DE07870164T1 - Verzögert freigesetzte formulierungen aus topiramat - Google Patents
Verzögert freigesetzte formulierungen aus topiramat Download PDFInfo
- Publication number
- DE07870164T1 DE07870164T1 DE07870164T DE07870164T DE07870164T1 DE 07870164 T1 DE07870164 T1 DE 07870164T1 DE 07870164 T DE07870164 T DE 07870164T DE 07870164 T DE07870164 T DE 07870164T DE 07870164 T1 DE07870164 T1 DE 07870164T1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- release
- topiramate
- maxir
- immediate release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
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- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85950206P | 2006-11-17 | 2006-11-17 | |
| US859502P | 2006-11-17 | ||
| PCT/US2007/084961 WO2008061226A2 (en) | 2006-11-17 | 2007-11-16 | Sustained-release formulations of topiramate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE07870164T1 true DE07870164T1 (de) | 2009-02-19 |
Family
ID=39400596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE07870164T Pending DE07870164T1 (de) | 2006-11-17 | 2007-11-16 | Verzögert freigesetzte formulierungen aus topiramat |
Country Status (9)
| Country | Link |
|---|---|
| US (10) | US8298576B2 (enExample) |
| EP (2) | EP1973528B1 (enExample) |
| JP (1) | JP5489719B2 (enExample) |
| AU (1) | AU2007319141B2 (enExample) |
| CA (1) | CA2618240C (enExample) |
| DE (1) | DE07870164T1 (enExample) |
| ES (2) | ES2555066T3 (enExample) |
| MX (1) | MX2009001711A (enExample) |
| WO (1) | WO2008061226A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7674776B2 (en) | 1999-06-14 | 2010-03-09 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
| WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| MX2009001711A (es) | 2006-11-17 | 2009-05-08 | Supernus Pharmaceuticals Inc | Formulaciones de liberacion sostenida de topiramato. |
| EP2363113B1 (en) * | 2006-12-04 | 2017-08-02 | Supernus Pharmaceuticals, Inc. | Enhanced immediate release formulations of topiramate |
| JP5424571B2 (ja) * | 2007-04-12 | 2014-02-26 | 協和発酵キリン株式会社 | トピラマート含有固形製剤 |
| US20090304789A1 (en) * | 2008-06-09 | 2009-12-10 | Thomas Najarian | Novel topiramate compositions and an escalating dosing strategy for treating obesity and related disorders |
| US8580298B2 (en) | 2008-06-09 | 2013-11-12 | Vivus, Inc. | Low dose topiramate/phentermine composition and methods of use thereof |
| CA2735934C (en) | 2008-09-05 | 2014-01-07 | Supernus Pharmaceuticals, Inc. | Method of treatment of attention deficit/hyperactivity disorder (adhd) |
| WO2010100657A2 (en) * | 2009-03-04 | 2010-09-10 | Fdc Limited | A novel oral controlled release dosage forms for water soluble drugs |
| CN102548544B (zh) * | 2009-10-09 | 2015-01-21 | 永进药品工业株式会社 | 同时具有速效特性和长效特性的药物组合物 |
| CN103153288B (zh) | 2010-07-09 | 2017-02-15 | 詹姆斯·特林卡·格林 | 用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统 |
| KR20180118801A (ko) * | 2010-09-01 | 2018-10-31 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리에 유용한 5-ht2c 작동제의 변형-방출 투여 형태 |
| US20120135104A1 (en) * | 2010-11-30 | 2012-05-31 | Bhiku Patel | Enhanced Absorption of Omega Fatty Acid Oils |
| MX356727B (es) | 2012-02-08 | 2018-06-12 | Supernus Pharmaceuticals Inc | Formulaciones de liberacion modificada de viloxacina. |
| JP6055076B2 (ja) | 2012-03-23 | 2016-12-27 | インスティテュート オブ ファーマコロジー アンド トキシコロジー アカデミー オブ ミリタリー メディカル サイエンシズ ピー.エル.エー.チャイナ | シネフリン及びトピラマートを含む組み合わせ製品 |
| CN102579367B (zh) * | 2012-03-23 | 2014-03-12 | 中国人民解放军军事医学科学院毒物药物研究所 | 托吡酯缓释药物组合物、其制备方法及用途 |
| CN103316026B (zh) | 2012-03-23 | 2016-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | 含芬特明和托吡酯的联合产品及其制备方法 |
| EP2832350B1 (en) * | 2012-03-29 | 2019-07-17 | Daicel Corporation | Method for producing disintegrating particulate composition comprising acid-type carboxymethylcellulose, disintegrating particulate composition comprising acid-type carboxymethylcellulose, and orally disintegrating tablet including disintegrating particulate composition comprising acid-type carboxymethylcellulose |
