23 | 1982-07-23 | Composes polyprenyliques, leur procede de preparation et medicaments contenant ces composes |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US4455316A (en, 2012) |
| JP (1) | JPS5815940A (en, 2012) |
| KR (1) | KR880001027B1 (en, 2012) |
| CA (1) | CA1189855A (en, 2012) |
| CH (1) | CH654574A5 (en, 2012) |
| DE (3) | DE3226687A1 (en, 2012) |
| ES (1) | ES514213A0 (en, 2012) |
| FR (1) | FR2510107A1 (en, 2012) |
| GB (1) | GB2104513B (en, 2012) |
| NL (1) | NL193023C (en, 2012) |
| PH (1) | PH18679A (en, 2012) |
| SE (2) | SE452461B (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0407815A3 (en) * | 1989-07-10 | 1991-02-27 | Eisai Co Ltd | Polyprenyl compound composition for soft capsules |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI901046A7 (fi) * | 1989-03-17 | 1990-09-18 | Eisai Co Ltd | Polyprenyyliyhdisteen stabiloiminen |
| US5298655A (en) * | 1991-09-27 | 1994-03-29 | Merck & Co., Inc. | Farnesyl pyrophosphate analogs |
| GB9403857D0 (en) * | 1994-03-01 | 1994-04-20 | Scotia Holdings Plc | Fatty acid derivatives |
| US7054969B1 (en) * | 1998-09-18 | 2006-05-30 | Clearspeed Technology Plc | Apparatus for use in a computer system |
| CN113880717B (zh) * | 2021-10-29 | 2022-09-13 | 中国农业大学 | 一类双酯基取代的水杨酸甲酯类似物及其制备方法和应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2124652A5 (en, 2012) * | 1970-12-30 | 1972-09-22 | Mitsubishi Chem Ind | |
| FR2422617A1 (fr) * | 1976-04-24 | 1979-11-09 | Sankyo Co | Derives polyprenyliques, leur procede de preparation et leur application en therapeutique |
| GB2069334A (en) * | 1980-02-18 | 1981-08-26 | Solvon Arznei Vertrieb Lizenz | Topical medicine containing indomethacin |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51113842A (en) | 1975-03-31 | 1976-10-07 | Ikeda Mohandou:Kk | Process for preparing o-(2,6-dichloroanilino)phenyl acetic acid |
| US4192953A (en) * | 1975-11-18 | 1980-03-11 | Sankyo Company Limited | Polyprenyl derivatives |
| US4059641A (en) * | 1975-11-18 | 1977-11-22 | Sankyo Company Limited | Polyprenyl derivatives |
| US4260551A (en) * | 1975-11-18 | 1981-04-07 | Sankyo Company Limited | Polyprenyl derivatives |
| DE2940373A1 (de) * | 1979-10-05 | 1981-04-23 | Troponwerke GmbH & Co KG, 5000 Köln | Lysin-(1-(p-chlorbenzoyl)-5-methoxy-2-methyl-3-indol) -acetoxy-acetate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| JPS56113718A (en) * | 1980-01-12 | 1981-09-07 | Agency Of Ind Science & Technol | Bifunctional terpenoid, its preparation, and ulcer preventive agent comprising it |
| JPS5731615A (en) * | 1980-07-31 | 1982-02-20 | Eisai Co Ltd | Remedy for skin disease with keratinization |
-
1981
- 1981-07-23 JP JP56114371A patent/JPS5815940A/ja active Granted
-
1982
- 1982-07-08 PH PH27540A patent/PH18679A/en unknown
- 1982-07-08 US US06/396,184 patent/US4455316A/en not_active Expired - Lifetime
- 1982-07-15 NL NL8202876A patent/NL193023C/nl not_active IP Right Cessation
- 1982-07-16 DE DE19823226687 patent/DE3226687A1/de active Granted
- 1982-07-16 SE SE8204367A patent/SE452461B/sv not_active IP Right Cessation
- 1982-07-16 DE DE3250048A patent/DE3250048C2/de not_active Expired - Fee Related
- 1982-07-16 DE DE3250046A patent/DE3250046C2/de not_active Expired - Fee Related
- 1982-07-19 CH CH4386/82A patent/CH654574A5/fr not_active IP Right Cessation
- 1982-07-21 ES ES514213A patent/ES514213A0/es active Granted
- 1982-07-22 CA CA000407861A patent/CA1189855A/en not_active Expired
- 1982-07-22 GB GB08221164A patent/GB2104513B/en not_active Expired
- 1982-07-23 FR FR8212911A patent/FR2510107A1/fr active Granted
- 1982-07-23 KR KR8203287A patent/KR880001027B1/ko not_active Expired
-
1984
- 1984-05-14 US US06/609,664 patent/US4576963A/en not_active Expired - Lifetime
-
1986
- 1986-01-17 US US06/820,488 patent/US4709079A/en not_active Expired - Fee Related
- 1986-05-12 SE SE8602138A patent/SE468812B/sv not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2124652A5 (en, 2012) * | 1970-12-30 | 1972-09-22 | Mitsubishi Chem Ind | |
| FR2422617A1 (fr) * | 1976-04-24 | 1979-11-09 | Sankyo Co | Derives polyprenyliques, leur procede de preparation et leur application en therapeutique |
| GB2069334A (en) * | 1980-02-18 | 1981-08-26 | Solvon Arznei Vertrieb Lizenz | Topical medicine containing indomethacin |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0407815A3 (en) * | 1989-07-10 | 1991-02-27 | Eisai Co Ltd | Polyprenyl compound composition for soft capsules |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3226687A1 (de) | 1983-02-10 |
| SE468812B (sv) | 1993-03-22 |
| GB2104513A (en) | 1983-03-09 |
| DE3250048C2 (en, 2012) | 1993-08-05 |
| SE8204367L (sv) | 1983-01-24 |
| NL193023C (nl) | 1998-08-04 |
| SE8204367D0 (sv) | 1982-07-16 |
| KR840000237A (ko) | 1984-02-18 |
| CA1189855A (en) | 1985-07-02 |
| DE3250046C2 (en, 2012) | 1992-01-02 |
| US4709079A (en) | 1987-11-24 |
| CH654574A5 (fr) | 1986-02-28 |
| SE452461B (sv) | 1987-11-30 |
| SE8602138D0 (sv) | 1986-05-12 |
| US4455316A (en) | 1984-06-19 |
| PH18679A (en) | 1985-08-29 |
| DE3226687C2 (en, 2012) | 1993-04-08 |
| KR880001027B1 (ko) | 1988-06-15 |
| NL193023B (nl) | 1998-04-01 |
| NL8202876A (nl) | 1983-02-16 |
| SE8602138L (sv) | 1986-05-12 |
| JPH0247463B2 (en, 2012) | 1990-10-19 |
| US4576963A (en) | 1986-03-18 |
| ES8308827A1 (es) | 1983-08-01 |
| ES514213A0 (es) | 1983-08-01 |
| JPS5815940A (ja) | 1983-01-29 |
| FR2510107B1 (en, 2012) | 1985-01-25 |
| GB2104513B (en) | 1984-12-19 |
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Legal Events
| Date | Code | Title | Description |
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| ST | Notification of lapse |