DK179290A - Rekombinante cmv-neutraliserende proteiner - Google Patents
Rekombinante cmv-neutraliserende proteiner Download PDFInfo
- Publication number
- DK179290A DK179290A DK179290A DK179290A DK179290A DK 179290 A DK179290 A DK 179290A DK 179290 A DK179290 A DK 179290A DK 179290 A DK179290 A DK 179290A DK 179290 A DK179290 A DK 179290A
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptides
- recombinant cmv
- glycoprotein
- neutralizing proteins
- cmv neutralizing
- Prior art date
Links
- 230000003472 neutralizing effect Effects 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 101710170453 Glycoprotein 55 Proteins 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 2
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 238000012512 characterization method Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/705—Specific hybridization probes for herpetoviridae, e.g. herpes simplex, varicella zoster
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/089—Cytomegalovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14971588A | 1988-01-29 | 1988-01-29 | |
| US14971588 | 1988-01-29 | ||
| PCT/US1989/000323 WO1989007143A1 (en) | 1988-01-29 | 1989-01-26 | Recombinant cmv neutralizing proteins |
| US8900323 | 1989-01-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK179290D0 DK179290D0 (da) | 1990-07-27 |
| DK179290A true DK179290A (da) | 1990-09-28 |
| DK176055B1 DK176055B1 (da) | 2006-02-27 |
Family
ID=22531490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK199001792A DK176055B1 (da) | 1988-01-29 | 1990-07-27 | C-terminalafkortet fragment af CMV-glycoprotein-gB, et polynukleotid, som koder for fragmentet, samt immunoanalyse, vaccine og fremgangsmåde til fremstilling af vaccinen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6190860B1 (da) |
| EP (2) | EP0436537A4 (da) |
| JP (2) | JP2607712B2 (da) |
| AT (1) | ATE246244T1 (da) |
| AU (1) | AU641121B2 (da) |
| CA (1) | CA1340832C (da) |
| DE (1) | DE68929478T2 (da) |
| DK (1) | DK176055B1 (da) |
| FI (1) | FI109604B (da) |
| WO (1) | WO1989007143A1 (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100064A (en) * | 1984-04-06 | 2000-08-08 | Chiron Corporation | Secreted viral proteins useful for vaccines and diagnostics |
| US6162620A (en) * | 1986-03-07 | 2000-12-19 | Cogent Limited | Processes for the production of HCMV glycoproteins, antibodies thereto and HCMV vaccines, and recombinant vectors therefor |
| US5124440A (en) * | 1986-11-24 | 1992-06-23 | The Childrens Hospital, Inc. | Antibody and T cell recognition sites on glycoproteins comprising the GCI complex of human cytomegalovirus |
| US5552143A (en) * | 1989-03-24 | 1996-09-03 | The Wistar Institute Of Anatomy & Biology | Recombinant cytomegalovirus vaccine |
| US5591439A (en) * | 1989-03-24 | 1997-01-07 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
| GB9008223D0 (en) * | 1990-04-11 | 1990-06-13 | Royal Free Hosp School Med | Improvements relating to the detection of viruses |
| US5997878A (en) * | 1991-03-07 | 1999-12-07 | Connaught Laboratories | Recombinant poxvirus-cytomegalovirus, compositions and uses |
| EP0625214A4 (en) * | 1991-12-23 | 1997-07-16 | Chiron Corp | Cmv probes for use in solution phase sandwich hybridization assays. |
| GB9409962D0 (en) * | 1994-05-18 | 1994-07-06 | Smithkline Beecham Biolog | Novel compounds |
