DE2230383C3 - Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben - Google Patents
Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselbenInfo
- Publication number
- DE2230383C3 DE2230383C3 DE2230383A DE2230383A DE2230383C3 DE 2230383 C3 DE2230383 C3 DE 2230383C3 DE 2230383 A DE2230383 A DE 2230383A DE 2230383 A DE2230383 A DE 2230383A DE 2230383 C3 DE2230383 C3 DE 2230383C3
- Authority
- DE
- Germany
- Prior art keywords
- acid
- acid derivatives
- processes
- making
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/67—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/68—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/73—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2230383A DE2230383C3 (de) | 1971-10-01 | 1972-06-22 | Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben |
US00287114A US3781328A (en) | 1971-10-01 | 1972-09-07 | Phenoxy-alkyl-carboxylic acid compounds |
FI2626/72A FI55493C (fi) | 1971-10-01 | 1972-09-25 | Foerfarande foer framstaellning av lipidsaenkande verksamma fenoxialkylkarbonsyraderivat |
NL727212931A NL146793B (nl) | 1971-10-01 | 1972-09-25 | Werkwijze voor het bereiden van een geneesmiddel met lipide-verlagende werking, het volgens die werkwijze verkregen gevormde geneesmiddel en een werkwijze voor het bereiden van een fenoxyalkaancarbonzuurderivaat, geschikt voor de toepassing in het geneesmiddel. |
SE7212397A SE393800B (sv) | 1971-10-01 | 1972-09-26 | Forfarande for framstellning av bensoylamino-alkyl-fenoxi-alkylkarbonsyraderivat med lipidsenkande effekt |
AR244285A AR193131A1 (es) | 1971-10-01 | 1972-09-26 | Un procedimiento para la obtencion de derivados de acido fenoxialquilcarboxilico |
GB4461172A GB1359264A (en) | 1971-10-01 | 1972-09-27 | Phenoxy-alkyl-carboxylic acid derivatives ant the preparation thereof |
CH1416772A CH576427A5 (fr) | 1971-10-01 | 1972-09-27 | |
AU47233/72A AU439063B2 (en) | 1972-09-28 | New phenoxy-alkyl-carboxylic acid derivatives and the preparation thereof | |
YU2455/72A YU36291B (en) | 1971-10-01 | 1972-09-28 | Process for preparing derivatives of phenoxyalkyl-carboxylic acid |
FR7234605A FR2154739B1 (fr) | 1971-10-01 | 1972-09-29 | |
HUBO1396A HU164572B (fr) | 1971-10-01 | 1972-09-29 | |
AT840872A AT319209B (de) | 1971-10-01 | 1972-09-29 | Verfahren zur Herstellung von neuen 4-Benzamidoalkylphenoxyalkansäuren und ihren Alkylestern oder Salzen |
CA152,967A CA1010892A (en) | 1971-10-01 | 1972-09-29 | Phenoxy-alkyl-carboxylic acid derivatives and process for their preparation |
ES407208A ES407208A1 (es) | 1971-10-01 | 1972-09-30 | Procedimiento para la preparacion de derivados de acidos fenoxialcohilcarboxilicos. |
JP47098866A JPS5112618B2 (fr) | 1971-10-01 | 1972-10-02 | |
BE179642A BE857160Q (fr) | 1971-10-01 | 1977-07-26 | Derives d'acide phenoxyalcoylcarboxylique et leur procede de fabrication |
KE2755A KE2755A (en) | 1971-10-01 | 1977-08-02 | New phenoxy-alkyl-carboxylic acid derivatives and the preparation thereof |
HK418/77A HK41877A (en) | 1971-10-01 | 1977-08-11 | New phenoxy-alkyl-carboxylic acid derivates and the preparation thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19712149070 DE2149070C3 (de) | 1971-10-01 | 1971-10-01 | Phenoxyalkylcarbonsäurederivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel |
DE2230383A DE2230383C3 (de) | 1971-10-01 | 1972-06-22 | Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben |
Publications (3)
Publication Number | Publication Date |
---|---|
DE2230383A1 DE2230383A1 (de) | 1974-01-17 |
DE2230383B2 DE2230383B2 (de) | 1980-10-09 |
DE2230383C3 true DE2230383C3 (de) | 1981-12-03 |
Family
ID=25761810
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE2230383A Expired DE2230383C3 (de) | 1971-10-01 | 1972-06-22 | Phenoxyalkylcarbonsäurederivate und Verfahren zur Herstellung derselben |
Country Status (18)
Country | Link |
---|---|
US (1) | US3781328A (fr) |
JP (1) | JPS5112618B2 (fr) |
AR (1) | AR193131A1 (fr) |
