CY1371A - Anti-tumor quinazoline compounds - Google Patents

Anti-tumor quinazoline compounds Download PDF

Info

Publication number
CY1371A
CY1371A CY137182A CY137182A CY1371A CY 1371 A CY1371 A CY 1371A CY 137182 A CY137182 A CY 137182A CY 137182 A CY137182 A CY 137182A CY 1371 A CY1371 A CY 1371A
Authority
CY
Cyprus
Prior art keywords
compound
formula
specified
methyl
ethyl
Prior art date
Application number
CY137182A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of CY1371A publication Critical patent/CY1371A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CY137182A 1981-03-06 1982-02-02 Anti-tumor quinazoline compounds CY1371A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (1)

Publication Number Publication Date
CY1371A true CY1371A (en) 1987-08-07

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
CY137182A CY1371A (en) 1981-03-06 1982-02-02 Anti-tumor quinazoline compounds

Country Status (31)

Country Link
US (1) US4343940A (enExample)
JP (1) JPS57158780A (enExample)
KR (1) KR880001852B1 (enExample)
AR (1) AR231138A1 (enExample)
AT (1) AT380476B (enExample)
AU (1) AU556099B2 (enExample)
BE (1) BE891936A (enExample)
CA (1) CA1163995A (enExample)
CH (1) CH647776A5 (enExample)
CY (1) CY1371A (enExample)
DE (1) DE3203770C2 (enExample)
DK (1) DK159442C (enExample)
ES (1) ES509434A0 (enExample)
FI (1) FI71559C (enExample)
FR (1) FR2501207B1 (enExample)
GB (1) GB2094295B (enExample)
GR (1) GR75903B (enExample)
HK (1) HK4588A (enExample)
HU (1) HU189997B (enExample)
IE (1) IE52385B1 (enExample)
IL (1) IL64875A0 (enExample)
IT (1) IT1154272B (enExample)
KE (1) KE3715A (enExample)
LU (1) LU83903A1 (enExample)
NL (1) NL8200473A (enExample)
NZ (1) NZ199576A (enExample)
PH (1) PH18529A (enExample)
PT (1) PT74394B (enExample)
SE (1) SE461732B (enExample)
SG (1) SG30787G (enExample)
YU (1) YU42031B (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US6645969B1 (en) 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
ATE188377T1 (de) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd Chinoline oder chinazolin-derivate und deren verwendung zur herstellung eines medikaments für die behandlung von osteoporose
CA2183655C (en) * 1994-02-23 2001-03-06 Lee D. Arnold 4-polycyclic amino-substituted quinazoline derivatives
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (enExample) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
EP0824525B1 (en) * 1995-04-27 2001-06-13 AstraZeneca AB Quinazoline derivatives
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
JPH11507052A (ja) * 1995-06-07 1999-06-22 スージェン・インコーポレーテッド キナゾリンおよび医薬組成物
DE69622183D1 (de) * 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
CA2242425C (en) 1996-02-13 2006-07-18 Zeneca Limited Quinazoline derivatives as vegf inhibitors
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
JP2001505779A (ja) * 1996-12-11 2001-05-08 スージェン・インコーポレーテッド Ｐｙｋ２関連産物および方法
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
US6495353B1 (en) * 1998-01-21 2002-12-17 Sugen, Inc. Human orthologues of wart
AU3642499A (en) * 1998-04-14 1999-11-01 Sugen, Inc. Ste20-related protein kinases
HUP0102793A3 (en) 1998-05-28 2002-07-29 Parker Hughes Inst St Paul Quinazolines for treating brain tumor and medicaments containing them
US6800649B1 (en) * 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
AU5682799A (en) * 1998-08-21 2000-03-14 Parker Hughes Institute Quinazoline derivatives
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
EP1222273A2 (en) * 1999-10-22 2002-07-17 PHARMACIA & UPJOHN COMPANY Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
PT1244647E (pt) * 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
CA2388865A1 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Novel g protein-coupled receptors
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
EP1265925A2 (en) * 2000-02-23 2002-12-18 PHARMACIA & UPJOHN COMPANY G protein-coupled receptors
IL151626A0 (en) * 2000-04-07 2003-04-10 Astrazeneca Ab Quinazoline compounds
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
MXPA05001277A (es) 2002-08-02 2005-10-06 Ab Science 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit.
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
ATE465731T1 (de) * 2003-10-23 2010-05-15 Ab Science 2-aminoaryloxazol-verbindungen als tyrosinkinase- hemmer
MX2007012392A (es) 2005-04-04 2007-12-05 Ab Science Derivados de oxazol sustituidos y su uso como inhibidores de tirosina cinasa.
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
CA2663436A1 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
EP2088863A2 (en) 2006-11-22 2009-08-19 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
US20110008347A1 (en) * 2006-12-01 2011-01-13 Agency For Science ,Technology And Research Cancer-related protein kinases
EP2680850B1 (en) 2011-03-04 2018-05-23 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compound and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
DE2162327C3 (de) * 1970-12-23 1975-09-18 Sumitomo Chemical Co., Ltd., Osaka (Japan) Verfahren zur Herstellung von 3,4-Oihydro-2(1 H)-chinazolinonen
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions

Also Published As

Publication number Publication date
DE3203770A1 (de) 1982-11-11
IT8247713A1 (it) 1983-08-03
KR880001852B1 (ko) 1988-09-22
AT380476B (de) 1986-05-26
KR830009050A (ko) 1983-12-17
BE891936A (fr) 1982-07-28
JPS57158780A (en) 1982-09-30
NL8200473A (nl) 1982-10-01
IE52385B1 (en) 1987-10-14
YU42031B (en) 1988-04-30
PT74394B (en) 1984-10-22
ES8304095A1 (es) 1983-02-16
PH18529A (en) 1985-08-02
GB2094295B (en) 1984-09-12
FI71559C (fi) 1987-01-19
AU556099B2 (en) 1986-10-23
PT74394A (en) 1982-03-01
IT8247713A0 (it) 1982-02-03
HK4588A (en) 1988-01-29
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
CA1163995A (en) 1984-03-20
GB2094295A (en) 1982-09-15
AR231138A1 (es) 1984-09-28
KE3715A (en) 1987-04-16
NZ199576A (en) 1986-05-09
IT1154272B (it) 1987-01-21
HU189997B (en) 1986-08-28
GR75903B (enExample) 1984-08-02
SE8200526L (sv) 1982-09-07
YU25682A (en) 1985-03-20
SE461732B (sv) 1990-03-19
FR2501207A1 (fr) 1982-09-10
ATA39582A (de) 1985-10-15
DK159442B (da) 1990-10-15
DE3203770C2 (de) 1993-11-04
DK159442C (da) 1991-03-18
AU7998182A (en) 1982-09-09
IL64875A0 (en) 1982-03-31
FR2501207B1 (fr) 1985-12-06
CH647776A5 (de) 1985-02-15
LU83903A1 (fr) 1982-09-13
ES509434A0 (es) 1983-02-16
FI71559B (fi) 1986-10-10
DK50482A (da) 1982-09-07
JPH0337552B2 (enExample) 1991-06-05
FI820399L (fi) 1982-09-07
IE820163L (en) 1982-09-06

Similar Documents

Publication Publication Date Title
US4343940A (en) Anti-tumor quinazoline compounds
Chern et al. Studies on quinazolines. 5. 2, 3-Dihydroimidazo [1, 2-c] quinazoline derivatives: a novel class of potent and selective. alpha. 1-adrenoceptor antagonists and antihypertensive agents
FI68398B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara tetrazolylalkoxikarbostyrilderivat
CA1215712A (en) Ortho substituted dihydroxy-2(1h) quinazolinone-1- alkanoic acids
AU708809B2 (en) 6-aryl pyrazolo{3,4-d}pyrimidin-4-ones and compositions and methods of use thereof
WO1995003279A1 (en) Sulfonamide and sulfonic ester derivatives each having tricyclic hetero ring
PL125321B1 (en) Process for preparing novel,condensed derivatives of pyrimidines
GB2173195A (en) Pharmaceutical compositions
EP0156331B1 (en) Benzofuran derivatives, processes for preparing the same and antihypertensive agents containing the same
CA1173033A (en) Process of preparing basically substituted pyridazines and their use
US4053600A (en) Tricyclic 1,2,4-triazolo-quinazolines
US4228167A (en) Diuretic and vasodilating tricyclic quinazolines
US4617392A (en) 4-alkyl-5,6-methylenedioxy-2-1[H]-quinazolinones useful as cardiotonic agents
CN115850237B (zh) 一种吲哚衍生物的合成方法
CA1103664A (en) Oxazolidinedione derivatives of vinca alkaloids
GB2142625A (en) Piperazino-quinazolines
AU2002342752B2 (en) Polycyclic compounds having anti-tumor activity
CN101619063B (zh) 具有抗肿瘤活性的3,7,8-多取代吡啶并[4,3-d]嘧啶衍生物及制备
US4536504A (en) Hexahydrodioxopyrimidines, their production and use
Mátyus et al. Synthesis of some novel 2‐phenylpyridazino [4, 5‐b][1, 5] thiazepines
JPH05504945A (ja) 四環状イミダゾキナゾリン誘導体、その製法及び製薬組成物
JPH01110680A (ja) １，２，３，４−テトラヒドロイソキノリン抗不整脈薬
CN121378290A (zh) 一种螺噻唑酮四氢吡啶化合物的合成方法
Wang et al. An improved synthesis of reduced 9-arylacridine-1, 8-diones from 3-amino-5, 5-dimethylcyclohex-2-enone, arylaldehydes and 1, 3-dicarbonyl compounds in aqueous medium
GB1567997A (en) Biologically active tetracyclic compounds and pharmaceutical compositions containing same