ES8201166A1 - Un procedimiento para preparar un solvato solido del acido sin-7-(2-(2-amino-4-tiazolil)-2-metoximino)-acetamido-3-acetoximetil-3-cefem-4-carboxilico - Google Patents

Un procedimiento para preparar un solvato solido del acido sin-7-(2-(2-amino-4-tiazolil)-2-metoximino)-acetamido-3-acetoximetil-3-cefem-4-carboxilico

Info

Publication number
ES8201166A1
ES8201166A1 ES495753A ES495753A ES8201166A1 ES 8201166 A1 ES8201166 A1 ES 8201166A1 ES 495753 A ES495753 A ES 495753A ES 495753 A ES495753 A ES 495753A ES 8201166 A1 ES8201166 A1 ES 8201166A1
Authority
ES
Spain
Prior art keywords
solvate
preparation
cefem
acid
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES495753A
Other languages
English (en)
Other versions
ES495753A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES495753A0 publication Critical patent/ES495753A0/es
Publication of ES8201166A1 publication Critical patent/ES8201166A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN SOLVATO SOLIDO DEL ACIDO SIN-7-(2-AMINO-4/TIAZOLIL)-2-METAXIIMINO)-ACETAMIDO-3-ACETOXIMETIL-3-CEFEM-4-CARBOXILICO. CONSISTE EN COMBINAR, EN UN MEDIO ACUOSO, ACIDO CEFEM CON UN ETER ALICICLICO, COMO TERRAHIDROFURANO; 1,4-DIOXANO, 1,3-DIOXOLANO O TERRAHIDROPIRANO. SE AJUSTA EL PH DE LA MEZCLA A UN VALOR COMPRENDIDO ENTRE 2,2 Y 3,5, Y SE DEJA QUE LA MISMA REPOSE, A TEMPERATURA AMBIENTE, HASTA QUE SE FORME UN PRECIPITADO DE SOLVATO, QUE SE AISLA. A PARTIR DE ESTE MOMENTO PUEDE VIEN SEPARARSE EL ETER DEL SOLVATO,PARA PRODUCIR EL ACIDO LIBRE, O BIEN HACERLO REACCIONAR CON UNA BASE PARA OBTENER UNA SAL DE ACIDO. DE APLICACION COMO COMPUESTOS INTERMEDIO EN LA ELABORACION DE SALES PARA PRODUCIR ANTIBIOTICOS.
ES495753A 1979-10-09 1980-10-08 Un procedimiento para preparar un solvato solido del acido sin-7-(2-(2-amino-4-tiazolil)-2-metoximino)-acetamido-3-acetoximetil-3-cefem-4-carboxilico Expired ES8201166A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/082,822 US4252951A (en) 1979-10-09 1979-10-09 Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid

Publications (2)

Publication Number Publication Date
ES495753A0 ES495753A0 (es) 1981-12-01
ES8201166A1 true ES8201166A1 (es) 1981-12-01

Family

ID=22173679

Family Applications (1)

Application Number Title Priority Date Filing Date
ES495753A Expired ES8201166A1 (es) 1979-10-09 1980-10-08 Un procedimiento para preparar un solvato solido del acido sin-7-(2-(2-amino-4-tiazolil)-2-metoximino)-acetamido-3-acetoximetil-3-cefem-4-carboxilico

Country Status (27)

Country Link
US (1) US4252951A (es)
EP (1) EP0027050B1 (es)
JP (1) JPS5661388A (es)
KR (1) KR840000866B1 (es)
AT (1) AT369008B (es)
AU (1) AU6306180A (es)
BE (1) BE885569A (es)
CA (1) CA1146539A (es)
CH (1) CH647523A5 (es)
CS (1) CS215142B2 (es)
DD (1) DD153375A5 (es)
DE (1) DE3065181D1 (es)
DK (1) DK424680A (es)
ES (1) ES8201166A1 (es)
FI (1) FI803200A7 (es)
FR (1) FR2467211A1 (es)
GB (1) GB2059966B (es)
GR (1) GR70219B (es)
HU (1) HU183230B (es)
IE (1) IE50390B1 (es)
IL (1) IL61227A (es)
IT (1) IT1132926B (es)
PH (1) PH15023A (es)
PT (1) PT71886B (es)
RO (1) RO80664B (es)
YU (1) YU256480A (es)
ZA (1) ZA806192B (es)

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JPH07116200B2 (ja) * 1985-09-20 1995-12-13 富山化学工業株式会社 セファロスポリンの製造方法
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CA2452977C (en) * 2001-03-08 2013-07-16 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers as anti-infective agents
JP2005527467A (ja) * 2001-08-29 2005-09-15 ネオーズ テクノロジーズ， インコーポレイテッド 新規な合成ガングリオシド誘導体およびその組成物
BR0314455A (pt) * 2002-09-19 2005-07-26 Kyorin Seiyaku Kk Derivados de aminoálcool, seus sais e agentes imunosupressores
US7056916B2 (en) * 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
WO2004082634A2 (en) 2003-03-17 2004-09-30 The Trustees Of The University Of Pennsylvania Facially amphiphilic polymers and oligomers and uses thereof
US7321065B2 (en) * 2003-04-18 2008-01-22 The Regents Of The University Of California Thyronamine derivatives and analogs and methods of use thereof
US20050203184A1 (en) 2003-09-10 2005-09-15 Petasis Nicos A. Benzo lipoxin analogues
EP1711455A4 (en) 2004-01-23 2007-11-07 Univ Pennsylvania FAZIAL AMPHIPHILE POLYARYL AND POLYARYL ALKINYL POLYMERS AND OLIGOMERS AND ITS APPLICATIONS
BRPI0510715A (pt) * 2004-05-06 2007-11-20 Univ California enaminonas substituìdas, seus derivados e usos destas
US7220742B2 (en) * 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
US20050255050A1 (en) * 2004-05-14 2005-11-17 Boehringer Ingelheim International Gmbh Powder formulations for inhalation, comprising enantiomerically pure beta agonists
TWI403334B (zh) * 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
JP2008531585A (ja) * 2005-02-25 2008-08-14 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 表面が両親媒性のポリマーおよびオリゴマー、それらの組成物そして癌治療方法におけるそれらの使用
KR101270841B1 (ko) * 2005-02-28 2013-06-05 가부시키가이샤 메이지 히드로퀴논 장쇄 유도체 및／또는 페녹시 장쇄 유도체 및 이들을 함유하는 의약
JP5484728B2 (ja) * 2005-08-10 2014-05-07 ジョンズ ホプキンス ユニバーシティ 抗寄生虫治療薬および抗癌治療薬ならびにリジン特異的デメチラーゼ阻害物質として有用なポリアミン類
PL1917253T3 (pl) * 2005-08-15 2015-06-30 Boehringer Ingelheim Int Sposób wytwarzania betamimetyków
DE602006009539D1 (de) * 2005-10-28 2009-11-12 Irm Llc Verbindungen und zusammensetzungen als proteinkinaseinhibitoren
WO2007063286A2 (en) * 2005-11-29 2007-06-07 Hammersmith Imanet Limited Amidine derivatives for in vivo imaging
ES2288107B1 (es) * 2006-01-27 2008-11-01 Fundacion Imabis Instituto Mediterraneo Para El Avance De La Biotecnologia Y La Investigacion Sanita Derivados aciclicos saturados e insaturados de cadena larga de sulfamidas como activadores especificos de receptores ppar-alfa.
FR2903004B1 (fr) * 2006-07-03 2009-07-10 Oreal Utilisation en cosmetique d'un derive c-glycoside en association avec de l'acide ascorbique
FR2902999B1 (fr) * 2006-07-03 2012-09-28 Oreal Utilisation de derives c-glycoside a titre d'actif prodesquamant
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FR2920000B1 (fr) * 2007-08-13 2010-01-29 Oreal Composition cosmetique ou pharmaceutique contenant de l'acide hyaluronique, et procede cosmetique pour diminuer les signes du vieilissement
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Also Published As

Publication number Publication date
RO80664B (ro) 1983-02-28
PT71886A (en) 1980-11-01
RO80664A (ro) 1983-02-15
KR840000866B1 (ko) 1984-06-20
FR2467211A1 (fr) 1981-04-17
DD153375A5 (de) 1982-01-06
CH647523A5 (fr) 1985-01-31
KR830004314A (ko) 1983-07-09
IE50390B1 (en) 1986-04-16
IT8025200A0 (it) 1980-10-08
GR70219B (es) 1982-08-31
ES495753A0 (es) 1981-12-01
BE885569A (fr) 1981-04-08
ATA498080A (de) 1982-04-15
GB2059966A (en) 1981-04-29
IT1132926B (it) 1986-07-09
DK424680A (da) 1981-04-10
IE802086L (en) 1981-04-09
PH15023A (en) 1982-05-13
PT71886B (en) 1981-08-13
US4252951A (en) 1981-02-24
YU256480A (en) 1983-02-28
AT369008B (de) 1982-11-25
DE3065181D1 (en) 1983-11-10
FI803200L (fi) 1981-04-10
GB2059966B (en) 1983-09-01
IL61227A0 (en) 1980-12-31
FR2467211B1 (es) 1983-06-10
CS215142B2 (en) 1982-07-30
CA1146539A (en) 1983-05-17
HU183230B (en) 1984-04-28
FI803200A7 (fi) 1981-04-10
JPS5661388A (en) 1981-05-26
EP0027050A1 (en) 1981-04-15
AU6306180A (en) 1981-04-16
EP0027050B1 (en) 1983-10-05
ZA806192B (en) 1982-05-26
IL61227A (en) 1983-07-31

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