| KR101446066B1 (ko) | 2012-12-14 | 2014-10-01 | 박재돈 | 구안파신 함유 경구용 서방성 캡슐제 조성물 |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| WO2014167439A1 (en) * | 2013-03-26 | 2014-10-16 | Wockhardt Limited | Modified release pharmaceutical compositions of topiramate or salts thereof |
| IN2013MU01868A (enExample) * | 2013-05-27 | 2015-06-26 | Cadila Healthcare Ltd | |
| FR3007651A1 (fr) * | 2013-06-27 | 2015-01-02 | Assist Publ Hopitaux De Paris | Composition pharmaceutique sous forme de granules pour le traitement de desordres metaboliques chez l'enfant |
| US10278948B1 (en) | 2015-09-03 | 2019-05-07 | Tian Xia | Method for transnasal delivery of anticonvulsant and therapeutic treatments |
| US20170348235A1 (en) * | 2015-09-16 | 2017-12-07 | Corr-Jensen, Inc. | Multi-phase release of sports nutrition and energy drink compositions utilizing lipid particulates |
| WO2017048859A1 (en) * | 2015-09-16 | 2017-03-23 | Corr-Jensen, Inc. | Multi-phase release of sports nutrition and energy drink compositions utilizing lipid particulates |
| CN105326814A (zh) * | 2015-10-09 | 2016-02-17 | 北京万全德众医药生物技术有限公司 | 托吡酯缓释制剂药物组合物 |
| CN107308119B (zh) * | 2017-07-10 | 2019-12-17 | 浙江万方生物科技有限公司 | 一种高水溶性酒石酸泰万菌素颗粒及其制备方法 |
| JP7005229B2 (ja) * | 2017-08-24 | 2022-01-21 | キヤノン株式会社 | 記録装置、及び記録装置の制御方法 |
| US11819482B2 (en) | 2017-08-29 | 2023-11-21 | Conrig Pharma Aps | Composition comprising suplatast tosilate |
| US20210000867A1 (en) * | 2019-06-19 | 2021-01-07 | Glycan Industries LLC | New route and engineering protocols for alzheimers disease prevention, treatment and neuronal rebuilding |
| CN110638791A (zh) * | 2019-10-31 | 2020-01-03 | 浙江普利药业有限公司 | 托吡酯缓释胶囊及其制备方法 |
| US20240009181A1 (en) * | 2022-07-08 | 2024-01-11 | Jason Eric Schiffman | Method for the treatment and prophylaxis of substance-related and/or addictive disorders including substance/medication-induced depressive disorders, bipolar and related disorders, and anxiety disorders and compositions useful for the same |
| GB2643925A (en) | 2024-09-09 | 2026-03-11 | Novumgen Ltd | An orodispersible tablet of topiramate and its process of preparation |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Family Cites Families (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2528378A (en) | 1947-09-20 | 1950-10-31 | John J Mccabe Jr | Metal salts of substituted quaternary hydroxy cycloimidinic acid metal alcoholates and process for preparation of same |
| NL128245C (enExample) | 1951-05-31 | |||
| US2675619A (en) | 1952-05-31 | 1954-04-20 | Mcbee Co | Drafting instrument |
| US2738303A (en) | 1952-07-18 | 1956-03-13 | Smith Kline French Lab | Sympathomimetic preparation |
| US2996431A (en) | 1953-12-16 | 1961-08-15 | Barry Richard Henry | Friable tablet and process for manufacturing same |
| US2781354A (en) | 1956-03-26 | 1957-02-12 | John J Mccabe Jr | Imidazoline derivatives and process |
| US3036118A (en) | 1957-09-11 | 1962-05-22 | Wyandotte Chemicals Corp | Mixtures of novel conjugated polyoxyethylene-polyoxypropylene compounds |
| US2979578A (en) | 1958-10-30 | 1961-04-11 | Litton Systems Inc | Omnipositional rotary switch |
| US3139383A (en) | 1961-06-26 | 1964-06-30 | Norton Co | Encapsulated time release pellets and method for encapsulating the same |
| NL130291C (enExample) | 1964-01-02 | |||
| US3829506A (en) | 1971-06-01 | 1974-08-13 | Basf Wyandotte Corp | Biodegradable surface active agents having good foam properties and foam stabilizing characteristics |
| US3962414A (en) | 1972-04-27 | 1976-06-08 | Alza Corporation | Structured bioerodible drug delivery device |
| US3811444A (en) | 1972-12-27 | 1974-05-21 | Alza Corp | Bioerodible ocular device |
