DE19826517B4 - Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette - Google Patents
Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette Download PDFInfo
- Publication number
- DE19826517B4 DE19826517B4 DE19826517A DE19826517A DE19826517B4 DE 19826517 B4 DE19826517 B4 DE 19826517B4 DE 19826517 A DE19826517 A DE 19826517A DE 19826517 A DE19826517 A DE 19826517A DE 19826517 B4 DE19826517 B4 DE 19826517B4
- Authority
- DE
- Germany
- Prior art keywords
- cyclophosphamide
- film
- tablets
- coated tablets
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 title claims abstract description 23
- 229960004397 cyclophosphamide Drugs 0.000 title claims abstract description 23
- 239000007941 film coated tablet Substances 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims abstract description 8
- 239000004480 active ingredient Substances 0.000 title claims abstract description 5
- 239000002706 dry binder Substances 0.000 claims abstract 2
- 239000000945 filler Substances 0.000 claims abstract 2
- 239000000314 lubricant Substances 0.000 claims abstract 2
- 239000003826 tablet Substances 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 239000000454 talc Substances 0.000 claims description 4
- 229910052623 talc Inorganic materials 0.000 claims description 4
- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 claims description 2
- 229920002261 Corn starch Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims description 2
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000008120 corn starch Substances 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims description 2
- 229910021485 fumed silica Inorganic materials 0.000 claims description 2
- 229960001021 lactose monohydrate Drugs 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 229950002273 simeticone Drugs 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 239000004408 titanium dioxide Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- XPNLOZNCOBKRNJ-UHFFFAOYSA-N ethyl prop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C=C.COC(=O)C(C)=C XPNLOZNCOBKRNJ-UHFFFAOYSA-N 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (32)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19826517A DE19826517B4 (de) | 1998-06-15 | 1998-06-15 | Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette |
| NZ508888A NZ508888A (en) | 1998-06-15 | 1999-06-08 | Cyclophosphamide coated tablets having no preswollen starch |
| SK1858-2000A SK286185B6 (sk) | 1998-06-15 | 1999-06-08 | Obalená tableta s cyklofosfamidom a spôsob jej výroby a spôsob výroby jadier tablety |
| RU2001101903/15A RU2236231C2 (ru) | 1998-06-15 | 1999-06-08 | Таблетка циклофосфамида с пленочным покрытием (варианты) и способ ее получения, ядро таблетки и способ его получения |
| JP2000554378A JP4891478B2 (ja) | 1998-06-15 | 1999-06-08 | シクロホスファミド被覆錠剤 |
| CZ20004489A CZ302157B6 (cs) | 1998-06-15 | 1999-06-08 | Potahovaná tableta s cyklofosfamidem, zpusob její výroby a zpusob výroby tabletového jádra |
| AU45085/99A AU771284B2 (en) | 1998-06-15 | 1999-06-08 | Cyclophosphamide coated tablets |
| PCT/EP1999/003920 WO1999065499A1 (de) | 1998-06-15 | 1999-06-08 | Cyclophosphamid filmtabletten |
| HU0102788A HU226528B1 (en) | 1998-06-15 | 1999-06-08 | Cyclophosphamide coated tablets |
| IL13994499A IL139944A0 (en) | 1998-06-15 | 1999-06-08 | Cyclophosphamide coated tablets |
| CA002333682A CA2333682C (en) | 1998-06-15 | 1999-06-08 | Cyclophosphamide film-coated tablets |
| AT99927902T ATE310523T1 (de) | 1998-06-15 | 1999-06-08 | Cyclophosphamid filmtabletten |
| PL99344832A PL193398B1 (pl) | 1998-06-15 | 1999-06-08 | Tabletki powlekane warstewką zawierające cyklofosfamid oraz sposób ich wytwarzania |
| KR1020007014142A KR100679872B1 (ko) | 1998-06-15 | 1999-06-08 | 사이클로포스파미드 제피 정제 및 이의 제조방법 |
| CNB998074330A CN1177590C (zh) | 1998-06-15 | 1999-06-08 | 环磷酰胺包衣片剂 |
| DK99927902T DK1089739T3 (da) | 1998-06-15 | 1999-06-08 | Cyclophosphamid-filmtabletter |
| TR2000/03702T TR200003702T2 (tr) | 1998-06-15 | 1999-06-08 | Siklofosfamid filmi kaplanmış tabletler |
| BR9911276-0A BR9911276A (pt) | 1998-06-15 | 1999-06-08 | Comprimidos com pelìcula de ciclofosfamida |
| ES99927902T ES2255276T3 (es) | 1998-06-15 | 1999-06-08 | Comprimidos de ciclofosfamida recubiertos. |
| HK01107939.8A HK1037959B (en) | 1998-06-15 | 1999-06-08 | Cyclophosphamide coated tablets |
| EP99927902A EP1089739B1 (de) | 1998-06-15 | 1999-06-08 | Cyclophosphamid filmtabletten |
| DE59912829T DE59912829D1 (de) | 1998-06-15 | 1999-06-08 | Cyclophosphamid filmtabletten |
| TW088109644A TWI242450B (en) | 1998-06-15 | 1999-06-09 | Cyclophosphamide film-coated tablets |
| DE29921466U DE29921466U1 (de) | 1998-06-15 | 1999-06-10 | Cyclophosphamid Filmtabletten |
| CO99036819A CO5070588A1 (es) | 1998-06-15 | 1999-06-11 | Comprimidos de ciclofosfamida recubiertos con pelicula |
| ARP990102862A AR019670A1 (es) | 1998-06-15 | 1999-06-15 | Comprimidos de ciclofosfamida, provistos de una pelicula de recubrimiento |
| US09/333,256 US20010046504A1 (en) | 1998-06-15 | 1999-06-15 | Cyclophosphamide film-coated tablets |
| UA2001010222A UA75566C2 (en) | 1998-06-15 | 1999-08-06 | Cyclophosphamide tablets, tablet cores, process for their manufacture |
| IL139944A IL139944A (en) | 1998-06-15 | 2000-11-27 | Cyclophosphamide-coated tablets |
| ZA200006998A ZA200006998B (en) | 1998-06-15 | 2000-11-28 | Cyclophosphamide coated tablets. |
| NO20006325A NO325154B1 (no) | 1998-06-15 | 2000-12-12 | Belagte cyklofosfamid tabletter, fremgangsmate for fremstilling av tablettkjerner og filmtabletter samt tablettkjerne og filmtabletter oppnadd ved disse fremgangsmater |
| BG105139A BG65253B1 (bg) | 1998-06-15 | 2001-01-10 | Циклофосфамидни филмови таблети |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19826517A DE19826517B4 (de) | 1998-06-15 | 1998-06-15 | Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE19826517A1 DE19826517A1 (de) | 2000-03-02 |
| DE19826517B4 true DE19826517B4 (de) | 2006-03-23 |
Family
ID=7870877
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19826517A Expired - Fee Related DE19826517B4 (de) | 1998-06-15 | 1998-06-15 | Verfahren zur Herstellung von Filmtabletten mit Cyclophosphamid als Wirkstoff und daraus hergestellte Cyclophosphamid-Filmtablette |
| DE59912829T Expired - Lifetime DE59912829D1 (de) | 1998-06-15 | 1999-06-08 | Cyclophosphamid filmtabletten |
| DE29921466U Expired - Lifetime DE29921466U1 (de) | 1998-06-15 | 1999-06-10 | Cyclophosphamid Filmtabletten |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59912829T Expired - Lifetime DE59912829D1 (de) | 1998-06-15 | 1999-06-08 | Cyclophosphamid filmtabletten |
| DE29921466U Expired - Lifetime DE29921466U1 (de) | 1998-06-15 | 1999-06-10 | Cyclophosphamid Filmtabletten |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US20010046504A1 (enExample) |
| EP (1) | EP1089739B1 (enExample) |
| JP (1) | JP4891478B2 (enExample) |
| KR (1) | KR100679872B1 (enExample) |
| CN (1) | CN1177590C (enExample) |
| AR (1) | AR019670A1 (enExample) |
| AT (1) | ATE310523T1 (enExample) |
| AU (1) | AU771284B2 (enExample) |
| BG (1) | BG65253B1 (enExample) |
| BR (1) | BR9911276A (enExample) |
| CA (1) | CA2333682C (enExample) |
| CO (1) | CO5070588A1 (enExample) |
| CZ (1) | CZ302157B6 (enExample) |
| DE (3) | DE19826517B4 (enExample) |
| DK (1) | DK1089739T3 (enExample) |
| ES (1) | ES2255276T3 (enExample) |
| HU (1) | HU226528B1 (enExample) |
| IL (2) | IL139944A0 (enExample) |
| NO (1) | NO325154B1 (enExample) |
| NZ (1) | NZ508888A (enExample) |
| PL (1) | PL193398B1 (enExample) |
| RU (1) | RU2236231C2 (enExample) |
| SK (1) | SK286185B6 (enExample) |
| TR (1) | TR200003702T2 (enExample) |
| TW (1) | TWI242450B (enExample) |
| UA (1) | UA75566C2 (enExample) |
| WO (1) | WO1999065499A1 (enExample) |
| ZA (1) | ZA200006998B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT500063A1 (de) | 1999-11-23 | 2005-10-15 | Sandoz Ag | Beschichtete tablettenkerne |
| ES2377729T3 (es) | 2002-02-21 | 2012-03-30 | Valeant International (Barbados) Srl | Formulaciones de liberación modificada de al menos una forma de tramadol |
| DE102005008797A1 (de) * | 2005-02-25 | 2006-09-07 | Baxter International Inc., Deerfield | Trofosfamid-haltige Filmtabletten und Verfahren zu deren Herstellung |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| JO3659B1 (ar) * | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
| UA112170C2 (uk) | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
| EP2745833A1 (en) * | 2012-12-21 | 2014-06-25 | Institut Gustave Roussy | Soluble, dispersible or orodispersible tablets comprising cyclophosphamide |
| US10016447B2 (en) | 2014-09-26 | 2018-07-10 | Intas Pharmaceuticals Ltd. | Pharmaceutical composition having improved content uniformity |
| HRP20201405T1 (hr) | 2016-03-17 | 2020-11-27 | F. Hoffmann - La Roche Ag | Derivat 5-etil-4-metil-pirazol-3-karboksamida, koji djeluje kao agonist taar-a |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047246A (en) * | 1988-09-09 | 1991-09-10 | Bristol-Myers Company | Direct compression cyclophosphamide tablet |
| US5110814A (en) * | 1989-01-11 | 1992-05-05 | Asta Pharma Ag | Azelastine and its salts used to combat psoriasis |
| UA26305A (uk) * | 1990-07-16 | 1999-08-30 | Аста Медіка Аг | Таблетка, спосіб її одержаhhя, граhулят та спосіб одержаhhя граhулята |
| DE59101431D1 (de) * | 1990-07-16 | 1994-05-26 | Asta Medica Ag | Tablette und Granulat welche als Wirkstoff Mesna enthalten. |
| RO113611B1 (ro) * | 1990-08-03 | 1998-09-30 | Asta Pharma Ag | Preparate solide de ifosfamida, administrate oral si procedeu de obtinere |
| GB9115160D0 (en) * | 1991-07-12 | 1991-08-28 | Erba Carlo Spa | Methylen-oxindole derivatives and process for their preparation |
| GB9119983D0 (en) * | 1991-09-19 | 1991-11-06 | Erba Carlo Spa | Dihydropyridine derivatives useful in antitumor therapy |
| DE4433764A1 (de) * | 1994-09-22 | 1996-03-28 | Asta Medica Ag | Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit |
| JP3049095B2 (ja) * | 1996-02-22 | 2000-06-05 | サムジン ファーマシューチカル カンパニー，リミテッド | 新規抗ウイルス性置換ピリミジンジオン単素炭素環式ヌクレオシド誘導体及びその製造方法とこれを活性成分として含有する組成物 |
| JPH11322596A (ja) * | 1998-05-12 | 1999-11-24 | Shionogi & Co Ltd | 白金錯体および環状リン酸エステルアミドを含有する抗癌剤 |
| US20040034099A1 (en) * | 2002-06-27 | 2004-02-19 | Ramsey Beverly J. | Pharmaceutical composition |
-
1998
- 1998-06-15 DE DE19826517A patent/DE19826517B4/de not_active Expired - Fee Related
-
1999
- 1999-06-08 JP JP2000554378A patent/JP4891478B2/ja not_active Expired - Fee Related
- 1999-06-08 ES ES99927902T patent/ES2255276T3/es not_active Expired - Lifetime
- 1999-06-08 CA CA002333682A patent/CA2333682C/en not_active Expired - Fee Related
- 1999-06-08 DK DK99927902T patent/DK1089739T3/da active
- 1999-06-08 DE DE59912829T patent/DE59912829D1/de not_active Expired - Lifetime
- 1999-06-08 PL PL99344832A patent/PL193398B1/pl not_active IP Right Cessation
- 1999-06-08 AT AT99927902T patent/ATE310523T1/de active
- 1999-06-08 TR TR2000/03702T patent/TR200003702T2/xx unknown
- 1999-06-08 HU HU0102788A patent/HU226528B1/hu not_active IP Right Cessation
- 1999-06-08 KR KR1020007014142A patent/KR100679872B1/ko not_active Expired - Fee Related
- 1999-06-08 EP EP99927902A patent/EP1089739B1/de not_active Expired - Lifetime
- 1999-06-08 RU RU2001101903/15A patent/RU2236231C2/ru not_active IP Right Cessation
- 1999-06-08 CZ CZ20004489A patent/CZ302157B6/cs not_active IP Right Cessation
- 1999-06-08 CN CNB998074330A patent/CN1177590C/zh not_active Expired - Fee Related
- 1999-06-08 NZ NZ508888A patent/NZ508888A/en not_active IP Right Cessation
- 1999-06-08 WO PCT/EP1999/003920 patent/WO1999065499A1/de not_active Ceased
- 1999-06-08 BR BR9911276-0A patent/BR9911276A/pt not_active Application Discontinuation
- 1999-06-08 IL IL13994499A patent/IL139944A0/xx active IP Right Grant
- 1999-06-08 AU AU45085/99A patent/AU771284B2/en not_active Ceased
- 1999-06-08 SK SK1858-2000A patent/SK286185B6/sk not_active IP Right Cessation
- 1999-06-09 TW TW088109644A patent/TWI242450B/zh not_active IP Right Cessation
- 1999-06-10 DE DE29921466U patent/DE29921466U1/de not_active Expired - Lifetime
- 1999-06-11 CO CO99036819A patent/CO5070588A1/es unknown
- 1999-06-15 AR ARP990102862A patent/AR019670A1/es not_active Application Discontinuation
- 1999-06-15 US US09/333,256 patent/US20010046504A1/en not_active Abandoned
- 1999-08-06 UA UA2001010222A patent/UA75566C2/uk unknown
-
2000
- 2000-11-27 IL IL139944A patent/IL139944A/en not_active IP Right Cessation
- 2000-11-28 ZA ZA200006998A patent/ZA200006998B/en unknown
- 2000-12-12 NO NO20006325A patent/NO325154B1/no not_active IP Right Cessation
-
2001
- 2001-01-10 BG BG105139A patent/BG65253B1/bg unknown
Non-Patent Citations (1)
| Title |
|---|
| Rote Liste 1998, Snr.86012 * |
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Effective date: 20150101 |