AT (1) | AT319209B (fr) |
BE (1) | BE857160Q (fr) |
CA (1) | CA1010892A (fr) |
CH (1) | CH576427A5 (fr) |
DE (1) | DE2230383C3 (fr) |
ES (1) | ES407208A1 (fr) |
FI (1) | FI55493C (fr) |
FR (1) | FR2154739B1 (fr) |
GB (1) | GB1359264A (fr) |
HK (1) | HK41877A (fr) |
HU (1) | HU164572B (fr) |
KE (1) | KE2755A (fr) |
NL (1) | NL146793B (fr) |
SE (1) | SE393800B (fr) |
YU (1) | YU36291B (fr) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3864366A (en) * | 1971-12-29 | 1975-02-04 | Eastman Kodak Co | Novel acylamidophenol photographic couplers |
GB1484413A (en) * | 1974-04-18 | 1977-09-01 | Kissei Pharmaceutical | Aromatic amidocarboxylic acid derivatives |
DE2500157C2 (de) * | 1975-01-03 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung |
US4042711A (en) * | 1975-01-09 | 1977-08-16 | Boehringer Ingelheim Gmbh | Derivatives of biphenyloxy-lower alkanoic acids, salts thereof and their use as antihyperlipidemics |
AT341512B (de) * | 1975-01-09 | 1978-02-10 | Thomae Gmbh Dr K | Verfahren zur herstellung von neuen biphenylathern |
DE2517229A1 (de) * | 1975-04-18 | 1976-10-28 | Boehringer Mannheim Gmbh | Phenylalkylcarbonsaeure-derivate und verfahren zu ihrer herstellung |
DE2532420A1 (de) * | 1975-07-19 | 1977-02-03 | Boehringer Mannheim Gmbh | Phenylessigsaeure-derivate und verfahren zu ihrer herstellung |
DE2541342A1 (de) * | 1975-09-17 | 1977-03-31 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeuren und verfahren zur herstellung derselben |
DE2546996C2 (de) * | 1975-10-21 | 1984-07-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Phenoxyalkylcarbonsäure-Derivate, Verfahren zur Herstellung derselben sowie Arzneimittel, die diese Verbindungen als Wirkstoff enthalten |
US4214094A (en) * | 1977-03-30 | 1980-07-22 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-phenyl substituted-alkyl ethers and the preparation thereof |
JPS5649906B2 (en) * | 1978-05-12 | 1981-11-25 | Boehringer Mannheim Gmbh | Manufacture of alphaa*44*44chlorobenzoylaminoo ethyl**phenoxy**isoethylacetic acid |
JPS56145261A (en) * | 1980-04-10 | 1981-11-11 | Kaken Pharmaceut Co Ltd | Novel oxyacetic acid derivative, its preparation, and lowering agent of lipid in blood comprising it as active ingredient |
US4281190A (en) * | 1980-08-14 | 1981-07-28 | Morton-Norwich Products, Inc. | Process for preparing N-[2-(p-hydroxyphenyl)-ethyl]-p-chlorobenzamide |
JPS57140754A (en) * | 1981-02-24 | 1982-08-31 | Kureha Chem Ind Co Ltd | Dihydroxybenzoic acid derivative and physiologically active preparation containing the same |
ATE116284T1 (de) * | 1987-08-12 | 1995-01-15 | Sanofi Sa | Verfahren zur o-alkylierung von n- (hydroxy)aralkylphenylethanolamin. |
IL102707A (en) * | 1992-08-02 | 1996-11-14 | Cherkez Stephen | Processes for the preparation of tyramine derivatives |
US6262277B1 (en) * | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
US6083497A (en) * | 1997-11-05 | 2000-07-04 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers |
IL143944A0 (en) * | 1998-12-23 | 2002-04-21 | Searle Llc | Combinations for cardiovascular indications |
DK1140190T3 (da) | 1998-12-23 | 2002-12-23 | Searle Llc | Kombinationer af ileumgaldesyretransport-inhibitorer og galdesyre-sekvestreringsmidler til cardiovaskulære indikatorer |
WO2000038722A1 (fr) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | COMBINAISONS D'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE L'ESTER DE CHOLESTERYLE ET D'INHIBITEURS DE LA HMG CoA-REDUCTASE UTILISEES DANS LE CADRE DE TROUBLES CARDIO-VASCULAIRES |
NZ512534A (en) | 1998-12-23 | 2003-11-28 | G | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
PT1140185E (pt) | 1998-12-23 | 2003-10-31 | Searle Llc | Combinacoes de inibidores de proteina de transferencia de ester de colesterilo com agentes sequestrantes de acido biliar para indicacoes cardiovasculares |
BR9916486A (pt) * | 1998-12-23 | 2002-02-05 | Searle Llc | Combinações de inibidores do transporte de ácidos biliares no ìleo e inibidores da proteìna de transferência do ester colesteril para indicações cardiovasculares |
EP1140184B1 (fr) * | 1998-12-23 | 2003-06-04 | G.D. Searle LLC. | Combinaisons d'inhibiteurs de la proteine de transfert du cholesteryle-ester et de derives de l'acide nicotinique utilisees dans le cadre de troubles cardio-vasculaires |
NZ512537A (en) | 1998-12-23 | 2003-11-28 | G | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
EP1246792B1 (fr) * | 2000-01-13 | 2014-08-13 | Emisphere Technologies, Inc. | Composes et compositions permettant d'administrer des principes actifs |
WO2001068637A2 (fr) | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Procede de preparation de tetrahydrobenzothiepines |
WO2001068096A2 (fr) * | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Polytherapie pour la prophylaxie et le traitement d'etats et de troubles hyperlipidemiques |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
ATE374641T1 (de) * | 2001-01-26 | 2007-10-15 | Schering Corp | Kombinationen vom ppar-aktivator fenofibrat mit dem hemmer der sterol-absorption ezetimibe zur behandlung von kardiovaskulären indikationen |
ATE331512T1 (de) * | 2001-01-26 | 2006-07-15 | Schering Corp | Verwendung azetidinone-substituierter verbindungen zur behandlung der sitosterolhämie |
SI1385548T1 (sl) * | 2001-01-26 | 2007-10-31 | Schering Corp | Kombinacije zaviralca(-ev) absorpcije sterola s kardiovaskularnim(-i) sredstvom(-i) za zdravljenje vaskularnih obolenj |
EP1911462A3 (fr) | 2001-01-26 | 2011-11-30 | Schering Corporation | Combinaisons comprenant un inhibiteur d'absorption de stérol |
EP1785144A3 (fr) * | 2001-01-26 | 2007-05-23 | Shering Corporation | Combinaisons de séquestrant(s) d'acides biliaires, et inhibiteur(s) d'absorption de stérol, et traitements pour les indications vasculaires |
WO2002058685A2 (fr) * | 2001-01-26 | 2002-08-01 | Schering Corporation | Combinaisons d'acide nicotinique et de derives de ce dernier, inhibiteur(s) d'absorption de sterols et traitements de conditions vasculaires |
EP1353694B1 (fr) * | 2001-01-26 | 2007-12-19 | Schering Corporation | Combinaisons du ezetimibe et de l'aspirine pour le traitement des troubles vasculaires |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
US20030013699A1 (en) * | 2001-05-25 | 2003-01-16 | Davis Harry R. | Methods for treating alzheimer's disease and/or regulating levels of amyloid beta peptides in a subject |
US20040077625A1 (en) * | 2001-07-25 | 2004-04-22 | Tremont Samuel J. | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
ATE345793T1 (de) * | 2001-09-21 | 2006-12-15 | Schering Corp | Behandlung von xanthom mittels azetidinon- derivate als hemmer der sterol absorption |
SI1427409T1 (sl) * | 2001-09-21 | 2009-02-28 | Schering Corp | Postopki za zdravljenje ali preprečevanje vaskularnega vnetja z uporabo zaviralca(-ev) absorpcije sterola |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
JP2005518347A (ja) * | 2001-11-02 | 2005-06-23 | ジー.ディー. サール エルエルシー | 頂端ナトリウム共依存性胆汁酸輸送(asbt)およびタウロコール酸塩取り込みの阻害剤としての新規一および二フッ化ベンゾチエピン化合物 |
CA2471639A1 (fr) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Nouveaux composes d'alkyl/aryl hydroxy ou cetothiepine servant d'inhibiteurs du transport des acides biliaires de type ileal et de l'absorption de taurocholate |
US7560449B2 (en) * | 2002-11-06 | 2009-07-14 | Schering Corporation | Methods and therapeutic combinations for the treatment of demyelination |
EP1601669B1 (fr) | 2003-03-07 | 2008-12-24 | Schering Corporation | Composes d'azetidinone substitues, leurs formulations et leur utilisation pour traiter l'hypercholesterolemie |
JP2006519869A (ja) * | 2003-03-07 | 2006-08-31 | シェーリング コーポレイション | 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用 |
ES2311806T3 (es) | 2003-03-07 | 2009-02-16 | Schering Corporation | Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
GEP20084406B (en) | 2003-05-30 | 2008-06-25 | Ranbaxy Lab Ltd | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
