DE1468333A1 - 17 alpha-Halogenaethinylsteroide der 19-nor-Androstanreihe und ein Verfahren zu ihrer Herstellung - Google Patents

17 alpha-Halogenaethinylsteroide der 19-nor-Androstanreihe und ein Verfahren zu ihrer Herstellung

Info

Publication number
DE1468333A1
DE1468333A1 DE19611468333 DE1468333A DE1468333A1 DE 1468333 A1 DE1468333 A1 DE 1468333A1 DE 19611468333 DE19611468333 DE 19611468333 DE 1468333 A DE1468333 A DE 1468333A DE 1468333 A1 DE1468333 A1 DE 1468333A1
Authority
DE
Germany
Prior art keywords
ether
androstadien
methoxy
bromine
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19611468333
Other languages
German (de)
English (en)
Inventor
Beyler Roger Eldon
Oberster Arthur Eugene
John Fried
Sarett Lewis Hastings
Bry Thomas Seth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE1468333A1 publication Critical patent/DE1468333A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19611468333 1961-03-02 1961-04-17 17 alpha-Halogenaethinylsteroide der 19-nor-Androstanreihe und ein Verfahren zu ihrer Herstellung Pending DE1468333A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US88575A US3072646A (en) 1961-03-02 1961-03-02 Novel 6-chloro-17alpha-haloethynyl-19-norandrostadienes and processes

Publications (1)

Publication Number Publication Date
DE1468333A1 true DE1468333A1 (de) 1968-12-19

Family

ID=22212174

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19611468333 Pending DE1468333A1 (de) 1961-03-02 1961-04-17 17 alpha-Halogenaethinylsteroide der 19-nor-Androstanreihe und ein Verfahren zu ihrer Herstellung
DE1593072A Expired DE1593072C3 (de) 1961-03-02 1961-04-17 17alpha-Halogenäthiny 1-17betahydroxy-19-nor-4,9-androstadien-3 one, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel. Ausscheidung aus: 1242607

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1593072A Expired DE1593072C3 (de) 1961-03-02 1961-04-17 17alpha-Halogenäthiny 1-17betahydroxy-19-nor-4,9-androstadien-3 one, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel. Ausscheidung aus: 1242607

Country Status (4)

Country Link
US (1) US3072646A (enExample)
DE (2) DE1468333A1 (enExample)
DK (1) DK108227C (enExample)
NO (1) NO122366B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3248405A (en) * 1962-02-09 1966-04-26 Merck & Co Inc Process for the preparation of 21-halo-19-nor-ethisterones and the 3-enol ethers thereof
DE1249264B (de) * 1962-08-24 1967-09-07 The British Drug Houses Limited London Verfahren zur Her Stellung von neuen YIi Chlorathmyl 17ß alkoxysteroiden
US3409643A (en) * 1966-03-11 1968-11-05 Schering Corp Process for the preparation of 17alpha-alkynl-17beta-alkanoyloxy steroids of the androstane and estrane series
GB1108276A (en) * 1966-03-14 1968-04-03 British Drug Houses Ltd 17ª‡-alka-1',3'-diynyl-oestra-4,9(10)-dien-3-ones
US3471531A (en) * 1966-04-07 1969-10-07 Herchel Smith Synthesis of gona-3,5-dienes

Also Published As

Publication number Publication date
US3072646A (en) 1963-01-08
NO122366B (enExample) 1971-06-21
DE1593072A1 (de) 1970-07-30
DE1593072B2 (de) 1973-08-23
DK108227C (da) 1967-10-23
DE1593072C3 (de) 1974-04-18

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Legal Events

Date Code Title Description
SH Request for examination between 03.10.1968 and 22.04.1971