KR970027048A - 안정한 결정질 테트라하이드로엽산염 - Google Patents

안정한 결정질 테트라하이드로엽산염 Download PDF

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Publication number
KR970027048A
KR970027048A KR1019960052354A KR19960052354A KR970027048A KR 970027048 A KR970027048 A KR 970027048A KR 1019960052354 A KR1019960052354 A KR 1019960052354A KR 19960052354 A KR19960052354 A KR 19960052354A KR 970027048 A KR970027048 A KR 970027048A
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South Korea
Prior art keywords
tetrahydrofolic acid
crystalline calcium
water
magnesium salts
crystalline
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KR1019960052354A
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English (en)
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KR100702201B1 (ko
Inventor
한스 루돌프 뮐러
마틴 울만
루돌프 모저
토마스 암만
Original Assignee
뮐러 에이치. 알, 퍼거 에이.
에프로바 아크티엔 게젤샤프트
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Application filed by 뮐러 에이치. 알, 퍼거 에이., 에프로바 아크티엔 게젤샤프트 filed Critical 뮐러 에이치. 알, 퍼거 에이.
Publication of KR970027048A publication Critical patent/KR970027048A/ko
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Publication of KR100702201B1 publication Critical patent/KR100702201B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

본 발명은 안정한 (6R, S)-, (6S)- 및 (6R)-테트라하이드로엽산의 결정질 염과 이들염의 제조방법에 관한 것이며, 또한 의약품 및 약제학적 제제 제조에 사용되는 이들의 용도에 관한 것이다.

Description

안정한 결정질 테트라하이드로엽산염
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. (6R, S)-, (6S)- 및 (6R)-테트라하이드로엽산의 결정질 칼슘염.
  2. (6R, S)-, (6S)- 및 (6R)-테트라하이드로엽산의 결정질 마그네슘염.
  3. (6R, S)-, (6S)- 및 (6R)-테트라하이드로엽산을 pH 7 내지 10의 범위의 극성 매질 중에서 결정화하는 것을 특징으로 하는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염의 제조방법.
  4. 제3항에 있어서, 상기 결정화가 고온에서 및/또는 묽은 용액으로부터 이루어지는 것을 특징으로 하는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염의 제조방법.
  5. 제4항에 있어서, 상기 결정화가 물 또는 물 및 물과 혼합될 수 있는 유기용매의 혼합물 중에서 이루어지는 것을 특징으로 하는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염의 제조방법.
  6. 제5항에 있어서, 상기 물과 혼화될 수 있는 용매가 아세트산 또는 저분자량 유기 알코올인 것을 특징으로 하는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염의 제조방법.
  7. 의약품 제조 성분으로 사용되는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염.
  8. (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염을 함유하는 약제학적 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960052354A 1995-11-07 1996-11-06 안정한결정질테트라하이드로엽산염 KR100702201B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH03145/95A CH689831A5 (de) 1995-11-07 1995-11-07 Stabile kristalline Tetrahydrofolsaeure-Salze.
CH03145/95 1995-11-07

Publications (2)

Publication Number Publication Date
KR970027048A true KR970027048A (ko) 1997-06-24
KR100702201B1 KR100702201B1 (ko) 2007-11-12

Family

ID=4249585

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019960050318A KR100296162B1 (ko) 1995-11-01 1996-10-30 니코틴아미드의제조방법
KR1019960052354A KR100702201B1 (ko) 1995-11-07 1996-11-06 안정한결정질테트라하이드로엽산염

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019960050318A KR100296162B1 (ko) 1995-11-01 1996-10-30 니코틴아미드의제조방법

Country Status (19)