WO2004108126A1 (fr) * | 2003-06-06 | 2004-12-16 | Snowden Pharmaceuticals, Llc | Derives d'acide fibrique convenant au traitement du syndrome colon irritable |
JP2007510659A (ja) * | 2003-11-05 | 2007-04-26 | シェーリング コーポレイション | 脂質調節剤および置換アゼチジノンの組み合わせならびに血管状態の処置 |
AU2006313430B2 (en) | 2005-11-08 | 2012-09-06 | Ranbaxy Laboratories Limited | Process for (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |
FR2898892A1 (fr) * | 2006-03-24 | 2007-09-28 | Genfit Sa | Derives de n-(phenethyl)benzamide substitues,preparation et utilisations |
FR2898894B1 (fr) * | 2006-03-24 | 2008-06-06 | Genfit Sa | Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations |
US20100210633A1 (en) * | 2006-10-12 | 2010-08-19 | Epix Delaware, Inc. | Carboxamide compounds and their use |
AR065670A1 (es) | 2007-03-09 | 2009-06-24 | Indigene Pharmaceuticals Inc | Combinacion de metformina r-(+) lipoato y agentes antihiperlipidemicos para el tratamiento de hiperglucemia diabetica y complicaciones diabeticas |
WO2009076404A1 (fr) * | 2007-12-10 | 2009-06-18 | Epix Delaware, Inc. | Composés de carboxyamide et leur utilisation comme antagonistes du récepteur ccr2de la chimiokine |
US8569282B2 (en) | 2007-12-11 | 2013-10-29 | Cytopathfinder, Inc. | Carboxamide compounds and their use |
US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
AR103624A1 (es) | 2015-02-06 | 2017-05-24 | Intercept Pharmaceuticals Inc | Composiciones farmacéuticas para terapia de combinación |
WO2019098238A1 (fr) | 2017-11-15 | 2019-05-23 | 日本ケミファ株式会社 | Activateur pour récepteur activé par les proliférateurs de peroxisomes |
SG11202113155XA (en) | 2019-05-30 | 2021-12-30 | Intercept Pharmaceuticals Inc | Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1080503A (en) * | 1965-07-02 | 1967-08-23 | Smith & Nephew | Substituted acetic acids and a process for their preparation |
-
1972
- 1972-06-22 DE DE2230383A patent/DE2230383C3/de not_active Expired
- 1972-09-07 US US00287114A patent/US3781328A/en not_active Expired - Lifetime
- 1972-09-25 NL NL727212931A patent/NL146793B/xx not_active IP Right Cessation
- 1972-09-25 FI FI2626/72A patent/FI55493C/fi active
- 1972-09-26 SE SE7212397A patent/SE393800B/xx unknown
- 1972-09-26 AR AR244285A patent/AR193131A1/es active
- 1972-09-27 CH CH1416772A patent/CH576427A5/xx not_active IP Right Cessation
- 1972-09-27 GB GB4461172A patent/GB1359264A/en not_active Expired
- 1972-09-28 YU YU2455/72A patent/YU36291B/xx unknown
- 1972-09-29 FR FR7234605A patent/FR2154739B1/fr not_active Expired
- 1972-09-29 HU HUBO1396A patent/HU164572B/hu unknown
- 1972-09-29 CA CA152,967A patent/CA1010892A/en not_active Expired
- 1972-09-29 AT AT840872A patent/AT319209B/de not_active IP Right Cessation
- 1972-09-30 ES ES407208A patent/ES407208A1/es not_active Expired
- 1972-10-02 JP JP47098866A patent/JPS5112618B2/ja not_active Expired
-
1977
- 1977-07-26 BE BE179642A patent/BE857160Q/fr not_active IP Right Cessation
- 1977-08-02 KE KE2755A patent/KE2755A/xx unknown
- 1977-08-11 HK HK418/77A patent/HK41877A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
NL146793B (nl) | 1975-08-15 |
US3781328A (en) | 1973-12-25 |
CH576427A5 (fr) | 1976-06-15 |
FI55493C (fi) | 1979-08-10 |
DE2230383A1 (de) | 1974-01-17 |
YU245572A (en) | 1980-10-31 |
FR2154739B1 (fr) | 1975-10-31 |
CA1010892A (en) | 1977-05-24 |
JPS5112618B2 (fr) | 1976-04-21 |
DE2230383B2 (de) | 1980-10-09 |
HU164572B (fr) | 1974-03-28 |
JPS4840741A (fr) | 1973-06-15 |
SE393800B (sv) | 1977-05-23 |
AU4723372A (en) | 1973-08-23 |
ES407208A1 (es) | 1975-11-01 |
GB1359264A (en) | 1974-07-10 |
FI55493B (fi) | 1979-04-30 |
BE857160Q (fr) | 1978-01-26 |
AT319209B (de) | 1974-12-10 |
KE2755A (en) | 1977-10-14 |
AR193131A1 (es) | 1973-03-30 |
FR2154739A1 (fr) | 1973-05-11 |
HK41877A (en) | 1977-08-19 |
YU36291B (en) | 1982-06-18 |
NL7212931A (fr) | 1973-04-03 |
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