ES8201166A1 - Un procedimiento para preparar un solvato solido del acido sin-7-(2-(2-amino-4-tiazolil)-2-metoximino)-acetamido-3-acetoximetil-3-cefem-4-carboxilico - Google Patents
Un procedimiento para preparar un solvato solido del acido sin-7-(2-(2-amino-4-tiazolil)-2-metoximino)-acetamido-3-acetoximetil-3-cefem-4-carboxilicoInfo
- Publication number
- ES8201166A1 ES8201166A1 ES495753A ES495753A ES8201166A1 ES 8201166 A1 ES8201166 A1 ES 8201166A1 ES 495753 A ES495753 A ES 495753A ES 495753 A ES495753 A ES 495753A ES 8201166 A1 ES8201166 A1 ES 8201166A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- cephalosporin derivatives
- cephem
- methoxyimino
- acetoxymethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UN SOLVATO SOLIDO DEL ACIDO SIN-7-(2-AMINO-4/TIAZOLIL)-2-METAXIIMINO)-ACETAMIDO-3-ACETOXIMETIL-3-CEFEM-4-CARBOXILICO. CONSISTE EN COMBINAR, EN UN MEDIO ACUOSO, ACIDO CEFEM CON UN ETER ALICICLICO, COMO TERRAHIDROFURANO; 1,4-DIOXANO, 1,3-DIOXOLANO O TERRAHIDROPIRANO. SE AJUSTA EL PH DE LA MEZCLA A UN VALOR COMPRENDIDO ENTRE 2,2 Y 3,5, Y SE DEJA QUE LA MISMA REPOSE, A TEMPERATURA AMBIENTE, HASTA QUE SE FORME UN PRECIPITADO DE SOLVATO, QUE SE AISLA. A PARTIR DE ESTE MOMENTO PUEDE VIEN SEPARARSE EL ETER DEL SOLVATO,PARA PRODUCIR EL ACIDO LIBRE, O BIEN HACERLO REACCIONAR CON UNA BASE PARA OBTENER UNA SAL DE ACIDO. DE APLICACION COMO COMPUESTOS INTERMEDIO EN LA ELABORACION DE SALES PARA PRODUCIR ANTIBIOTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/082,822 US4252951A (en) | 1979-10-09 | 1979-10-09 | Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8201166A1 true ES8201166A1 (es) | 1981-12-01 |
ES495753A0 ES495753A0 (es) | 1981-12-01 |
Family
ID=22173679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES495753A Granted ES495753A0 (es) | 1979-10-09 | 1980-10-08 | Un procedimiento para preparar un solvato solido del acido sin-7-(2-(2-amino-4-tiazolil)-2-metoximino)-acetamido-3-acetoximetil-3-cefem-4-carboxilico |
Country Status (27)
Country | Link |
---|---|
US (1) | US4252951A (es) |
EP (1) | EP0027050B1 (es) |
JP (1) | JPS5661388A (es) |
KR (1) | KR840000866B1 (es) |
AT (1) | AT369008B (es) |
AU (1) | AU6306180A (es) |
BE (1) | BE885569A (es) |
CA (1) | CA1146539A (es) |
CH (1) | CH647523A5 (es) |
CS (1) | CS215142B2 (es) |
DD (1) | DD153375A5 (es) |
DE (1) | DE3065181D1 (es) |
DK (1) | DK424680A (es) |
ES (1) | ES495753A0 (es) |
FI (1) | FI803200L (es) |
FR (1) | FR2467211A1 (es) |
GB (1) | GB2059966B (es) |
GR (1) | GR70219B (es) |
HU (1) | HU183230B (es) |
IE (1) | IE50390B1 (es) |
IL (1) | IL61227A (es) |
IT (1) | IT1132926B (es) |
PH (1) | PH15023A (es) |
PT (1) | PT71886B (es) |
RO (1) | RO80664B (es) |
YU (1) | YU256480A (es) |
ZA (1) | ZA806192B (es) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS588086A (ja) * | 1981-07-07 | 1983-01-18 | Takeda Chem Ind Ltd | セフアロスポリン溶媒和物およびその製造法 |
JPH07116200B2 (ja) * | 1985-09-20 | 1995-12-13 | 富山化学工業株式会社 | セファロスポリンの製造方法 |
JPH08831B2 (ja) * | 1985-09-20 | 1996-01-10 | 富山化学工業株式会社 | セファロスポリンの精製法 |
DE60039132D1 (de) * | 1999-04-06 | 2008-07-17 | Sepracor Inc | O-Desmethylvenlafaxin-Succinat |
ATE504572T1 (de) * | 1999-09-02 | 2011-04-15 | Shionogi & Co | Derivate von aromatische heterocyclen enthaltende integraseinhibitoren |
CA2284459C (en) * | 1999-10-04 | 2012-12-11 | Neokimia Inc. | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery |
EP1246792B1 (en) * | 2000-01-13 | 2014-08-13 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