| DE2336218C3 (de) | 1973-07-17 | 1985-11-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Orale Arzneiform |
| US3992518A (en) | 1974-10-24 | 1976-11-16 | G. D. Searle & Co. | Method for making a microsealed delivery device |
| US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| US4079038A (en) | 1976-03-05 | 1978-03-14 | Alza Corporation | Poly(carbonates) |
| US4066747A (en) | 1976-04-08 | 1978-01-03 | Alza Corporation | Polymeric orthoesters housing beneficial drug for controlled release therefrom |
| US4070347A (en) | 1976-08-16 | 1978-01-24 | Alza Corporation | Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality |
| US4290426A (en) | 1978-05-04 | 1981-09-22 | Alza Corporation | Dispenser for dispensing beneficial agent |
| US4434153A (en) | 1982-03-22 | 1984-02-28 | Alza Corporation | Drug delivery system comprising a reservoir containing a plurality of tiny pills |
| US4721613A (en) | 1982-12-13 | 1988-01-26 | Alza Corporation | Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use |
| US4757128A (en) | 1986-08-01 | 1988-07-12 | Massachusetts Institute Of Technology | High molecular weight polyanhydride and preparation thereof |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US4727064A (en) | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US4752470A (en) | 1986-11-24 | 1988-06-21 | Mehta Atul M | Controlled release indomethacin |
| US4853229A (en) | 1987-10-26 | 1989-08-01 | Alza Corporation | Method for adminstering tiny pills |
| US5030447A (en) | 1988-03-31 | 1991-07-09 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions having good stability |
| US5180589A (en) | 1988-03-31 | 1993-01-19 | E. R. Squibb & Sons, Inc. | Pravastatin pharmaceuatical compositions having good stability |
| US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5133974A (en) | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| US4997904A (en) | 1989-08-25 | 1991-03-05 | Nova Pharmaceutical Corporation | Aromatic polyanhydride compositions |
| US5175235A (en) | 1990-06-04 | 1992-12-29 | Nova Pharmaceutical Corporation | Branched polyanhydrides |
| US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| US5286497A (en) | 1991-05-20 | 1994-02-15 | Carderm Capital L.P. | Diltiazem formulation |
| US5326570A (en) | 1991-07-23 | 1994-07-05 | Pharmavene, Inc. | Advanced drug delivery system and method of treating psychiatric, neurological and other disorders with carbamazepine |
| US5225202A (en) | 1991-09-30 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Enteric coated pharmaceutical compositions |
| US5478577A (en) | 1993-11-23 | 1995-12-26 | Euroceltique, S.A. | Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US6197346B1 (en) | 1992-04-24 | 2001-03-06 | Brown Universtiy Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| US6235313B1 (en) | 1992-04-24 | 2001-05-22 | Brown University Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
| US5256440A (en) | 1992-06-22 | 1993-10-26 | Merck & Co., Inc. | Process for producing a tablet core aperture |
| US5500227A (en) | 1993-11-23 | 1996-03-19 | Euro-Celtique, S.A. | Immediate release tablet cores of insoluble drugs having sustained-release coating |
| US5576311A (en) | 1994-11-30 | 1996-11-19 | Pharmos Corporation | Cyclodextrins as suspending agents for pharmaceutical suspensions |
| NZ270078A (en) | 1994-12-06 | 1998-05-27 | Bernard Charles Sherman | Diltiazem hydrochloride formulation comprising beads with immediate, intermediate, and delayed release dissolution profiles |
| US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| US5998380A (en) | 1995-10-13 | 1999-12-07 | New England Medical Center Hospitals, Inc. | Treatment of migraine |
| US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US5985312A (en) | 1996-01-26 | 1999-11-16 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