| US6022542A (en) * | 1995-09-26 | 2000-02-08 | University Of Washington | Glycoprotein B of the RFHV/KSHV subfamily of herpes viruses |
| US6448389B1 (en) | 1996-04-23 | 2002-09-10 | The Wistar Institute Of Anatomy And Biology | Human cytomegalovirus DNA constructs and uses therefor |
| EP1137664A2 (en) * | 1998-12-10 | 2001-10-04 | Washington University | Protein transduction system and methods of use thereof |
| JP2002537102A (ja) | 1999-02-26 | 2002-11-05 | カイロン コーポレイション | 吸着された高分子および微粒子を有するミクロエマルジョン |
| US20050232936A1 (en) | 2001-07-27 | 2005-10-20 | Chiron Corporation | Meningococcus adhesins nada, app and orf 40 |
| DE60333035D1 (de) | 2002-12-23 | 2010-07-29 | Vical Inc | Impfstoffe gegen infektionen mit dem humanen zytomegalivirus auf grundlage von codonoptimierten polynukleotiden |
| AR054822A1 (es) | 2005-07-07 | 2007-07-18 | Sanofi Pasteur | Emulsion inmuno adyuvante |
| CA2766907A1 (en) | 2009-07-06 | 2011-01-13 | Novartis Ag | Self replicating rna molecules and uses thereof |
| US8802106B2 (en) | 2009-10-30 | 2014-08-12 | The Administrators Of The Tulane Educational Fund | Peptide compositions and methods for inhibiting herpesvirus infection |
| JP5833565B2 (ja) | 2009-12-23 | 2015-12-16 | ４−アンティボディ・アクチェンゲゼルシャフト４−Ａｎｔｉｂｏｄｙ Ａｇ | ヒトサイトメガロウイルスに対する結合メンバー |
| RU2625546C2 (ru) | 2010-07-06 | 2017-07-14 | Новартис Аг | Катионные эмульсии "масло-в-воде" |
| EP2502631A1 (en) * | 2011-03-22 | 2012-09-26 | Medizinische Hochschule Hannover | Immune suppressor and its use |
| JP6059220B2 (ja) | 2011-07-06 | 2017-01-18 | ノバルティス アーゲー | 核酸を含む水中油型エマルジョン |
| CN103796639B (zh) | 2011-07-06 | 2017-05-31 | 诺华股份有限公司 | 阳离子水包油乳液 |
| JP6305925B2 (ja) | 2011-10-11 | 2018-04-18 | ノバルティス アーゲー | 組換え自己複製ポリシストロニックｒｎａ分子 |
| MX353189B (es) | 2011-11-11 | 2018-01-05 | Variation Biotechnologies Inc | Composiciones y su uso en el tratamiento de citomegalovirus. |
| HUE054579T2 (hu) * | 2013-12-03 | 2021-09-28 | Hookipa Biotech Gmbh | CMV vakcinák |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| BR112018076015A8 (pt) | 2016-06-17 | 2022-06-28 | Sanofi Pasteur | Formulações imunogênicas compreendendo adjuvantes de polímero do ácido poliacrílico linear ou ramificado . |
| WO2020085457A1 (ja) * | 2018-10-25 | 2020-04-30 | Ｋｍバイオロジクス株式会社 | 改変ＣＭＶ ｇＢタンパク質及びこれを含むＣＭＶワクチン |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| US11857622B2 (en) | 2020-06-21 | 2024-01-02 | Pfizer Inc. | Human cytomegalovirus GB polypeptide |
| CN112662694A (zh) * | 2020-12-25 | 2021-04-16 | 康九生物科技(长春)有限公司 | 一种麦芽糖结合蛋白、麦芽糖结合蛋白表达载体、重组工程菌及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4313927A (en) * | 1979-10-19 | 1982-02-02 | Ames-Yissum Ltd. | Immunoassay method for detecting viral antibodies in whole blood samples |
| US4554101A (en) * | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4460689A (en) * | 1982-04-15 | 1984-07-17 | Merck & Co., Inc. | DNA Cloning vector TG1, derivatives, and processes of making |
| US5173402A (en) * | 1982-11-02 | 1992-12-22 | The Regents Of The University Of California | Method and compositions for screening and diagnosing human cytomegalovirus ("hCMV") |
| US4762780A (en) * | 1984-04-17 | 1988-08-09 | The Regents Of The University Of California | Method and composition for screening and diagnosing "HCMV" |
| US4783399A (en) | 1984-05-04 | 1988-11-08 | Scripps Clinic And Research Foundation | Diagnostic system for the detection of cytomegalovirus |
| ATE73349T1 (de) * | 1984-06-18 | 1992-03-15 | Chiron Corp | Hepatitisoberflaechenantigenpartikelvakzin. |
| US5075213A (en) * | 1984-07-27 | 1991-12-24 | City Of Hope | Method for detection and prevention of human cytomegalovirus infection |
| US4689225A (en) * | 1984-11-02 | 1987-08-25 | Institut Merieux | Vaccine for cytomegalovirus |
| WO1987003602A1 (en) * | 1985-12-06 | 1987-06-18 | Teijin Limited | Anticytomegaloviral human monoclonal antibody and process for its preparation |
| CA1335429C (en) * | 1986-03-07 | 1995-05-02 | Geoffrey L. Smith | Processes for the production of hcmv glycoproteins, antibodies thereto and hcmv vaccines, and recombinant vectors therefor |
| DE3619720A1 (de) * | 1986-06-12 | 1987-12-17 | Behringwerke Ag | Hauptglykoprotein des menschlichen cytomegalovirus, seine herstellung und verwendung |
| US5124440A (en) * | 1986-11-24 | 1992-06-23 | The Childrens Hospital, Inc. | Antibody and T cell recognition sites on glycoproteins comprising the GCI complex of human cytomegalovirus |
| US5126130A (en) | 1986-11-24 | 1992-06-30 | The Childrens Hospital Incorporated | Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a |
| US5403711A (en) * | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| WO1989010966A1 (en) * | 1988-05-09 | 1989-11-16 | The Children's Hospital, Incorporated | Vectors encoding hcmv glycoprotein and expression products |
| US5262297A (en) * | 1990-06-18 | 1993-11-16 | Eastman Kodak Company | Specific binding analytical and separation methods using carboxy containing polymers |
| EP0625214A4 (en) * | 1991-12-23 | 1997-07-16 | Chiron Corp | Cmv probes for use in solution phase sandwich hybridization assays. |
-
1989
- 1989-01-26 DE DE68929478T patent/DE68929478T2/de not_active Expired - Lifetime
- 1989-01-26 WO PCT/US1989/000323 patent/WO1989007143A1/en active IP Right Grant
- 1989-01-26 AT AT93203533T patent/ATE246244T1/de not_active IP Right Cessation
- 1989-01-26 EP EP19890902156 patent/EP0436537A4/en not_active Withdrawn
- 1989-01-26 EP EP93203533A patent/EP0609580B1/en not_active Expired - Lifetime
- 1989-01-26 JP JP1502008A patent/JP2607712B2/ja not_active Expired - Lifetime
- 1989-01-26 AU AU30413/89A patent/AU641121B2/en not_active Ceased
- 1989-01-27 CA CA000589457A patent/CA1340832C/en not_active Expired - Fee Related
-
1990
- 1990-07-25 FI FI903724A patent/FI109604B/fi not_active IP Right Cessation
- 1990-07-27 DK DK199001792A patent/DK176055B1/da not_active IP Right Cessation
-
1995
- 1995-05-24 US US08/448,780 patent/US6190860B1/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,671 patent/US5834307A/en not_active Expired - Lifetime
-
1996
- 1996-07-25 JP JP8196805A patent/JPH09176190A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE68929478T2 (de) | 2004-04-29 |
| AU3041389A (en) | 1989-08-25 |
| DE68929478D1 (de) | 2003-09-04 |
| CA1340832C (en) | 1999-11-30 |
| DK179290D0 (da) | 1990-07-27 |
| EP0609580B1 (en) | 2003-07-30 |
| FI903724A0 (fi) | 1990-07-25 |
| EP0436537A1 (en) | 1991-07-17 |
| JPH03503478A (ja) | 1991-08-08 |
| DK176055B1 (da) | 2006-02-27 |
| AU641121B2 (en) | 1993-09-16 |
| WO1989007143A1 (en) | 1989-08-10 |
| FI109604B (fi) | 2002-09-13 |
| EP0609580A1 (en) | 1994-08-10 |
| EP0436537A4 (en) | 1992-04-08 |
| US6190860B1 (en) | 2001-02-20 |
| US5834307A (en) | 1998-11-10 |
| JPH09176190A (ja) | 1997-07-08 |
| JP2607712B2 (ja) | 1997-05-07 |
| ATE246244T1 (de) | 2003-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |