DD202428A5 - Verfahren zur herstellung von prostaglandinsaeurederivaten - Google Patents
Verfahren zur herstellung von prostaglandinsaeurederivaten Download PDFInfo
- Publication number
- DD202428A5 DD202428A5 DD81232562A DD23256281A DD202428A5 DD 202428 A5 DD202428 A5 DD 202428A5 DD 81232562 A DD81232562 A DD 81232562A DD 23256281 A DD23256281 A DD 23256281A DD 202428 A5 DD202428 A5 DD 202428A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- hydrogen
- derivatives
- group
- general formula
- compound
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 18
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- FWTBRZMBHIYQSW-UHFFFAOYSA-N epifriedelanol Natural products CC1C(O)C(O)CC2C1(C)CCC3C2(C)CCC4(C)C5CC(C)(C)CCC5(C)C(O)CC34C FWTBRZMBHIYQSW-UHFFFAOYSA-N 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- HFSACQSILLSUII-ISSAZSKYSA-N glutinol Chemical compound C([C@@H]1[C@@]2(C)CC[C@@]3(C)CCC(C[C@H]3[C@]2(C)CC[C@]11C)(C)C)C=C2[C@H]1CC[C@H](O)C2(C)C HFSACQSILLSUII-ISSAZSKYSA-N 0.000 description 1
- OLWSWWUSGLHFEB-UHFFFAOYSA-N glutinol Natural products CC1C(O)CCC2C1=CCC3C2(C)CCC4(C)C5CC(C)(C)CCC5(C)CCC34C OLWSWWUSGLHFEB-UHFFFAOYSA-N 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000003284 homeostatic effect Effects 0.000 description 1
- 238000007327 hydrogenolysis reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- VCRYGHPVKURQMM-UHFFFAOYSA-N methane;platinum Chemical compound C.[Pt] VCRYGHPVKURQMM-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- PCZXEAAHGUQDNV-XBNKRBCZSA-N tetrahymanol Natural products CC1(C)CC[C@]2(C)CC[C@]3(C)[C@H]4CC[C@H]5[C@@H](CC[C@H](O)C5(C)C)[C@]4(C)CC[C@@]3(C)[C@@H]2C1 PCZXEAAHGUQDNV-XBNKRBCZSA-N 0.000 description 1
- 125000001382 thioacetal group Chemical group 0.000 description 1
- 150000003555 thioacetals Chemical class 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000006257 total synthesis reaction Methods 0.000 description 1
- 210000005092 tracheal tissue Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
- C07C47/47—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8026240 | 1980-08-12 | ||
GB8113487 | 1981-05-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
DD202428A5 true DD202428A5 (de) | 1983-09-14 |
Family
ID=26276527
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DD81232562A DD202428A5 (de) | 1980-08-12 | 1981-08-12 | Verfahren zur herstellung von prostaglandinsaeurederivaten |
DD81250873A DD213437A5 (de) | 1980-08-12 | 1981-08-12 | Verfahren zur herstellung von cyclopentenderivaten |
DD83263174A DD223712A5 (de) | 1980-08-12 | 1983-05-12 | Verfahren zur herstellung von cyclopentenderivaten |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DD81250873A DD213437A5 (de) | 1980-08-12 | 1981-08-12 | Verfahren zur herstellung von cyclopentenderivaten |
DD83263174A DD223712A5 (de) | 1980-08-12 | 1983-05-12 | Verfahren zur herstellung von cyclopentenderivaten |
Country Status (27)
Country | Link |
---|---|
US (1) | US4377704A (sv) |
AU (2) | AU542975B2 (sv) |
BG (1) | BG36345A3 (sv) |
CH (2) | CH650251A5 (sv) |
DD (3) | DD202428A5 (sv) |
DE (1) | DE3131616A1 (sv) |
DK (1) | DK356481A (sv) |
ES (2) | ES8301465A1 (sv) |
FI (1) | FI812468L (sv) |
FR (2) | FR2488604A1 (sv) |
GR (1) | GR74314B (sv) |
HU (1) | HU191416B (sv) |
IL (1) | IL63369A (sv) |
IS (1) | IS1184B6 (sv) |
IT (1) | IT1214436B (sv) |
LU (1) | LU83547A1 (sv) |
NL (1) | NL8103710A (sv) |
NO (1) | NO812720L (sv) |
NZ (1) | NZ197729A (sv) |
OA (1) | OA06879A (sv) |
PL (2) | PL133879B1 (sv) |
PT (1) | PT73457B (sv) |
RO (2) | RO82680B (sv) |
SE (2) | SE442297B (sv) |
SU (1) | SU1187716A3 (sv) |
YU (2) | YU193781A (sv) |
ZW (1) | ZW17881A1 (sv) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8510277D0 (en) * | 1985-04-23 | 1985-05-30 | Glaxo Group Ltd | Carbocyclic compounds |
AU635065B2 (en) * | 1989-09-08 | 1993-03-11 | Emmanouilidis, Theo | Mountable washing device |
US6711436B1 (en) | 1997-08-08 | 2004-03-23 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
AU758370B2 (en) * | 1997-08-08 | 2003-03-20 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3664502A (en) * | 1970-06-26 | 1972-05-23 | Bird Machine Co | Slurry screen and process of making it |
US4229592A (en) * | 1978-02-06 | 1980-10-21 | Kansas University Endowment Association | Intermediate for prostaglandins and process for preparing the intermediate |
SE7906017L (sv) * | 1978-07-11 | 1980-02-13 | Glaxo Group Ltd | Prostanoida foreningar |
-
1981
- 1981-07-15 NZ NZ197729A patent/NZ197729A/en unknown
- 1981-07-17 IS IS2661A patent/IS1184B6/is unknown
- 1981-07-20 IL IL63369A patent/IL63369A/xx unknown
- 1981-07-24 CH CH4851/81A patent/CH650251A5/fr not_active IP Right Cessation
- 1981-07-24 ZW ZW178/81A patent/ZW17881A1/xx unknown
- 1981-07-24 CH CH5353/84A patent/CH655716A5/fr not_active IP Right Cessation
- 1981-07-28 GR GR65656A patent/GR74314B/el unknown
- 1981-07-29 RO RO104999A patent/RO82680B/ro unknown
- 1981-07-29 RO RO81110834A patent/RO87011A/ro unknown
- 1981-07-31 PT PT73457A patent/PT73457B/pt unknown
- 1981-07-31 FR FR8114910A patent/FR2488604A1/fr active Granted
- 1981-08-03 US US06/289,391 patent/US4377704A/en not_active Expired - Fee Related
- 1981-08-05 SE SE8104703A patent/SE442297B/sv not_active IP Right Cessation
- 1981-08-06 NL NL8103710A patent/NL8103710A/nl not_active Application Discontinuation
- 1981-08-10 PL PL1981232567A patent/PL133879B1/pl unknown
- 1981-08-10 YU YU01937/81A patent/YU193781A/xx unknown
- 1981-08-10 PL PL1981238065A patent/PL137212B1/pl unknown
- 1981-08-10 DE DE19813131616 patent/DE3131616A1/de not_active Withdrawn
- 1981-08-10 IT IT8123455A patent/IT1214436B/it active
- 1981-08-10 FI FI812468A patent/FI812468L/fi not_active Application Discontinuation
- 1981-08-11 DK DK356481A patent/DK356481A/da not_active Application Discontinuation
- 1981-08-11 ES ES504681A patent/ES8301465A1/es not_active Expired
- 1981-08-11 BG BG8153247A patent/BG36345A3/xx unknown
- 1981-08-11 LU LU83547A patent/LU83547A1/fr unknown
- 1981-08-11 NO NO812720A patent/NO812720L/no unknown
- 1981-08-11 HU HU841788A patent/HU191416B/hu unknown
- 1981-08-12 DD DD81232562A patent/DD202428A5/de unknown
- 1981-08-12 OA OA57472A patent/OA06879A/xx unknown
- 1981-08-12 DD DD81250873A patent/DD213437A5/de unknown
- 1981-08-12 AU AU74007/81A patent/AU542975B2/en not_active Ceased
-
1982
- 1982-03-23 FR FR8204877A patent/FR2509306A1/fr active Granted
- 1982-07-30 ES ES514592A patent/ES514592A0/es active Granted
- 1982-08-05 SU SU823473001A patent/SU1187716A3/ru active
-
1983
- 1983-04-15 YU YU00861/83A patent/YU86183A/xx unknown
- 1983-05-12 DD DD83263174A patent/DD223712A5/de unknown
-
1984
- 1984-10-09 AU AU34067/84A patent/AU3406784A/en not_active Abandoned
-
1985
- 1985-04-25 SE SE8502007A patent/SE8502007L/sv not_active Application Discontinuation
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