DE19520398B4 - Magnetisches Pigment - Google Patents
Magnetisches Pigment Download PDFInfo
- Publication number
- DE19520398B4 DE19520398B4 DE19520398A DE19520398A DE19520398B4 DE 19520398 B4 DE19520398 B4 DE 19520398B4 DE 19520398 A DE19520398 A DE 19520398A DE 19520398 A DE19520398 A DE 19520398A DE 19520398 B4 DE19520398 B4 DE 19520398B4
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acids
- sample
- particles
- composition according
- magnetic particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 230000005291 magnetic effect Effects 0.000 title description 15
- 239000000049 pigment Substances 0.000 title description 2
- 239000011521 glass Substances 0.000 claims abstract description 30
- 239000006249 magnetic particle Substances 0.000 claims abstract description 29
- 230000005294 ferromagnetic effect Effects 0.000 claims abstract description 13
- 102000039446 nucleic acids Human genes 0.000 claims description 51
- 108020004707 nucleic acids Proteins 0.000 claims description 51
- 150000007523 nucleic acids Chemical class 0.000 claims description 51
- 239000000523 sample Substances 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 24
- 238000002955 isolation Methods 0.000 claims description 15
- 230000003196 chaotropic effect Effects 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 239000000243 solution Substances 0.000 claims description 11
- 238000005406 washing Methods 0.000 claims description 11
- 239000003153 chemical reaction reagent Substances 0.000 claims description 10
- 239000012149 elution buffer Substances 0.000 claims description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical group [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 7
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims description 7
- -1 serum Substances 0.000 claims description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims description 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 4
- 230000003321 amplification Effects 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 4
- 238000006911 enzymatic reaction Methods 0.000 claims description 4
- ZJYYHGLJYGJLLN-UHFFFAOYSA-N guanidinium thiocyanate Chemical compound SC#N.NC(N)=N ZJYYHGLJYGJLLN-UHFFFAOYSA-N 0.000 claims description 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 claims description 3
- 229910001488 sodium perchlorate Inorganic materials 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 206010036790 Productive cough Diseases 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 239000000919 ceramic Substances 0.000 claims description 2
- 230000002490 cerebral effect Effects 0.000 claims description 2
- 238000003891 environmental analysis Methods 0.000 claims description 2
- 238000004186 food analysis Methods 0.000 claims description 2
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 239000006166 lysate Substances 0.000 claims description 2
- 239000002324 mouth wash Substances 0.000 claims description 2
- 229940051866 mouthwash Drugs 0.000 claims description 2
- 230000002285 radioactive effect Effects 0.000 claims description 2
- 238000000163 radioactive labelling Methods 0.000 claims description 2
- 238000011160 research Methods 0.000 claims description 2
- 238000012163 sequencing technique Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 235000009518 sodium iodide Nutrition 0.000 claims description 2
- 210000003802 sputum Anatomy 0.000 claims description 2
- 208000024794 sputum Diseases 0.000 claims description 2
- 238000013518 transcription Methods 0.000 claims description 2
- 230000035897 transcription Effects 0.000 claims description 2
- 238000013519 translation Methods 0.000 claims description 2
- 210000002700 urine Anatomy 0.000 claims description 2
- 238000010828 elution Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 abstract description 66
- 239000011148 porous material Substances 0.000 abstract description 12
- 239000012620 biological material Substances 0.000 description 29
- 210000004027 cell Anatomy 0.000 description 25
- 239000007788 liquid Substances 0.000 description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 14
- 239000008279 sol Substances 0.000 description 14
- 239000000463 material Substances 0.000 description 12
- 239000012071 phase Substances 0.000 description 12
- 230000008569 process Effects 0.000 description 12
- 238000000926 separation method Methods 0.000 description 12
- 229910004298 SiO 2 Inorganic materials 0.000 description 8
- 238000011534 incubation Methods 0.000 description 8
- 230000015572 biosynthetic process Effects 0.000 description 7
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- 238000003786 synthesis reaction Methods 0.000 description 6
- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 6
- 239000012535 impurity Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 4
- 229910010413 TiO 2 Inorganic materials 0.000 description 4
- 230000009089 cytolysis Effects 0.000 description 4
- 239000003365 glass fiber Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000007790 solid phase Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000012267 brine Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000010445 mica Substances 0.000 description 3
- 229910052618 mica group Inorganic materials 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000005373 porous glass Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 101100203596 Caenorhabditis elegans sol-1 gene Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 239000003302 ferromagnetic material Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000019833 protease Nutrition 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 241001524679 Escherichia virus M13 Species 0.000 description 1
- 229910005793 GeO 2 Inorganic materials 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- GEIAQOFPUVMAGM-UHFFFAOYSA-N ZrO Inorganic materials [Zr]=O GEIAQOFPUVMAGM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910001413 alkali metal ion Inorganic materials 0.000 description 1
- 150000004703 alkoxides Chemical class 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229910000424 chromium(II) oxide Inorganic materials 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000005308 flint glass Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000000696 magnetic material Substances 0.000 description 1
- 238000002826 magnetic-activated cell sorting Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 239000011325 microbead Substances 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 238000004537 pulping Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000005368 silicate glass Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- IUOAWALEYWGAFR-UHFFFAOYSA-M sodium iodite Chemical compound [Na+].[O-]I=O IUOAWALEYWGAFR-UHFFFAOYSA-M 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- GBNDTYKAOXLLID-UHFFFAOYSA-N zirconium(4+) ion Chemical compound [Zr+4] GBNDTYKAOXLLID-UHFFFAOYSA-N 0.000 description 1
- 229910000859 α-Fe Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/11—Glass compositions containing silica with 40% to 90% silica, by weight containing halogen or nitrogen
- C03C3/111—Glass compositions containing silica with 40% to 90% silica, by weight containing halogen or nitrogen containing nitrogen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/078—Glass compositions containing silica with 40% to 90% silica, by weight containing an oxide of a divalent metal, e.g. an oxide of zinc
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/083—Glass compositions containing silica with 40% to 90% silica, by weight containing aluminium oxide or an iron compound
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/083—Glass compositions containing silica with 40% to 90% silica, by weight containing aluminium oxide or an iron compound
- C03C3/085—Glass compositions containing silica with 40% to 90% silica, by weight containing aluminium oxide or an iron compound containing an oxide of a divalent metal
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/083—Glass compositions containing silica with 40% to 90% silica, by weight containing aluminium oxide or an iron compound
- C03C3/085—Glass compositions containing silica with 40% to 90% silica, by weight containing aluminium oxide or an iron compound containing an oxide of a divalent metal
- C03C3/087—Glass compositions containing silica with 40% to 90% silica, by weight containing aluminium oxide or an iron compound containing an oxide of a divalent metal containing calcium oxide, e.g. common sheet or container glass
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/089—Glass compositions containing silica with 40% to 90% silica, by weight containing boron
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/089—Glass compositions containing silica with 40% to 90% silica, by weight containing boron
- C03C3/091—Glass compositions containing silica with 40% to 90% silica, by weight containing boron containing aluminium
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/102—Glass compositions containing silica with 40% to 90% silica, by weight containing lead
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/102—Glass compositions containing silica with 40% to 90% silica, by weight containing lead
- C03C3/105—Glass compositions containing silica with 40% to 90% silica, by weight containing lead containing aluminium
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/102—Glass compositions containing silica with 40% to 90% silica, by weight containing lead
- C03C3/108—Glass compositions containing silica with 40% to 90% silica, by weight containing lead containing boron
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
- H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
- H01F1/0063—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use in a non-magnetic matrix, e.g. granular solids
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
- H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
- H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
- H01F1/10—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure
- H01F1/11—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles
- H01F1/112—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles with a skin
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
- H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
- H01F1/12—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials
- H01F1/34—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites
- H01F1/36—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites in the form of particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S428/00—Stock material or miscellaneous articles
- Y10S428/90—Magnetic feature
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/814—Enzyme separation or purification
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
- Y10T428/2996—Glass particles or spheres
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Geochemistry & Mineralogy (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Power Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Soft Magnetic Materials (AREA)
- Paints Or Removers (AREA)
- Developing Agents For Electrophotography (AREA)
- Glass Compositions (AREA)
- Hard Magnetic Materials (AREA)
- Pigments, Carbon Blacks, Or Wood Stains (AREA)
- Saccharide Compounds (AREA)
Priority Applications (46)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19520398A DE19520398B4 (de) | 1995-06-08 | 1995-06-08 | Magnetisches Pigment |
| DE19537985A DE19537985A1 (de) | 1995-06-08 | 1995-10-12 | Magnetisches Pigment |
| EP02016299A EP1281714B1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches Pigment |
| CA2605671A CA2605671C (en) | 1995-06-08 | 1996-06-06 | Magnetic particles with a glass surface and their use |
| ES02016299T ES2247236T3 (es) | 1995-06-08 | 1996-06-06 | Pigmento magnetico. |
| NZ311648A NZ311648A (en) | 1995-06-08 | 1996-06-06 | Magnetic pigment |
| EP05004214.2A EP1577389B2 (de) | 1995-06-08 | 1996-06-06 | Verfahren zur enzymatischen Reaktion an Nukleinsäuren |
| ES96921935T ES2197947T3 (es) | 1995-06-08 | 1996-06-06 | Pigmento magnetico. |
| EP96921935A EP0837871B1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches pigment |
| CA002607563A CA2607563A1 (en) | 1995-06-08 | 1996-06-06 | Magnetic particles with a glass surface and their use |
| DE59611440T DE59611440D1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches Pigment |
| DE59610405T DE59610405D1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches pigment |
| ES05004214T ES2290803T3 (es) | 1995-06-08 | 1996-06-06 | Pigmento magnetico. |
| DK05004214T DK1577389T3 (da) | 1995-06-08 | 1996-06-06 | Magnetisk pigment |
| JP50259397A JP3950478B2 (ja) | 1995-06-08 | 1996-06-06 | 磁性色素 |
| US08/952,969 US6255477B1 (en) | 1995-06-08 | 1996-06-06 | Particles having a magnetic core and outer glass layer for separating biological material |
| CN96195985A CN1106401C (zh) | 1995-06-08 | 1996-06-06 | 磁性色素 |
| DE59611258T DE59611258D1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches Pigment |
| AT02016299T ATE301665T1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches pigment |
| CN2006101016360A CN1974781B (zh) | 1995-06-08 | 1996-06-06 | 对核酸进行酶反应的方法及离析核酸的组合物 |
| CA002440504A CA2440504C (en) | 1995-06-08 | 1996-06-06 | Magnetic pigment |
| KR1019970709195A KR100463475B1 (ko) | 1995-06-08 | 1996-06-06 | 자기성피그먼트 |
| DK96921935T DK0837871T3 (da) | 1995-06-08 | 1996-06-06 | Magnetisk pigment |
| PCT/EP1996/002459 WO1996041811A1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches pigment |
| CA002223821A CA2223821C (en) | 1995-06-08 | 1996-06-06 | Magnetic particles with a glass surface and their use |
| AT96921935T ATE239031T1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches pigment |
| AU63007/96A AU707115B2 (en) | 1995-06-08 | 1996-06-06 | Magnetic pigment |
| AT05004214T ATE368109T1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches pigment |
| DK02016299T DK1281714T3 (da) | 1995-06-08 | 1996-06-06 | Magnetisk pigment |
| EP05004213A EP1602724A1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches Pigment |
| NO19975772A NO325384B1 (no) | 1995-06-08 | 1997-12-08 | Magnetiske partikler med ytre glassoverflate, fremstilling av partiklene og fremgangsmate for isolering av nukleinsyre ved partiklene |
