DE19602095A1 - Halogenpyrimidine - Google Patents

Halogenpyrimidine

Info

Publication number
DE19602095A1
DE19602095A1 DE19602095A DE19602095A DE19602095A1 DE 19602095 A1 DE19602095 A1 DE 19602095A1 DE 19602095 A DE19602095 A DE 19602095A DE 19602095 A DE19602095 A DE 19602095A DE 19602095 A1 DE19602095 A1 DE 19602095A1
Authority
DE
Germany
Prior art keywords
carbon atoms
formula
compounds
methyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19602095A
Other languages
German (de)
English (en)
Inventor
Ulrich Dr Heinemann
Herbert Dr Gayer
Peter Dr Gerdes
Bernd-Wieland Dr Krueger
Bernd Dr Gallenkamp
Uwe Dr Stelzer
Albrecht Dr Marhold
Ralf Dr Tiemann
Stefan Dipl Ing Dutzmann
Gerd Haensler
Klaus Dr Stenzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19602095A priority Critical patent/DE19602095A1/de
Priority to IN113DE1997 priority patent/IN187450B/en
Priority to HU9900582A priority patent/HU227488B1/hu
Priority to TW86100357A priority patent/TW349001B/zh
Priority to IL12497497A priority patent/IL124974A/en
Priority to RU98116047/04A priority patent/RU2191186C2/ru
Priority to PCT/EP1997/000151 priority patent/WO1997027189A1/de
Priority to HK99102462.7A priority patent/HK1017354B/xx
Priority to AT97900603T priority patent/ATE223407T1/de
Priority to PT97900603T priority patent/PT882043E/pt
Priority to SK989-98A priority patent/SK283815B6/sk
Priority to CZ19982310A priority patent/CZ295548B6/cs
Priority to IL13566297A priority patent/IL135662A/xx
Priority to CNB031598080A priority patent/CN1213037C/zh
Priority to AU13121/97A priority patent/AU720066B2/en
Priority to CA002243591A priority patent/CA2243591C/en
Priority to UA98084522A priority patent/UA56156C2/uk
Priority to DK97900603T priority patent/DK0882043T3/da
Priority to EP97900603A priority patent/EP0882043B1/de
Priority to JP52648497A priority patent/JP3262277B2/ja
Priority to ES97900603T priority patent/ES2180021T3/es
Priority to NZ325869A priority patent/NZ325869A/xx
Priority to TR1998/01392T priority patent/TR199801392T2/xx
Priority to IL13566397A priority patent/IL135663A/en
Priority to IL13566197A priority patent/IL135661A0/xx
Priority to CN97191795A priority patent/CN1072223C/zh
Priority to KR19980705067A priority patent/KR100383906B1/ko
Priority to BR9707160A priority patent/BR9707160A/pt
Priority to MX9805742A priority patent/MX203302B/es
Priority to US09/101,791 priority patent/US6103717A/en
Priority to DE59708129T priority patent/DE59708129D1/de
Priority to PL32792497A priority patent/PL187756B1/pl
Priority to CO97002475A priority patent/CO4770925A1/es
Priority to ZA9700478A priority patent/ZA97478B/xx
Priority to IDP970165A priority patent/ID15839A/id
Publication of DE19602095A1 publication Critical patent/DE19602095A1/de
Priority to BG102622A priority patent/BG64178B1/bg
Priority to US09/560,021 priority patent/US6407233B1/en
Priority to IN551DE2000 priority patent/IN187520B/en
Priority to CNB00138063XA priority patent/CN1146550C/zh
Priority to HK02106830.9A priority patent/HK1045310A1/zh
Priority to CL200401128A priority patent/CL2004001128A1/es
Priority to NL350025C priority patent/NL350025I1/nl
Priority to FR06C0042C priority patent/FR06C0042I2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19602095A 1996-01-22 1996-01-22 Halogenpyrimidine Withdrawn DE19602095A1 (de)

Priority Applications (43)

Application Number Priority Date Filing Date Title
DE19602095A DE19602095A1 (de) 1996-01-22 1996-01-22 Halogenpyrimidine
TR1998/01392T TR199801392T2 (xx) 1996-01-22 1997-01-15 Halojenopirimidinler.
HU9900582A HU227488B1 (en) 1996-01-22 1997-01-15 Halogen pyrimidine derivatives, intermediates, preparation and use thereof as fungicides
TW86100357A TW349001B (en) 1996-01-22 1997-01-15 Halogenopyrimidines.
IL12497497A IL124974A (en) 1996-01-22 1997-01-15 Halogen pyrimidines, their preparation and preparations containing them
RU98116047/04A RU2191186C2 (ru) 1996-01-22 1997-01-15 Производные галоидпиримидина, фунгицид, способ борьбы с грибковыми заболеваниями сельскохозяйственных культур и промежуточные соединения
PCT/EP1997/000151 WO1997027189A1 (de) 1996-01-22 1997-01-15 Halogenpyrimidine und ihre verwendung als schädlingsbekämpfungsmittel
HK99102462.7A HK1017354B (en) 1996-01-22 1997-01-15 Halogen pyrimidines, their preparation and the pesticites containing the same
AT97900603T ATE223407T1 (de) 1996-01-22 1997-01-15 Halogenpyrimidine und ihre verwendung als schädlingsbekämpfungsmittel
PT97900603T PT882043E (pt) 1996-01-22 1997-01-15 Pirimidinas halogenadas e sua utilizacao como agentes de combate a parasitas
SK989-98A SK283815B6 (sk) 1996-01-22 1997-01-15 Halogénpyrimidíny, spôsob ich výroby, prostriedok na ničenie mikroorganizmov a ich použitie na ničenie mikroorganizmov
CZ19982310A CZ295548B6 (cs) 1996-01-22 1997-01-15 Halogenpyrimidiny, způsob jejich výroby, meziprodukty pro jejich výrobu a jejich použití pro potírání škůdců
IL13566297A IL135662A (en) 1996-01-22 1997-01-15 Dioxazine amide compounds
CNB031598080A CN1213037C (zh) 1996-01-22 1997-01-15 卤代嘧啶类及其作为减少寄生虫方法的应用
AU13121/97A AU720066B2 (en) 1996-01-22 1997-01-15 Halogenopyrimidines and their use as pesticides
CA002243591A CA2243591C (en) 1996-01-22 1997-01-15 Halogen pyrimidines and its use thereof as parasite abatement means
UA98084522A UA56156C2 (uk) 1996-01-22 1997-01-15 Похідні галогенопіримідинів, засіб та спосіб боротьби із шкідниками, проміжні сполуки
DK97900603T DK0882043T3 (da) 1996-01-22 1997-01-15 Halogenpyrimidiner samt deres anvendelse som midler til bekæmpelse af skadelige organismer
EP97900603A EP0882043B1 (de) 1996-01-22 1997-01-15 Halogenpyrimidine und ihre verwendung als schädlingsbekämpfungsmittel
JP52648497A JP3262277B2 (ja) 1996-01-22 1997-01-15 ハロゲノピリミジン類およびそれらの有害生物防除剤としての使用
ES97900603T ES2180021T3 (es) 1996-01-22 1997-01-15 Halogenopirimidinas y su empleo como pesticidas.
IN113DE1997 IN187450B (enExample) 1996-01-22 1997-01-15
IL13566397A IL135663A (en) 1996-01-22 1997-01-15 Dioxazine substituted phenoxy pyrimidines
NZ325869A NZ325869A (en) 1996-01-22 1997-01-15 Halogen pyrimidines and its use thereof as parasite abatement means
IL13566197A IL135661A0 (en) 1996-01-22 1997-01-15 Keto compounds
CN97191795A CN1072223C (zh) 1996-01-22 1997-01-15 卤代嘧啶类、其制备方法及含有它们的农药
KR19980705067A KR100383906B1 (ko) 1996-01-22 1997-01-15 할로겐피리미딘및기생충구제제로서의그의용도
BR9707160A BR9707160A (pt) 1996-01-22 1997-01-15 Halogenopirimidinas
MX9805742A MX203302B (enExample) 1996-01-22 1997-01-15
US09/101,791 US6103717A (en) 1996-01-22 1997-01-15 Halogen pyrimidines and its use thereof as parasite abatement means
DE59708129T DE59708129D1 (de) 1996-01-22 1997-01-15 Halogenpyrimidine und ihre verwendung als schädlingsbekämpfungsmittel
PL32792497A PL187756B1 (pl) 1996-01-22 1997-01-15 Chlorowcopirymidyny, sposób ich wytwarzania, środki do zwalczania szkodników oraz zastosowanie związków do zwalczania niepożądanych mikroorganizmów
IDP970165A ID15839A (id) 1996-01-22 1997-01-21 Halogenpirimidin-halogenpirimidin
CO97002475A CO4770925A1 (es) 1996-01-22 1997-01-21 Halogenopirimidinas
ZA9700478A ZA97478B (en) 1996-01-22 1997-01-21 Halogenopyrimidines.
BG102622A BG64178B1 (bg) 1996-01-22 1998-07-10 Халогенопиримидини и използването им като средство за борба с вредители
US09/560,021 US6407233B1 (en) 1996-01-22 2000-04-27 Halogen pyrimidines and its use thereof as parasite abatement means
IN551DE2000 IN187520B (enExample) 1996-01-22 2000-06-01
CNB00138063XA CN1146550C (zh) 1996-01-22 2000-12-27 卤代嘧啶类及其作为减少寄生虫方法的应用
HK02106830.9A HK1045310A1 (zh) 1996-01-22 2002-09-18 鹵代嘧啶類及其作為減少寄生蟲方法的應用
CL200401128A CL2004001128A1 (es) 1996-01-22 2004-05-19 Compuestos derivados de halogenopirimidinas aril eter; composicion pesticida; procedimiento de preparacion; compuestos intermediarios; y uso del compuesto como agente pesticida.
NL350025C NL350025I1 (nl) 1996-01-22 2005-12-21 Halogeenpyrimidinen met hun toepassing als bestrijdingsmiddelen tegen schadelijke organismen.
FR06C0042C FR06C0042I2 (enExample) 1996-01-22 2006-12-01

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19602095A DE19602095A1 (de) 1996-01-22 1996-01-22 Halogenpyrimidine

Publications (1)

Publication Number Publication Date
DE19602095A1 true DE19602095A1 (de) 1997-07-24

Family

ID=7783320

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19602095A Withdrawn DE19602095A1 (de) 1996-01-22 1996-01-22 Halogenpyrimidine
DE59708129T Expired - Lifetime DE59708129D1 (de) 1996-01-22 1997-01-15 Halogenpyrimidine und ihre verwendung als schädlingsbekämpfungsmittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59708129T Expired - Lifetime DE59708129D1 (de) 1996-01-22 1997-01-15 Halogenpyrimidine und ihre verwendung als schädlingsbekämpfungsmittel

Country Status (34)

Country Link
US (2) US6103717A (enExample)
EP (1) EP0882043B1 (enExample)
JP (1) JP3262277B2 (enExample)
KR (1) KR100383906B1 (enExample)
CN (3) CN1072223C (enExample)
AT (1) ATE223407T1 (enExample)
AU (1) AU720066B2 (enExample)
BG (1) BG64178B1 (enExample)
BR (1) BR9707160A (enExample)
CA (1) CA2243591C (enExample)
CL (1) CL2004001128A1 (enExample)
CO (1) CO4770925A1 (enExample)
CZ (1) CZ295548B6 (enExample)
DE (2) DE19602095A1 (enExample)
DK (1) DK0882043T3 (enExample)
ES (1) ES2180021T3 (enExample)
FR (1) FR06C0042I2 (enExample)
HK (1) HK1045310A1 (enExample)
HU (1) HU227488B1 (enExample)
ID (1) ID15839A (enExample)
IL (1) IL124974A (enExample)
IN (2) IN187450B (enExample)
MX (1) MX203302B (enExample)
NL (1) NL350025I1 (enExample)
NZ (1) NZ325869A (enExample)
PL (1) PL187756B1 (enExample)
PT (1) PT882043E (enExample)
RU (1) RU2191186C2 (enExample)
SK (1) SK283815B6 (enExample)
TR (1) TR199801392T2 (enExample)
TW (1) TW349001B (enExample)
UA (1) UA56156C2 (enExample)
WO (1) WO1997027189A1 (enExample)
ZA (1) ZA97478B (enExample)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0846691A1 (de) * 1996-12-09 1998-06-10 Bayer Ag Verfahren zur Herstellung von 3-(1-Hydroxyphenyl-1-alkoximinomethyl)dioxazinen
WO1998055454A3 (en) * 1997-06-05 1999-03-04 Takeda Chemical Industries Ltd Benzofurans and benzothophenes as suppressors of neurodegeneration
EP0972770A1 (en) * 1998-07-14 2000-01-19 American Cyanamid Company Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof
US6194590B1 (en) 1997-10-10 2001-02-27 Bayer Aktiengesellschaft Method for preparing optionally substituted benzofuranones
US6297236B1 (en) 1998-04-06 2001-10-02 Bayer Aktiengesellschaft Fungicide active substance combinations
WO2001072719A1 (de) * 2000-03-24 2001-10-04 Bayer Aktiengesellschaft Verfahren zur herstellung von unsymmetrischen 4,6-bis(aryloxy)pyrimidin-derivaten
US6306850B1 (en) 1997-04-18 2001-10-23 Bayer Aktiengesellschaft Fungicide active substance combinations
US6372737B1 (en) 1996-12-10 2002-04-16 Bayer Aktiengesellschaft Fungicidal active substance combinations
JP2002532391A (ja) * 1998-12-16 2002-10-02 バイエル アクチェンゲゼルシャフト 農薬調合物
RU2192743C2 (ru) * 1996-12-10 2002-11-20 Байер Акциенгезелльшафт Композиции из веществ с фунгицидной активностью
WO2005034628A1 (de) 2003-10-10 2005-04-21 Bayer Cropscience Aktiengesellschaft Synergistische fungizide wirkstoffkombinationen
WO2005041653A2 (de) 2003-10-23 2005-05-12 Bayer Cropscience Aktiengesellschaft Synergistische fungizide wirkstoffkombinationen
WO2007031141A1 (de) 2005-07-28 2007-03-22 Bayer Cropscience Aktiengesellschaft Synergistische fungizide wirkstoffkombinatiomen, enthaltend ein carboxamid, ein azol, ein zweiten azol oder ein strobilurin
WO2007134778A2 (de) 2006-05-18 2007-11-29 Bayer Cropscience Ag Synergistische wirkstoffkombinationen
US7470699B2 (en) 2003-07-11 2008-12-30 Arena Pharmaceuticals, Inc. Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
DE102007045920A1 (de) 2007-09-26 2009-04-09 Bayer Cropscience Ag Synergistische Wirkstoffkombinationen
EP2100506A2 (en) 2009-01-23 2009-09-16 Bayer CropScience AG Uses of fluopyram
EP2132989A2 (de) 2005-06-09 2009-12-16 Bayer CropScience AG Wirkstoffkombinationen
US7812159B2 (en) 2005-01-10 2010-10-12 Arena Pharamaceuticals, Inc. Processes for preparing aromatic ethers
EP2255648A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
WO2011006603A2 (de) 2009-07-16 2011-01-20 Bayer Cropscience Ag Synergistische wirkstoffkombinationen mit phenyltriazolen
WO2012139889A1 (en) 2011-04-13 2012-10-18 Bayer Cropscience Ag Ternary fungicidal compositions comprising a dithiino-tetracarboxamide fungicide
WO2012139886A1 (en) 2011-04-13 2012-10-18 Bayer Cropscience Ag Ternary fungicidal compositions comprising a dithiino-tetracarboxamide fungicide
US8293751B2 (en) 2003-01-14 2012-10-23 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
US8362248B2 (en) 2005-01-10 2013-01-29 Arena Pharmaceuticals, Inc. Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
EP2910126A1 (en) 2015-05-05 2015-08-26 Bayer CropScience AG Active compound combinations having insecticidal properties
EP3372079A1 (de) 2017-03-06 2018-09-12 Bayer CropScience Aktiengesellschaft Neue emulsionskonzentrate auf basis von agrochemischen wirkstoffen
US10894787B2 (en) 2010-09-22 2021-01-19 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
US11007175B2 (en) 2015-01-06 2021-05-18 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
US11884626B2 (en) 2015-06-22 2024-01-30 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compound1) for use in S1P1 receptor-associated disorders
US12156866B2 (en) 2018-06-06 2024-12-03 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19713762A1 (de) * 1997-04-03 1998-10-08 Bayer Ag Methoximinomethyldioxazine
DE19819828A1 (de) 1998-05-04 1999-11-11 Bayer Ag Methoximinomethyloxathiazine
DE19939841A1 (de) * 1998-11-20 2000-05-25 Bayer Ag Fungizide Wirkstoffkombinationen
JP2002534522A (ja) 1999-01-13 2002-10-15 ビーエーエスエフ アクチェンゲゼルシャフト アザジオキサシクロアルケン並びに有害菌類及び動物害虫の駆除のためのその使用
EP1228050A1 (de) * 1999-11-12 2002-08-07 Basf Aktiengesellschaft Azadioxacycloalkene
AU2164101A (en) * 1999-12-13 2001-06-25 Bayer Aktiengesellschaft Fungicidal combinations of active substances
DE10019758A1 (de) * 2000-04-20 2001-10-25 Bayer Ag Fungizide Wirkstoffkombinationen
DE10103832A1 (de) * 2000-05-11 2001-11-15 Bayer Ag Fungizide Wirkstoffkombinationen
DE10049804A1 (de) * 2000-10-09 2002-04-18 Bayer Ag Wirkstoffkombinationen mit fungiziden und akariziden Eigenschaften
DE10059605A1 (de) 2000-12-01 2002-06-06 Bayer Ag Fungizide Wirkstoffkombinationen
DE10209145A1 (de) * 2002-03-01 2003-09-04 Bayer Cropscience Ag Halogenbenzole
WO2003084329A1 (de) * 2002-04-05 2003-10-16 Basf Aktiengesellschaft Fungizide mischungen auf der basis von benzamidoxim-derivaten und einem strobilurin-derivat
DK1496745T3 (da) * 2002-04-10 2011-05-09 Basf Se Fremgangsmåde til forhøjelse af planters modstands-kraft over for agrokemikaliers phytotoksicitet
DE10228104A1 (de) * 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombination
DE10337885A1 (de) 2003-08-18 2005-03-24 Bayer Cropscience Ag Verfahren zur Herstellung von α-Fluormalonsäuredialkylestern
DE10343872A1 (de) * 2003-09-23 2005-04-21 Bayer Cropscience Ag Suspensionskonzentrate
AU2005237235B8 (en) 2004-04-30 2010-10-21 Basf Aktiengesellschaft Fungicidal mixtures
DE102004033525A1 (de) * 2004-07-08 2006-02-02 Lanxess Deutschland Gmbh Verbessertes Verfahren zur Herstellung kernfluorierter Aromaten
DE102004040702B4 (de) 2004-08-23 2019-03-28 Bayer Cropscience Aktiengesellschaft Verfahren zur Herstellung eines Dioxazin-Derivats
DE102004049761A1 (de) * 2004-10-12 2006-04-13 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
BRPI0606987B8 (pt) 2005-02-22 2019-04-09 Basf Ag misturas pesticidas, métodos para melhorar a saúde de plantas, método de controle ou de prevenção de infestação por fungos em plantas, partes das plantas, sementes, ou em seu local de crescimento e método de proteção de sementes
DE102005015677A1 (de) 2005-04-06 2006-10-12 Bayer Cropscience Ag Synergistische fungizide Wirkstoffkombinationen
CN100443463C (zh) * 2005-06-28 2008-12-17 沈阳化工研究院 取代的对三氟甲基苯醚类化合物及其制备与应用
AU2006307966B2 (en) * 2005-10-28 2012-03-22 Basf Se Method of inducing resistance to harmful fungi
BRPI0708713A2 (pt) * 2006-03-10 2011-06-07 Basf Se uso de um composto ativo, e, método para melhorar a toleráncia das plantas às baixas temperaturas
BRPI0708283A2 (pt) * 2006-03-14 2011-05-24 Basf Se método para induzir toleráncia contra bacterioses de plantas, e, uso das combinações
AU2007229569B2 (en) 2006-03-24 2012-07-12 Basf Se Method for combating phytopathogenic fungi
EP2489265A3 (en) 2006-09-18 2012-10-24 Basf Se Pesticidal mixtures comprising an anthranilamide insecticide and a fungicide
BR122019020360B1 (pt) 2007-02-06 2020-08-18 Basf Se misturas, composição pesticida, método para controlar fungos nocivos fitopatogênicos, método para proteger plantas do ataque ou infestação pelos insetos, acarídeos ou nematódeos e método para proteger semente
CL2008001181A1 (es) 2007-04-23 2009-10-23 Basf Se Metodo para mejorar la salud de la planta y/o controlar plagas en plantas con al menos una modificacion transgenica relacionada con el aumento del rendimiento que consiste en la aplicacion de una composicion quimica que comprende al menos un ingrediente activo seleccionado de insecticidas, fungicidas o herbicidas.
EP2000030A1 (de) * 2007-06-06 2008-12-10 Bayer CropScience AG Fungizide Wirkstoffkombinationen
NZ581625A (en) * 2007-06-29 2012-08-31 Basf Se Strobilurins for increasing the resistance of plants to abiotic stress
JP2010540495A (ja) 2007-09-26 2010-12-24 ビーエーエスエフ ソシエタス・ヨーロピア ボスカリド及びクロロタロニルを含む三成分殺菌組成物
