DE2827566A1 - 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung - Google Patents

1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung

Info

Publication number
DE2827566A1
DE2827566A1 DE19782827566 DE2827566A DE2827566A1 DE 2827566 A1 DE2827566 A1 DE 2827566A1 DE 19782827566 DE19782827566 DE 19782827566 DE 2827566 A DE2827566 A DE 2827566A DE 2827566 A1 DE2827566 A1 DE 2827566A1
Authority
DE
Germany
Prior art keywords
dihydro
general formula
radical
hydrogen
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19782827566
Other languages
German (de)
English (en)
Inventor
Walter-Gunar Dr Rer Nat Friebe
Wolfgang Dr Rer Nat Kampe
Androniki Dr Med Roesch
Otto-Henning Dr Rer N Wilhelms
Werner Dr Rer Nat Winter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE19782827566 priority Critical patent/DE2827566A1/de
Priority to US06/045,472 priority patent/US4234585A/en
Priority to EP79101827A priority patent/EP0006506B1/de
Priority to DE7979101827T priority patent/DE2960820D1/de
Priority to AT79101827T priority patent/ATE224T1/de
Priority to CA000329712A priority patent/CA1122218A/en
Priority to IL57577A priority patent/IL57577A/xx
Priority to PL1979216409A priority patent/PL115260B1/pl
Priority to ES481729A priority patent/ES481729A1/es
Priority to CS798953A priority patent/CS207799B2/cs
Priority to CS794286A priority patent/CS207798B2/cs
Priority to HU79BO1793A priority patent/HU177959B/hu
Priority to JP7823079A priority patent/JPS552693A/ja
Priority to SU792782353A priority patent/SU831077A3/ru
Publication of DE2827566A1 publication Critical patent/DE2827566A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DE19782827566 1978-06-23 1978-06-23 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung Withdrawn DE2827566A1 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE19782827566 DE2827566A1 (de) 1978-06-23 1978-06-23 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
US06/045,472 US4234585A (en) 1978-06-23 1979-06-04 1,2-Dihydroquinoline-2-one derivatives
EP79101827A EP0006506B1 (de) 1978-06-23 1979-06-08 1,2-Dihydro-chinolin-2-on-Derivate, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel
DE7979101827T DE2960820D1 (en) 1978-06-23 1979-06-08 Carbostyrile derivatives, processes for their preparation and pharmaceutical compositions containing them
AT79101827T ATE224T1 (de) 1978-06-23 1979-06-08 1,2-dihydro-chinolin-2-on-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel.
CA000329712A CA1122218A (en) 1978-06-23 1979-06-13 1,2-dihydroquinolin-2-one derivatives
IL57577A IL57577A (en) 1978-06-23 1979-06-17 1,2-dihydroquinolin-2-one derivatives,processes for their preparation and pharmaceutical compositions containing the same
PL1979216409A PL115260B1 (en) 1978-06-23 1979-06-18 Process for preparing novel derivatives of 1,2-dihydroquinolin-2-one
ES481729A ES481729A1 (es) 1978-06-23 1979-06-20 Procedimiento para la preparacion de derivados de 1,2-dihi- droquinolein-2-onas.
CS798953A CS207799B2 (en) 1978-06-23 1979-06-21 Method of making the derivatives of the 1,2-dihydrochinoline-2-on
CS794286A CS207798B2 (en) 1978-06-23 1979-06-21 Method of making the derivatives of the 1,2-dihydrochinoline-2-on
HU79BO1793A HU177959B (en) 1978-06-23 1979-06-22 Process for producing 1,2-dihydro-quinoline-2-one derivatives
JP7823079A JPS552693A (en) 1978-06-23 1979-06-22 1*22dihydrooquinolinee22one derivative*its manufacture and allurgic affection therapeutic drug containing it
SU792782353A SU831077A3 (ru) 1978-06-23 1979-06-22 Способ получени 1,2-дигидрохино-ли-2-OHOB или иХ СОлЕй (ЕгО ВАРиАН-Ты)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782827566 DE2827566A1 (de) 1978-06-23 1978-06-23 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DE2827566A1 true DE2827566A1 (de) 1980-01-10

Family

ID=6042551

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19782827566 Withdrawn DE2827566A1 (de) 1978-06-23 1978-06-23 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
DE7979101827T Expired DE2960820D1 (en) 1978-06-23 1979-06-08 Carbostyrile derivatives, processes for their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE7979101827T Expired DE2960820D1 (en) 1978-06-23 1979-06-08 Carbostyrile derivatives, processes for their preparation and pharmaceutical compositions containing them

Country Status (12)

