KR890013031A - 세프타지딤 이염산염 포름산 용매화물 - Google Patents
세프타지딤 이염산염 포름산 용매화물 Download PDFInfo
- Publication number
- KR890013031A KR890013031A KR1019890001322A KR890001322A KR890013031A KR 890013031 A KR890013031 A KR 890013031A KR 1019890001322 A KR1019890001322 A KR 1019890001322A KR 890001322 A KR890001322 A KR 890001322A KR 890013031 A KR890013031 A KR 890013031A
- Authority
- KR
- South Korea
- Prior art keywords
- formic acid
- dihydrochloride
- ceftazidime
- solvate
- crystalline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 결정성 포름산 용매 화물 형태의 (6R,7R)-7-[(X)-2-(2-아이노티아졸-4-일)-2-(2-카르복시프로프-2-옥시이미노)아세트아미도]-3-(1-피리디늄메틸)세프-3-엠-4-카르복실레이트 이염산염(세프타지딤 이염산염).
- 제1항에 있어서, Nujol중에서 실질적으로 다음과 같은 적외선 스펙트럼을 나타내는 것을 특징으로 하는 결정성 세프타지딤 이염산염 포름산 용매화물.νmax-3368,3175,1775,1731,1680,1541,1500,1411,1203,1190,1150,1134,1014,997,753.671 및 597cm-1
- 제1항에 있어서, 실질적으로 다음과 같은 X-선 회절패턴(d 면간격 및 상대적 강도로 표시됨)을 나타내는 것을 특징으로 하는 결정성 세프타지딤 이염산염 포름산 용매화물.
- 실질적으로 무정형 세프타지딤 염 및(또는) 용매화물이 없는 제1항의 결정성 세프타지딤 이염산염 포름산 용매화물.
- 포름산을 함유하는 세프타지딤 이염산염의 용액 중에서 용매화물을 결정화시키는 것으로 됨을 특징으로 하는 제1항의 결정성 세프타지딤 이염산염 포름산 용매화물의 제조방법.
- 제5항에 있어서, 세프타지딤 이염산염의 포름산 용액을 유기 반대용매와 혼합시켜서 결정화를 행하는 것을 특징으로 하는 방법.
- 제5항에 있어서, 세프타지딤 이염산염 포름산 용매화물이 종정을 첨가하여 결정화를 행하는 것을 특징으로 하는 방법.
- 제6항에 있어서, 세프타지딤 이염산염 포름산 용매화물이 종정을 첨가하여 결정화를 행하는 것을 특징으로 하는 방법.
- 제5항에 있어서, 포름산을 함유하는 충분한 염산용액중에서 (6R,7R)-7-[(Z)-2-(2-트리페닐메틸 아미노티아졸-4-일)-2-(2-t-부톡시카르보닐프로프-2-옥시이미노)아세트아미도]-3-(1-피리디늄메틸)세프-3-엠-4-카르복실레이트 또는 그의 용매화물을 탈보호시켜서 이염산염을 형성함으로써 포름산 중의 세프타지딤 이염산염의 용액을 제조하는 것을 특징으로 하는 방법.