ATE510547T1 (de) * | 2001-03-08 | 2011-06-15 | Univ Pennsylvania | Faciale amphiphile polymere als infektionsbekämpfende mittel |
NZ531139A (en) * | 2001-08-29 | 2007-09-28 | Neose Technologies Inc | Synthetic ganglioside derivatives and compositions thereof |
CA2498944C (en) * | 2002-09-19 | 2011-05-17 | Yasushi Kohno | Amino alcohol derivatives, salts thereof and immunosuppressive agents |
US7056916B2 (en) * | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
JP2006521355A (ja) * | 2003-03-17 | 2006-09-21 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア・センター・フオー・テクノロジー・トランスフアー | 表面的に両親媒性のポリマー及びオリゴマーならびにそれらの使用 |
US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
US20050203184A1 (en) | 2003-09-10 | 2005-09-15 | Petasis Nicos A. | Benzo lipoxin analogues |
CN1922133A (zh) * | 2004-01-23 | 2007-02-28 | 宾夕法尼亚州大学理事会 | 表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途 |
US7825278B2 (en) * | 2004-05-06 | 2010-11-02 | The Regents Of The University Of California | Substituted enaminones, their derivatives and uses thereof |
US20050255050A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Powder formulations for inhalation, comprising enantiomerically pure beta agonists |
US7220742B2 (en) * | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
TWI403334B (zh) * | 2004-12-23 | 2013-08-01 | Merck Sharp & Dohme | 包含生物素殘基之抗血栓雙重抑制劑 |
JP2008531585A (ja) * | 2005-02-25 | 2008-08-14 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 表面が両親媒性のポリマーおよびオリゴマー、それらの組成物そして癌治療方法におけるそれらの使用 |
CN101166706B (zh) * | 2005-02-28 | 2011-08-24 | 明治乳业株式会社 | 氢醌长链衍生物和/或苯氧基长链衍生物及含有它们的药品 |
AU2006279943B2 (en) * | 2005-08-10 | 2012-02-16 | The Johns Hopkins University | Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors |
JP5270343B2 (ja) * | 2005-08-15 | 2013-08-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ベータミメティックスの製造方法 |
US8592433B2 (en) * | 2005-10-28 | 2013-11-26 | Advait Nagle | Compounds and compositions as protein kinase inhibitors |
EP1954259A2 (en) * | 2005-11-29 | 2008-08-13 | Hammersmith Imanet, Ltd | Amidine derivatives for in vivo imaging |
ES2288107B1 (es) * | 2006-01-27 | 2008-11-01 | Fundacion Imabis Instituto Mediterraneo Para El Avance De La Biotecnologia Y La Investigacion Sanita | Derivados aciclicos saturados e insaturados de cadena larga de sulfamidas como activadores especificos de receptores ppar-alfa. |
FR2903004B1 (fr) * | 2006-07-03 | 2009-07-10 | Oreal | Utilisation en cosmetique d'un derive c-glycoside en association avec de l'acide ascorbique |
FR2902996B1 (fr) * | 2006-07-03 | 2008-09-26 | Oreal | Compositions cosmetiques associant un derive c-glycoside et un derive n-acylaminoamide |
US20090075935A1 (en) * | 2006-07-03 | 2009-03-19 | L'oreal | Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use |
FR2902999B1 (fr) * | 2006-07-03 | 2012-09-28 | Oreal | Utilisation de derives c-glycoside a titre d'actif prodesquamant |
ES2375761T3 (es) * | 2006-12-14 | 2012-03-06 | Teva Pharmaceutical Industries Ltd. | Base de rasagilina cristalina sólida. |
CN101730706B (zh) * | 2007-05-11 | 2015-04-15 | 生物科技研究有限公司 | 具有神经保护和增强记忆活性的受体拮抗剂 |
US7696383B2 (en) * | 2007-06-26 | 2010-04-13 | Solvay Pharmaceuticals B.V. | N-oxides of venlafaxine and o-desmethylvenlafaxine as prodrugs |
FR2920000B1 (fr) * | 2007-08-13 | 2010-01-29 | Oreal | Composition cosmetique ou pharmaceutique contenant de l'acide hyaluronique, et procede cosmetique pour diminuer les signes du vieilissement |
US8252935B2 (en) * | 2007-10-19 | 2012-08-28 | Janssen Pharmaceutica N.V. | Piperidinyl and piperazinyl modulators of γ-secretase |
WO2009052334A1 (en) * | 2007-10-19 | 2009-04-23 | Janssen Pharmaceutica, N.V. | Carbon linked modulators of y-secretase |
AU2008312371B2 (en) * | 2007-10-19 | 2013-06-20 | Janssen Pharmaceutica, N.V. | Amine linked modulators of gamma-secretase |
EP2093207A1 (en) * | 2008-02-06 | 2009-08-26 | Julius-Maximilians-Universität Würzburg | Antiinfective and antitumoral compounds isolated from tropical lianas |
US8063249B1 (en) * | 2008-04-25 | 2011-11-22 | Olema Pharmaceuticals, Inc. | Substituted triphenyl butenes |
US20100056475A1 (en) * | 2008-08-06 | 2010-03-04 | Alexander Chucholowski | Cyclodextrin conjugates |
JP5773877B2 (ja) * | 2008-10-22 | 2015-09-02 | アキュセラ インコーポレイテッド | 眼の疾患及び障害を治療する化合物 |
FR2940610B1 (fr) * | 2008-12-30 | 2011-05-06 | Oreal | Association de monosaccharides avec des derives c-glycosides et son utilisation en cosmetique |
WO2010111530A1 (en) | 2009-03-25 | 2010-09-30 | Seneb Biosciences, Inc. | Glycolipids as treatment for disease |
US9187482B2 (en) * | 2009-05-14 | 2015-11-17 | Millennium Pharmaceuticals, Inc. | Hydrochloride salt of((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
WO2010138828A2 (en) * | 2009-05-29 | 2010-12-02 | Abbott Laboratories | Potassium channel modulators |
US8288592B2 (en) * | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
WO2012067824A1 (en) | 2010-11-16 | 2012-05-24 | Abbott Laboratories | Potassium channel modulators |
CN108272782B (zh) * | 2011-09-06 | 2021-04-23 | 库尔纳公司 | 小分子在制备治疗Dravet综合征或全面性癫痫伴热性惊厥附加症的药物中的用途 |
US8377946B1 (en) * | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3925372A (en) * | 1973-02-23 | 1975-12-09 | Lilly Co Eli | Alpha-aminoacyl-3-halo cephalosporins |
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
-
1979
- 1979-10-09 US US06/082,822 patent/US4252951A/en not_active Expired - Lifetime
-
1980
- 1980-10-07 DE DE8080303525T patent/DE3065181D1/de not_active Expired
- 1980-10-07 YU YU02564/80A patent/YU256480A/xx unknown
- 1980-10-07 JP JP14111980A patent/JPS5661388A/ja active Pending
- 1980-10-07 IL IL61227A patent/IL61227A/xx unknown
- 1980-10-07 PH PH24677A patent/PH15023A/en unknown
- 1980-10-07 GR GR63068A patent/GR70219B/el unknown
- 1980-10-07 CS CS806756A patent/CS215142B2/cs unknown
- 1980-10-07 CA CA000361704A patent/CA1146539A/en not_active Expired
- 1980-10-07 GB GB8032258A patent/GB2059966B/en not_active Expired
- 1980-10-07 FR FR8021431A patent/FR2467211A1/fr active Granted
- 1980-10-07 ZA ZA00806192A patent/ZA806192B/xx unknown
- 1980-10-07 AT AT0498080A patent/AT369008B/de not_active IP Right Cessation
- 1980-10-07 PT PT71886A patent/PT71886B/pt unknown
- 1980-10-07 EP EP80303525A patent/EP0027050B1/en not_active Expired
- 1980-10-08 DD DD80224408A patent/DD153375A5/de unknown
- 1980-10-08 ES ES495753A patent/ES495753A0/es active Granted
- 1980-10-08 RO RO102315A patent/RO80664B/ro unknown
- 1980-10-08 DK DK424680A patent/DK424680A/da not_active Application Discontinuation
- 1980-10-08 CH CH7518/80A patent/CH647523A5/fr not_active IP Right Cessation
- 1980-10-08 AU AU63061/80A patent/AU6306180A/en not_active Abandoned
- 1980-10-08 HU HU802455A patent/HU183230B/hu unknown
- 1980-10-08 KR KR1019800003868A patent/KR840000866B1/ko active
- 1980-10-08 BE BE1/9975A patent/BE885569A/fr not_active IP Right Cessation
- 1980-10-08 IT IT25200/80A patent/IT1132926B/it active
- 1980-10-08 IE IE2086/80A patent/IE50390B1/en unknown
- 1980-10-09 FI FI803200A patent/FI803200L/fi not_active Application Discontinuation
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