| US6368586B1 (en) | 1996-01-26 | 2002-04-09 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
| KR100341829B1 (ko) * | 1996-03-08 | 2002-08-22 | 니코메드 덴마크 에이/에스 | 방출특성이변형된다-유니트투여량조성물 |
| US5955096A (en) | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
| US5753693A (en) | 1996-06-28 | 1998-05-19 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating manic-depressive bipolar disorder |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| US5760007A (en) | 1997-07-16 | 1998-06-02 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating neuropathic pain |
| US5935933A (en) | 1997-07-16 | 1999-08-10 | Ortho-Mcneil Pharmaceutical, Inc. | Anticonvulsant derivatives useful in treating neuropathic pain |
| US6066339A (en) | 1997-10-17 | 2000-05-23 | Elan Corporation, Plc | Oral morphine multiparticulate formulation |
| US20040028735A1 (en) | 1997-11-14 | 2004-02-12 | Unchalee Kositprapa | Pharmaceutical formulation |
| UA65607C2 (uk) | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
| US6235311B1 (en) | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
| US6524620B2 (en) * | 1998-07-20 | 2003-02-25 | Andrx Pharmaceuticals, Inc. | Diltiazem controlled release formulation and method of manufacture |
| DK1126826T6 (en) * | 1998-11-02 | 2019-06-24 | Alkermes Pharma Ireland Ltd | Multiparticulate modified release of methylphenidate |
| EP1005863A1 (en) * | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
| US6528090B2 (en) | 1998-12-18 | 2003-03-04 | Abbott Laboratories | Controlled release formulation of divalproex sodium |
| US6797283B1 (en) | 1998-12-23 | 2004-09-28 | Alza Corporation | Gastric retention dosage form having multiple layers |
| CZ20012620A3 (cs) | 1999-01-19 | 2002-09-11 | Ortho-Mcneil Pharmaceutical, Inc. | Léčivo pro léčení histaminové cefalalgie |
| US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| JP4825353B2 (ja) | 1999-04-08 | 2011-11-30 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | 血圧を下げることに有用な抗痙攣薬誘導体 |
| US7056890B2 (en) | 1999-06-14 | 2006-06-06 | Vivus, Inc. | Combination therapy for effecting weight loss and treating obesity |
| US6562865B1 (en) | 1999-08-20 | 2003-05-13 | Ortho-Mcneil Pharmaceutical, Inc. | Composition comprising a tramadol material and an anticonvulsant drug |
| US6479467B1 (en) | 1999-12-16 | 2002-11-12 | Eastman Chemical Company | Cyclodextrin ethers |
| SE0000601D0 (sv) | 2000-02-24 | 2000-02-24 | Jan Hedner | Sätt att behandla och diagnostisera andningsstörningar i sömnen och medel för att utföra sättet |
| US20020044962A1 (en) | 2000-06-06 | 2002-04-18 | Cherukuri S. Rao | Encapsulation products for controlled or extended release |
| PT1309324E (pt) | 2000-07-07 | 2006-06-30 | Ortho Mcneil Pharm Inc | Derivados de anticonvulsivos uteis para o tratamento e prevencao do desenvolvimento de diabetes mellitus do tipo ii e da sindroma x |
| US6191117B1 (en) | 2000-07-10 | 2001-02-20 | Walter E. Kozachuk | Methods of producing weight loss and treatment of obesity |
| US6344215B1 (en) | 2000-10-27 | 2002-02-05 | Eurand America, Inc. | Methylphenidate modified release formulations |
| ATE334718T1 (de) | 2000-10-30 | 2006-08-15 | Ortho Mcneil Pharm Inc | Kombinationstherapie mit antidiabetischen und antikonvulsiven mitteln |
| ATE474572T1 (de) | 2000-11-30 | 2010-08-15 | Novodermix Internat Ltd | Heilung von wunden |
| TWI321054B (en) | 2000-12-19 | 2010-03-01 | California Inst Of Techn | Compositions containing inclusion complexes |
| IL159715A0 (en) | 2001-07-10 | 2004-06-20 | Teva Pharma | Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery |
| US6500454B1 (en) | 2001-10-04 | 2002-12-31 | Eurand Pharmaceuticals Ltd. | Timed, sustained release systems for propranolol |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| US20030072802A1 (en) | 2001-10-11 | 2003-04-17 | R.T. Alamo Ventures, Inc. | Sustained release topiramate |