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UA104887C2 (uk) 2009-03-25 2014-03-25 Баєр Кропсаєнс Аг Синергічні комбінації активних речовин
WO2011026796A1 (en) 2009-09-01 2011-03-10 Basf Se Synergistic fungicidal mixtures comprising lactylates and method for combating phytopathogenic fungi
US20130267476A1 (en) 2010-12-20 2013-10-10 Basf Se Pesticidal Active Mixtures Comprising Pyrazole Compounds
EP2481284A3 (en) 2011-01-27 2012-10-17 Basf Se Pesticidal mixtures
JP6049684B2 (ja) 2011-03-23 2016-12-21 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ イミダゾリウム基を含むポリマーのイオン性化合物を含有する組成物
EP2750507A2 (en) 2011-09-02 2014-07-09 Basf Se Agricultural mixtures comprising arylquinazolinone compounds
CN102396484A (zh) * 2011-12-03 2012-04-04 陕西美邦农药有限公司 一种含异菌脲和甲氧基丙烯酸酯类的杀菌组合物
CN102640758B (zh) * 2012-04-24 2013-11-13 杭州宇龙化工有限公司 一种含有噻呋酰胺与氟嘧菌酯的杀菌组合物
CN103371153B (zh) * 2012-04-28 2016-12-14 陕西韦尔奇作物保护有限公司 含噻呋酰胺与甲氧基丙烯酸酯类的杀菌组合物
PL3300602T3 (pl) 2012-06-20 2020-08-24 Basf Se Mieszaniny szkodnikobójcze zawierające związek pirazolowy
WO2014056780A1 (en) 2012-10-12 2014-04-17 Basf Se A method for combating phytopathogenic harmful microbes on cultivated plants or plant propagation material
WO2014095994A1 (en) 2012-12-20 2014-06-26 Basf Se Compositions comprising a triazole compound
EP2783569A1 (en) 2013-03-28 2014-10-01 Basf Se Compositions comprising a triazole compound
US9193698B2 (en) * 2013-07-08 2015-11-24 Advinus Therapeutics, Ltd. Process for preparing fluoxastrobin
EP2835052A1 (en) 2013-08-07 2015-02-11 Basf Se Fungicidal mixtures comprising pyrimidine fungicides
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
CA2923101A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
CN104430366A (zh) * 2013-09-24 2015-03-25 中国中化股份有限公司 取代芳醚类化合物作为抗植物病毒剂的应用
CN105284832A (zh) * 2014-05-29 2016-02-03 深圳诺普信农化股份有限公司 杀菌组合物
EP2979549A1 (en) 2014-07-31 2016-02-03 Basf Se Method for improving the health of a plant
CN104186501A (zh) * 2014-09-22 2014-12-10 江苏省绿盾植保农药实验有限公司 一种含有叶菌唑和氟嘧菌酯的杀菌组合物及其应用
JP2017538860A (ja) 2014-10-24 2017-12-28 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 固体粒子の表面荷電を改変するための、非両性の四級化可能な水溶性ポリマー
CN106543163A (zh) * 2016-11-08 2017-03-29 佛山市飞时达新材料科技有限公司 一种氟嘧菌酯半抗原的制备方法及其应用
WO2020212928A1 (en) * 2019-04-18 2020-10-22 Upl Limited Process for the preparation of fungicidally active strobilurin compounds and intermediates thereof
CA3136908A1 (en) 2019-04-18 2020-10-22 Upl Limited Process for preparation of azoxystrobin and intermediates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903019D0 (en) * 1989-02-10 1989-03-30 Ici Plc Fungicides
JPH02233602A (ja) 1989-03-08 1990-09-17 Hokko Chem Ind Co Ltd 除草剤
JP3188286B2 (ja) 1991-08-20 2001-07-16 塩野義製薬株式会社 フェニルメトキシイミノ化合物およびそれを用いる農業用殺菌剤
GB9307247D0 (en) 1993-04-07 1993-06-02 Zeneca Ltd Fungicidal compounds
DE4408005A1 (de) * 1993-08-11 1995-02-16 Bayer Ag Substituierte Azadioxacycloalkene
ZW8594A1 (en) * 1993-08-11 1994-10-12 Bayer Ag Substituted azadioxacycbalkenes
DE19501842A1 (de) * 1995-01-23 1996-07-25 Bayer Ag Substituierte Arylazadioxacycloalkene
DE19526047C1 (de) 1995-07-17 1997-03-06 Hoechst Ag Verfahren zur Herstellung sekundärer Arylphosphane

Cited By (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335454B1 (en) 1996-12-09 2002-01-01 Bayer Aktiengesellschaft Process for preparing 3-(1-hydroxphenyl-1-alkoximinomethyl)dioxazines
EP0846691A1 (de) * 1996-12-09 1998-06-10 Bayer Ag Verfahren zur Herstellung von 3-(1-Hydroxyphenyl-1-alkoximinomethyl)dioxazinen
US6005104A (en) * 1996-12-09 1999-12-21 Bayer Aktiengesellschaft Process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl) dioxazines
US6437153B1 (en) 1996-12-09 2002-08-20 Bayer Aktiengesellschaft Process for preparing 3-(1-hydroxyphenyl-1-alkoximinomethyl)dioxazines
RU2192743C2 (ru) * 1996-12-10 2002-11-20 Байер Акциенгезелльшафт Композиции из веществ с фунгицидной активностью
US6372737B1 (en) 1996-12-10 2002-04-16 Bayer Aktiengesellschaft Fungicidal active substance combinations
US6509343B1 (en) 1996-12-10 2003-01-21 Bayer Aktiengesellschaft Fungicidal active substance combinations
US8637534B2 (en) 1997-04-18 2014-01-28 Bayer Intellectual Property Gmbh Fungicide active substance combinations
US6306850B1 (en) 1997-04-18 2001-10-23 Bayer Aktiengesellschaft Fungicide active substance combinations
US8846738B2 (en) 1997-04-18 2014-09-30 Bayer Intellectual Property Gmbh Fungicide active substance combinations
US9253982B2 (en) 1997-04-18 2016-02-09 Bayer Intellectual Property Gmbh Fungicide active substance combinations
US9445601B2 (en) 1997-04-18 2016-09-20 Bayer Intellectual Property Gmbh Fungicide active substance combinations
WO1998055454A3 (en) * 1997-06-05 1999-03-04 Takeda Chemical Industries Ltd Benzofurans and benzothophenes as suppressors of neurodegeneration
US7008950B1 (en) 1997-06-05 2006-03-07 Takeda Chemical Industries, Ltd. Benzofurans as suppressors of neurodegeneration
US6194590B1 (en) 1997-10-10 2001-02-27 Bayer Aktiengesellschaft Method for preparing optionally substituted benzofuranones
US6297236B1 (en) 1998-04-06 2001-10-02 Bayer Aktiengesellschaft Fungicide active substance combinations
EP0972770A1 (en) * 1998-07-14 2000-01-19 American Cyanamid Company Acaricidal and insecticidal substituted pyrimidines and a process for the preparation thereof
JP2002532391A (ja) * 1998-12-16 2002-10-02 バイエル アクチェンゲゼルシャフト 農薬調合物
WO2001072719A1 (de) * 2000-03-24 2001-10-04 Bayer Aktiengesellschaft Verfahren zur herstellung von unsymmetrischen 4,6-bis(aryloxy)pyrimidin-derivaten
US6734304B2 (en) 2000-03-24 2004-05-11 Bayer Aktiengesellschaft Method for producing asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives
US8293751B2 (en) 2003-01-14 2012-10-23 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
US8933083B2 (en) 2003-01-14 2015-01-13 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
US7838525B2 (en) 2003-07-11 2010-11-23 Arena Pharmaceuticals, Inc. Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
US7470699B2 (en) 2003-07-11 2008-12-30 Arena Pharmaceuticals, Inc. Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
US8546429B2 (en) 2003-07-11 2013-10-01 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
EP2220939A2 (de) 2003-10-10 2010-08-25 Bayer CropScience AG Synergistische fungizide Wirkstoffkombinationen
US9844220B2 (en) 2003-10-10 2017-12-19 Fmc Corporation Synergistic fungicidal active substance combinations
EP2220936A2 (de) 2003-10-10 2010-08-25 Bayer CropScience AG Synergistische fungizide Wirkstoffkombinationen
EP2220938A2 (de) 2003-10-10 2010-08-25 Bayer CropScience AG Synergistische fungizide Wirkstoffkombinationen
EP2220937A2 (de) 2003-10-10 2010-08-25 Bayer CropScience AG Synergistische fungizide Wirkstoffkombinationen
EP2229815A2 (de) 2003-10-10 2010-09-22 Bayer CropScience AG Synergistische fungizide Wirkstoffkombinationen
US8415274B2 (en) 2003-10-10 2013-04-09 Bayer Cropscience Ag Synergistic fungicidal active substance combinations
EP2220935A2 (de) 2003-10-10 2010-08-25 Bayer CropScience AG Synergistische fungizide Wirkstoffkombinationen
US9006143B2 (en) 2003-10-10 2015-04-14 Bayer Intellectual Property Gmbh Synergistic fungicidal active substance combinations
EP2220940A2 (de) 2003-10-10 2010-08-25 Bayer CropScience AG Synergistische fungizide Wirkstoffkombinationen
US9288988B2 (en) 2003-10-10 2016-03-22 Fmc Corporation Synergistic fungicidal active substance combinations
US9049867B2 (en) 2003-10-10 2015-06-09 Bayer Intellectual Property Gmbh Synergistic fungicidal active substance combinations
WO2005034628A1 (de) 2003-10-10 2005-04-21 Bayer Cropscience Aktiengesellschaft Synergistische fungizide wirkstoffkombinationen
EP2796043A1 (de) 2003-10-23 2014-10-29 Bayer CropScience AG Synergistische fungizide Wirkstoffkombinationen
WO2005041653A2 (de) 2003-10-23 2005-05-12 Bayer Cropscience Aktiengesellschaft Synergistische fungizide wirkstoffkombinationen
EP2364592A1 (de) 2003-10-23 2011-09-14 Bayer Cropscience AG Synergistische fungizide Wirkstoffkombinationen
EP2356905A1 (de) 2003-10-23 2011-08-17 Bayer Cropscience AG Synergistische fungizide Wirkstoffkombinationen
