NO964699L - Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike - Google Patents

Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike

Info

Publication number
NO964699L
NO964699L NO964699A NO964699A NO964699L NO 964699 L NO964699 L NO 964699L NO 964699 A NO964699 A NO 964699A NO 964699 A NO964699 A NO 964699A NO 964699 L NO964699 L NO 964699L
Authority
NO
Norway
Prior art keywords
preparation
processes
tetrahydrofolic acid
stable crystalline
acid salts
Prior art date
Application number
NO964699A
Other languages
English (en)
Other versions
NO964699D0 (no
Inventor
Hans Rudolf Mueller
Martin Ulmann
Rudolf Moser
Thomas Ammann
Original Assignee
Eprova Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eprova Ag filed Critical Eprova Ag
Publication of NO964699D0 publication Critical patent/NO964699D0/no
Publication of NO964699L publication Critical patent/NO964699L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Stabile, krystallinske salter av(6R,S)-, (6S)- og (6R)-tetrahydrofolin- syre fremstilles ved utkrystallisering i et polart medium ved en pH mellom 7 og 10. Saltene anvendes som en bestanddel ved fremstilling av legemidler og kan inngå i farmasøytiske preparater.
NO964699A 1995-11-07 1996-11-06 Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike NO964699L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH03145/95A CH689831A5 (de) 1995-11-07 1995-11-07 Stabile kristalline Tetrahydrofolsaeure-Salze.

Publications (2)

Publication Number Publication Date
NO964699D0 NO964699D0 (no) 1996-11-06
NO964699L true NO964699L (no) 1997-05-09

Family

ID=4249585

Family Applications (1)

Application Number Title Priority Date Filing Date
NO964699A NO964699L (no) 1995-11-07 1996-11-06 Stabile, krystallinske tetrahydrofolinsyresalter og fremgangsmåter for fremstilling av slike

Country Status (19)

Country Link
US (1) US5817659A (no)
EP (1) EP0773221B1 (no)
JP (1) JP3382103B2 (no)
KR (2) KR100296162B1 (no)
CN (1) CN1067392C (no)
AT (1) ATE191482T1 (no)
AU (1) AU707443B2 (no)
CA (1) CA2187409C (no)
CH (1) CH689831A5 (no)
DE (1) DE59604878D1 (no)
DK (1) DK0773221T3 (no)
ES (1) ES2145360T3 (no)
GR (1) GR3033727T3 (no)
HU (1) HUP9603072A3 (no)
NO (1) NO964699L (no)
PT (1) PT773221E (no)
RU (1) RU2187508C2 (no)
TW (1) TW533214B (no)
ZA (1) ZA969284B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH693255A5 (de) * 1997-06-13 2003-05-15 Eprova Ag Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels.
WO2000023448A1 (en) * 1998-10-22 2000-04-27 Moheno Phillip B B Novel pterin antineoplastic agents
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH694251A5 (de) * 1999-07-14 2004-10-15 Eprova Ag Herstellung von Tetrahydropterin und Derivaten.
FR2816944B1 (fr) * 2000-11-17 2005-10-21 Dospharma Nouveaux sels de lithium, les compositions pharmaceutiques a base de ces sels de lithium et leurs applications comme medicament
KR20060051135A (ko) * 2004-09-15 2006-05-19 니프로 가부시키가이샤 안정화된 주사용 수용액 제재
WO2009103334A1 (en) * 2008-02-20 2009-08-27 Gnosis S.P.A. Folates, compositions and uses thereof
US7947662B2 (en) 2008-02-20 2011-05-24 Gnosis S.P.A. Folates, compositions and uses thereof
US9492421B1 (en) 2013-11-14 2016-11-15 Argent Development Group, Llc Nutritional supplements for treatment of iron deficiency anemia
US9629846B1 (en) 2013-11-14 2017-04-25 Argent Development Group, Llc Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women
WO2016185413A1 (en) 2015-05-20 2016-11-24 Nestec S.A. Modified release formulations
KR102665004B1 (ko) 2017-03-31 2024-05-09 메르크 파텐트 게엠베하 5-메틸-(6s)-테트라히드로폴산의 결정질 소듐 염
CA3058252A1 (en) 2017-03-31 2018-10-04 Merck Patent Gmbh Crystalline sodium salt of 5-methyl-(6s)-tetrahydrofolic acid
EP3461826A1 (en) 2017-09-29 2019-04-03 Aprofol AG Multifunctional folate salts
CN108976232A (zh) * 2018-09-19 2018-12-11 江苏红豆杉药业有限公司 一种四氢叶酸钙的合成方法
EP3646873A1 (en) 2018-10-31 2020-05-06 Aprofol AG Folate salts
CN109456330B (zh) * 2018-11-26 2021-05-14 连云港德洋化工有限公司 叶酸类稳定复合物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
DD274631A5 (de) * 1987-09-18 1989-12-27 Kk Verfahren zur biologischen herstellung von amiden
DE3821875C1 (no) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH681303A5 (no) * 1991-01-16 1993-02-26 Eprova Ag
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
GEP20012441B (en) * 1993-04-02 2001-05-25 Lonza Ag Process for Preparing 3-Methylpiperidine and 3-Methylpyridine
CH686369A5 (de) * 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
CN1086311C (zh) * 1994-05-23 2002-06-19 隆萨股份公司 烷基吡啶的氧化氨解

Also Published As

Publication number Publication date
DE59604878D1 (de) 2000-05-11
CN1153176A (zh) 1997-07-02
CH689831A5 (de) 1999-12-15
CA2187409A1 (en) 1997-05-08
ES2145360T3 (es) 2000-07-01
AU7053396A (en) 1997-05-15
HU9603072D0 (en) 1996-12-30
KR970027056A (ko) 1997-06-24
RU2187508C2 (ru) 2002-08-20
HUP9603072A2 (en) 1997-08-28
PT773221E (pt) 2000-09-29
KR100702201B1 (ko) 2007-11-12
NO964699D0 (no) 1996-11-06
ZA969284B (en) 1997-05-07
EP0773221A1 (de) 1997-05-14
CA2187409C (en) 2000-08-22
AU707443B2 (en) 1999-07-08
US5817659A (en) 1998-10-06
CN1067392C (zh) 2001-06-20
KR100296162B1 (ko) 2001-09-10
JPH09169759A (ja) 1997-06-30
EP0773221B1 (de) 2000-04-05
JP3382103B2 (ja) 2003-03-04
KR970027048A (ko) 1997-06-24
DK0773221T3 (da) 2000-07-10
GR3033727T3 (en) 2000-10-31
ATE191482T1 (de) 2000-04-15
HUP9603072A3 (en) 1998-01-28
TW533214B (en) 2003-05-21

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