KR970027048A - 안정한 결정질 테트라하이드로엽산염 - Google Patents
안정한 결정질 테트라하이드로엽산염 Download PDFInfo
- Publication number
- KR970027048A KR970027048A KR1019960052354A KR19960052354A KR970027048A KR 970027048 A KR970027048 A KR 970027048A KR 1019960052354 A KR1019960052354 A KR 1019960052354A KR 19960052354 A KR19960052354 A KR 19960052354A KR 970027048 A KR970027048 A KR 970027048A
- Authority
- KR
- South Korea
- Prior art keywords
- tetrahydrofolic acid
- crystalline calcium
- water
- magnesium salts
- crystalline
- Prior art date
Links
- MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 title claims abstract 10
- 239000005460 tetrahydrofolate Substances 0.000 title 1
- MSTNYGQPCMXVAQ-NEPJUHHUSA-N 6R-Tetrahydrofolic acid Chemical compound C([C@@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-NEPJUHHUSA-N 0.000 claims abstract 9
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 239000003814 drug Substances 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims abstract 2
- 159000000003 magnesium salts Chemical class 0.000 claims 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 6
- 229910052791 calcium Inorganic materials 0.000 claims 6
- 239000011575 calcium Substances 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 230000008025 crystallization Effects 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical compound N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 159000000007 calcium salts Chemical class 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
본 발명은 안정한 (6R, S)-, (6S)- 및 (6R)-테트라하이드로엽산의 결정질 염과 이들염의 제조방법에 관한 것이며, 또한 의약품 및 약제학적 제제 제조에 사용되는 이들의 용도에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- (6R, S)-, (6S)- 및 (6R)-테트라하이드로엽산의 결정질 칼슘염.
- (6R, S)-, (6S)- 및 (6R)-테트라하이드로엽산의 결정질 마그네슘염.
- (6R, S)-, (6S)- 및 (6R)-테트라하이드로엽산을 pH 7 내지 10의 범위의 극성 매질 중에서 결정화하는 것을 특징으로 하는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염의 제조방법.
- 제3항에 있어서, 상기 결정화가 고온에서 및/또는 묽은 용액으로부터 이루어지는 것을 특징으로 하는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염의 제조방법.
- 제4항에 있어서, 상기 결정화가 물 또는 물 및 물과 혼합될 수 있는 유기용매의 혼합물 중에서 이루어지는 것을 특징으로 하는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염의 제조방법.
- 제5항에 있어서, 상기 물과 혼화될 수 있는 용매가 아세트산 또는 저분자량 유기 알코올인 것을 특징으로 하는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염의 제조방법.
- 의약품 제조 성분으로 사용되는 (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염.
- (6R, S)-, (6S)- 및/또는 (6R)-테트라하이드로엽산의 결정질 칼슘 또는 마그네슘염을 함유하는 약제학적 제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH03145/95A CH689831A5 (de) | 1995-11-07 | 1995-11-07 | Stabile kristalline Tetrahydrofolsaeure-Salze. |
CH03145/95 | 1995-11-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR970027048A true KR970027048A (ko) | 1997-06-24 |
KR100702201B1 KR100702201B1 (ko) | 2007-11-12 |
Family
ID=4249585
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960050318A KR100296162B1 (ko) | 1995-11-01 | 1996-10-30 | 니코틴아미드의제조방법 |
KR1019960052354A KR100702201B1 (ko) | 1995-11-07 | 1996-11-06 | 안정한결정질테트라하이드로엽산염 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960050318A KR100296162B1 (ko) | 1995-11-01 | 1996-10-30 | 니코틴아미드의제조방법 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5817659A (ko) |
