DE05014998T1 - Schweinecircoviren, Nukleinsäuren, Polypeptide und Impfstoffe - Google Patents
Schweinecircoviren, Nukleinsäuren, Polypeptide und Impfstoffe Download PDFInfo
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- DE05014998T1 DE05014998T1 DE05014998T DE05014998T DE05014998T1 DE 05014998 T1 DE05014998 T1 DE 05014998T1 DE 05014998 T DE05014998 T DE 05014998T DE 05014998 T DE05014998 T DE 05014998T DE 05014998 T1 DE05014998 T1 DE 05014998T1
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- nucleic acid
- acid fragment
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- expression vector
- polypeptide
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- 150000007523 nucleic acids Chemical class 0.000 title claims abstract 16
- 229920001184 polypeptide Polymers 0.000 title claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 8
- 229960005486 vaccine Drugs 0.000 title claims 4
- 241000700605 Viruses Species 0.000 title claims 3
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 241000202347 Porcine circovirus Species 0.000 claims abstract 9
- 239000013604 expression vector Substances 0.000 claims 9
- 241000282898 Sus scrofa Species 0.000 claims 3
- 241000282887 Suidae Species 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 238000009396 hybridization Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000700663 Avipoxvirus Species 0.000 claims 1
- 241000178270 Canarypox virus Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 claims 1
- 241000188845 Porcine adenovirus Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 claims 1
- 241000700618 Vaccinia virus Species 0.000 claims 1
- 241000700647 Variola virus Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 230000008105 immune reaction Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
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- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/02—Making cheese curd
- A23C19/032—Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin
- A23C19/0321—Propionic acid bacteria
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/02—Making cheese curd
- A23C19/032—Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin
- A23C19/0323—Making cheese curd characterised by the use of specific microorganisms, or enzymes of microbial origin using only lactic acid bacteria, e.g. Pediococcus and Leuconostoc species; Bifidobacteria; Microbial starters in general
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
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Abstract
Nukleinsäurefragment,
dadurch gekennzeichnet, daß es
eine Sequenz des Genoms eines porcinen Circovirus (PCV) Typ II gemäß SEQ ID
NO: 1 enthält.
Claims (23)
- Nukleinsäurefragment, dadurch gekennzeichnet, daß es eine Sequenz des Genoms eines porcinen Circovirus (PCV) Typ II gemäß SEQ ID NO: 1 enthält.
- Nukleinsäurefragment, dadurch gekennzeichnet, daß es eine Sequenz des Genoms eines PCV Typ II mit mindestens 76% Homologie zu der Sequenz nach Anspruch 1 enthält.
- Nukleinsäurefragment, dadurch gekennzeichnet, daß die Sequenz des PCV Typ II-Genoms fähig ist, spezifisch mit der Sequenz nach Anspruch 1 zu hybridisieren.
- Nukleinsäurefragment nach Anspruch 3, dadurch gekennzeichnet, daß die Hybridisierung unter Bedingungen mit hoher Stringenz durchgeführt wird.
- Nukleinsäurefragment, dadurch gekennzeichnet, daß es eine Sequenz des Genoms eines porcinen Circovirus (PCV) Typ II ausgewählt aus der Reihe SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 und SEQ ID NO: 6 enthält.
- Nukleinsäurefragment, dadurch gekennzeichnet, daß es eine Sequenz, die fähig ist, spezifisch mit einer der Sequenzen nach Anspruch 5 zu hybridisieren.
- Nukleinsäurefragment nach Anspruch 6, dadurch gekennzeichnet, daß die Hybridisierung unter Bedingungen mit hoher Stringenz durchgeführt wird.
- Nukleinsäurefragment, dadurch gekennzeichnet, daß es die Sequenz nach einem der Ansprüche 1 bis 7 ganz oder teilweise enthält, wobei das genannte Fragment eine Sequenz enthält, die für ein Epitop codiert, welches fähig ist, beim Schwein eine Immumreaktion gegen PCV Typ II zu induzieren.
- Nukleinsäurefragment nach Anspruch 8, dadurch gekennzeichnet, daß das Epitop mindestens 13 bis 25 Aminosäuren enthält.
- Nukleinsäurefragment, dadurch gekennzeichnet, daß es die Sequenz nach einem der Ansprüche 1 bis 7 ganz oder teilweise enthält, wobei dieses Fragment für ein Polypeptid codiert, das mindestens ein offenes Leseraster (OLR) enthält.
- Nukleinsäurefragment nach Anspruch 10, dadurch gekennzeichnet, daß das OLR aus der Gruppe OLR 1 bis 13, vorzugsweise OLR 4, 7, 10 und 13, stammt.
- Polypeptid, das von dem Nukleinsäurefragment nach einem der Ansprüche 1 bis 11 codiert wird.
- Expressionsvektor, der ein Nukleinsäurefragment nach einem der Ansprüche 1 bis 11 enthält und der ein Polypeptid in vitro exprimiert.
- Expressionsvektor nach Anspruch 13, dadurch gekennzeichnet, daß es sich um ein Baculovirus handelt.
- Expressionsvektor nach einem der Ansprüche 13 bis 14, dadurch gekennzeichnet, daß er ein Polypeptid in E. coli oder Insektenzellen oder Eukaryontenzellen, vorzugsweise aus der Gruppe der Hefen oder Säugetierzellen, exprimiert.
- Polypeptide, die von einem Expressionsvektor nach einem der Ansprüche 13 bis 15 produziert wurden.
- Spaltimpfstoff, der mindestens ein Polypeptid nach Anspruch 12 oder 16 in einem tierärztlich annehmbaren Träger- oder Verdünnungsmittel sowie gegebenenfalls einen tierärztlich annehmbaren Hilfsstoff enthält.
- Expressionsvektor, dadurch gekennzeichnet, daß er ein Nukleinsäurefragment nach einem der Ansprüche 1 bis 11 in sein Genom in vivo integriert und ein Polypeptid exprimiert.
- Expressionsvektor nach Anspruch 18, dadurch gekennzeichnet, daß er ausgewählt ist aus der Gruppe der lebenden Viren, die entweder natürlich nicht pathogen sind oder für das Schwein attenuiert worden sind, und den Plasmiden.
- Expressionsvektor nach Anspruch 19, dadurch gekennzeichnet, daß er zur Vermehrung im Schwein fähig ist.
- Expressionsvektor nach einem der Ansprüche 18 bis 20, dadurch gekennzeichnet, daß das Virus ausgewählt ist aus der Gruppe Schweine-Herpesviren wie Virus der Aujeszky-Krankheit, Schweine-Adenovirus, Poxviren, insbesondere Vaccinia-Virus, Avipox-Virus, Canarypox-Virus, Schweinepocken-Virus.
- Lebend- oder Plasmidimpfstoff, dadurch gekennzeichnet, daß er mindestens einen Expressionsvektor nach einem der Ansprüche 18 bis 21 enthält.
- Impfstoff nach Anspruch 22, dadurch gekennzeichnet, daß er weiterhin ein tierärztlich annehmbares Träger- oder Verdünnungsmittel enthält.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9712382A FR2769321B1 (fr) | 1997-10-03 | 1997-10-03 | Nouveaux circovirus porcins, vaccins et reactifs de diagnostics |
FR9712382 | 1997-10-03 | ||
FR9800873 | 1998-01-22 | ||
FR9800873A FR2769322B1 (fr) | 1997-10-03 | 1998-01-22 | Nouveaux circovirus porcins, vaccins et reactifs de diagnostic |
FR9803707A FR2776294B1 (fr) | 1998-03-20 | 1998-03-20 | Nouveaux circovirus porcins ; vaccins et reactifs de diagnostic |
FR9803707 | 1998-03-20 |
Publications (1)
Publication Number | Publication Date |
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DE05014998T1 true DE05014998T1 (de) | 2008-11-20 |
Family
ID=27253376
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE200512000009 Pending DE122005000009I1 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren abgeleitete Impfstoffe. |
DE69830858A Expired - Lifetime DE69830858D1 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren |
DE69816460T Expired - Lifetime DE69816460T2 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren abgeleitete impfstoffe |
DE122008000069C Pending DE122008000069I1 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren abgeleitete impfstoffe |
DE05014998T Pending DE05014998T1 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren, Nukleinsäuren, Polypeptide und Impfstoffe |
DE69839227T Expired - Lifetime DE69839227T2 (de) | 1997-10-03 | 1998-10-01 | Verfahren zur in vitro-Diagnose von Infektionen durch Schweinecircovirus vom Typ II und diagnostische Reagenzien |
DE69830858T Expired - Lifetime DE69830858T4 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE200512000009 Pending DE122005000009I1 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren abgeleitete Impfstoffe. |
DE69830858A Expired - Lifetime DE69830858D1 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren |
DE69816460T Expired - Lifetime DE69816460T2 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren abgeleitete impfstoffe |
DE122008000069C Pending DE122008000069I1 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren abgeleitete impfstoffe |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69839227T Expired - Lifetime DE69839227T2 (de) | 1997-10-03 | 1998-10-01 | Verfahren zur in vitro-Diagnose von Infektionen durch Schweinecircovirus vom Typ II und diagnostische Reagenzien |
DE69830858T Expired - Lifetime DE69830858T4 (de) | 1997-10-03 | 1998-10-01 | Schweinecircoviren |
Country Status (21)
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US (1) | US6368601B1 (de) |
EP (4) | EP1281760B9 (de) |
JP (5) | JP5008218B2 (de) |
KR (4) | KR100854615B1 (de) |
CN (2) | CN100584948C (de) |
AT (3) | ATE245191T1 (de) |
AU (1) | AU756554C (de) |
BR (1) | BR9812845B1 (de) |
CA (1) | CA2305623C (de) |
CY (3) | CY1110359T1 (de) |
DE (7) | DE122005000009I1 (de) |
DK (4) | DK1281760T5 (de) |
ES (4) | ES2524359T3 (de) |
FR (1) | FR05C0021I2 (de) |
HK (1) | HK1095161A1 (de) |
HU (2) | HU230340B1 (de) |
NL (1) | NL300326I2 (de) |
PL (1) | PL198506B1 (de) |
PT (4) | PT1386617E (de) |
UA (1) | UA78180C2 (de) |
WO (1) | WO1999018214A1 (de) |
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