EP2356906A1 (de) 2003-10-23 2011-08-17 Bayer Cropscience AG Synergistische fungizide Wirkstoffkombinationen
US7812159B2 (en) 2005-01-10 2010-10-12 Arena Pharamaceuticals, Inc. Processes for preparing aromatic ethers
US8362248B2 (en) 2005-01-10 2013-01-29 Arena Pharmaceuticals, Inc. Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
EP2255658A1 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255654A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255651A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255659A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255644A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255657A1 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255649A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255647A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2258197A1 (de) 2005-06-09 2010-12-08 Bayer CropScience AG Wirkstoffkombinationen
EP2258198A1 (de) 2005-06-09 2010-12-08 Bayer CropScience AG Wirkstoffkombinationen
EP2258196A2 (de) 2005-06-09 2010-12-08 Bayer CropScience AG Wirkstoffkombinationen
EP2260711A2 (de) 2005-06-09 2010-12-15 Bayer CropScience AG Wirkstoffkombinationen
EP2260709A1 (de) 2005-06-09 2010-12-15 Bayer CropScience AG Wirkstoffkombinationen
EP2260710A1 (de) 2005-06-09 2010-12-15 Bayer CropScience AG Wirkstoffkombinationen
EP2263463A1 (de) 2005-06-09 2010-12-22 Bayer CropScience AG Wirkstoffkombinationen
EP2263462A1 (de) 2005-06-09 2010-12-22 Bayer CropScience AG Wirkstoffkombinationen
EP2269460A1 (de) 2005-06-09 2011-01-05 Bayer CropScience AG Wirkstoffkombinationen
EP2272369A1 (de) 2005-06-09 2011-01-12 Bayer CropScience AG Wirkstoffkombinationen
EP2272368A1 (de) 2005-06-09 2011-01-12 Bayer CropScience AG Wirkstoffkombinationen
EP2132989A2 (de) 2005-06-09 2009-12-16 Bayer CropScience AG Wirkstoffkombinationen
EP2279664A1 (de) 2005-06-09 2011-02-02 Bayer CropScience AG Wirkstoffkombinationen
EP2253210A1 (de) 2005-06-09 2010-11-24 Bayer CropScience AG Wirkstoffkombinationen
EP2255656A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255646A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2253213A1 (de) 2005-06-09 2010-11-24 Bayer CropScience AG Wirkstoffkombinationen
EP2255645A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255650A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255655A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2255648A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
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EP2255652A2 (de) 2005-06-09 2010-12-01 Bayer CropScience AG Wirkstoffkombinationen
EP2253211A1 (de) 2005-06-09 2010-11-24 Bayer CropScience AG Wirkstoffkombinationen
EP2253212A1 (de) 2005-06-09 2010-11-24 Bayer CropScience AG Wirkstoffkombinationen
US8765636B2 (en) 2005-07-28 2014-07-01 Bayer Intellectual Property Gmbh Synergistic fungicidal active compound combinations containing a carboxamide, an azole, a second azole or a strobilurin
WO2007031141A1 (de) 2005-07-28 2007-03-22 Bayer Cropscience Aktiengesellschaft Synergistische fungizide wirkstoffkombinatiomen, enthaltend ein carboxamid, ein azol, ein zweiten azol oder ein strobilurin
WO2007134778A2 (de) 2006-05-18 2007-11-29 Bayer Cropscience Ag Synergistische wirkstoffkombinationen
DE102007045920B4 (de) 2007-09-26 2018-07-05 Bayer Intellectual Property Gmbh Synergistische Wirkstoffkombinationen
DE102007045920A1 (de) 2007-09-26 2009-04-09 Bayer Cropscience Ag Synergistische Wirkstoffkombinationen
EP2100506A2 (en) 2009-01-23 2009-09-16 Bayer CropScience AG Uses of fluopyram
WO2011006603A2 (de) 2009-07-16 2011-01-20 Bayer Cropscience Ag Synergistische wirkstoffkombinationen mit phenyltriazolen
US10894787B2 (en) 2010-09-22 2021-01-19 Arena Pharmaceuticals, Inc. Modulators of the GPR119 receptor and the treatment of disorders related thereto
WO2012139886A1 (en) 2011-04-13 2012-10-18 Bayer Cropscience Ag Ternary fungicidal compositions comprising a dithiino-tetracarboxamide fungicide
WO2012139889A1 (en) 2011-04-13 2012-10-18 Bayer Cropscience Ag Ternary fungicidal compositions comprising a dithiino-tetracarboxamide fungicide
US11007175B2 (en) 2015-01-06 2021-05-18 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
EP2910126A1 (en) 2015-05-05 2015-08-26 Bayer CropScience AG Active compound combinations having insecticidal properties
US11884626B2 (en) 2015-06-22 2024-01-30 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compound1) for use in S1P1 receptor-associated disorders
EP3372079A1 (de) 2017-03-06 2018-09-12 Bayer CropScience Aktiengesellschaft Neue emulsionskonzentrate auf basis von agrochemischen wirkstoffen
WO2018162389A1 (de) 2017-03-06 2018-09-13 Bayer Cropscience Aktiengesellschaft Neue emulsionskonzentrate auf basis von agrochemischen wirkstoffen
US12156866B2 (en) 2018-06-06 2024-12-03 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor

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