IL51074A - Isoquinolinium derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

Isoquinolinium derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL51074A
IL51074A IL51074A IL5107476A IL51074A IL 51074 A IL51074 A IL 51074A IL 51074 A IL51074 A IL 51074A IL 5107476 A IL5107476 A IL 5107476A IL 51074 A IL51074 A IL 51074A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
isoquinolinium
derivatives
Prior art date
Application number
IL51074A
Other languages
English (en)
Other versions
IL51074A0 (en
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26265501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL51074(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB4502876A external-priority patent/GB1579822A/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL51074A0 publication Critical patent/IL51074A0/xx
Publication of IL51074A publication Critical patent/IL51074A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18Aralkyl radicals
    • C07D217/20Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/14Preparation of carboxylic acid esters from carboxylic acid halides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL51074A 1975-12-10 1976-12-09 Isoquinolinium derivatives,their preparation and pharmaceutical compositions containing them IL51074A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5058975 1975-12-10
GB4502876A GB1579822A (en) 1976-10-29 1976-10-29 Tetrahydroisoquinolinium muscle relaxants

Publications (2)

Publication Number Publication Date
IL51074A0 IL51074A0 (en) 1977-02-28
IL51074A true IL51074A (en) 1980-05-30

Family

ID=26265501

Family Applications (1)

Application Number Title Priority Date Filing Date
IL51074A IL51074A (en) 1975-12-10 1976-12-09 Isoquinolinium derivatives,their preparation and pharmaceutical compositions containing them

Country Status (24)

Country Link
US (1) US4179507A (xx)
JP (1) JPS6043342B2 (xx)
AT (1) AT365579B (xx)
AU (1) AU506657B2 (xx)
CA (1) CA1075241A (xx)
CH (1) CH625223A5 (xx)
CY (1) CY1217A (xx)
DD (1) DD128320A5 (xx)
DE (1) DE2655883A1 (xx)
DK (1) DK149751C (xx)
FI (1) FI61485C (xx)
FR (1) FR2334359A1 (xx)
HK (1) HK35084A (xx)
IE (1) IE44569B1 (xx)
IL (1) IL51074A (xx)
IT (1) IT1188908B (xx)
KE (1) KE3361A (xx)
LU (1) LU76355A1 (xx)
MC (1) MC1119A1 (xx)
MY (1) MY8500287A (xx)
NL (1) NL178688C (xx)
NZ (1) NZ182847A (xx)
SE (1) SE434154B (xx)
SU (1) SU718008A3 (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1125287A (en) * 1978-07-21 1982-06-08 John J. Savarese Bis isoquinolinium compositions and methods of use
US4235906A (en) 1978-07-21 1980-11-25 Massachusetts General Hospital Bis-isoquinolinium compounds, compositions and methods of use
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds
US4315935A (en) * 1980-04-14 1982-02-16 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolinolyl]disulfonylimides and antiallergic compositions and method of use
US4317826A (en) * 1980-05-27 1982-03-02 Smithkline Corporation N,N'-Bis[substituted-1,2,3,4 tetrahydroisoquinolyl]disulfonylimides and antiallergic compositions and method of use
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
GB9015473D0 (en) 1990-07-13 1990-08-29 Wellcome Found Neuromuscular blocking agents
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
US5510355A (en) * 1994-09-06 1996-04-23 Bencherif; Merouane Depolarizing skeletal muscle relaxants
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
AU745382B2 (en) 1997-03-25 2002-03-21 Cornell Research Foundation Inc. Substituted isoquinolines as ultra short acting neuromuscular blockers
GB0204087D0 (en) * 2002-02-21 2002-04-10 Legislator 1563 Ltd Di-ester derivatives as short acting neuromuscular blockers
ATE554769T1 (de) * 2006-12-06 2012-05-15 Cornell Res Foundation Inc Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
US8461338B2 (en) * 2007-03-08 2013-06-11 Chemagis Ltd. (1R, 1′R)-atracurium salts separation process
AU2008231470A1 (en) * 2007-03-26 2008-10-02 Chemagis Ltd. (1R,1'R)-atracurium salts separation process
US8357807B2 (en) * 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
CA2685491A1 (en) * 2007-05-01 2008-11-06 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
WO2009007946A1 (en) * 2007-07-09 2009-01-15 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
US8357805B2 (en) * 2007-06-18 2013-01-22 Chemagis Ltd. (1R,1′R)-atracurium salts separation process
CN101337935B (zh) * 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CN101337936B (zh) * 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
WO2009057086A1 (en) * 2007-10-29 2009-05-07 Chemagis Ltd. Novel r,r'-atracurium salts
US20110185796A1 (en) * 2008-05-01 2011-08-04 Chemagis Ltd. Cisatracurium derivatives, preparation and uses thereof
US8592451B2 (en) 2009-03-17 2013-11-26 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
KR101720154B1 (ko) * 2009-04-14 2017-03-27 글락소 그룹 리미티드 바이페닐­2­일카르밤산 에스테르의 제조 방법
WO2011022491A1 (en) 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
EP2514754B1 (en) 2011-04-08 2013-08-21 King Saud University 6,7-dihydro-[1,3,4]thiadiazolo-[3,2-a][1,3]diazepin derivatives and pharmaceutical composition containing the same as neuromuscular blocker or skeletal muscle relaxant, and method for the preparation
CN102249998B (zh) * 2011-06-20 2013-09-25 浙江仙琚制药股份有限公司 一种制备顺苯磺酸阿曲库铵的方法
CN102898370A (zh) * 2012-11-11 2013-01-30 苏州二叶制药有限公司 注射用顺苯磺阿曲库铵
WO2018193463A1 (en) * 2017-04-21 2018-10-25 Neon Laboratories Limited An improved process for the preparation of tetrahydroisoquinoline compounds
CN114181147A (zh) * 2021-12-27 2022-03-15 上海药坦药物研究开发有限公司 一种苯磺阿曲库铵的处理方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB1125619A (en) * 1965-11-15 1968-08-28 Wellcome Found Derivatives of bis-isoquinolines