| US20030091630A1 (en) | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
| US7815936B2 (en) | 2001-10-30 | 2010-10-19 | Evonik Degussa Gmbh | Use of granular materials based on pyrogenically produced silicon dioxide in pharmaceutical compositions |
| NZ552514A (en) | 2001-12-24 | 2008-08-29 | Teva Pharma | Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it |
| US20040052843A1 (en) | 2001-12-24 | 2004-03-18 | Lerner E. Itzhak | Controlled release dosage forms |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| US6559293B1 (en) | 2002-02-15 | 2003-05-06 | Transform Pharmaceuticals, Inc. | Topiramate sodium trihydrate |
| EP1478400A1 (en) | 2002-02-26 | 2004-11-24 | Ortho-McNeil Pharmaceutical, Inc. | Therapy for the treatment of migraine comprising anticonvulsant derivatives and antimigraine agents |
| EP1499300B1 (en) | 2002-04-29 | 2009-03-18 | Supernus Pharmaceuticals, Inc. | Pharmaceutical formulations with improved bioavailability |
| AR039744A1 (es) | 2002-06-26 | 2005-03-09 | Alza Corp | Metodos y formas de dosificacion para aumentar la solubilidad de las composiciones de farmacos para la administracion controlada |
| AU2003263760A1 (en) | 2002-06-27 | 2004-01-19 | The General Hospital Corporation | Methods for the treatment or prevention of obesity |
| NZ537543A (en) | 2002-07-29 | 2007-08-31 | Alza Corp | Formulations and high dose osmotic dosage forms for controlled delivery of topiramate |
| US8268352B2 (en) | 2002-08-05 | 2012-09-18 | Torrent Pharmaceuticals Limited | Modified release composition for highly soluble drugs |
| US8216609B2 (en) | 2002-08-05 | 2012-07-10 | Torrent Pharmaceuticals Limited | Modified release composition of highly soluble drugs |
| US7985422B2 (en) | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
| RU2005109909A (ru) * | 2002-09-04 | 2006-10-10 | Рэнбакси Лабораториз Лимитед (In) | Лекарственные формы с замаскированным вкусом и способы их получения |
| US20040132826A1 (en) | 2002-10-25 | 2004-07-08 | Collegium Pharmaceutical, Inc. | Modified release compositions of milnacipran |
| WO2004050068A1 (en) | 2002-11-29 | 2004-06-17 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
| US7670627B2 (en) | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| AU2003296672A1 (en) | 2002-12-13 | 2004-07-09 | Cilag Ag | Controlled release preparations comprising tramadol and topiramate |
| CA2513064C (en) | 2003-01-31 | 2009-11-10 | Elan Pharma International, Ltd. | Nanoparticulate topiramate formulations |
| US20040185097A1 (en) | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US20060210633A1 (en) | 2003-04-03 | 2006-09-21 | Sun Pharmaceutical Industries Limited | Programmed drug delivery system |
| CA2521885C (en) | 2003-04-07 | 2013-06-25 | Shire Laboratories, Inc. | Once daily formulations of tetracyclines |
| MXPA06001548A (es) | 2003-08-06 | 2006-09-04 | Johnson & Johnson | Suministro uniforme de topiramato durante un periodo prolongado con formulaciones de dispersion. |
| US20050136108A1 (en) | 2003-08-22 | 2005-06-23 | Yam Noymi V. | Stepwise delivery of topiramate over prolonged period of time |
| US20050069587A1 (en) * | 2003-09-02 | 2005-03-31 | Modi Nishit Bachulal | Novel drug compositions and dosage forms of topiramate |
| US7737133B2 (en) | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
| US7611728B2 (en) | 2003-09-05 | 2009-11-03 | Supernus Pharmaceuticals, Inc. | Osmotic delivery of therapeutic compounds by solubility enhancement |
| KR20060115860A (ko) | 2003-09-26 | 2006-11-10 | 알자 코포레이션 | 활성 제제의 서방성 전달을 위한 oros 푸시-스틱 |
| DE602004030931D1 (enExample) | 2003-11-04 | 2011-02-17 | Supernus Pharmaceuticals Inc | |
| TW200533374A (en) | 2003-11-13 | 2005-10-16 | Alza Corp | Melt blend dispersions |
| KR20060120193A (ko) | 2003-11-14 | 2006-11-24 | 알자 코포레이션 | 액체 제형내 토피라메이트의 제어된 방출 |
| US7387793B2 (en) * | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
| US7470435B2 (en) | 2003-11-17 | 2008-12-30 | Andrx Pharmaceuticals, Llc | Extended release venlafaxine formulation |
| WO2005053612A2 (en) | 2003-11-26 | 2005-06-16 | Shire Laboratories, Inc. | Micellar systems useful for delivery of lipophilic or hydrophobic compounds |
| JP2007516297A (ja) | 2003-12-23 | 2007-06-21 | アルザ・コーポレーシヨン | 制御送達用薬剤組成物の溶解度を高くする方法および投薬形態物 |
| CA2550699A1 (en) | 2003-12-29 | 2005-07-21 | Alza Corporation, Inc. | Novel drug compositions and dosage forms of topiramate |
| ES2241478B1 (es) * | 2004-02-13 | 2006-11-16 | Lacer S.A. | Preparacion farmaceutica para la liberacion sostenida de un principio farmaceuticamente activo. |
| WO2005079773A2 (en) | 2004-02-13 | 2005-09-01 | Neuromolecular, Inc. | Combination of an nmda receptor antagonist and an anti-epileptic drug for the treatment of epilepsy and other cns disorders |
| US20050220596A1 (en) | 2004-03-30 | 2005-10-06 | Cnh America Llc | Method and apparatus for hydraulically produced ground following of an unloading ramp for a cotton harvester |
| DE602005019449D1 (de) * | 2004-07-02 | 2010-04-01 | Univ Edinburgh | Fluid-bikontinuierliche teilchenstabilisierte gele |
| CA2572928A1 (en) * | 2004-07-22 | 2006-02-26 | Amorepacific Corporation | Sustained-release preparations containing topiramate and the producing method thereof |
| JP2008509144A (ja) | 2004-08-04 | 2008-03-27 | アルザ・コーポレーシヨン | 上昇するゼロ次放出パターンを示す持続薬剤放出組成物、そのような組成物を製造する方法 |
| US20060045912A1 (en) | 2004-08-30 | 2006-03-02 | Peter Truog | 4-phenylbutyric acid controlled-release formulations for therapeutic use |
| US20060105045A1 (en) | 2004-11-08 | 2006-05-18 | Buchanan Charles M | Cyclodextrin solubilizers for liquid and semi-solid formulations |
| US20060121112A1 (en) | 2004-12-08 | 2006-06-08 | Elan Corporation, Plc | Topiramate pharmaceutical composition |
| GB2422149A (en) | 2005-01-14 | 2006-07-19 | Portela & Ca Sa | Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide |
| US20060233892A1 (en) | 2005-04-19 | 2006-10-19 | Curt Hendrix | Topiramate compositions for treatment of headache |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| US8491929B2 (en) | 2005-06-23 | 2013-07-23 | Vaunnex Inc. | Bioadhesive polymers |
| US8784886B2 (en) | 2006-03-09 | 2014-07-22 | GlaxoSmithKline, LLC | Coating capsules with active pharmaceutical ingredients |
| US8846100B2 (en) | 2006-05-12 | 2014-09-30 | Shire Llc | Controlled dose drug delivery system |
| WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| TW201811315A (zh) | 2006-11-09 | 2018-04-01 | 美商歐瑞根治療有限公司 | 層狀醫藥調配物 |
| MX2009001711A (es) | 2006-11-17 | 2009-05-08 | Supernus Pharmaceuticals Inc | Formulaciones de liberacion sostenida de topiramato. |
| EP2363113B1 (en) | 2006-12-04 | 2017-08-02 | Supernus Pharmaceuticals, Inc. | Enhanced immediate release formulations of topiramate |
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2007
- 2007-11-16 MX MX2009001711A patent/MX2009001711A/es active IP Right Grant
- 2007-11-16 ES ES11179776.7T patent/ES2555066T3/es active Active
- 2007-11-16 US US11/941,475 patent/US8298576B2/en active Active
- 2007-11-16 EP EP07870164A patent/EP1973528B1/en active Active
- 2007-11-16 CA CA2618240A patent/CA2618240C/en active Active
- 2007-11-16 WO PCT/US2007/084961 patent/WO2008061226A2/en not_active Ceased
- 2007-11-16 JP JP2009537388A patent/JP5489719B2/ja not_active Expired - Fee Related
- 2007-11-16 ES ES07870164T patent/ES2312308T3/es active Active
- 2007-11-16 EP EP11179776.7A patent/EP2394643B1/en active Active
- 2007-11-16 AU AU2007319141A patent/AU2007319141B2/en not_active Ceased
- 2007-11-16 DE DE07870164T patent/DE07870164T1/de active Pending
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2010
- 2010-12-17 US US12/926,936 patent/US8889191B2/en active Active
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