DD300433A5 - N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, verfahren zu deren herstellung und deren verwendung als medikamente - Google Patents

N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, verfahren zu deren herstellung und deren verwendung als medikamente Download PDF

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Publication number
DD300433A5
DD300433A5 DD340772A DD34077290A DD300433A5 DD 300433 A5 DD300433 A5 DD 300433A5 DD 340772 A DD340772 A DD 340772A DD 34077290 A DD34077290 A DD 34077290A DD 300433 A5 DD300433 A5 DD 300433A5
Authority
DD
German Democratic Republic
Prior art keywords
piperidinyl
fluoro
ethanone
alkyl
compound
Prior art date
Application number
DD340772A
Other languages
German (de)
English (en)
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DD300433A5 publication Critical patent/DD300433A5/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D275/00Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DD340772A 1989-05-19 1990-05-17 N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, verfahren zu deren herstellung und deren verwendung als medikamente DD300433A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35441189A 1989-05-19 1989-05-19
US45679089A 1989-12-29 1989-12-29

Publications (1)

Publication Number Publication Date
DD300433A5 true DD300433A5 (de) 1992-06-11

Family

ID=26998389

Family Applications (1)

Application Number Title Priority Date Filing Date
DD340772A DD300433A5 (de) 1989-05-19 1990-05-17 N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, verfahren zu deren herstellung und deren verwendung als medikamente

Country Status (24)

Country Link
EP (1) EP0402644B1 (no)
JP (1) JPH0662580B2 (no)
KR (1) KR0157308B1 (no)
CN (2) CN1086387C (no)
AT (1) ATE126512T1 (no)
AU (1) AU640653B2 (no)
CA (1) CA2017193C (no)
CZ (1) CZ282385B6 (no)
DD (1) DD300433A5 (no)
DE (1) DE69021645T2 (no)
DK (1) DK0402644T3 (no)
ES (1) ES2076253T3 (no)
FI (2) FI104072B1 (no)
GR (1) GR3017447T3 (no)
HK (2) HK1006710A1 (no)
HU (2) HU218200B (no)
IE (1) IE68431B1 (no)
IL (1) IL94425A (no)
NO (1) NO177301C (no)
NZ (1) NZ233710A (no)
PL (1) PL163965B1 (no)
PT (1) PT94084B (no)
RU (3) RU2147583C1 (no)
SK (1) SK242590A3 (no)

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US5364866A (en) 1989-05-19 1994-11-15 Hoechst-Roussel Pharmaceuticals, Inc. Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
US5561128A (en) * 1989-05-19 1996-10-01 Hoechst-Roussel Pharmaceuticals, Inc. N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility
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US5177088A (en) * 1991-04-17 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 3-(pyridinylamino)-indoles
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
TW241263B (no) * 1991-08-22 1995-02-21 Hoechst Roussel Pharma
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
WO1993010742A2 (en) * 1991-11-27 1993-06-10 Novo Nordisk A/S Chemical compounds, their preparation and use
US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
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DK60793D0 (da) * 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
GB9318691D0 (en) * 1993-09-09 1993-10-27 Merck Sharp & Dohme Therapeutic agents
WO1995007893A1 (en) * 1993-09-15 1995-03-23 Merck Sharp & Dohme Limited Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
ES2101646B1 (es) * 1995-04-12 1998-04-01 Ferrer Int Nuevo compuesto derivado del cromeno.
US5668148A (en) * 1995-04-20 1997-09-16 Merck & Co., Inc. Alpha1a adrenergic receptor antagonists
PT833820E (pt) * 1995-06-06 2001-07-31 Aventis Pharmaceuticals Inc Av Derivados de benzisoxazol e indazol uteis como agentes antipsicoticos
KR100308748B1 (ko) * 1996-01-05 2001-12-12 게리 디. 스트리트, 스티븐 엘. 네스비트 Cns활성을갖는4,5-디히드로나프트(1,2-c)이속사졸및그의유도체
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
ES2144355B1 (es) * 1997-12-30 2001-01-01 Ferrer Int Compuestos derivados del cromeno.
WO2001017993A1 (en) * 1999-09-09 2001-03-15 EGIS Gyógyszergyár Rt. Alkylpiperidi nylbenzo [d] isoxazole derivatives having psychotropic activity, pharmaceutical compositions containing the same, and a process for the preparation of the active ingredient
GB0102841D0 (en) * 2001-02-05 2001-03-21 Novartis Ag Organic compounds
AU2006201188B2 (en) * 2001-02-05 2007-11-15 Novartis Ag New use of iloperidone
DK1425272T3 (da) * 2001-08-31 2011-11-21 Novartis Ag Optiske isomerer af en iloperidon-metabolit
CN101912367A (zh) * 2001-10-30 2010-12-15 诺瓦提斯公司 伊潘立酮和星状聚合物的贮库制剂
US6995144B2 (en) * 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
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AU2003263413A1 (en) * 2002-09-17 2004-04-08 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
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US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
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US7696229B2 (en) 2006-02-17 2010-04-13 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
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WO2008128166A1 (en) * 2007-04-13 2008-10-23 Concert Pharmaceuticals Inc. Deuterated derivatives of 4-(6-fluoro-1, 2-benzisoxazol-3-yl) piperidine compounds
CN101824030B (zh) * 2009-03-04 2014-06-18 北京德众万全药物技术开发有限公司 一种伊潘立酮的制备方法
PT2445502T (pt) 2009-06-25 2017-09-22 Alkermes Pharma Ireland Ltd Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos
US8802855B2 (en) 2009-09-19 2014-08-12 Zhejiang Huahai Pharmaceutical Co., Ltd. Method for preparation of iloperidone and crystallization method thereof
CN102030744B (zh) * 2009-09-30 2013-04-17 天津药物研究院 伊潘立酮晶体、其制备方法及药物组合物
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Also Published As

Publication number Publication date
KR0157308B1 (ko) 1998-11-16
IE901809L (en) 1990-11-19
IE68431B1 (en) 1996-06-12
NO902214L (no) 1990-11-20
HU211853A9 (en) 1995-12-28
FI902449A0 (fi) 1990-05-17
GR3017447T3 (en) 1995-12-31
HUT58720A (en) 1992-03-30
DE69021645T2 (de) 1996-02-22
PT94084B (pt) 1996-12-31
IL94425A (en) 1994-02-27
AU5577090A (en) 1990-11-22
FI19991869A (fi) 1999-09-02
ATE126512T1 (de) 1995-09-15
CN1305812A (zh) 2001-08-01
DK0402644T3 (da) 1996-01-02
CA2017193A1 (en) 1990-11-19
AU640653B2 (en) 1993-09-02
NO177301B (no) 1995-05-15
KR900018070A (ko) 1990-12-20
DE69021645D1 (de) 1995-09-21
NO177301C (no) 1995-08-23
ES2076253T3 (es) 1995-11-01
HK1038316A1 (en) 2002-03-15
RU2147583C1 (ru) 2000-04-20
CZ282385B6 (cs) 1997-07-16
FI104072B (fi) 1999-11-15
CA2017193C (en) 2000-06-27
CN1048037A (zh) 1990-12-26
HU903090D0 (en) 1990-09-28
PL163965B1 (pl) 1994-05-31
EP0402644B1 (en) 1995-08-16
NO902214D0 (no) 1990-05-18
JPH0363263A (ja) 1991-03-19
JPH0662580B2 (ja) 1994-08-17
RU2062776C1 (ru) 1996-06-27
NZ233710A (en) 1992-05-26
CN1223348C (zh) 2005-10-19
CZ242590A3 (en) 1997-03-12
SK279474B6 (sk) 1998-11-04
PL285247A1 (en) 1991-02-11
FI104072B1 (fi) 1999-11-15
HU218200B (hu) 2000-06-28
HK1006710A1 (en) 1999-03-12
CN1086387C (zh) 2002-06-19
RU2239434C2 (ru) 2004-11-10
SK242590A3 (en) 1998-11-04
IL94425A0 (en) 1991-03-10
PT94084A (pt) 1991-01-08
EP0402644A1 (en) 1990-12-19

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