Also Published As

Publication number Publication date
HK35084A (en) 1984-04-27
AU506657B2 (en) 1980-01-17
DK553676A (da) 1977-06-11
DK149751C (da) 1987-03-23
JPS5277069A (en) 1977-06-29
AU2037576A (en) 1978-06-15
IT8048000A0 (it) 1980-02-25
CH625223A5 (xx) 1981-09-15
IT1188908B (it) 1988-01-28
SU718008A3 (ru) 1980-02-25
CY1217A (en) 1984-04-06
NL7613695A (nl) 1977-06-14
IE44569L (en) 1977-06-10
IL51074A0 (en) 1977-02-28
NZ182847A (en) 1979-06-08
ATA908476A (de) 1981-06-15
MC1119A1 (fr) 1977-08-12
SE434154B (sv) 1984-07-09
NL178688B (nl) 1985-12-02
FI763543A (xx) 1977-06-11
KE3361A (en) 1984-02-17
AT365579B (de) 1982-01-25
FI61485B (fi) 1982-04-30
NL178688C (nl) 1986-05-01
DE2655883A1 (de) 1977-06-23
CA1075241A (en) 1980-04-08
FR2334359A1 (fr) 1977-07-08
IE44569B1 (en) 1982-01-13
SE7613824L (sv) 1977-06-11
LU76355A1 (xx) 1977-06-24
FI61485C (fi) 1982-08-10
FR2334359B1 (xx) 1981-10-16
DK149751B (da) 1986-09-22
DD128320A5 (de) 1977-11-09
US4179507A (en) 1979-12-18
JPS6043342B2 (ja) 1985-09-27
IT8048000A1 (it) 1981-08-25
DE2655883C2 (xx) 1990-02-01
MY8500287A (en) 1985-12-31

Similar Documents

Publication Publication Date Title
IL51074A (en) Isoquinolinium derivatives,their preparation and pharmaceutical compositions containing them
IL50176A0 (en) Novel tetrahydroisoquinoline derivatives,their preparation and pharmaceutical compositions containing them
IL49238A (en) O-aminoethyl trifluoromethyl-phenyl-ketoximes, their preparation and pharmaceutical compositions containing them
IL50019A0 (en) New benzylidene derivatives,their preparation and pharmaceutical compositions containing them
IL51124A (en) Quinazolone derivatives,their preparation and pharmaceutical compositions containing them
IL49911A0 (en) New 5-aroylpyrrole derivatives,their preparation and pharmaceutical compositions containing them
IL49405A0 (en) Thieno-pyridine derivatives,their preparation and therapeutic compositions containing them
IL49359A0 (en) New erythromycin derivatives,their preparation and pharmaceutical compositions containing them
IL48806A0 (en) New biphenyloxy derivatives,their preparation and pharmaceutical compositions containing them
IL50869A (en) Heterocyclylthio-ethylimidazole derivatives,their preparation and pharmaceutical compositions containing them
IL55765A0 (en) New dihydtrophyridine derivatives,their preparation and pharmaceutical compositions containing them
IL50631A0 (en) 1-benzazolylalkyl-4-substituted-piperidines,their preparation and pharmaceutical compositions containing them
IL49422A (en) Substitutet 1-(w-triarylalkyl)-4-phenyl-4-piperidine-methanol derivatives, their preparation and pharmaceutical compositions containing them
IL49325A (en) 8-aza-11-deoxy-pge1 derivatives,their preparation and pharmaceutical compositions containing them
IL49788A0 (en) 11-desoxy-16-aryloxy-omega-pentanorprostaglandins,their preparation and pharmaceutical compositions containing them
IL53857A0 (en) New aminoalkoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
IL49629A0 (en) New derivatives of 2-phenylamino-2-imidazoline,their preparation and pharmaceutical compositions containing them
IL50335A (en) Diphenylalkylpolyamine derivatives,their preparation and pharmaceutical compositions containing them
IL50355A (en) N-tetrahydrofurfuryl noroxymorphone derivatives,their preparation and pharmaceutical compositions containing them
IL52857A (en) Oxo-benzopyrane derivatives,their preparation and pharmaceutical compositions containing them
IL49360A0 (en) New erythromycin derivatives,their preparation and pharmaceutical compositions containing them
IL50156A0 (en) New homophthalimide derivatives,their preparation and pharmaceutical compositions containing them
IL49971A0 (en) New 2-benzoypranone derivatives,their preparation and pharmaceutical compositions containing them
IL49099A0 (en) New xanthene-9-carboxylates,their preparation and pharmaceutical compositions containing them
IL51468A (en) 17 -hydroxy- -d-homosteroid derivatives,their preparation and pharmaceutical compositions containing them