DE1812205C3 - Verfahren zur Herstellung von 1-(2-Diäthylaminoäthyl)-5-phenyI-7-chlor-13-dihydro-2H-l,4-benzodiazepin-2-onen und H2-Diäthylaminoäthyl)-2-aminomethyl-S-phenyl-S-chlorindol-Zwischenprodukte - Google Patents

Verfahren zur Herstellung von 1-(2-Diäthylaminoäthyl)-5-phenyI-7-chlor-13-dihydro-2H-l,4-benzodiazepin-2-onen und H2-Diäthylaminoäthyl)-2-aminomethyl-S-phenyl-S-chlorindol-Zwischenprodukte

Info

Publication number
DE1812205C3
DE1812205C3 DE1812205A DE1812205A DE1812205C3 DE 1812205 C3 DE1812205 C3 DE 1812205C3 DE 1812205 A DE1812205 A DE 1812205A DE 1812205 A DE1812205 A DE 1812205A DE 1812205 C3 DE1812205 C3 DE 1812205C3
Authority
DE
Germany
Prior art keywords
mixture
diethylaminoethyl
solution
water
yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1812205A
Other languages
German (de)
English (en)
Other versions
DE1812205A1 (de
DE1812205B2 (de
Inventor
Toshiyuki Hyogo Kobe Hirohashi
Shigeho Takarazuka Inaba
Kikuo Ishizumi
Isamu Maruyama
Kazuo Kobe Mori
Hisao Nishinomiya Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of DE1812205A1 publication Critical patent/DE1812205A1/de
Publication of DE1812205B2 publication Critical patent/DE1812205B2/de
Application granted granted Critical
Publication of DE1812205C3 publication Critical patent/DE1812205C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1812205A 1967-12-08 1968-12-02 Verfahren zur Herstellung von 1-(2-Diäthylaminoäthyl)-5-phenyI-7-chlor-13-dihydro-2H-l,4-benzodiazepin-2-onen und H2-Diäthylaminoäthyl)-2-aminomethyl-S-phenyl-S-chlorindol-Zwischenprodukte Expired DE1812205C3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP7890367 1967-12-08
JP7890467 1967-12-08
JP7916967 1967-12-09
JP8227467 1967-12-21

Publications (3)

Publication Number Publication Date
DE1812205A1 DE1812205A1 (de) 1969-07-03
DE1812205B2 DE1812205B2 (de) 1978-02-09
DE1812205C3 true DE1812205C3 (de) 1978-10-19

Family

ID=27466229

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1812205A Expired DE1812205C3 (de) 1967-12-08 1968-12-02 Verfahren zur Herstellung von 1-(2-Diäthylaminoäthyl)-5-phenyI-7-chlor-13-dihydro-2H-l,4-benzodiazepin-2-onen und H2-Diäthylaminoäthyl)-2-aminomethyl-S-phenyl-S-chlorindol-Zwischenprodukte

Country Status (11)

Country Link
US (1) US3632805A (enExample)
BE (1) BE725159A (enExample)
CH (1) CH529145A (enExample)
DE (1) DE1812205C3 (enExample)
FI (1) FI48839C (enExample)
FR (1) FR1602150A (enExample)
GB (1) GB1260479A (enExample)
IL (1) IL31242A (enExample)
NL (1) NL146814B (enExample)
NO (1) NO123855B (enExample)
SE (1) SE353327B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3922264A (en) * 1967-12-07 1975-11-25 Sumitomo Chemical Co Production of benzodiazepine derivatives
DE2617062C2 (de) * 1976-04-17 1985-07-04 Cassella Ag, 6000 Frankfurt Wasserlösliche Hydrazone der Phthalocyaninreihe, ihre Herstellung und Verwendung
DE3807922A1 (de) * 1988-03-10 1989-09-21 Boehringer Mannheim Gmbh Substituierte heterocyclen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US20110104109A1 (en) * 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
MX2009006878A (es) * 2006-12-22 2009-07-07 Schering Corp Derivados indolicos con anillo unido en las posiciones 4,5 para tratar o prevenir infecciones virales por virus de la hepatitis c e infecciones virales relacionadas.
KR20090094154A (ko) 2006-12-22 2009-09-03 쉐링 코포레이션 Ｈｃｖ 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체
US8268803B2 (en) 2006-12-22 2012-09-18 Merck Sharp & Dohme Corp. 5, 6-ring annulated indole derivatives and use thereof
DK2134685T3 (en) 2007-04-16 2015-12-07 Abbvie Inc 7-unsubstituted indole derivatives as MCL-1 inhibitors
KR20100065167A (ko) * 2007-08-29 2010-06-15 쉐링 코포레이션 바이러스 감염 치료용 2,3-치환된 아자인돌 유도체
CN101821252A (zh) * 2007-08-29 2010-09-01 先灵公司 取代的吲哚衍生物及其使用方法
TW200924751A (en) * 2007-08-29 2009-06-16 Schering Corp 2,3-substituted indole derivatives and methods of use thereof
MX2010005355A (es) * 2007-11-16 2010-06-02 Schering Corp Derivados de indol sustituidos con 3-aminosulfonilo y metodos de uso de los mismos.
US8765757B2 (en) * 2007-11-16 2014-07-01 Merck Sharp & Dohme Corp. 3-heterocyclic substituted indole derivatives and methods of use thereof
MX2010013630A (es) * 2008-06-13 2010-12-21 Schering Corp Derivados triciclicos de indol y metodos de uso de los mismos.