| CNA200610093596XA CN1891833A (zh) | 1995-06-08 | 1999-06-06 | 对核酸进行酶反应的方法及离析核酸的组合物 |
| US09/756,743 US6870047B2 (en) | 1995-06-08 | 2001-01-10 | Magnetic pigment |
| US10/202,618 US20030135038A1 (en) | 1995-06-08 | 2002-07-23 | Magnetic pigment |
| CNB031066364A CN1267447C (zh) | 1995-06-08 | 2003-02-27 | 离析核酸的方法 |
| HK03103250.6A HK1051048B (en) | 1995-06-08 | 2003-05-07 | Magnetic pigment |
| US11/041,750 US7371830B2 (en) | 1995-06-08 | 2005-01-24 | Method for separating biological material from a fluid using magnetic particles |
| US11/128,024 US8129118B2 (en) | 1995-06-08 | 2005-05-11 | Magnetic glass particles, method for their preparation and uses thereof |
| JP2005248331A JP4456046B2 (ja) | 1995-06-08 | 2005-08-29 | 磁性色素 |
| HK05109110.1A HK1075065B (en) | 1995-06-08 | 2005-10-14 | Magnetic pigment |
| US11/638,289 US20070082360A1 (en) | 1995-06-08 | 2006-12-12 | Magnetic pigment |
| NO20072301A NO330520B1 (no) | 1995-06-08 | 2007-05-03 | Reagenspreparat til isolering av nukleinsyrer fra en prove, samt anvendelse av dette for isolering av nukleinsyrer |
| JP2009238436A JP5537894B2 (ja) | 1995-06-08 | 2009-10-15 | 磁性色素 |
| US12/957,157 US20110117561A1 (en) | 1995-06-08 | 2010-11-30 | Magnetic Pigment |
| US13/269,195 US20120022246A1 (en) | 1995-06-08 | 2011-10-07 | Magnetic Pigment |
| US13/372,218 US20120247150A1 (en) | 1995-06-08 | 2012-02-13 | Magnetic Glass Particles, Method for Their Preparation and Uses Thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19520398A DE19520398B4 (de) | 1995-06-08 | 1995-06-08 | Magnetisches Pigment |
| DE19537985A DE19537985A1 (de) | 1995-06-08 | 1995-10-12 | Magnetisches Pigment |
| CA002440504A CA2440504C (en) | 1995-06-08 | 1996-06-06 | Magnetic pigment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE19520398A1 DE19520398A1 (de) | 1996-12-12 |
| DE19520398B4 true DE19520398B4 (de) | 2009-04-16 |
Family
ID=34426455
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19520398A Revoked DE19520398B4 (de) | 1995-06-08 | 1995-06-08 | Magnetisches Pigment |
| DE19537985A Ceased DE19537985A1 (de) | 1995-06-08 | 1995-10-12 | Magnetisches Pigment |
| DE59611258T Expired - Lifetime DE59611258D1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches Pigment |
| DE59611440T Expired - Lifetime DE59611440D1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches Pigment |
| DE59610405T Expired - Lifetime DE59610405D1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches pigment |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19537985A Ceased DE19537985A1 (de) | 1995-06-08 | 1995-10-12 | Magnetisches Pigment |
| DE59611258T Expired - Lifetime DE59611258D1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches Pigment |
| DE59611440T Expired - Lifetime DE59611440D1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches Pigment |
| DE59610405T Expired - Lifetime DE59610405D1 (de) | 1995-06-08 | 1996-06-06 | Magnetisches pigment |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US6255477B1 (enExample) |
| EP (4) | EP1602724A1 (enExample) |
| JP (2) | JP3950478B2 (enExample) |
| CN (4) | CN1106401C (enExample) |
| AT (3) | ATE368109T1 (enExample) |
| AU (1) | AU707115B2 (enExample) |
| CA (4) | CA2607563A1 (enExample) |
| DE (5) | DE19520398B4 (enExample) |
| DK (3) | DK1281714T3 (enExample) |
| ES (3) | ES2197947T3 (enExample) |
| NO (2) | NO325384B1 (enExample) |
| NZ (1) | NZ311648A (enExample) |
| WO (1) | WO1996041811A1 (enExample) |
Families Citing this family (149)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
| DE19854973B4 (de) * | 1998-11-30 | 2010-02-04 | Institut Für Neue Materialien Gem. Gmbh | Verfahren zur Reinigung von Nukleinsäuren |
| KR100463475B1 (ko) * | 1995-06-08 | 2005-06-22 | 로셰 디아그노스틱스 게엠베하 | 자기성피그먼트 |
| DE19520398B4 (de) * | 1995-06-08 | 2009-04-16 | Roche Diagnostics Gmbh | Magnetisches Pigment |
| JP2965131B2 (ja) | 1995-07-07 | 1999-10-18 | 東洋紡績株式会社 | 核酸結合用磁性担体およびそれを用いる核酸単離方法 |
| CN1229415C (zh) | 1995-07-28 | 2005-11-30 | 陶氏环球技术公司 | 2,7-芳基-9-取代的芴和9-取代的芴的低聚物和聚合物 |
| DE19622885A1 (de) | 1996-06-07 | 1997-12-11 | Boehringer Mannheim Gmbh | Reagenzzubereitung enthaltend magnetische Partikel in Form einer Tablette |
| US20050287583A1 (en) * | 1997-01-21 | 2005-12-29 | Promega Corporation | Methods and kits for isolating biological target materials using silica magnetic particles |
| US6027945A (en) | 1997-01-21 | 2000-02-22 | Promega Corporation | Methods of isolating biological target materials using silica magnetic particles |
| GB9709728D0 (en) | 1997-05-13 | 1997-07-02 | Dynal As | Single step method |
| DE19743518A1 (de) * | 1997-10-01 | 1999-04-15 | Roche Diagnostics Gmbh | Automatisierbare universell anwendbare Probenvorbereitungsmethode |
| EP1071691B1 (de) * | 1998-02-04 | 2005-09-28 | MERCK PATENT GmbH | Verfahren zur isolierung und aufreinigung von nucleinsäuren |
| US7078224B1 (en) | 1999-05-14 | 2006-07-18 | Promega Corporation | Cell concentration and lysate clearance using paramagnetic particles |
| US6194562B1 (en) | 1998-04-22 | 2001-02-27 | Promega Corporation | Endotoxin reduction in nucleic acid purification |
| US5973138A (en) * | 1998-10-30 | 1999-10-26 | Becton Dickinson And Company | Method for purification and manipulation of nucleic acids using paramagnetic particles |
| DE19851156C1 (de) | 1998-11-06 | 2000-04-27 | Merck Patent Gmbh | Verfahren zur Isolierung von Plasmid-DNA |
| DE59906909D1 (de) | 1998-11-30 | 2003-10-09 | Roche Diagnostics Gmbh | Magnetische partikel zur reinigung von nukleinsäuren |
| US6270970B1 (en) | 1999-05-14 | 2001-08-07 | Promega Corporation | Mixed-bed solid phase and its use in the isolation of nucleic acids |
| US6310199B1 (en) | 1999-05-14 | 2001-10-30 | Promega Corporation | pH dependent ion exchange matrix and method of use in the isolation of nucleic acids |
| DE19937607A1 (de) * | 1999-08-09 | 2001-02-15 | Bilatec Ges Zur Entwicklung Bi | Reagenzienkit zur Isolierung von Nukleinsäuren |
| WO2001011364A1 (en) * | 1999-08-09 | 2001-02-15 | Precision System Science Co., Ltd. | Method for automatic labeling using dispenser, method for automatically separating target substance, method for determining base sequence, and automatic dispensing system |
| DK1232502T3 (da) * | 1999-11-17 | 2006-05-22 | Roche Diagnostics Gmbh | Magnetiske glaspartikler, fremgangsmåde til deres fremstilling samt anvendelser deraf |
| US6936414B2 (en) | 1999-12-22 | 2005-08-30 | Abbott Laboratories | Nucleic acid isolation method and kit |
| DE10006662A1 (de) | 2000-02-15 | 2001-08-23 | Antigen Produktions Gmbh | Gefäß zur Nukleinsäureanalytik |
| DE10013995A1 (de) * | 2000-03-22 | 2001-09-27 | Chemagen Biopolymer Technologi | Magnetische, silanisierte Trägermaterialien auf Basis von Polyvinylalkohol |
| US7183002B2 (en) * | 2000-03-24 | 2007-02-27 | Qiagen, Gmbh | Porous ferro- or ferrimagnetic glass particles for isolating molecules |
| DE10035953A1 (de) * | 2000-07-21 | 2002-01-31 | Fraunhofer Ges Forschung | Sphärische, magnetische Silica-Partikel mit einstellbarer Teilchen- und Porengröße sowie einstellbarem Magnetgehalt für die Aufreinigung von Nukleinsäuren und anderen Biomolekülen |
| US20050239125A1 (en) * | 2000-09-06 | 2005-10-27 | Hodge Timothy A | Methods for genotype screening |
| US20050272085A1 (en) * | 2000-09-06 | 2005-12-08 | Hodge Timothy A | Methods for forensic and congenic screening |
| US7011943B2 (en) * | 2000-09-06 | 2006-03-14 | Transnetyx, Inc. | Method for detecting a designated genetic sequence in murine genomic DNA |
| US7494817B2 (en) * | 2000-09-06 | 2009-02-24 | Transnet Yx, Inc. | Methods for genotype screening using magnetic particles |
| US20050266494A1 (en) * | 2000-09-06 | 2005-12-01 | Hodge Timothy A | System and method for computer network ordering of biological testing |
| US20040209303A1 (en) | 2000-10-03 | 2004-10-21 | Martin Mark T. | Methods and compositions for directed microwave chemistry |
| JP4833498B2 (ja) * | 2000-10-03 | 2011-12-07 | ミラリ バイオサイエンシズ,インコーポレーテッド | 指向性マイクロ波化学のための方法および組成物 |
| US7348182B2 (en) * | 2000-10-03 | 2008-03-25 | Mirari Biosciences, Inc. | Directed microwave chemistry |
| DE10129815A1 (de) * | 2001-06-24 | 2003-01-09 | Profos Ag | Verfahren zur Aufreinigung von Bakterienzellen und Zellbestandteilen |
| US6921283B2 (en) * | 2001-08-27 | 2005-07-26 | Trompeter Electronics, Inc. | BNC connector having visual indication |
| ES2294287T5 (es) | 2002-01-08 | 2015-10-27 | F. Hoffmann-La Roche Ag | Empleo de un material de sílice en una reacción de amplificación |
| US8110351B2 (en) * | 2002-01-16 | 2012-02-07 | Invitrogen Dynal As | Method for isolating nucleic acids and protein from a single sample |
| DE60316748T2 (de) * | 2002-06-27 | 2008-02-07 | Toyo Boseki K.K. | Magnetischer Träger für biologische Substanzen, Verfahren zur seiner Produktion und seiner Verwendung zur Isolierung dieser biologischen Substanzen |
| GB0215185D0 (en) | 2002-07-01 | 2002-08-07 | Genovision As | Binding a target substance |
| US9394332B2 (en) | 2002-08-29 | 2016-07-19 | Epigenomics Ag | Method for bisulfite treatment |
| US7560231B2 (en) | 2002-12-20 | 2009-07-14 | Roche Molecular Systems, Inc. | Mannitol and glucitol derivatives |
| JP4073323B2 (ja) * | 2003-01-23 | 2008-04-09 | 日立ソフトウエアエンジニアリング株式会社 | 機能性ビーズ、その読み取り方法および読み取り装置 |
| EP1590362B8 (en) | 2003-01-29 | 2015-06-03 | Epigenomics AG | Improved method for bisulfite treatment |
| JP2004000922A (ja) * | 2003-03-26 | 2004-01-08 | Toyobo Co Ltd | 核酸またはタンパク質抽出用シリカ粒子組成物 |
| CA2463719A1 (en) | 2003-04-05 | 2004-10-05 | F. Hoffmann-La Roche Ag | Nucleotide analogs with six membered rings |
| US8651113B2 (en) * | 2003-06-18 | 2014-02-18 | Swr&D Inc. | Magnetically responsive nanoparticle therapeutic constructs and methods of making and using |
| DE10355409A1 (de) | 2003-11-25 | 2005-06-30 | Magnamedics Gmbh | Sphärische, magnetische Silicagel-Träger mit vergrößerter Oberfläche für die Aufreinigung von Nukleinsäuren |
| CA2547743C (en) | 2003-12-02 | 2011-06-28 | F. Hoffmann-La Roche Ag | Improved method for bisulfite treatment |
| EP2251441B1 (en) | 2004-02-10 | 2013-05-08 | F. Hoffmann-La Roche AG | Detection of parvovirus B19 |
| US20050287515A1 (en) * | 2004-06-24 | 2005-12-29 | Reinhold Deppisch | Removal of bacterial DNA from therapeutic fluid formulations |
| US9267167B2 (en) | 2004-06-28 | 2016-02-23 | Becton, Dickinson And Company | Dissolvable films and methods including the same |
| JP4476050B2 (ja) * | 2004-06-30 | 2010-06-09 | 株式会社ニデック | 視野計 |
| EP1632578A1 (en) | 2004-09-03 | 2006-03-08 | Roche Diagnostics GmbH | DNA decontamination method |
| EP1642648A1 (de) | 2004-09-30 | 2006-04-05 | Roche Diagnostics GmbH | Vorrichtung und Verfahren zum Einstellen einer Temperatur einer Flüssigkeit |
| US20060234251A1 (en) * | 2005-04-19 | 2006-10-19 | Lumigen, Inc. | Methods of enhancing isolation of RNA from biological samples |
| KR101157174B1 (ko) * | 2005-11-24 | 2012-06-20 | 삼성전자주식회사 | 세포 또는 바이러스의 신속한 파괴 방법 및 장치 |
| WO2007070381A2 (en) | 2005-12-09 | 2007-06-21 | Promega Corporation | Nucleic acid purification with a binding matrix |
| EP1932913B1 (en) | 2006-12-11 | 2013-01-16 | Roche Diagnostics GmbH | Nucleic acid isolation using polidocanol and derivatives |
| KR100850430B1 (ko) * | 2006-12-11 | 2008-08-05 | (주)바이오니아 | 입자상 물질을 사용하는 핵산 분리 방법 및 핵산 분리용조성물 |
| JP5354894B2 (ja) | 2006-12-11 | 2013-11-27 | エフ.ホフマン−ラ ロシュ アーゲー | ポリドカノールおよび誘導体を用いた核酸単離 |
| KR101489830B1 (ko) * | 2006-12-18 | 2015-02-04 | 콜로로삐아 이탈리아 에스.피.에이 | 발열요법에 적용하기 위한 자성 나노 입자, 그의 제조 및 약리 적용을 갖는 구조체에의 용도 |
| US8535888B2 (en) | 2006-12-29 | 2013-09-17 | Mayo Foundation For Medical Education And Research | Compositions and methods for detecting methicillin-resistant S. aureus |
| DE102007035250A1 (de) * | 2007-07-27 | 2009-01-29 | Qiagen Gmbh | Verfahren zum Abtrennen von nicht-proteinhaltigen Biomolekülen, insbesondere Nukleinsäuren aus proteinhaltigen Proben |
| EP2067867A1 (en) | 2007-12-03 | 2009-06-10 | Siemens Aktiengesellschaft | Process for concentrating nucleic acid molecules |
| EP2108699B1 (en) | 2008-04-08 | 2014-06-25 | F.Hoffmann-La Roche Ag | Analytical processing and detection device |
| EP2138234A1 (en) | 2008-06-24 | 2009-12-30 | F. Hoffmann-Roche AG | Flexible disposable tip interface |
| EP2186570A1 (en) | 2008-11-12 | 2010-05-19 | F.Hoffmann-La Roche Ag | Method and device for separating a component bound to magnetic particles |
| US8404347B2 (en) * | 2009-01-26 | 2013-03-26 | Hong Kong Polytechnic University | Method of synthesis of amphiphilic magnetic composite particles |
| US8911663B2 (en) * | 2009-03-05 | 2014-12-16 | Quebec Metal Powders, Ltd. | Insulated iron-base powder for soft magnetic applications |
| EP2244268B1 (en) | 2009-04-23 | 2016-04-13 | Turbobeads GmbH | Process for manufacturing chemically stable magnetic carriers |
| US8039613B2 (en) | 2009-08-28 | 2011-10-18 | Promega Corporation | Methods of purifying a nucleic acid and formulation and kit for use in performing such methods |
| US8222397B2 (en) | 2009-08-28 | 2012-07-17 | Promega Corporation | Methods of optimal purification of nucleic acids and kit for use in performing such methods |
| EP2473595A4 (en) * | 2009-08-31 | 2013-04-24 | Mbio Diagnostics Inc | INTEGRATED SAMPLE PREPARATION AND ANALYTE IDENTIFICATION |
| TWI407994B (zh) * | 2009-10-22 | 2013-09-11 | Ind Tech Res Inst | 分離核酸的方法、試劑及套組 |
| US20120258553A1 (en) * | 2009-12-23 | 2012-10-11 | Koninklijke Philips Electronics N.V. | Analyte measurement apparatus and method |
| US8420801B2 (en) * | 2010-01-08 | 2013-04-16 | Roche Molecular Systems, Inc. | Recovery of nucleic acids from magnetic glass particles |
| JP2010123984A (ja) * | 2010-01-12 | 2010-06-03 | Bando Chem Ind Ltd | 磁性粒子及び磁性粒子分散液 |
| EP2345719A1 (en) | 2010-01-18 | 2011-07-20 | Qiagen GmbH | Method for isolating small RNA |
| CN102363624B (zh) | 2010-06-18 | 2016-03-30 | 香港理工大学 | 使用两亲核-壳型纳米吸附剂对内毒素的去除 |
| ES2569220T3 (es) | 2010-06-22 | 2016-05-09 | F. Hoffmann-La Roche Ag | Envase de suspensión para partículas de unión para el aislamiento de material biológico |
| EP2407540A1 (en) | 2010-07-15 | 2012-01-18 | Qiagen GmbH | Method for purifying a target nucleic acid |
| EP2754496A3 (en) | 2010-07-23 | 2017-08-02 | Beckman Coulter, Inc. | System Or Method Of Including Analytical Units |
| CA2802563C (en) * | 2010-07-29 | 2018-08-28 | F. Hoffmann-La Roche Ag | Preparation of nucleic acids from different types of biological fluid samples |
| DE102010034083A1 (de) | 2010-08-12 | 2012-02-16 | Süd-Chemie AG | Magnetische Glaspartikel zum Einsatz in Biogasanlagen, Fermentations- und Separationsprozessen |
| EP2535712A1 (en) | 2011-06-15 | 2012-12-19 | F. Hoffmann-La Roche AG | Analytical system for the preparation of biological material |
| GB201113698D0 (en) * | 2011-08-09 | 2011-09-21 | Wirtz Ralf M | Matrix and method for purifying and/or isolating nucleic acids |
| EP3789500A1 (en) | 2011-08-12 | 2021-03-10 | QIAGEN GmbH | Method for isolating nucleic acids |
| BR112014011048A2 (pt) | 2011-11-07 | 2017-05-02 | Beckman Coulter Inc | braço robótico |
| BR112014010955A2 (pt) | 2011-11-07 | 2017-06-06 | Beckman Coulter Inc | sistema e método para processar amostras |
| EP2776847A1 (en) | 2011-11-07 | 2014-09-17 | Beckman Coulter, Inc. | Magnetic damping for specimen transport system |
| KR20140091033A (ko) | 2011-11-07 | 2014-07-18 | 베크만 컬터, 인코포레이티드 | 검체 컨테이너 검출 |
| ES2729283T3 (es) | 2011-11-07 | 2019-10-31 | Beckman Coulter Inc | Sistema de centrífuga y flujo de trabajo |
| EP3373015A1 (en) | 2011-11-07 | 2018-09-12 | Beckman Coulter Inc. | Aliquotter system and workflow |
| WO2013112224A2 (en) * | 2011-11-09 | 2013-08-01 | The Regents Of The University Of California | Superparamagnetic colloids with enhanced charge stability for high quality magnetically tunable photonic structures |
| TWI575062B (zh) | 2011-12-16 | 2017-03-21 | 拜歐菲樂Ip有限責任公司 | 低溫注射組成物,用於低溫調節導管中流量之系統及方法 |
| EP2607904B1 (en) | 2011-12-21 | 2020-01-15 | Roche Diagnostics GmbH | Method for disposing of a liquid within an automated analytical system, tip rack assembly and analytical system |
| EP2634254A1 (en) | 2012-02-29 | 2013-09-04 | QIAGEN GmbH | Method for isolating nucleic acids from a food sample |
| ES2567091T3 (es) | 2012-04-05 | 2016-04-19 | F. Hoffmann-La Roche Ag | Compuestos de amina para la preparación selectiva de muestras biológicas |
| CA2862373C (en) | 2012-04-18 | 2016-07-19 | F. Hoffmann-La Roche Ag | Hev assay |
| DE102012210155A1 (de) * | 2012-06-15 | 2013-12-19 | Siemens Aktiengesellschaft | Verfahren zur Extraktion spezifischer Blutbestandteile und Kit zur Durchführung dieses Verfahrens |
| US10233508B2 (en) | 2012-08-21 | 2019-03-19 | Qiagen Gmbh | Virus particle stabilisation and method for isolating viral nucleic acids |
| US20150225712A1 (en) | 2012-08-21 | 2015-08-13 | Qiagen Gmbh | Method for isolating nucleic acids from a formaldehyde releaser stabilized sample |
| AU2013310861B2 (en) | 2012-09-03 | 2019-02-14 | Qiagen Gmbh | Method for isolating RNA including small RNA with high yield |
| US20140322706A1 (en) | 2012-10-24 | 2014-10-30 | Jon Faiz Kayyem | Integrated multipelx target analysis |
| JP1628116S (enExample) | 2012-10-24 | 2019-04-01 | ||
| WO2014090838A1 (en) | 2012-12-11 | 2014-06-19 | Qiagen Gmbh | Preparation of silica particles |
| EP2954054B1 (en) | 2013-02-08 | 2018-12-05 | Qiagen GmbH | Method for separating dna by size |
| WO2014144209A1 (en) | 2013-03-15 | 2014-09-18 | Abbott Molecular Inc. | One-step procedure for the purification of nucleic acids |
| WO2014150905A2 (en) | 2013-03-15 | 2014-09-25 | Genmark Diagnostics, Inc. | Systems, methods, and apparatus for manipulating deformable fluid vessels |
| US9409148B2 (en) | 2013-08-08 | 2016-08-09 | Uchicago Argonne, Llc | Compositions and methods for direct capture of organic materials from process streams |
| TWI583880B (zh) | 2013-09-13 | 2017-05-21 | 拜歐菲樂Ip有限責任公司 | 用於調節管道中的流動的磁性低溫閥門、系統和方法 |
| US9498778B2 (en) | 2014-11-11 | 2016-11-22 | Genmark Diagnostics, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| USD881409S1 (en) | 2013-10-24 | 2020-04-14 | Genmark Diagnostics, Inc. | Biochip cartridge |
| US9663780B2 (en) | 2014-10-15 | 2017-05-30 | Alpaqua Engineering, LLC | Solid-core ring-magnet |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| US9598722B2 (en) | 2014-11-11 | 2017-03-21 | Genmark Diagnostics, Inc. | Cartridge for performing assays in a closed sample preparation and reaction system |
| EP3059312A1 (en) | 2015-02-20 | 2016-08-24 | QIAGEN GmbH | Nucleic acid extraction method |
| JP6716683B2 (ja) | 2015-05-01 | 2020-07-01 | バイオレジェンド,インコーポレイテッド | 安定なナノ磁性粒子分散 |
| US10711265B2 (en) | 2015-06-01 | 2020-07-14 | Qiagen Gmbh | Electrophoresis assisted method for purifying a target nucleic acid using a delayed elution approach |
| EP3303582A1 (en) | 2015-06-01 | 2018-04-11 | Qiagen GmbH | Electrophoresis assisted method and device for purifying a charged target molecule from a sample |
| WO2016193490A1 (en) | 2015-06-05 | 2016-12-08 | Qiagen Gmbh | Method for separating dna by size |
| CN108474024B (zh) | 2016-01-05 | 2022-08-02 | 豪夫迈·罗氏有限公司 | 磁性玻璃颗粒对核酸的连续捕获 |
| US11608489B2 (en) | 2016-04-30 | 2023-03-21 | BioLegend, Inc. | Compositions and methods for performing magnetibuoyant separations |
| CA3023621C (en) | 2016-05-13 | 2021-07-27 | F. Hoffmann-La Roche Ag | Protein-based sample collection matrices and devices |
| CN106268649A (zh) * | 2016-08-11 | 2017-01-04 | 北京蛋白质组研究中心 | 一种磁性纳米材料及其在磷酸肽富集中的应用 |
| ES2951666T3 (es) | 2016-09-12 | 2023-10-24 | Hoffmann La Roche | Procedimientos y composiciones para purificar ácidos nucleicos bicatenarios |
| CN106984280A (zh) * | 2017-03-16 | 2017-07-28 | 东华大学 | 一种用细菌纤维素球制备磁性金属吸附材料的方法 |
| US11725200B2 (en) | 2017-09-27 | 2023-08-15 | Qiagen Gmbh | Method for isolating RNA with high yield |
| EP3470141B1 (en) | 2017-10-11 | 2024-04-24 | F. Hoffmann-La Roche AG | Apparatus and method for processing a biological sample with magnetic particles |
| EP3728586B1 (en) | 2017-12-21 | 2023-06-07 | F. Hoffmann-La Roche AG | Target enrichment by unidirectional dual probe primer extension |
| CN107955810A (zh) * | 2017-12-25 | 2018-04-24 | 宁波卡尔新材料科技有限公司 | 一种新型动物肝脏核酸提取试剂盒及提取方法 |
| EP3520893B1 (en) | 2018-02-02 | 2020-07-22 | F. Hoffmann-La Roche AG | System for the thermally controlled processing of a biological sample |
| JP7096893B2 (ja) | 2018-02-05 | 2022-07-06 | エフ.ホフマン-ラ ロシュ アーゲー | 単一分子のための一本鎖環状dna鋳型の作製 |
| CN111936635B (zh) | 2018-03-02 | 2024-08-23 | 豪夫迈·罗氏有限公司 | 用于单分子测序的单链环状dna模板的产生 |
| MX2021000692A (es) * | 2018-07-19 | 2021-05-12 | Beckman Coulter Inc | Particulas magneticas. |
| US11242519B2 (en) | 2018-08-23 | 2022-02-08 | Alpaqua Engineering, LLC | Discontinuous wall hollow core magnet |
| MA53439A (fr) | 2018-08-23 | 2021-06-30 | Alpaqua Eng Llc | Aimant à noyau solide |
| CN109337309B (zh) * | 2018-08-30 | 2021-01-29 | 英芮诚生化科技(上海)有限公司 | 储水多孔二氧化硅磁性颗粒及其制备工艺与应用 |
| US12270125B2 (en) | 2018-09-21 | 2025-04-08 | Roche Sequencing Solutions, Inc. | System and method for modular and combinatorial nucleic acid sample preparation for sequencing |
| US11591591B2 (en) | 2019-08-21 | 2023-02-28 | New England Biolabs, Inc. | Isolation of high molecular weight DNA using beads |
| US20220372566A1 (en) | 2019-09-20 | 2022-11-24 | Roche Sequencing Solutions, Inc. | Immune repertoire profiling by primer extension target enrichment |
| CN112176029B (zh) | 2020-06-12 | 2021-05-14 | 中山大学达安基因股份有限公司 | 一种拭子核酸样本释放剂及其应用 |
| CN115956128A (zh) | 2020-07-08 | 2023-04-11 | 豪夫迈·罗氏有限公司 | 在下一代测序文库的靶捕获过程中使用毒性引物对非靶文库分子进行靶向消耗 |
| US12378596B2 (en) | 2020-12-03 | 2025-08-05 | Roche Sequencing Solutions, Inc. | Whole transcriptome analysis in single cells |
| US12372497B2 (en) | 2021-08-18 | 2025-07-29 | Alpaqua Engineering, LLC | Plate cushion device having a compression gap lock |
| EP4555101A1 (en) | 2022-07-14 | 2025-05-21 | F. Hoffmann-La Roche AG | Variant allele enrichment by unidirectional dual probe primer extension |
| WO2025240460A2 (en) | 2024-05-14 | 2025-11-20 | Roche Molecular Systems, Inc. | Assay for detection of mutations conferring resistance to treatment with an immunotherapeutic agent |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4233169A (en) * | 1979-04-13 | 1980-11-11 | Corning Glass Works | Porous magnetic glass structure |
| DE2810995C2 (de) * | 1977-03-15 | 1985-02-14 | Hitachi, Ltd., Tokio/Tokyo | Magnetisches Adsorbens und Verfahren zu seiner Herstellung |
| DE3603061A1 (de) * | 1985-03-01 | 1986-09-04 | Bbc Brown Boveri Ag, Baden, Aargau | Verfahren zur herstellung eines weichmagnetischen verbundwerkstoffes mit geringen wirbelstromverlusten auf der basis eines weichmagnetischen, metallischen werkstoffs und danach hergestellter verbundwerkstoff |
| WO1988006633A1 (en) * | 1987-03-02 | 1988-09-07 | Arnold Lyle John Jr | Polycationic supports for nucleic acid purification, separation and hybridization |
| DE3724442A1 (de) * | 1987-07-23 | 1989-02-02 | Europ Lab Molekularbiolog | Verfahren und vorrichtung zur reinigung von m-13-phagen-dna |
| EP0343934A2 (en) * | 1988-05-24 | 1989-11-29 | Anagen (U.K.) Limited | Magnetically attractable particles and method of preparation |
Family Cites Families (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2913419A (en) | 1956-04-18 | 1959-11-17 | Du Pont | Chemical process and composition |
| US2885366A (en) | 1956-06-28 | 1959-05-05 | Du Pont | Product comprising a skin of dense, hydrated amorphous silica bound upon a core of another solid material and process of making same |
| DE2313331C2 (de) * | 1973-03-17 | 1986-11-13 | Merck Patent Gmbh, 6100 Darmstadt | Eisenoxidhaltige Glimmerschuppenpigmente |
| US3945862A (en) * | 1973-06-26 | 1976-03-23 | Merck & Co., Inc. | Coated ferrous substrates comprising an amorphous magnesia-silica complex |
| DE2625106C2 (de) | 1976-06-04 | 1982-03-11 | Bayer Ag, 5090 Leverkusen | Eisenoxidschwarz-Pigmente mit verbesserter Oxidationsbeständigkeit und Verfahren zu ihrer Herstellung |
| US4124385A (en) | 1976-12-02 | 1978-11-07 | Xerox Corporation | Magnetic glass carrier materials |
| US4126437A (en) | 1976-12-02 | 1978-11-21 | Xerox Corporation | Magnetic glass carrier materials |
| US4124735A (en) | 1976-12-02 | 1978-11-07 | Xerox Corporation | Magnetic glass carrier materials |
| US4223169A (en) * | 1978-02-03 | 1980-09-16 | Ferro Corporation | Process for polybrominating bisphenoxyalkanes |
| US4297337A (en) * | 1979-04-13 | 1981-10-27 | Corning Glass Works | Solid-phase immunoassays using magnetic glass |
| US4395271A (en) | 1979-04-13 | 1983-07-26 | Corning Glass Works | Method for making porous magnetic glass and crystal-containing structures |
| JPS5676510A (en) | 1979-11-28 | 1981-06-24 | Tdk Corp | Manufacture of magnetic recording material |
| JPS56105337A (en) | 1980-01-28 | 1981-08-21 | Tdk Corp | Magnetic recording medium and its production |
| US4280918A (en) | 1980-03-10 | 1981-07-28 | International Business Machines Corporation | Magnetic particle dispersions |
| US4360441A (en) | 1981-06-25 | 1982-11-23 | Corning Glass Works | Glass-encapsulated magnetic materials and methods for making them |
| US4448884A (en) * | 1982-03-03 | 1984-05-15 | Kms Fusion, Inc. | Glass-surface microcarrier for growth of cell cultures |
| DE3211309A1 (de) | 1982-03-26 | 1983-09-29 | Metin Dipl.-Ing. 6100 Darmstadt Colpan | Chromatographisches verfahren zur isolierung von makromolekuelen |
| US4672040A (en) | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
| US4628037A (en) | 1983-05-12 | 1986-12-09 | Advanced Magnetics, Inc. | Binding assays employing magnetic particles |
| US4698302A (en) | 1983-05-12 | 1987-10-06 | Advanced Magnetics, Inc. | Enzymatic reactions using magnetic particles |
| US4695393A (en) | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4554088A (en) | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| US4695392A (en) | 1983-05-12 | 1987-09-22 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
| GB8401636D0 (en) | 1984-01-21 | 1984-02-22 | British Petroleum Co Plc | Coating process |
| US5236623A (en) | 1984-07-11 | 1993-08-17 | Rhone-Poulenc Chimie | Process for the production of a silica colloid |
| US4824712A (en) * | 1984-07-16 | 1989-04-25 | Ppg Industries, Inc. | Treatment of glass to reduce venting during thermal treatment and a glass article made thereby |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5512332A (en) | 1985-10-04 | 1996-04-30 | Immunivest Corporation | Process of making resuspendable coated magnetic particles |
| US5597531A (en) | 1985-10-04 | 1997-01-28 | Immunivest Corporation | Resuspendable coated magnetic particles and stable magnetic particle suspensions |
| US5076950A (en) | 1985-12-20 | 1991-12-31 | Syntex (U.S.A.) Inc. | Magnetic composition for particle separation |
| US5206568A (en) | 1986-03-26 | 1993-04-27 | Beckman Instruments, Inc. | Coordinated control of stepper motors |
| US4751211A (en) | 1986-08-07 | 1988-06-14 | Aluminum Company Of America | Composite adsorbent for removing acids from organophosphate functional fluids |
| JPS63109105A (ja) | 1986-10-25 | 1988-05-13 | Chisso Corp | 強磁性金属微粒子の製造方法 |
| DE3639949A1 (de) | 1986-11-22 | 1988-06-09 | Diagen Inst Molekularbio | Verfahren zur trennung von langkettigen nukleinsaeuren |
| US4767670A (en) | 1987-01-21 | 1988-08-30 | E. I. Du Pont De Nemours And Company | Chromatographic supports for separation of oligonucleotides |
| NO162946C (no) | 1987-08-21 | 1990-03-14 | Otto Soerensen | Anordning for magnetisk separasjon av celler. |
| US5312485A (en) | 1988-08-05 | 1994-05-17 | J. M. Huber Corporation | Precipitated encapsulated paper pigments and methods |
| US5075430A (en) | 1988-12-12 | 1991-12-24 | Bio-Rad Laboratories, Inc. | Process for the purification of DNA on diatomaceous earth |
| US5234809A (en) | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
| NL8900725A (nl) * | 1989-03-23 | 1990-10-16 | Az Univ Amsterdam | Werkwijze en combinatie van middelen voor het isoleren van nucleinezuur. |
| US5352645A (en) * | 1989-04-14 | 1994-10-04 | E. I. Du Pont De Nemours And Company | Silica microspheres, method of improving attrition resistance and use |
| US5055194A (en) | 1989-07-28 | 1991-10-08 | University Of Pennsylvania | Support for high performance liquid chromatography in a magnetically stabilized fluidized bed |
| US5698271A (en) | 1989-08-22 | 1997-12-16 | Immunivest Corporation | Methods for the manufacture of magnetically responsive particles |
| US5279936A (en) | 1989-12-22 | 1994-01-18 | Syntex (U.S.A.) Inc. | Method of separation employing magnetic particles and second medium |