EP (1) | EP0773221B1 (ko) |
JP (1) | JP3382103B2 (ko) |
KR (2) | KR100296162B1 (ko) |
CN (1) | CN1067392C (ko) |
AT (1) | ATE191482T1 (ko) |
AU (1) | AU707443B2 (ko) |
CA (1) | CA2187409C (ko) |
CH (1) | CH689831A5 (ko) |
DE (1) | DE59604878D1 (ko) |
DK (1) | DK0773221T3 (ko) |
ES (1) | ES2145360T3 (ko) |
GR (1) | GR3033727T3 (ko) |
HU (1) | HUP9603072A3 (ko) |
NO (1) | NO964699L (ko) |
PT (1) | PT773221E (ko) |
RU (1) | RU2187508C2 (ko) |
TW (1) | TW533214B (ko) |
ZA (1) | ZA969284B (ko) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH693255A5 (de) * | 1997-06-13 | 2003-05-15 | Eprova Ag | Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels. |
US6358953B1 (en) * | 1998-10-22 | 2002-03-19 | Phillip B. B. Moheno | Pterin antineoplastic agents |
CH693905A5 (de) * | 1999-04-15 | 2004-04-15 | Eprova Ag | Stabile kristalline Salze von 5-Methyltetrahydrofolsäure. |
CH694251A5 (de) * | 1999-07-14 | 2004-10-15 | Eprova Ag | Herstellung von Tetrahydropterin und Derivaten. |
FR2816944B1 (fr) * | 2000-11-17 | 2005-10-21 | Dospharma | Nouveaux sels de lithium, les compositions pharmaceutiques a base de ces sels de lithium et leurs applications comme medicament |
DE602005026352D1 (de) * | 2004-09-15 | 2011-03-31 | Nipro Corp | Wässrige, stabile (6S)-Folinsäurelösung zur Injektion |
US7947662B2 (en) | 2008-02-20 | 2011-05-24 | Gnosis S.P.A. | Folates, compositions and uses thereof |
PT2245032E (pt) * | 2008-02-20 | 2015-07-21 | Gnosis Spa | Folatos, composições e suas utilizações |
US9492421B1 (en) | 2013-11-14 | 2016-11-15 | Argent Development Group, Llc | Nutritional supplements for treatment of iron deficiency anemia |
US9629846B1 (en) | 2013-11-14 | 2017-04-25 | Argent Development Group, Llc | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women |
WO2016185413A1 (en) | 2015-05-20 | 2016-11-24 | Nestec S.A. | Modified release formulations |
AU2018246265B2 (en) | 2017-03-31 | 2022-07-07 | Merck Patent Gmbh | Crystalline sodium salt of 5-methyl-(6S)-tetrahydrofolic acid |
CA3058252A1 (en) | 2017-03-31 | 2018-10-04 | Merck Patent Gmbh | Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid |
EP3461826A1 (en) | 2017-09-29 | 2019-04-03 | Aprofol AG | Multifunctional folate salts |
CN108976232A (zh) * | 2018-09-19 | 2018-12-11 | 江苏红豆杉药业有限公司 | 一种四氢叶酸钙的合成方法 |
EP3646873A1 (en) | 2018-10-31 | 2020-05-06 | Aprofol AG | Folate salts |
CN109456330B (zh) * | 2018-11-26 | 2021-05-14 | 连云港德洋化工有限公司 | 叶酸类稳定复合物及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5124452A (en) * | 1978-07-10 | 1992-06-23 | Bioresearch S.P.A. | Process for producing d,1-5-methyltetrahydrofolic acid and its salts |
DD274631A5 (de) * | 1987-09-18 | 1989-12-27 | Kk | Verfahren zur biologischen herstellung von amiden |
DE3821875C1 (ko) * | 1988-06-29 | 1990-02-15 | Eprova Ag, Forschungsinstitut, Schaffhausen, Ch | |
CH681303A5 (ko) * | 1991-01-16 | 1993-02-26 | Eprova Ag | |
CH684270A5 (de) * | 1991-10-04 | 1994-08-15 | Sapec Fine Chemicals | Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure. |
CH686672A5 (de) * | 1992-12-01 | 1996-05-31 | Cerbios Pharma Sa | Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure. |
GEP20012441B (en) * | 1993-04-02 | 2001-05-25 | Lonza Ag | Process for Preparing 3-Methylpiperidine and 3-Methylpyridine |
CH686369A5 (de) * | 1994-05-09 | 1996-03-15 | Eprova Ag | Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure. |
CZ338596A3 (en) * | 1994-05-23 | 1997-07-16 | Lonza Ag | Catalytic mixture for oxidative amonolysis of alkyl pyridines, process of its preparation and use |
-
1995
- 1995-11-07 CH CH03145/95A patent/CH689831A5/de not_active IP Right Cessation
-
1996
- 1996-10-07 TW TW085112241A patent/TW533214B/zh not_active IP Right Cessation
- 1996-10-08 CA CA002187409A patent/CA2187409C/en not_active Expired - Lifetime
- 1996-10-14 EP EP96116403A patent/EP0773221B1/de not_active Expired - Lifetime
- 1996-10-14 DK DK96116403T patent/DK0773221T3/da active
- 1996-10-14 ES ES96116403T patent/ES2145360T3/es not_active Expired - Lifetime
- 1996-10-14 AT AT96116403T patent/ATE191482T1/de not_active IP Right Cessation
- 1996-10-14 DE DE59604878T patent/DE59604878D1/de not_active Expired - Lifetime
- 1996-10-14 PT PT96116403T patent/PT773221E/pt unknown
- 1996-10-30 KR KR1019960050318A patent/KR100296162B1/ko not_active IP Right Cessation
- 1996-10-31 AU AU70533/96A patent/AU707443B2/en not_active Ceased
- 1996-11-05 CN CN96112040A patent/CN1067392C/zh not_active Expired - Fee Related
- 1996-11-05 ZA ZA969284A patent/ZA969284B/xx unknown
- 1996-11-06 NO NO964699A patent/NO964699L/no not_active Application Discontinuation
- 1996-11-06 RU RU96121625/04A patent/RU2187508C2/ru active
- 1996-11-06 KR KR1019960052354A patent/KR100702201B1/ko not_active IP Right Cessation
- 1996-11-06 JP JP29416096A patent/JP3382103B2/ja not_active Expired - Fee Related
- 1996-11-06 HU HU9603072A patent/HUP9603072A3/hu unknown
- 1996-11-07 US US08/744,952 patent/US5817659A/en not_active Expired - Lifetime
-
2000
- 2000-06-20 GR GR20000401421T patent/GR3033727T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2187508C2 (ru) | 2002-08-20 |
CN1067392C (zh) | 2001-06-20 |
KR970027056A (ko) | 1997-06-24 |
EP0773221B1 (de) | 2000-04-05 |
DE59604878D1 (de) | 2000-05-11 |
CA2187409C (en) | 2000-08-22 |
HUP9603072A3 (en) | 1998-01-28 |
ES2145360T3 (es) | 2000-07-01 |
ATE191482T1 (de) | 2000-04-15 |
KR100296162B1 (ko) | 2001-09-10 |
TW533214B (en) | 2003-05-21 |
HU9603072D0 (en) | 1996-12-30 |
EP0773221A1 (de) | 1997-05-14 |
JP3382103B2 (ja) | 2003-03-04 |
AU7053396A (en) | 1997-05-15 |
ZA969284B (en) | 1997-05-07 |
CH689831A5 (de) | 1999-12-15 |
CA2187409A1 (en) | 1997-05-08 |
US5817659A (en) | 1998-10-06 |
AU707443B2 (en) | 1999-07-08 |
KR100702201B1 (ko) | 2007-11-12 |
NO964699L (no) | 1997-05-09 |
JPH09169759A (ja) | 1997-06-30 |
PT773221E (pt) | 2000-09-29 |
HUP9603072A2 (en) | 1997-08-28 |
GR3033727T3 (en) | 2000-10-31 |
NO964699D0 (no) | 1996-11-06 |
CN1153176A (zh) | 1997-07-02 |
DK0773221T3 (da) | 2000-07-10 |
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