Country Link
US (1) US4234585A (enExample)
EP (1) EP0006506B1 (enExample)
JP (1) JPS552693A (enExample)
AT (1) ATE224T1 (enExample)
CA (1) CA1122218A (enExample)
CS (2) CS207798B2 (enExample)
DE (2) DE2827566A1 (enExample)
ES (1) ES481729A1 (enExample)
HU (1) HU177959B (enExample)
IL (1) IL57577A (enExample)
PL (1) PL115260B1 (enExample)
SU (1) SU831077A3 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2912105A1 (de) 1978-03-30 1979-10-11 Otsuka Pharma Co Ltd Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel
EP0753515A3 (en) * 1995-07-10 1997-01-22 Senju Pharmaceutical Co., Ltd. Benzylpiperazine derivatives as antiallergic and anti-inflammatory agents

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55162774A (en) * 1979-06-06 1980-12-18 Otsuka Pharmaceut Co Ltd Carbostyril derivative
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
DE3033112A1 (de) * 1980-09-03 1982-04-01 Hochtemperatur-Reaktorbau GmbH, 5000 Köln Atomkernreaktor
JPS57130210A (en) * 1981-02-06 1982-08-12 Kinseishiya Kk Power switch noise remover for audio appliance
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2
DE3225169A1 (de) * 1982-07-06 1984-01-12 Basf Ag, 6700 Ludwigshafen Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von pilzen
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3442570A1 (de) * 1984-11-22 1986-05-22 Hoechst Ag, 6230 Frankfurt Neue substituierte phenylpiperazinderivate, verfahren zu deren herstellung und die verwendung substituierter phenylpiperazinderivate als aggressionshemmer fuer tiere
GB8502267D0 (en) * 1985-01-30 1985-02-27 Pfizer Ltd Quinolone inotropic agents
JPS63119467A (ja) * 1987-10-21 1988-05-24 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JP2608788B2 (ja) * 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
US5457099A (en) * 1992-07-02 1995-10-10 Sawai Pharmaceutical Co., Ltd. Carbostyril derivatives and antiallergic agent
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
GB0203778D0 (en) * 2002-02-18 2002-04-03 Glaxo Group Ltd Compounds
CN100497325C (zh) * 2004-04-21 2009-06-10 齐鲁制药有限公司 哌嗪衍生物及其在制备喹啉酮衍生物中的用途
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
CN101538252B (zh) * 2008-03-20 2011-04-20 成都康弘药业集团股份有限公司 阿立哌唑的制备方法及其中间体
CN103025318B (zh) 2010-08-24 2016-07-06 大塚制药株式会社 含有喹啉酮衍生物、和硅油和/或硅油衍生物的悬浮液和块状组合物
EP2847193B1 (en) * 2012-05-09 2019-08-07 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
CN109180577B (zh) * 2018-10-15 2021-11-16 迪嘉药业集团有限公司 一种阿立哌唑的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH523899A (de) * 1968-07-05 1972-06-15 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des 2-Oxo-1,2-dihydro-chinolins
JPS48103590A (enExample) * 1972-04-13 1973-12-25
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
GB1501149A (en) * 1975-07-11 1978-02-15 Nisshin Flour Milling Co Isocarbostyril derivatives
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS55124766A (en) * 1979-03-20 1980-09-26 Otsuka Pharmaceut Co Ltd Antihistaminic

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2912105A1 (de) 1978-03-30 1979-10-11 Otsuka Pharma Co Ltd Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel
DE2953723C2 (de) * 1978-03-30 1989-01-12 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel
EP0753515A3 (en) * 1995-07-10 1997-01-22 Senju Pharmaceutical Co., Ltd. Benzylpiperazine derivatives as antiallergic and anti-inflammatory agents
US5789409A (en) * 1995-07-10 1998-08-04 Senju Pharmaceutical Co., Ltd. Benzylpiperazine derivative

Also Published As

Publication number Publication date
ATE224T1 (de) 1981-10-15
IL57577A (en) 1982-03-31
ES481729A1 (es) 1980-03-01
US4234585A (en) 1980-11-18
SU831077A3 (ru) 1981-05-15
CS207799B2 (en) 1981-08-31
CS207798B2 (en) 1981-08-31
HU177959B (en) 1982-02-28
EP0006506B1 (de) 1981-09-16
EP0006506A1 (de) 1980-01-09
IL57577A0 (en) 1979-10-31
JPS6331465B2 (enExample) 1988-06-23
PL216409A1 (enExample) 1980-03-24
JPS552693A (en) 1980-01-10
PL115260B1 (en) 1981-03-31
CA1122218A (en) 1982-04-20
DE2960820D1 (en) 1981-12-03

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee