DE19680509T1 - (-)-(3R)-3-Methyl-4-(4-(4-(4pyridyl)piperazin-1-yl)phenoxybuttersäure als Zellaadhäsionsinhibitor - Google Patents

(-)-(3R)-3-Methyl-4-(4-(4-(4pyridyl)piperazin-1-yl)phenoxybuttersäure als Zellaadhäsionsinhibitor

Info

Publication number
DE19680509T1
DE19680509T1 DE19680509T DE19680509T DE19680509T1 DE 19680509 T1 DE19680509 T1 DE 19680509T1 DE 19680509 T DE19680509 T DE 19680509T DE 19680509 T DE19680509 T DE 19680509T DE 19680509 T1 DE19680509 T1 DE 19680509T1
Authority
DE
Germany
Prior art keywords
4pyridyl
piperazin
methyl
cell adhesion
adhesion inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19680509T
Other languages
German (de)
English (en)
Inventor
Stuart Dennett Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DE19680509T1 publication Critical patent/DE19680509T1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
DE19680509T 1995-06-01 1996-05-28 (-)-(3R)-3-Methyl-4-(4-(4-(4pyridyl)piperazin-1-yl)phenoxybuttersäure als Zellaadhäsionsinhibitor Withdrawn DE19680509T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative
PCT/GB1996/001260 WO1996038416A1 (fr) 1995-06-01 1996-05-28 Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy}butyrique inhibiteur d'adhesion cellulaire

Publications (1)

Publication Number Publication Date
DE19680509T1 true DE19680509T1 (de) 1997-12-04

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19680509T Withdrawn DE19680509T1 (de) 1995-06-01 1996-05-28 (-)-(3R)-3-Methyl-4-(4-(4-(4pyridyl)piperazin-1-yl)phenoxybuttersäure als Zellaadhäsionsinhibitor

Country Status (31)

Country Link
EP (1) EP0796247A1 (fr)
JP (1) JP2885941B2 (fr)
KR (1) KR100245957B1 (fr)
AT (1) AT406675B (fr)
AU (1) AU710105B2 (fr)
BE (1) BE1009520A5 (fr)
BR (1) BR9606409A (fr)
CA (1) CA2194397A1 (fr)
CH (1) CH691808A5 (fr)
CZ (1) CZ26997A3 (fr)
DE (1) DE19680509T1 (fr)
DK (1) DK10697A (fr)
ES (1) ES2137886B1 (fr)
FI (1) FI970393A (fr)
GB (1) GB2304340B (fr)
GR (1) GR1002702B (fr)
HU (1) HUP9700274A3 (fr)
IE (1) IE960405A1 (fr)
IL (1) IL118477A0 (fr)
IT (1) IT1290839B1 (fr)
LU (1) LU90008B1 (fr)
MC (1) MC2418A1 (fr)
MX (1) MX9700379A (fr)
NL (1) NL1003243C2 (fr)
NO (1) NO307460B1 (fr)
NZ (1) NZ308597A (fr)
PL (1) PL318440A1 (fr)
SE (1) SE510812C2 (fr)
SK (1) SK13097A3 (fr)
TR (1) TR199700020T1 (fr)
WO (1) WO1996038416A1 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (fr) * 1982-07-28 1985-03-27 The Upjohn Company Hétéroalkysylalkanoles 3-pyridinyliques, leurs acides alkanoiques et leurs esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
ZW4194A1 (en) * 1993-03-29 1994-12-21 Zeneca Ltd Heterocyclic compounds
PT825184E (pt) * 1993-03-29 2001-11-30 Astrazeneca Ab Derivados heterociclicos como inibidores de agregacao de plaquetas

Also Published As

Publication number Publication date
NO307460B1 (no) 2000-04-10
SK13097A3 (en) 1997-08-06
AU710105B2 (en) 1999-09-16
SE9700203D0 (sv) 1997-01-24
IT1290839B1 (it) 1998-12-14
JPH09512836A (ja) 1997-12-22
PL318440A1 (en) 1997-06-09
CA2194397A1 (fr) 1996-12-05
NO970437L (no) 1997-02-20
GB2304340B (en) 1998-07-29
NO970437D0 (no) 1997-01-31
AT406675B (de) 2000-07-25
NZ308597A (en) 1998-11-25
ES2137886A1 (es) 1999-12-16
JP2885941B2 (ja) 1999-04-26
ITMI961113A0 (it) 1996-05-31
EP0796247A1 (fr) 1997-09-24
GB2304340A (en) 1997-03-19
HUP9700274A3 (en) 2000-02-28
ES2137886B1 (es) 2000-08-16
ATA900596A (de) 1999-12-15
HU9700274D0 (en) 1997-04-28
NL1003243C2 (nl) 1996-12-04
GB9627127D0 (en) 1997-02-19
FI970393A0 (fi) 1997-01-30
GR1002702B (el) 1997-05-22
ITMI961113A1 (it) 1997-12-01
TR199700020T1 (tr) 1997-04-22
DK10697A (da) 1997-04-01
BR9606409A (pt) 1997-09-30
SE510812C2 (sv) 1999-06-28
LU90008B1 (fr) 1997-04-16
SE9700203L (sv) 1997-01-24
IL118477A0 (en) 1996-09-12
WO1996038416A1 (fr) 1996-12-05
FI970393A (fi) 1997-01-30
AU5827296A (en) 1996-12-18
CH691808A5 (de) 2001-10-31
CZ26997A3 (en) 1997-08-13
KR100245957B1 (ko) 2000-04-01
IE960405A1 (en) 1996-12-11
HUP9700274A2 (hu) 1999-06-28
BE1009520A5 (fr) 1997-04-01
MX9700379A (es) 1997-04-30
KR970704689A (ko) 1997-09-06
MC2418A1 (fr) 1997-05-23

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Legal Events

Date Code Title Description
8181 Inventor (new situation)

Free format text: MILLS, STUART, MACCLESFIELD, CHESHIRE, GB

8180 Miscellaneous part 1

Free format text: DIE BEZEICHNUNG IST ZU AENDERN IN: (-)-(3R)-3-METHYL-4-(4-(4-(4-PYRIDYL)PIPERAZIN-1-YL)PHENOXY)BUTTERSAEURE ALS ZELLADHAESIONSINHIBITOR

8139 Disposal/non-payment of the annual fee