- 제5항에 있어서, 이와같이 생성된 세프타지딤 이염산염 포름산 용매화물을 결정성 세프타지딤 오수화물의 제조에 사용하는 것을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8802622 | 1988-02-05 | ||
GB888802622A GB8802622D0 (en) | 1988-02-05 | 1988-02-05 | Chemical compound |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890013031A true KR890013031A (ko) | 1989-09-21 |
KR0123015B1 KR0123015B1 (ko) | 1997-11-13 |
Family
ID=10631146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890001322A KR0123015B1 (ko) | 1988-02-05 | 1989-02-04 | 세프타지딤 이염산염 포름산 용매화물 |
Country Status (9)
Country | Link |
---|---|
US (1) | US4943632A (ko) |
EP (1) | EP0327358B1 (ko) |
JP (1) | JP2780800B2 (ko) |
KR (1) | KR0123015B1 (ko) |
AT (1) | ATE122678T1 (ko) |
DE (1) | DE68922629T2 (ko) |
ES (1) | ES2072293T3 (ko) |
GB (1) | GB8802622D0 (ko) |
TW (1) | TW266212B (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210015065A (ko) | 2019-07-31 | 2021-02-10 | 김윤성 | 운전자의 개성을 표현하고 운전자, 보행자, 자동차를 보호하기 위한 차량용 보호 케이스 |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2514092C (en) * | 2003-01-21 | 2013-03-19 | S.S.C.I., Inc. | Novel cocrystallization of hydrochloric acid salt of an active agent |
EP1740930A4 (en) | 2004-03-12 | 2010-09-15 | Aptuit Kansas City Llc | SEARCH FOR FORMATS BY ULTRASOUND CRYSTALLIZATION AND COKRISTALLIZATION USING ULTRASOUND |
HUP0700353A2 (en) | 2007-05-18 | 2008-12-29 | Richter Gedeon Nyrt | Metabolites of (thio)carbamoyl-cyclohexane derivatives |
US20110059980A1 (en) * | 2008-02-21 | 2011-03-10 | Yasuaki Oobayashi | Solid preparation for oral administration |
RS53866B1 (en) | 2008-07-16 | 2015-08-31 | Richter Gedeon Nyrt. | PHARMACEUTICAL FORMULATIONS CONTAINING DOPAMINE RECEPTOR LIGANDS |
US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR229883A1 (es) * | 1978-05-26 | 1983-12-30 | Glaxo Group Ltd | Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato |
US4329453A (en) * | 1979-10-02 | 1982-05-11 | Glaxo Group Limited | Cephalosporin antibiotic |
NZ195116A (en) * | 1979-10-02 | 1982-09-07 | Glaxo Group Ltd | The crystalline bishydrochloride of a certain cephalosporin medicinal preparations |
GB2132616B (en) * | 1982-12-27 | 1986-08-06 | Lilly Co Eli | Improvements in or relating to novel cephalosporin intermediates |
US4537959A (en) * | 1984-03-26 | 1985-08-27 | Eli Lilly And Company | Crystalline cephalosporin antibiotic salt |
EP0166580A3 (en) * | 1984-06-25 | 1987-03-18 | Eli Lilly And Company | Improvements in or relating to ceftazidime |
US4616080A (en) * | 1984-07-02 | 1986-10-07 | Eli Lilly And Company | Simplified process of forming crystalline ceftazidime pentahydrate |
-
1988
- 1988-02-05 GB GB888802622A patent/GB8802622D0/en active Pending
-
1989
- 1989-02-02 DE DE68922629T patent/DE68922629T2/de not_active Expired - Lifetime
- 1989-02-02 ES ES89301004T patent/ES2072293T3/es not_active Expired - Lifetime
- 1989-02-02 EP EP89301004A patent/EP0327358B1/en not_active Expired - Lifetime
- 1989-02-02 AT AT89301004T patent/ATE122678T1/de not_active IP Right Cessation
- 1989-02-03 JP JP1024143A patent/JP2780800B2/ja not_active Expired - Lifetime
- 1989-02-03 US US07/305,541 patent/US4943632A/en not_active Expired - Lifetime
- 1989-02-04 TW TW078100842A patent/TW266212B/zh active
- 1989-02-04 KR KR1019890001322A patent/KR0123015B1/ko not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210015065A (ko) | 2019-07-31 | 2021-02-10 | 김윤성 | 운전자의 개성을 표현하고 운전자, 보행자, 자동차를 보호하기 위한 차량용 보호 케이스 |
Also Published As
Publication number | Publication date |
---|---|
ES2072293T3 (es) | 1995-07-16 |
ATE122678T1 (de) | 1995-06-15 |
EP0327358A3 (en) | 1991-04-03 |
TW266212B (ko) | 1995-12-21 |
EP0327358B1 (en) | 1995-05-17 |
DE68922629T2 (de) | 1995-10-19 |
KR0123015B1 (ko) | 1997-11-13 |
EP0327358A2 (en) | 1989-08-09 |
US4943632A (en) | 1990-07-24 |
DE68922629D1 (de) | 1995-06-22 |
JPH01308284A (ja) | 1989-12-12 |
JP2780800B2 (ja) | 1998-07-30 |
GB8802622D0 (en) | 1988-03-02 |
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