Country Link
US (1) US5817659A (ko)
EP (1) EP0773221B1 (ko)
JP (1) JP3382103B2 (ko)
KR (2) KR100296162B1 (ko)
CN (1) CN1067392C (ko)
AT (1) ATE191482T1 (ko)
AU (1) AU707443B2 (ko)
CA (1) CA2187409C (ko)
CH (1) CH689831A5 (ko)
DE (1) DE59604878D1 (ko)
DK (1) DK0773221T3 (ko)
ES (1) ES2145360T3 (ko)
GR (1) GR3033727T3 (ko)
HU (1) HUP9603072A3 (ko)
NO (1) NO964699L (ko)
PT (1) PT773221E (ko)
RU (1) RU2187508C2 (ko)
TW (1) TW533214B (ko)
ZA (1) ZA969284B (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH693255A5 (de) * 1997-06-13 2003-05-15 Eprova Ag Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels.
US6358953B1 (en) * 1998-10-22 2002-03-19 Phillip B. B. Moheno Pterin antineoplastic agents
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
FR2816944B1 (fr) * 2000-11-17 2005-10-21 Dospharma Nouveaux sels de lithium, les compositions pharmaceutiques a base de ces sels de lithium et leurs applications comme medicament
DE602005026352D1 (de) * 2004-09-15 2011-03-31 Nipro Corp Wässrige, stabile (6S)-Folinsäurelösung zur Injektion
US7947662B2 (en) 2008-02-20 2011-05-24 Gnosis S.P.A. Folates, compositions and uses thereof
PT2245032E (pt) * 2008-02-20 2015-07-21 Gnosis Spa Folatos, composições e suas utilizações
US9492421B1 (en) 2013-11-14 2016-11-15 Argent Development Group, Llc Nutritional supplements for treatment of iron deficiency anemia
US9629846B1 (en) 2013-11-14 2017-04-25 Argent Development Group, Llc Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
WO2016185413A1 (en) 2015-05-20 2016-11-24 Nestec S.A. Modified release formulations
AU2018246265B2 (en) 2017-03-31 2022-07-07 Merck Patent Gmbh Crystalline sodium salt of 5-methyl-(6S)-tetrahydrofolic acid
CA3058252A1 (en) 2017-03-31 2018-10-04 Merck Patent Gmbh Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid
EP3461826A1 (en) 2017-09-29 2019-04-03 Aprofol AG Multifunctional folate salts
CN108976232A (zh) * 2018-09-19 2018-12-11 江苏红豆杉药业有限公司 一种四氢叶酸钙的合成方法
EP3646873A1 (en) 2018-10-31 2020-05-06 Aprofol AG Folate salts
CN109456330B (zh) * 2018-11-26 2021-05-14 连云港德洋化工有限公司 叶酸类稳定复合物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
DD274631A5 (de) * 1987-09-18 1989-12-27 Kk Verfahren zur biologischen herstellung von amiden
DE3821875C1 (ko) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH681303A5 (ko) * 1991-01-16 1993-02-26 Eprova Ag
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
GEP20012441B (en) * 1993-04-02 2001-05-25 Lonza Ag Process for Preparing 3-Methylpiperidine and 3-Methylpyridine
CH686369A5 (de) * 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
CZ338596A3 (en) * 1994-05-23 1997-07-16 Lonza Ag Catalytic mixture for oxidative amonolysis of alkyl pyridines, process of its preparation and use

Also Published As

Publication number Publication date
RU2187508C2 (ru) 2002-08-20
CN1067392C (zh) 2001-06-20
KR970027056A (ko) 1997-06-24
EP0773221B1 (de) 2000-04-05
DE59604878D1 (de) 2000-05-11
CA2187409C (en) 2000-08-22
HUP9603072A3 (en) 1998-01-28
ES2145360T3 (es) 2000-07-01
ATE191482T1 (de) 2000-04-15
KR100296162B1 (ko) 2001-09-10
TW533214B (en) 2003-05-21
HU9603072D0 (en) 1996-12-30
EP0773221A1 (de) 1997-05-14
JP3382103B2 (ja) 2003-03-04
AU7053396A (en) 1997-05-15
ZA969284B (en) 1997-05-07
CH689831A5 (de) 1999-12-15
CA2187409A1 (en) 1997-05-08
US5817659A (en) 1998-10-06
AU707443B2 (en) 1999-07-08
KR100702201B1 (ko) 2007-11-12
NO964699L (no) 1997-05-09
JPH09169759A (ja) 1997-06-30
PT773221E (pt) 2000-09-29
HUP9603072A2 (en) 1997-08-28
GR3033727T3 (en) 2000-10-31
NO964699D0 (no) 1996-11-06
CN1153176A (zh) 1997-07-02
DK0773221T3 (da) 2000-07-10

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