DE3203770C2 - Chinazolinverbindungen mit antitumorwirkung, ein verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten - Google Patents

Chinazolinverbindungen mit antitumorwirkung, ein verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten

Info

Publication number
DE3203770C2
DE3203770C2 DE3203770A DE3203770A DE3203770C2 DE 3203770 C2 DE3203770 C2 DE 3203770C2 DE 3203770 A DE3203770 A DE 3203770A DE 3203770 A DE3203770 A DE 3203770A DE 3203770 C2 DE3203770 C2 DE 3203770C2
Authority
DE
Germany
Prior art keywords
compounds
ethyl
general formula
hydrogen atom
oxiranylmethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3203770A
Other languages
German (de)
English (en)
Other versions
DE3203770A1 (de
Inventor
William E Kreighbaum
William T Comer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DE3203770A1 publication Critical patent/DE3203770A1/de
Application granted granted Critical
Publication of DE3203770C2 publication Critical patent/DE3203770C2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3203770A 1981-03-06 1982-02-04 Chinazolinverbindungen mit antitumorwirkung, ein verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten Expired - Fee Related DE3203770C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (2)

Publication Number Publication Date
DE3203770A1 DE3203770A1 (de) 1982-11-11
DE3203770C2 true DE3203770C2 (de) 1993-11-04

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3203770A Expired - Fee Related DE3203770C2 (de) 1981-03-06 1982-02-04 Chinazolinverbindungen mit antitumorwirkung, ein verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten

Country Status (31)

Country Link
US (1) US4343940A (enExample)
JP (1) JPS57158780A (enExample)
KR (1) KR880001852B1 (enExample)
AR (1) AR231138A1 (enExample)
AT (1) AT380476B (enExample)
AU (1) AU556099B2 (enExample)
BE (1) BE891936A (enExample)
CA (1) CA1163995A (enExample)
CH (1) CH647776A5 (enExample)
CY (1) CY1371A (enExample)
DE (1) DE3203770C2 (enExample)
DK (1) DK159442C (enExample)
ES (1) ES509434A0 (enExample)
FI (1) FI71559C (enExample)
FR (1) FR2501207B1 (enExample)
GB (1) GB2094295B (enExample)
GR (1) GR75903B (enExample)
HK (1) HK4588A (enExample)
HU (1) HU189997B (enExample)
IE (1) IE52385B1 (enExample)
IL (1) IL64875A0 (enExample)
IT (1) IT1154272B (enExample)
KE (1) KE3715A (enExample)
LU (1) LU83903A1 (enExample)
NL (1) NL8200473A (enExample)
NZ (1) NZ199576A (enExample)
PH (1) PH18529A (enExample)
PT (1) PT74394B (enExample)
SE (1) SE461732B (enExample)
SG (1) SG30787G (enExample)
YU (1) YU42031B (enExample)

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DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US6645969B1 (en) 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
ATE188377T1 (de) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd Chinoline oder chinazolin-derivate und deren verwendung zur herstellung eines medikaments für die behandlung von osteoporose
CA2183655C (en) * 1994-02-23 2001-03-06 Lee D. Arnold 4-polycyclic amino-substituted quinazoline derivatives
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (enExample) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
EP0824525B1 (en) * 1995-04-27 2001-06-13 AstraZeneca AB Quinazoline derivatives
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
JPH11507052A (ja) * 1995-06-07 1999-06-22 スージェン・インコーポレーテッド キナゾリンおよび医薬組成物
DE69622183D1 (de) * 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
CA2242425C (en) 1996-02-13 2006-07-18 Zeneca Limited Quinazoline derivatives as vegf inhibitors
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
JP2001505779A (ja) * 1996-12-11 2001-05-08 スージェン・インコーポレーテッド Ｐｙｋ２関連産物および方法
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
US6495353B1 (en) * 1998-01-21 2002-12-17 Sugen, Inc. Human orthologues of wart
AU3642499A (en) * 1998-04-14 1999-11-01 Sugen, Inc. Ste20-related protein kinases
HUP0102793A3 (en) 1998-05-28 2002-07-29 Parker Hughes Inst St Paul Quinazolines for treating brain tumor and medicaments containing them
US6800649B1 (en) * 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
AU5682799A (en) * 1998-08-21 2000-03-14 Parker Hughes Institute Quinazoline derivatives
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
EP1222273A2 (en) * 1999-10-22 2002-07-17 PHARMACIA & UPJOHN COMPANY Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
PT1244647E (pt) * 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
CA2388865A1 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Novel g protein-coupled receptors
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
EP1265925A2 (en) * 2000-02-23 2002-12-18 PHARMACIA & UPJOHN COMPANY G protein-coupled receptors
IL151626A0 (en) * 2000-04-07 2003-04-10 Astrazeneca Ab Quinazoline compounds
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
MXPA05001277A (es) 2002-08-02 2005-10-06 Ab Science 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit.
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
ATE465731T1 (de) * 2003-10-23 2010-05-15 Ab Science 2-aminoaryloxazol-verbindungen als tyrosinkinase- hemmer
MX2007012392A (es) 2005-04-04 2007-12-05 Ab Science Derivados de oxazol sustituidos y su uso como inhibidores de tirosina cinasa.
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
CA2663436A1 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
EP2088863A2 (en) 2006-11-22 2009-08-19 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
US20110008347A1 (en) * 2006-12-01 2011-01-13 Agency For Science ,Technology And Research Cancer-related protein kinases
EP2680850B1 (en) 2011-03-04 2018-05-23 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compound and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE844136A (fr) * 1975-12-16 1976-11-03 Nouveaux derives de la 5-fluoropyrimidin-4-one
DE2633359A1 (de) * 1975-12-16 1977-06-30 Taiho Pharmaceutical Co Ltd 5-fluorpyrimidin-4-on-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
DE2162327C3 (de) * 1970-12-23 1975-09-18 Sumitomo Chemical Co., Ltd., Osaka (Japan) Verfahren zur Herstellung von 3,4-Oihydro-2(1 H)-chinazolinonen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE844136A (fr) * 1975-12-16 1976-11-03 Nouveaux derives de la 5-fluoropyrimidin-4-one
DE2633359A1 (de) * 1975-12-16 1977-06-30 Taiho Pharmaceutical Co Ltd 5-fluorpyrimidin-4-on-derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel

Also Published As

Publication number Publication date
DE3203770A1 (de) 1982-11-11
IT8247713A1 (it) 1983-08-03
CY1371A (en) 1987-08-07
KR880001852B1 (ko) 1988-09-22
AT380476B (de) 1986-05-26
KR830009050A (ko) 1983-12-17
BE891936A (fr) 1982-07-28
JPS57158780A (en) 1982-09-30
NL8200473A (nl) 1982-10-01
IE52385B1 (en) 1987-10-14
YU42031B (en) 1988-04-30
PT74394B (en) 1984-10-22
ES8304095A1 (es) 1983-02-16
PH18529A (en) 1985-08-02
GB2094295B (en) 1984-09-12
FI71559C (fi) 1987-01-19
AU556099B2 (en) 1986-10-23
PT74394A (en) 1982-03-01
IT8247713A0 (it) 1982-02-03
HK4588A (en) 1988-01-29
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
CA1163995A (en) 1984-03-20
GB2094295A (en) 1982-09-15
AR231138A1 (es) 1984-09-28
KE3715A (en) 1987-04-16
NZ199576A (en) 1986-05-09
IT1154272B (it) 1987-01-21
HU189997B (en) 1986-08-28
GR75903B (enExample) 1984-08-02
SE8200526L (sv) 1982-09-07
YU25682A (en) 1985-03-20
SE461732B (sv) 1990-03-19
FR2501207A1 (fr) 1982-09-10
ATA39582A (de) 1985-10-15
DK159442B (da) 1990-10-15
DK159442C (da) 1991-03-18
AU7998182A (en) 1982-09-09
IL64875A0 (en) 1982-03-31
FR2501207B1 (fr) 1985-12-06
CH647776A5 (de) 1985-02-15
LU83903A1 (fr) 1982-09-13
ES509434A0 (es) 1983-02-16
FI71559B (fi) 1986-10-10
DK50482A (da) 1982-09-07
JPH0337552B2 (enExample) 1991-06-05
FI820399L (fi) 1982-09-07
IE820163L (en) 1982-09-06

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: BRISTOL-MYERS SQUIBB CO. (N.D.GES.D.STAATES DELAWA

8128 New person/name/address of the agent

Representative=s name: KINZEBACH, W., DIPL.-CHEM. DR.PHIL. RIEDL, P., DIP

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee