DE1816993C3 - Verfahren zur Herstellung von Indolyl-3-essigsäuren - Google Patents
Verfahren zur Herstellung von Indolyl-3-essigsäurenInfo
- Publication number
- DE1816993C3 DE1816993C3 DE19681816993 DE1816993A DE1816993C3 DE 1816993 C3 DE1816993 C3 DE 1816993C3 DE 19681816993 DE19681816993 DE 19681816993 DE 1816993 A DE1816993 A DE 1816993A DE 1816993 C3 DE1816993 C3 DE 1816993C3
- Authority
- DE
- Germany
- Prior art keywords
- acid
- formylhydrazine
- indolyl
- reaction mixture
- filtered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL124321A PL62464B1 (US20080293856A1-20081127-C00150.png) | 1967-12-27 | ||
| PL127148A PL65769B1 (US20080293856A1-20081127-C00150.png) | 1968-05-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE1816993A1 DE1816993A1 (de) | 1969-10-16 |
| DE1816993B2 DE1816993B2 (de) | 1973-08-09 |
| DE1816993C3 true DE1816993C3 (de) | 1982-05-06 |
Family
ID=26652821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19681816993 Expired DE1816993C3 (de) | 1967-12-27 | 1968-12-24 | Verfahren zur Herstellung von Indolyl-3-essigsäuren |
Country Status (10)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5272145A (en) * | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5204344A (en) * | 1989-08-22 | 1993-04-20 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
| JPH0764841B2 (ja) * | 1990-10-03 | 1995-07-12 | ファイザー製薬株式会社 | インドール誘導体およびその用途 |
| US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5374635A (en) * | 1993-03-29 | 1994-12-20 | Merck Frosst Canada, Inc. | Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT262993B (de) * | 1965-04-19 | 1968-07-10 | Sumitomo Chemical Co | Verfahren zur Herstellung von zum Teil neuen aliphatischen (3-Indolyl)-carbonsäuren bzw. von funktionellen Derivaten derselben |
-
1968
- 1968-12-19 CH CH1897968A patent/CH498831A/fr not_active IP Right Cessation
- 1968-12-19 DK DK622768A patent/DK136033B/da unknown
- 1968-12-20 SE SE1765268A patent/SE350494B/xx unknown
- 1968-12-20 CS CS868268A patent/CS162665B2/cs unknown
- 1968-12-24 DE DE19681816993 patent/DE1816993C3/de not_active Expired
- 1968-12-26 RO RO5863568A patent/RO55545A/ro unknown
- 1968-12-27 FR FR1599484D patent/FR1599484A/fr not_active Expired
- 1968-12-27 YU YU311968A patent/YU311968A/xx unknown
- 1968-12-27 NL NL6818723A patent/NL6818723A/xx not_active Application Discontinuation
- 1968-12-30 GB GB1228848D patent/GB1228848A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE350494B (US20080293856A1-20081127-C00150.png) | 1972-10-30 |
| FR1599484A (US20080293856A1-20081127-C00150.png) | 1970-07-15 |
| DE1816993A1 (de) | 1969-10-16 |
| NL6818723A (US20080293856A1-20081127-C00150.png) | 1969-07-01 |
| RO55545A (US20080293856A1-20081127-C00150.png) | 1974-04-01 |
| DK136033B (da) | 1977-08-01 |
| DE1816993B2 (de) | 1973-08-09 |
| GB1228848A (US20080293856A1-20081127-C00150.png) | 1971-04-21 |
| CS162665B2 (US20080293856A1-20081127-C00150.png) | 1975-07-15 |
| CH498831A (fr) | 1970-11-15 |
| YU311968A (en) | 1973-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| SH | Request for examination between 03.10.1968 and 22.04.1971 | ||
| C3 | Grant after two publication steps (3rd publication) |