DE2655883C2 - - Google Patents

Info

Publication number
DE2655883C2
DE2655883C2 DE2655883A DE2655883A DE2655883C2 DE 2655883 C2 DE2655883 C2 DE 2655883C2 DE 2655883 A DE2655883 A DE 2655883A DE 2655883 A DE2655883 A DE 2655883A DE 2655883 C2 DE2655883 C2 DE 2655883C2
Authority
DE
Germany
Prior art keywords
dioxa
general formula
bis
compounds
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE2655883A
Other languages
German (de)
English (en)
Other versions
DE2655883A1 (de
Inventor
John Bedford Prof. Uddington Glasgow Schottland/Scotland Gb Stenlake
Roger David Wilmslow Cheshire Gb Waigh
George Henry Claverton Down Bath Gb Dewar
John South Shields Co. Durham Gb Urwin
Nirmal Chandra Glasgow Schottland/Scotland Gb Dhar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26265501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE2655883(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB4502876A external-priority patent/GB1579822A/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE2655883A1 publication Critical patent/DE2655883A1/de
Application granted granted Critical
Publication of DE2655883C2 publication Critical patent/DE2655883C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE19762655883 1975-12-10 1976-12-09 Quarternaere ammoniumverbindungen und verfahren zu ihrer herstellung Granted DE2655883A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5058975 1975-12-10
GB4502876A GB1579822A (en) 1976-10-29 1976-10-29 Tetrahydroisoquinolinium muscle relaxants

Publications (2)

Publication Number Publication Date
DE2655883A1 DE2655883A1 (de) 1977-06-23
DE2655883C2 true DE2655883C2 (US08124317-20120228-C00026.png) 1990-02-01

Family

ID=26265501

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762655883 Granted DE2655883A1 (de) 1975-12-10 1976-12-09 Quarternaere ammoniumverbindungen und verfahren zu ihrer herstellung

Country Status (24)

Country Link
US (1) US4179507A (US08124317-20120228-C00026.png)
JP (1) JPS6043342B2 (US08124317-20120228-C00026.png)
AT (1) AT365579B (US08124317-20120228-C00026.png)
AU (1) AU506657B2 (US08124317-20120228-C00026.png)
CA (1) CA1075241A (US08124317-20120228-C00026.png)
CH (1) CH625223A5 (US08124317-20120228-C00026.png)
CY (1) CY1217A (US08124317-20120228-C00026.png)
DD (1) DD128320A5 (US08124317-20120228-C00026.png)
DE (1) DE2655883A1 (US08124317-20120228-C00026.png)
DK (1) DK149751C (US08124317-20120228-C00026.png)
FI (1) FI61485C (US08124317-20120228-C00026.png)
FR (1) FR2334359A1 (US08124317-20120228-C00026.png)
HK (1) HK35084A (US08124317-20120228-C00026.png)
IE (1) IE44569B1 (US08124317-20120228-C00026.png)
IL (1) IL51074A (US08124317-20120228-C00026.png)
IT (1) IT1188908B (US08124317-20120228-C00026.png)
KE (1) KE3361A (US08124317-20120228-C00026.png)
LU (1) LU76355A1 (US08124317-20120228-C00026.png)
MC (1) MC1119A1 (US08124317-20120228-C00026.png)
MY (1) MY8500287A (US08124317-20120228-C00026.png)
NL (1) NL178688C (US08124317-20120228-C00026.png)
NZ (1) NZ182847A (US08124317-20120228-C00026.png)
SE (1) SE434154B (US08124317-20120228-C00026.png)
SU (1) SU718008A3 (US08124317-20120228-C00026.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4191541T1 (de) * 1990-07-13 1993-05-13 Wellcome Found Neuromuskuläre blocker

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4315935A (en) * 1980-04-14 1982-02-16 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4317826A (en) * 1980-05-27 1982-03-02 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
KR100554601B1 (ko) * 1997-03-25 2006-03-03 아베라 파마슈티칼스, 인크. 초단기 작용성 신경근 차단제인 치환된 이소퀴놀린
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
JP5213137B2 (ja) * 2006-12-06 2013-06-19 コーネル リサーチ ファウンデーション， インコーポレイテッド 中程度の持続時間の神経筋遮断剤およびそのアンタゴニスト
EP2125742A2 (en) * 2007-03-08 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
WO2008132748A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
AU2008273724B2 (en) * 2007-05-01 2013-05-23 Chemagis Ltd. Process for Producing Cisatracurium and Associated Intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
CN101337936B (zh) * 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
CN101337935B (zh) * 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
US20100256381A1 (en) * 2007-07-09 2010-10-07 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
US8354537B2 (en) * 2007-10-29 2013-01-15 Chemagis Ltd. R,R1-atracurium salts
EP2283005A4 (en) * 2008-05-01 2011-08-31 Chemagis Ltd CISATRACURIUM DERIVATIVES, PREPARATION AND USES THEREOF
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
EP2419409B1 (en) * 2009-04-14 2015-01-28 Glaxo Group Limited Process for the preparation of a biphenyl-2-ylcarbamic acid ester
US9220700B2 (en) 2009-08-19 2015-12-29 Cornell University Cysteine for physiological injection
EP2514754B1 (en) 2011-04-08 2013-08-21 King Saud University 6,7-dihydro-[1,3,4]thiadiazolo-[3,2-a][1,3]diazepin derivatives and pharmaceutical composition containing the same as neuromuscular blocker or skeletal muscle relaxant, and method for the preparation
CN102249998B (zh) * 2011-06-20 2013-09-25 浙江仙琚制药股份有限公司 一种制备顺苯磺酸阿曲库铵的方法
CN102898370A (zh) * 2012-11-11 2013-01-30 苏州二叶制药有限公司 注射用顺苯磺阿曲库铵
WO2018193463A1 (en) * 2017-04-21 2018-10-25 Neon Laboratories Limited An improved process for the preparation of tetrahydroisoquinoline compounds
CN114181147A (zh) * 2021-12-27 2022-03-15 上海药坦药物研究开发有限公司 一种苯磺阿曲库铵的处理方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB1125619A (en) * 1965-11-15 1968-08-28 Wellcome Found Derivatives of bis-isoquinolines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4191541T1 (de) * 1990-07-13 1993-05-13 Wellcome Found Neuromuskuläre blocker

Also Published As

Publication number Publication date
MC1119A1 (fr) 1977-08-12
KE3361A (en) 1984-02-17
IE44569B1 (en) 1982-01-13
IL51074A0 (en) 1977-02-28
FI61485B (fi) 1982-04-30
SE434154B (sv) 1984-07-09
LU76355A1 (US08124317-20120228-C00026.png) 1977-06-24
CH625223A5 (US08124317-20120228-C00026.png) 1981-09-15
US4179507A (en) 1979-12-18
CA1075241A (en) 1980-04-08
NL178688C (nl) 1986-05-01
FI61485C (fi) 1982-08-10
DD128320A5 (de) 1977-11-09
ATA908476A (de) 1981-06-15
DK149751C (da) 1987-03-23
FR2334359B1 (US08124317-20120228-C00026.png) 1981-10-16
IT1188908B (it) 1988-01-28
DE2655883A1 (de) 1977-06-23
JPS5277069A (en) 1977-06-29
FI763543A (US08124317-20120228-C00026.png) 1977-06-11
DK149751B (da) 1986-09-22
NZ182847A (en) 1979-06-08
SU718008A3 (ru) 1980-02-25
AT365579B (de) 1982-01-25
DK553676A (da) 1977-06-11
IT8048000A1 (it) 1981-08-25
AU506657B2 (en) 1980-01-17
IE44569L (en) 1977-06-10
CY1217A (en) 1984-04-06
FR2334359A1 (fr) 1977-07-08
NL178688B (nl) 1985-12-02
HK35084A (en) 1984-04-27
AU2037576A (en) 1978-06-15
SE7613824L (sv) 1977-06-11
IL51074A (en) 1980-05-30
JPS6043342B2 (ja) 1985-09-27
NL7613695A (nl) 1977-06-14
IT8048000A0 (it) 1980-02-25
MY8500287A (en) 1985-12-31

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8128 New person/name/address of the agent

Representative=s name: BERG, W., DIPL.-CHEM. DR.RER.NAT. SCHWABE, H., DIP

D2 Grant after examination
8364 No opposition during term of opposition