| GB9003253D0 (en) * | 1990-02-13 | 1990-04-11 | Amersham Int Plc | Precipitating polymers |
| US5523231A (en) | 1990-02-13 | 1996-06-04 | Amersham International Plc | Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules |
| US5236783A (en) | 1990-02-21 | 1993-08-17 | Toda Kogyo Corp. | Superparamagnetic fine particles of iron oxide and magnetic recording media containing said particles |
| US5316699A (en) | 1990-03-28 | 1994-05-31 | The United States Of America As Repesented By The Secretary Of Commerce | Process for the controlled preparation of a composite of ultrafine magnetic particles homogeneously dispersed in a dielectric matrix |
| EP0478753B1 (en) | 1990-04-06 | 1997-07-02 | The Perkin-Elmer Corporation | Automated molecular biology laboratory |
| US5763173A (en) | 1990-06-11 | 1998-06-09 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
| US5693502A (en) | 1990-06-11 | 1997-12-02 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5217804A (en) | 1990-11-06 | 1993-06-08 | Eastman Kodak Company | Magnetic particles |
| US5155018A (en) | 1991-07-10 | 1992-10-13 | Hahnemann University | Process and kit for isolating and purifying RNA from biological sources |
| US5395498A (en) | 1991-11-06 | 1995-03-07 | Gombinsky; Moshe | Method for separating biological macromolecules and means therfor |
| US5734020A (en) | 1991-11-20 | 1998-03-31 | Cpg, Inc. | Production and use of magnetic porous inorganic materials |
| US5610274A (en) † | 1991-11-20 | 1997-03-11 | Cpg, Inc. | Production and use of magnetic porous inorganic materials |
| US5346994A (en) | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| EP0555798B1 (en) | 1992-02-13 | 1999-05-06 | Becton, Dickinson and Company | Hydrated celite and purification of DNA |
| EP0566790B1 (en) | 1992-04-23 | 1996-08-07 | Toda Kogyo Corp. | Magnetic powder and magnetic toner |
| TW221381B (enExample) | 1992-04-28 | 1994-03-01 | Du Pont | |
| IT1256064B (it) * | 1992-07-28 | 1995-11-27 | Donegani Guido Ist | Metodo per la preparazione di geli porosi contenenti boro |
| CA2107524C (en) | 1992-10-06 | 1999-01-19 | Hiromitsu Misawa | Iron oxide particles and process for producing the same |
| US5578238A (en) | 1992-10-30 | 1996-11-26 | Lord Corporation | Magnetorheological materials utilizing surface-modified particles |
| CA2102264C (en) | 1992-11-13 | 2000-08-01 | Daniel Lee Woodard | Boron silicates, aluminum silicates, phosphosilicates and purification of dna |
| DE4307262A1 (de) * | 1993-03-02 | 1994-09-08 | Christian Bergemann | Magnetisches polymeres Siliciumdioxid |
| US5648170A (en) | 1993-04-27 | 1997-07-15 | Toda Kogyo Corporation | Coated granular magnetite particles and process for producing the same |
| WO1995004140A1 (en) * | 1993-07-28 | 1995-02-09 | Akzo Nobel N.V. | Process for isolating nucleic acid from gram positive microorganisms |
| AU689815B2 (en) * | 1993-08-30 | 1998-04-09 | Promega Corporation | Nucleic acid purification compositions and methods |
| US5503816A (en) * | 1993-09-27 | 1996-04-02 | Becton Dickinson And Company | Silicate compounds for DNA purification |
| US5438127A (en) | 1993-09-27 | 1995-08-01 | Becton Dickinson And Company | DNA purification by solid phase extraction using a PCl3 modified glass fiber membrane |
| US5599627A (en) | 1993-10-08 | 1997-02-04 | Toda Kogyo Corporation | Magnetic particles comprising magnetite core and process for producing the same |
| US5990301A (en) | 1994-02-07 | 1999-11-23 | Qiagen Gmbh | Process for the separation and purification of nucleic acids from biological sources |
| US5747663A (en) | 1994-02-07 | 1998-05-05 | Qiagen Gmbh | Process for the depletion or removal of endotoxins |
| GB9411572D0 (en) | 1994-06-09 | 1994-08-03 | Amersham Int Plc | Magnetic bead precipitation method |
| EP0772776B1 (de) | 1994-07-27 | 2000-03-22 | Herbert Dr. Pilgrimm | Superparamagnetische teilchen, verfahren zur herstellung und deren verwendung |
| US5582988A (en) | 1994-09-15 | 1996-12-10 | Johnson & Johnson Clinical Diagnostics, Inc. | Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same |
| US5705628A (en) | 1994-09-20 | 1998-01-06 | Whitehead Institute For Biomedical Research | DNA purification and isolation using magnetic particles |
| IL111186A (en) | 1994-10-06 | 1999-09-22 | Univ Bar Ilan | Process for the preparation of microspheres and microspheres made thereby |
| US5660984A (en) | 1994-12-09 | 1997-08-26 | Davis; Thomas E. | DNA isolating apparatus comprising a non-porous DNA binding, anion exchange resin and methods of use thereof |
| FR2732116B1 (fr) | 1995-03-21 | 1997-05-09 | Bio Merieux | Procede et dispositif pour la determination qualitative et/ou quantitative d'un analyte, notamment d'une bacterie, dans un echantillon, par voie magnetique |
| US5683875A (en) | 1995-05-04 | 1997-11-04 | Hewlett-Packard Company | Method for detecting a target nucleic acid analyte in a sample |
| IN188702B (enExample) | 1995-06-01 | 2002-10-26 | Degussa | |
| DE19520398B4 (de) | 1995-06-08 | 2009-04-16 | Roche Diagnostics Gmbh | Magnetisches Pigment |
| DE19520964A1 (de) | 1995-06-08 | 1996-12-12 | Inst Neue Mat Gemein Gmbh | Beschichtete anorganische Pigmente, Verfahren zu deren Herstellung und deren Verwendung |
| JP2965131B2 (ja) | 1995-07-07 | 1999-10-18 | 東洋紡績株式会社 | 核酸結合用磁性担体およびそれを用いる核酸単離方法 |
| US6017739A (en) | 1995-09-13 | 2000-01-25 | Wakunga Seiyaku Kabushiki Kaisha | Method and nucleic acid-concentratiing assay kit for concentrating mutant nucleic acid |
| US5783686A (en) | 1995-09-15 | 1998-07-21 | Beckman Instruments, Inc. | Method for purifying nucleic acids from heterogenous mixtures |
| SE9600590D0 (sv) | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| US5904848A (en) | 1996-02-21 | 1999-05-18 | Cpg, Inc. | Controlled pore glass-synthetic resin membrane |
| US5972721A (en) | 1996-03-14 | 1999-10-26 | The United States Of America As Represented By The Secretary Of The Air Force | Immunomagnetic assay system for clinical diagnosis and other purposes |
| US6224913B1 (en) | 1996-05-09 | 2001-05-01 | The Trustees Of The University Of Pennsylvania | Conditioning of bioactive glass surfaces in protein containing solutions |
| DE19622885A1 (de) | 1996-06-07 | 1997-12-11 | Boehringer Mannheim Gmbh | Reagenzzubereitung enthaltend magnetische Partikel in Form einer Tablette |
| US5954071A (en) | 1997-01-15 | 1999-09-21 | Magliocca; Charles Thomas | Parts washing apparatus with centrifugal filter |
| US6027945A (en) | 1997-01-21 | 2000-02-22 | Promega Corporation | Methods of isolating biological target materials using silica magnetic particles |
| DE69810080T2 (de) | 1997-01-21 | 2003-10-09 | Grace W R & Co | Siliciumdioxidadsorbent auf magnetischem träger |
| EP0866071B1 (en) | 1997-03-20 | 2004-10-20 | F. Hoffmann-La Roche Ag | Modified primers |
| DE19743518A1 (de) | 1997-10-01 | 1999-04-15 | Roche Diagnostics Gmbh | Automatisierbare universell anwendbare Probenvorbereitungsmethode |
| US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| DE69815282T2 (de) | 1997-12-25 | 2004-05-06 | Tosoh Corp., Shinnanyo | Magnetischer Träger, seine Herstellung, und Verfahren zum Extrahieren von Nukleinsäuren |