Also Published As

Publication number Publication date
NL146814B (nl) 1975-08-15
US3632805A (en) 1972-01-04
IL31242A (en) 1973-07-30
DE1812205A1 (de) 1969-07-03
DE1812205B2 (de) 1978-02-09
IL31242A0 (en) 1969-02-27
FI48839B (enExample) 1974-09-30
NO123855B (enExample) 1972-01-24
FI48839C (fi) 1975-01-10
CH529145A (de) 1972-10-15
SE353327B (enExample) 1973-01-29
BE725159A (enExample) 1969-05-16
NL6817433A (enExample) 1969-06-10
FR1602150A (enExample) 1970-10-12
GB1260479A (en) 1972-01-19

Similar Documents

Publication Publication Date Title
DE1812205C3 (de) Verfahren zur Herstellung von 1-(2-Diäthylaminoäthyl)-5-phenyI-7-chlor-13-dihydro-2H-l,4-benzodiazepin-2-onen und H2-Diäthylaminoäthyl)-2-aminomethyl-S-phenyl-S-chlorindol-Zwischenprodukte
DE2166657C2 (enExample)
DE1928726A1 (de) Diazepinoindole
DE1920207B2 (de) Verfahren zur herstellung von 1,3- dihydro-2h-1,4-benzodiazepin-2-onderivaten
EP0017181A1 (de) Neues Verfahren zur Herstellung von Imidazobenzodiazepinderivaten sowie Zwischenprodukte zu deren Herstellung
DE2841644C2 (enExample)
DE1935671C3 (de) 2-Aminomethylindole und ihre Salze
CH497436A (de) Verfahren zur Herstellung von Benzodiazepin-Derivaten
CH642370A5 (en) Process for the preparation of imidazo[2,1-a]isoindoles
DE2340159C2 (enExample)
CH507966A (de) Verfahren zur Herstellung von Benzodiazepinderivaten
DE1770421C3 (de) Verfahren zur Herstellung von 1,3-Dihydro-2H-1,4-benzodiazepin-2-onderivaten
DE1817791C3 (de) 2-Aminomethyl-3-phenylindole und ihre Salze mit Säuren
DE1795372C3 (de) 10.01.68 Japan 1501-68 Verfahren zur Herstellung von 5-(o-Halogenphenyl)-7-halogen-1,3-dihydro-2H-1,4-benzodiazepin-2-onen und 2-Aminomethylindole und ihre Salze
DE2045378C3 (de) Verfahren zur Herstellung von t-Hydroxyalkyl-5-phenyl-1,3-dihydro-2H-1,4benzodiazepin-2-on-derivaten
AT308115B (de) Verfahren zur Herstellung von Benzodiazepinderivaten sowie von Säureadditionssalzen dieser Verbindungen
DE1814332C3 (de) Verfahren zur Herstellung von 1,5-Benzo-diazocinen oder 1,6-Benzodiazoninen
DE1770420C3 (de) Verfahren zur Herstellung von 1,3-Dihydro-2H-1,4-benzodiazepin-2-onderivaten
DE1811830C3 (de) Verfahren zur Herstellung von 7-Nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-on-derivaten
AT292002B (de) Verfahren zur Herstellung von Benzodiazepinen bzw. von Salzen derselben
AT299207B (de) Verfahren zur Herstellung neuer Benzodiazepin-Derivaten und ihren Salzen
CH502354A (de) Verfahren zur Herstellung von Benzodiazepin-Derivaten
CH538491A (de) Verfahren zur Herstellung von Benzodiazepinderivaten
DE1770420B2 (de) Verfahren zur Herstellung von 1,3-Dihydro-2H-1,4-benzodiazepin-2-on-derivaten
DD150053A5 (de) Verfahren zur herstellung von neuen hydroxyiminosubstituierten aminoacetonitrilen

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee