DE1111642B - Verfahren zur Herstellung von basisch substituierten Diphenylmethan-Derivaten mit Herz- und Kreislaufwirksamkeit - Google Patents

Verfahren zur Herstellung von basisch substituierten Diphenylmethan-Derivaten mit Herz- und Kreislaufwirksamkeit

Info

Publication number
DE1111642B
DE1111642B DEF25702A DEF0025702A DE1111642B DE 1111642 B DE1111642 B DE 1111642B DE F25702 A DEF25702 A DE F25702A DE F0025702 A DEF0025702 A DE F0025702A DE 1111642 B DE1111642 B DE 1111642B
Authority
DE
Germany
Prior art keywords
general formula
amines
hydrogen
meaning given
diphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEF25702A
Other languages
German (de)
English (en)
Inventor
Dr Gustav Ehrhart
Dr Ernst Lindner
Heinrich Ott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NL238796D priority Critical patent/NL238796A/xx
Priority to BE578515D priority patent/BE578515A/xx
Priority to NL108640D priority patent/NL108640C/xx
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DEF25702A priority patent/DE1111642B/de
Priority to CH462764A priority patent/CH388332A/de
Priority to CH708765A priority patent/CH397710A/de
Priority to US811011A priority patent/US3152173A/en
Priority to CH462864A priority patent/CH388333A/de
Priority to CH462964A priority patent/CH388334A/de
Priority to CH463064A priority patent/CH396931A/de
Priority to CH463164A priority patent/CH388328A/de
Priority to CH463264A priority patent/CH388329A/de
Priority to CH7291559A priority patent/CH385878A/de
Priority to GB15785/59A priority patent/GB916644A/en
Priority to FR794221A priority patent/FR1292922A/fr
Priority to FR837345A priority patent/FR553M/fr
Publication of DE1111642B publication Critical patent/DE1111642B/de
Priority to CY27764A priority patent/CY277A/xx
Priority to OA51809A priority patent/OA01363A/xx
Priority to MY196449A priority patent/MY6400049A/xx
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DEF25702A 1958-05-07 1958-05-07 Verfahren zur Herstellung von basisch substituierten Diphenylmethan-Derivaten mit Herz- und Kreislaufwirksamkeit Pending DE1111642B (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
NL238796D NL238796A (oth) 1958-05-07
BE578515D BE578515A (oth) 1958-05-07
NL108640D NL108640C (oth) 1958-05-07
DEF25702A DE1111642B (de) 1958-05-07 1958-05-07 Verfahren zur Herstellung von basisch substituierten Diphenylmethan-Derivaten mit Herz- und Kreislaufwirksamkeit
CH463064A CH396931A (de) 1958-05-07 1959-05-05 Verfahren zur Herstellung von basisch substituierten Diphenylalkan-Derivaten
CH708765A CH397710A (de) 1958-05-07 1959-05-05 Verfahren zur Herstellung von basisch substituierten Diphenylalkan-Derivaten
US811011A US3152173A (en) 1958-05-07 1959-05-05 Basically substituted diphenyl-methane derivatives and process for preparing them
CH462864A CH388333A (de) 1958-05-07 1959-05-05 Verfahren zur Herstellung von basisch substituierten Diphenylalkan-Derivaten
CH462964A CH388334A (de) 1958-05-07 1959-05-05 Verfahren zur Herstellung von basisch substituierten Diphenylalkan-Derivaten
CH462764A CH388332A (de) 1958-05-07 1959-05-05 Verfahren zur Herstellung von basisch substituierten Diphenylalkan-Derivaten
CH463164A CH388328A (de) 1958-05-07 1959-05-05 Verfahren zur Herstellung von basisch substituierten Diphenylalkan-Derivaten
CH463264A CH388329A (de) 1958-05-07 1959-05-05 Verfahren zur Herstellung von basisch substituierten Diphenylalkan-Derivaten
CH7291559A CH385878A (de) 1958-05-07 1959-05-05 Verfahren zur Herstellung von basisch substituierten Diphenylalkan-Derivaten
GB15785/59A GB916644A (en) 1958-05-07 1959-05-07 Basically substituted diphenyl-methane compounds and process for their manufacture
FR794221A FR1292922A (fr) 1958-05-07 1959-05-09 Procédé de préparation de dérivés de diphényl-méthane portant des substituants basiques
FR837345A FR553M (oth) 1958-05-07 1960-08-31
CY27764A CY277A (en) 1958-05-07 1964-02-12 Basically substituted diphenyl-methane compounds and process for their manufacture
OA51809A OA01363A (fr) 1958-05-07 1964-12-31 Procédé de préparation de dérivés de diphényl-méthane portant des substituants basiques.
MY196449A MY6400049A (en) 1958-05-07 1964-12-31 Basically substituted diphenyl-methane compounds and process for their manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF25702A DE1111642B (de) 1958-05-07 1958-05-07 Verfahren zur Herstellung von basisch substituierten Diphenylmethan-Derivaten mit Herz- und Kreislaufwirksamkeit

Publications (1)

Publication Number Publication Date
DE1111642B true DE1111642B (de) 1961-07-27

Family

ID=7091732

Family Applications (1)

Application Number Title Priority Date Filing Date
DEF25702A Pending DE1111642B (de) 1958-05-07 1958-05-07 Verfahren zur Herstellung von basisch substituierten Diphenylmethan-Derivaten mit Herz- und Kreislaufwirksamkeit

Country Status (10)

Country Link
US (1) US3152173A (oth)
BE (1) BE578515A (oth)
CH (8) CH385878A (oth)
CY (1) CY277A (oth)
DE (1) DE1111642B (oth)
FR (1) FR553M (oth)
GB (1) GB916644A (oth)
MY (1) MY6400049A (oth)
NL (2) NL238796A (oth)
OA (1) OA01363A (oth)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1216318B (de) 1962-11-15 1966-05-12 Hoechst Ag Verfahren zur Herstellung von Diphenylalkylaminen
DE1231704B (de) 1963-12-19 1967-01-05 Josef Klosa Dipl Chem Dr Rer N Verfahren zur Herstellung neuer Diaryl-alkylaminoverbindungen mit heterocyclischen Ringen
US3457354A (en) * 1965-09-21 1969-07-22 Merck & Co Inc Treatment of hypertension with 2-hydroxy (or amino) - 4,5 - dihydroxyphenethylamine derivatives
DE2902172A1 (de) * 1979-01-20 1980-07-24 Uop Inc Verfahren zur herstellung eines n,n'-dialkylphenylendiamins

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3262977A (en) * 1962-03-10 1966-07-26 Chinoin Gyogyszer Es Vegyeszet N-aralkyl-1, 1-diphenyl-propylamine derivatives
NL296693A (oth) * 1962-08-16
FR95908E (fr) * 1963-11-09 1972-01-31 Degussa Procédé de préparation de nouvelles aminocétones et des alcools secondaires correspondants.
US3895057A (en) * 1967-10-13 1975-07-15 Dainippon Pharmaceutical Co Aminoalkanols and their pharmaceutically acceptable acid-addition salts, and production thereof
US4329367A (en) * 1974-08-05 1982-05-11 Ciba-Geigy Corporation 1-(Aralkoxyphenyl)-2-(bis-arylalkylamino)-alkanes
ATE33208T1 (de) * 1982-04-23 1988-04-15 Caola Kozmetikai Kosmetische zusammensetzungen enthaltend phenylamin und deren herstellung.
ATE41655T1 (de) * 1985-04-16 1989-04-15 Hoffmann La Roche Phenaethanolaminderivate.
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
MXPA03006728A (es) * 2001-01-26 2003-10-24 Schering Corp Combinaciones de inhibidor(es) de la absorcion de esterol con modificador(es) sanguineos para tratar cuadros vasculares.
RS50406B (sr) * 2001-01-26 2009-12-31 Schering Corporation, Upotreba supstituisanih jedinjenja azetidinona za lečenje sitosterolemije
JP2004521894A (ja) * 2001-01-26 2004-07-22 シェーリング　コーポレイション 胆汁酸金属イオン封鎖剤およびステロール吸収阻害剤の併用および血管適応症の治療
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
JP2004517919A (ja) * 2001-01-26 2004-06-17 シェーリング　コーポレイション 血管状態の処置のための心臓血管薬剤とステロール吸収インヒビターとの組み合わせ
US20020183305A1 (en) * 2001-01-26 2002-12-05 Schering Corporation Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications
SI1413331T1 (sl) * 2001-01-26 2008-02-29 Schering Corp Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
EP1392287B8 (en) * 2001-05-25 2007-01-10 Schering Corporation Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
DK1427409T3 (da) * 2001-09-21 2009-01-12 Schering Corp Fremgangsmåde til behandling eller forhindring af vaskulær inflammation under brug af en eller flere sterolabssorptionsinhibitorer
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
MXPA04002573A (es) * 2001-09-21 2004-06-18 Schering Corp Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
AU2003250483A1 (en) 2002-08-19 2004-03-11 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
EP1562582A1 (en) * 2002-11-06 2005-08-17 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7192944B2 (en) * 2003-03-07 2007-03-20 Schering Corp. Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
ES2311806T3 (es) 2003-03-07 2009-02-16 Schering Corporation Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
JP4589919B2 (ja) 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US20050096307A1 (en) * 2003-11-05 2005-05-05 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
WO2006014930A2 (en) * 2004-07-26 2006-02-09 Cotherix, Inc. Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2111863B1 (en) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
HK1220611A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 用於治疗胃肠道病症的组成物
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
FI3911648T3 (fi) 2019-01-18 2025-01-10 Astrazeneca Ab 6'-[[[(1s,3s)-3-[[5-(difluorometoksi)-2-pyrimidinyyli]amino]syklopentyyli]amino][1(2h),3'-bipyridin]-2-oni pcsk9:n estäjänä ja menetelmät sen käyttöön

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1058063B (de) * 1957-02-08 1959-05-27 Hoechst Ag Verfahren zur Herstellung von analgetisch wirksamen substituierten Phenylaethylaminen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2601323A (en) * 1949-02-02 1952-06-24 Upjohn Co Process for preparing 4, 4-diphenyl-6-dimethylamino-heptanone-3
US2681934A (en) * 1950-01-06 1954-06-22 Commercial Solvents Corp Substituted diphenylalkylamines
US2797242A (en) * 1953-08-11 1957-06-25 Parke Davis & Co Substituted alpha-benzylphenethylamines and methods for producing the same
US2738347A (en) * 1954-12-13 1956-03-13 Olin Mathieson Penicillin salt of benzhydryl-phenethylamine
US2872374A (en) * 1955-02-02 1959-02-03 Nat Drug Co Muscle-relaxing tranquilizer compositions
US2894033A (en) * 1955-11-15 1959-07-07 Nl Combinatie Chem Ind Antispasmodic 1, 1-diphenyl-3-dialkylaminopropane, and its tertiary and quaternary salts
US2854379A (en) * 1956-06-06 1958-09-30 Miles Lab Tranquilizing composition comprising 2-ethyl-cis-crotonylurea

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1058063B (de) * 1957-02-08 1959-05-27 Hoechst Ag Verfahren zur Herstellung von analgetisch wirksamen substituierten Phenylaethylaminen

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1216318B (de) 1962-11-15 1966-05-12 Hoechst Ag Verfahren zur Herstellung von Diphenylalkylaminen
DE1231704B (de) 1963-12-19 1967-01-05 Josef Klosa Dipl Chem Dr Rer N Verfahren zur Herstellung neuer Diaryl-alkylaminoverbindungen mit heterocyclischen Ringen
US3457354A (en) * 1965-09-21 1969-07-22 Merck & Co Inc Treatment of hypertension with 2-hydroxy (or amino) - 4,5 - dihydroxyphenethylamine derivatives
DE2902172A1 (de) * 1979-01-20 1980-07-24 Uop Inc Verfahren zur herstellung eines n,n'-dialkylphenylendiamins

Also Published As

Publication number Publication date
CH388329A (de) 1965-02-28
CH388333A (de) 1965-02-28
GB916644A (en) 1963-01-23
US3152173A (en) 1964-10-06
CH397710A (de) 1965-08-31
CH388334A (de) 1965-02-28
OA01363A (fr) 1969-07-04
MY6400049A (en) 1964-12-31
CH396931A (de) 1965-08-15
CH388328A (de) 1965-02-28
CH385878A (de) 1964-12-31
CH388332A (de) 1965-02-28
BE578515A (oth)
FR553M (oth) 1961-05-29
NL238796A (oth)
CY277A (en) 1964-02-12
NL108640C (oth)

Similar Documents

Publication Publication Date Title
DE1111642B (de) Verfahren zur Herstellung von basisch substituierten Diphenylmethan-Derivaten mit Herz- und Kreislaufwirksamkeit
DE1543374C3 (de) 3,4 Dihydroxyphenylalkanolamine und ihre Saureadditionssalze, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen
CH621115A5 (oth)
DE2845499A1 (de) Alkanoylprolin-derivate und deren homologen, ihre herstellung und verwendung
DE2060816C3 (de) 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE1620198C3 (de) 5H-Benz eckige Klammer auf f eckige Klammer zu 2,5-oxazocine oder Benz eckige Klammer auf g eckige Klammer zu 2,6-oxazonine, ihre Salze und Arzneimittel
DE2062001A1 (de) Isochinolin Derivate
DD272648A5 (de) Chromon-derivate
DE2225332A1 (de) 1 eckige Klammer auf 4 Hydroxy 3 (hydroxymethyl) phenyl eckige Klammer zu 1 hydroxy 2 aralkylaminoathane
DE2701705A1 (de) Neue organische verbindungen, ihre verwendung und herstellung
EP0000013B1 (de) 4-Phenyl-8-amino-tetrahydroisochinoline, diese enthaltende pharmazeutische Präparate und Verfahren zur Herstellung dieser Präparate
DE1802297C3 (de) Isopropylaminderivate und Verfahren zu ihrer Herstellung
EP0612745B1 (de) Verfahren zur Herstellung von 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin und seiner Salze
AT213877B (de) Verfahren zur Herstellung von neuen basisch substituierten Diphenylalkan-Derivaten und deren Säureadditionssalzen bzw. quartären Ammoniumsalzen
AT338242B (de) Verfahren zur herstellung neuer racemischer und optisch aktiver 1-hydroxyphenyl-2-(3',4'-dimethoxyphenathyl)aminoathanole-(1)
AT212314B (de) Verfahren zur Herstellung von neuen, in threo- oder erythro-Form, als Racemat oder als optisch aktive Verbindungen vorliegenden Derivaten des Piperidyl-(2)-phenylmethanols
DE10112828C1 (de) Verfahren zur Herstellung von Citalopram
DE2304414A1 (de) Aminopropanderivate und verfahren zu ihrer herstellung
EP0031910B1 (de) Anilinderivate, diese enthaltende pharmazeutische Zubereitungen und Verfahren zu ihrer Herstellung
DE1231704B (de) Verfahren zur Herstellung neuer Diaryl-alkylaminoverbindungen mit heterocyclischen Ringen
DE1620206C (de) N-Cyclopropylmethyl-6,14-endo-äthanotetrahydronororipavine und ihre Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zubereitungen
AT263014B (de) Verfahren zur Herstellung von neuen Phenanthridinderivaten, deren Salzen und optisch isomeren Formen
CH634820A5 (en) Process for the preparation of novel 1-(2-phenyl-2-hydroxyethylamino)-3-phenoxypropan-2-ols and their acid addition salts.
DE1445800C (de) Verfahren zur Herstellung von Diben zoazepinen
DE1169450B (de) Verfahren zur Herstellung von Indolinderivaten und deren Salzen