| US6242235B1 (en) | 1998-06-24 | 2001-06-05 | Promega Corp. | Polymerase stabilization by polyethoxylated amine surfactants |
| US6368366B1 (en) * | 1999-07-07 | 2002-04-09 | The Lubrizol Corporation | Process and apparatus for making aqueous hydrocarbon fuel compositions, and aqueous hydrocarbon fuel composition |
| DE59906909D1 (de) | 1998-11-30 | 2003-10-09 | Roche Diagnostics Gmbh | Magnetische partikel zur reinigung von nukleinsäuren |
| DK1232502T3 (da) | 1999-11-17 | 2006-05-22 | Roche Diagnostics Gmbh | Magnetiske glaspartikler, fremgangsmåde til deres fremstilling samt anvendelser deraf |
-
1995
- 1995-06-08 DE DE19520398A patent/DE19520398B4/de not_active Revoked
- 1995-10-12 DE DE19537985A patent/DE19537985A1/de not_active Ceased
-
1996
- 1996-06-06 ES ES96921935T patent/ES2197947T3/es not_active Expired - Lifetime
- 1996-06-06 EP EP05004213A patent/EP1602724A1/de not_active Withdrawn
- 1996-06-06 CN CN96195985A patent/CN1106401C/zh not_active Expired - Lifetime
- 1996-06-06 ES ES05004214T patent/ES2290803T3/es not_active Expired - Lifetime
- 1996-06-06 AU AU63007/96A patent/AU707115B2/en not_active Expired
- 1996-06-06 NZ NZ311648A patent/NZ311648A/xx not_active IP Right Cessation
- 1996-06-06 AT AT05004214T patent/ATE368109T1/de active
- 1996-06-06 DE DE59611258T patent/DE59611258D1/de not_active Expired - Lifetime
- 1996-06-06 DK DK02016299T patent/DK1281714T3/da active
- 1996-06-06 EP EP05004214.2A patent/EP1577389B2/de not_active Expired - Lifetime
- 1996-06-06 US US08/952,969 patent/US6255477B1/en not_active Expired - Lifetime
- 1996-06-06 DE DE59611440T patent/DE59611440D1/de not_active Expired - Lifetime
- 1996-06-06 DK DK96921935T patent/DK0837871T3/da active
- 1996-06-06 DK DK05004214T patent/DK1577389T3/da active
- 1996-06-06 CA CA002607563A patent/CA2607563A1/en not_active Abandoned
- 1996-06-06 AT AT02016299T patent/ATE301665T1/de active
- 1996-06-06 ES ES02016299T patent/ES2247236T3/es not_active Expired - Lifetime
- 1996-06-06 WO PCT/EP1996/002459 patent/WO1996041811A1/de not_active Ceased
- 1996-06-06 CA CA002223821A patent/CA2223821C/en not_active Expired - Lifetime
- 1996-06-06 CA CA2605671A patent/CA2605671C/en not_active Expired - Lifetime
- 1996-06-06 EP EP96921935A patent/EP0837871B1/de not_active Expired - Lifetime
- 1996-06-06 CA CA002440504A patent/CA2440504C/en not_active Expired - Lifetime
- 1996-06-06 CN CN2006101016360A patent/CN1974781B/zh not_active Expired - Lifetime
- 1996-06-06 AT AT96921935T patent/ATE239031T1/de active
- 1996-06-06 JP JP50259397A patent/JP3950478B2/ja not_active Expired - Lifetime
- 1996-06-06 EP EP02016299A patent/EP1281714B1/de not_active Expired - Lifetime
- 1996-06-06 DE DE59610405T patent/DE59610405D1/de not_active Expired - Lifetime
-
1997
- 1997-12-08 NO NO19975772A patent/NO325384B1/no not_active IP Right Cessation
-
1999
- 1999-06-06 CN CNA200610093596XA patent/CN1891833A/zh active Pending
-
2001
- 2001-01-10 US US09/756,743 patent/US6870047B2/en not_active Expired - Fee Related
-
2002
- 2002-07-23 US US10/202,618 patent/US20030135038A1/en not_active Abandoned
-
2003
- 2003-02-27 CN CNB031066364A patent/CN1267447C/zh not_active Expired - Lifetime
-
2005
- 2005-08-29 JP JP2005248331A patent/JP4456046B2/ja not_active Expired - Lifetime
-
2007
- 2007-05-03 NO NO20072301A patent/NO330520B1/no not_active IP Right Cessation
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2810995C2 (de) * | 1977-03-15 | 1985-02-14 | Hitachi, Ltd., Tokio/Tokyo | Magnetisches Adsorbens und Verfahren zu seiner Herstellung |
| US4233169A (en) * | 1979-04-13 | 1980-11-11 | Corning Glass Works | Porous magnetic glass structure |
| DE3603061A1 (de) * | 1985-03-01 | 1986-09-04 | Bbc Brown Boveri Ag, Baden, Aargau | Verfahren zur herstellung eines weichmagnetischen verbundwerkstoffes mit geringen wirbelstromverlusten auf der basis eines weichmagnetischen, metallischen werkstoffs und danach hergestellter verbundwerkstoff |
| WO1988006633A1 (en) * | 1987-03-02 | 1988-09-07 | Arnold Lyle John Jr | Polycationic supports for nucleic acid purification, separation and hybridization |
| DE3724442A1 (de) * | 1987-07-23 | 1989-02-02 | Europ Lab Molekularbiolog | Verfahren und vorrichtung zur reinigung von m-13-phagen-dna |
| EP0343934A2 (en) * | 1988-05-24 | 1989-11-29 | Anagen (U.K.) Limited | Magnetically attractable particles and method of preparation |
Non-Patent Citations (10)
| Title |
|---|
| Anal. Biochem. 121, 382-387 (1982) * |
| Anal. Biochem. 175, 196-201 (1988) * |
| Anal. Biochem. 201, 166-169 (1992) * |
| Ausubel et al.: Current Protocols in Molecular Biology. 1987. N.Y. * |
| C.J. Brinker, G.W. Scherer: "Sol Gel science". NY 1990 (Academic Press) * |
| C.J. Brinker, G.W. Scherer: "Sol Gel science". NY 1990 (Academic Press); Lisa C. Klein, Ed. Kluwer: Sol-Gel Optics. Academic Publishers 1994; Sambrook et al.: Molecular Cloning. A Laboratory Manual. C old Spring Harbour Laboratory Press.; Ausubel et a l.: Current Protocols in Molecular Biology. 1987. NY. |
| Lisa C. Klein, Ed. Kluwer: Sol-Gel Optics. Academic Publishers 1994 * |
| Proc. Natl. Acad. USA 76, 615-619 (1979) * |
| Proc. Natl. Acad. USA 76, 615-619 (1979); Anal. Bi ochem. 121, 382-387 (1982); Anal. Biochem. 175, 19 6-201 (1988); Anal. Biochem. 201, 166-169 (1992) |
| Sambrook et al.: Molecular Cloning. A Laboratory Manual. C old Spring Harbour Laboratory Press. * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE19520398B4 (de) | Magnetisches Pigment | |
| DE69817484T2 (de) | Verfahren zur isolierung bestimmter biologischer stoffe mittels magnetischer silika-partikel | |
| JP5537894B2 (ja) | 磁性色素 | |
| DE60122138T2 (de) | Isolierung von nukleinsäuren | |
| DE60015148T2 (de) | Simultane isolierung und quantifizierung von dna | |
| EP1274745B1 (de) | Magnetische, silanisierte trägermaterialien auf basis von polyvinylalkohol | |
| EP1468430A1 (de) | Siliziumhaltige magnetpartikel, verfahren zu deren herstellung und verwendung der partikel | |
| DE19549875B4 (de) | Verwendung von magnetischen Partikeln zur Isolierung von Nukleinsäuren | |
| DE19854973B4 (de) | Verfahren zur Reinigung von Nukleinsäuren | |
| DE10157624A1 (de) | Verfahren zur Anreicherung und zum Nachweis von HIV | |
| DE10103652A1 (de) | Magnetische Polyvinylalkoholpartikel mit modifizierter Oberfläche zur Isolierung und Reinigung von Nucleinsäuren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8127 | New person/name/address of the applicant |
Owner name: ROCHE DIAGNOSTICS GMBH, 68305 MANNHEIM, DE |
|
| 8110 | Request for examination paragraph 44 | ||
| 8369 | Partition in: |
Ref document number: 19549875 Country of ref document: DE Kind code of ref document: P |
|
| AH | Division in |
Ref document number: 19549875 Country of ref document: DE Kind code of ref document: P |
|
| Q171 | Divided out to: |
Ref document number: 19549875 Country of ref document: DE Kind code of ref document: P |
|
| 8363 | Opposition against the patent | ||
| 8325 | Change of the main classification |
Ipc: C07H 1/06 AFI20061219BHDE |
|
| 8331 | Complete revocation |