DD153375A5 - Verfahren zur herstellung eines festen solvats aus syn-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino]acetamido-3-acetoxymethyl-3-cephem-4-carbonsaeure und einem alicyclischen ether - Google Patents

Verfahren zur herstellung eines festen solvats aus syn-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino]acetamido-3-acetoxymethyl-3-cephem-4-carbonsaeure und einem alicyclischen ether Download PDF

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Publication number
DD153375A5
DD153375A5 DD80224408A DD22440880A DD153375A5 DD 153375 A5 DD153375 A5 DD 153375A5 DD 80224408 A DD80224408 A DD 80224408A DD 22440880 A DD22440880 A DD 22440880A DD 153375 A5 DD153375 A5 DD 153375A5
Authority
DD
German Democratic Republic
Prior art keywords
compound
solvate
acid
mixture
reaction mixture
Prior art date
Application number
DD80224408A
Other languages
German (de)
English (en)
Inventor
Billy G Jackson
Donna N Gardner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD153375A5 publication Critical patent/DD153375A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD80224408A 1979-10-09 1980-10-08 Verfahren zur herstellung eines festen solvats aus syn-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino]acetamido-3-acetoxymethyl-3-cephem-4-carbonsaeure und einem alicyclischen ether DD153375A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/082,822 US4252951A (en) 1979-10-09 1979-10-09 Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid

Publications (1)

Publication Number Publication Date
DD153375A5 true DD153375A5 (de) 1982-01-06

Family

ID=22173679

Family Applications (1)

Application Number Title Priority Date Filing Date
DD80224408A DD153375A5 (de) 1979-10-09 1980-10-08 Verfahren zur herstellung eines festen solvats aus syn-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino]acetamido-3-acetoxymethyl-3-cephem-4-carbonsaeure und einem alicyclischen ether

Country Status (27)

Country Link
US (1) US4252951A (fr)
EP (1) EP0027050B1 (fr)
JP (1) JPS5661388A (fr)
KR (1) KR840000866B1 (fr)
AT (1) AT369008B (fr)
AU (1) AU6306180A (fr)
BE (1) BE885569A (fr)
CA (1) CA1146539A (fr)
CH (1) CH647523A5 (fr)
CS (1) CS215142B2 (fr)
DD (1) DD153375A5 (fr)
DE (1) DE3065181D1 (fr)
DK (1) DK424680A (fr)
ES (1) ES8201166A1 (fr)
FI (1) FI803200L (fr)
FR (1) FR2467211A1 (fr)
GB (1) GB2059966B (fr)
GR (1) GR70219B (fr)
HU (1) HU183230B (fr)
IE (1) IE50390B1 (fr)
IL (1) IL61227A (fr)
IT (1) IT1132926B (fr)
PH (1) PH15023A (fr)
PT (1) PT71886B (fr)
RO (1) RO80664B (fr)
YU (1) YU256480A (fr)
ZA (1) ZA806192B (fr)

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JP2005527467A (ja) * 2001-08-29 2005-09-15 ネオーズ テクノロジーズ， インコーポレイテッド 新規な合成ガングリオシド誘導体およびその組成物
JP4571497B2 (ja) * 2002-09-19 2010-10-27 杏林製薬株式会社 アミノアルコール誘導体とその付加塩及び免疫抑制剤
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
EP2471527A3 (fr) * 2003-03-17 2012-12-12 The Trustees Of The University Of Pennsylvania Polymères amphiphiles faciaux et oligomères et leurs utilisations
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
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CA2554163A1 (fr) * 2004-01-23 2005-08-11 The Trustees Of The University Of Pennsylvania Polymeres et oligomeres de polyaryle et de polyarylalkynyle amphiphiles au niveau facial
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TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
EP2301349A2 (fr) * 2005-02-25 2011-03-30 The Trustees of The University of Pennsylvania Polymères et oligomères amphiphiles faciaux, compositions associées et utilisation associée aux méthodes de traitement du cancer
EP2418191A1 (fr) * 2005-02-28 2012-02-15 Meiji Co., Ltd. Dérivés à longue chaîne de triméthoxyphénylalcanols et produits pharmaceutiques les comprenant
BRPI0614805A2 (pt) * 2005-08-10 2011-04-12 Univ Johns Hopkins poliaminas úteis como produtos terapêuticos antiparasìticos e anticáncer e como inibidores de demetilase lisina-especìficos
MX2008001976A (es) * 2005-08-15 2008-03-25 Boehringer Ingelheim Int Procedimiento para la preparacion de betamimeticos.
RU2008120850A (ru) * 2005-10-28 2009-12-10 Айрм Ллк (Bm) Соединения и композиции в качестве ингибиторов протеинкиназ
WO2007063286A2 (fr) * 2005-11-29 2007-06-07 Hammersmith Imanet Limited Composes d'imagerie in vivo
ES2288107B1 (es) * 2006-01-27 2008-11-01 Fundacion Imabis Instituto Mediterraneo Para El Avance De La Biotecnologia Y La Investigacion Sanita Derivados aciclicos saturados e insaturados de cadena larga de sulfamidas como activadores especificos de receptores ppar-alfa.
FR2902996B1 (fr) * 2006-07-03 2008-09-26 Oreal Compositions cosmetiques associant un derive c-glycoside et un derive n-acylaminoamide
FR2902999B1 (fr) * 2006-07-03 2012-09-28 Oreal Utilisation de derives c-glycoside a titre d'actif prodesquamant
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US20090075935A1 (en) * 2006-07-03 2009-03-19 L'oreal Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use
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Also Published As

Publication number Publication date
ES495753A0 (es) 1981-12-01
RO80664A (fr) 1983-02-15
CA1146539A (fr) 1983-05-17
IE802086L (en) 1981-04-09
GB2059966A (en) 1981-04-29
BE885569A (fr) 1981-04-08
FI803200L (fi) 1981-04-10
FR2467211B1 (fr) 1983-06-10
KR830004314A (ko) 1983-07-09
AU6306180A (en) 1981-04-16
YU256480A (en) 1983-02-28
GB2059966B (en) 1983-09-01
IL61227A0 (en) 1980-12-31
FR2467211A1 (fr) 1981-04-17
HU183230B (en) 1984-04-28
EP0027050A1 (fr) 1981-04-15
GR70219B (fr) 1982-08-31
AT369008B (de) 1982-11-25
US4252951A (en) 1981-02-24
IE50390B1 (en) 1986-04-16
IT1132926B (it) 1986-07-09
ATA498080A (de) 1982-04-15
DE3065181D1 (en) 1983-11-10
RO80664B (ro) 1983-02-28
CH647523A5 (fr) 1985-01-31
JPS5661388A (en) 1981-05-26
DK424680A (da) 1981-04-10
IL61227A (en) 1983-07-31
KR840000866B1 (ko) 1984-06-20
PT71886B (en) 1981-08-13
PH15023A (en) 1982-05-13
PT71886A (en) 1980-11-01
CS215142B2 (en) 1982-07-30
IT8025200A0 (it) 1980-10-08
ZA806192B (en) 1982-05-26
ES8201166A1 (es) 1981-12-01
EP0027050B1 (fr) 1983-10-05

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