KR890003778A - 결정성 7-[2-(2-아미노티아졸-4-일)- 2- 히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체] - Google Patents

결정성 7-[2-(2-아미노티아졸-4-일)- 2- 히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체] Download PDF

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Publication number
KR890003778A
KR890003778A KR1019880010489A KR880010489A KR890003778A KR 890003778 A KR890003778 A KR 890003778A KR 1019880010489 A KR1019880010489 A KR 1019880010489A KR 880010489 A KR880010489 A KR 880010489A KR 890003778 A KR890003778 A KR 890003778A
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Prior art keywords
aminothiazol
vinyl
carboxylic acid
hydroxyiminoacetamido
solution
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KR1019880010489A
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English (en)
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KR970008126B1 (ko
Inventor
다까오 다까야
후미유끼 시라이
히또시 나까무라
야스노부 이나바
Original Assignee
후지사와 도모끼찌로
후지사와 세이야꾸 고교 가부시끼가이샤
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Application filed by 후지사와 도모끼찌로, 후지사와 세이야꾸 고교 가부시끼가이샤 filed Critical 후지사와 도모끼찌로
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

Abstract

내용 없음

Description

결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체]
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 화합물(Ⅰ)의 크리스탈 A의 분말 X-선 회절패턴의 챠트를 나타낸다. 제 2도는 화합물(Ⅰ)의 크리스탈 A의 적외선 흡수 스펙트럼의 차트를 나타낸다.

Claims (9)

  1. 분말 X-선 회절 패턴에서 하기표에 나타낸 회절각에서 피크를 나타내는 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록이미노아세트아미도]-3-비닐-3-세팸-4-카복실산(신 이성체).
    회절각(°)
    약 14.7
    약 17.8
    약 21.5
    약 22.0
    약 23.4
    약 24.5
    약 28.1
  2. 7--[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 함유하는 용액을 실온 또는 가온하에서 산성화함으로써 수득할수 있는 결정성7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체).
  3. 제 2 항에 있어서,7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 함유하는 용액이 상기한 화합물의 알칼리금속염 수용액인 결정성 물질.
  4. 제 3 항에 있어서, 용액의 산성화를 실온 내지 40℃의 온도에서 1 내지 4의 pH에서 수행하는 결정성 물질.
  5. 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 알코올중에 용해시키고 계속해서 용액을 가온하에서 천천히 교반시킨다음, 용액을 실온으로 냉각시켜 용액을 정지시킴으로써 수득할 수 있는 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체).
  6. 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 함유하는 용액을 실온 또는 가온하에서 산성화시킴을 특지으로 하는 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)의 제조방법.
  7. 제 6 항에 있어서,7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 함유하는 용액이 상기한 화합물의 알칼리금속염 수용액인 방법.
  8. 제 7 항에 있어서, 용액의 산성화를 실온 내지 40℃의 온도에서 1 내지 4의 pH에서 수행하는 방법.
  9. 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 알코올중에 용해시키고 계속해서 용액을 가온하에서 천천히 교반시킨다음, 용액을 실온으로 냉각시켜 용액을 정지시킴을 특징으로 하는 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880010489A 1987-08-19 1988-08-18 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체] KR970008126B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62-206199 1987-08-19
JP20619987 1987-08-19

Publications (2)

Publication Number Publication Date
KR890003778A true KR890003778A (ko) 1989-04-18
KR970008126B1 KR970008126B1 (ko) 1997-05-21

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KR1019880010489A KR970008126B1 (ko) 1987-08-19 1988-08-18 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체]

Country Status (11)

Country Link
US (1) US4935507A (ko)
EP (1) EP0304019B1 (ko)
KR (1) KR970008126B1 (ko)
AT (1) ATE123221T1 (ko)
AU (1) AU617347B2 (ko)
CA (1) CA1297096C (ko)
DE (1) DE3853901T2 (ko)
ES (1) ES2072856T3 (ko)
HK (1) HK18496A (ko)
IE (1) IE67348B1 (ko)
ZA (1) ZA885709B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030018536A (ko) * 2001-08-30 2003-03-06 임득수 유리제품의 표면처리방법

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405283B (de) * 1997-04-04 1999-06-25 Biochemie Gmbh Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
US6888124B1 (en) 1999-03-24 2005-05-03 Shell Oil Company Method to monitor internal parameters of electrical motor systems
CN1520418A (zh) * 2001-04-17 2004-08-11 ʵ 制备头孢泊肟酸的方法
KR100451672B1 (ko) 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
WO2003050124A1 (en) * 2001-12-13 2003-06-19 Ranbaxy Laboratories Limited Crystalline cefdinir potassium dihydrate
US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
TWI353979B (en) * 2002-04-10 2011-12-11 Nippon Zoki Pharmaceutical Co Novel crystal form of 5-hydroxy-1-methylhydantoin
ITMI20020913A0 (it) * 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
US7250508B2 (en) * 2002-08-13 2007-07-31 Sandoz Ag Cefdinir intermediate
DK1533376T3 (da) 2002-08-26 2010-07-19 Ajinomoto Kk Nye aldolaser og fremgangsmåde til fremstilling af substitueret alfa-ketosyre
WO2004046154A1 (en) * 2002-11-15 2004-06-03 Orchid Chemicals & Pharmaceuticals Ltd Novel amorphous hydrate of a cephalosporin antibiotic
BR0316927A (pt) 2002-12-09 2005-10-18 Ajinomoto Kk Proteìna, métodos para produzir um derivado de ácido glutâmico oticamente ativo e para produzir uma proteìna tendo uma atividade de d-aminotransferase, dna, célula
ITMI20022724A1 (it) * 2002-12-20 2004-06-21 Antibioticos Spa Sali cristallini del cefdinir.
EP3025718A1 (en) 2003-01-14 2016-06-01 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
JPWO2004085443A1 (ja) * 2003-03-24 2006-06-29 ア・チ・エツセ・ドブフアル・エツセ・ピー・アー ７−［２−（２−アミノチアゾール−４−イル）−２−ヒドロキシイミノアセトアミド−３−ビニル−３−セフェム−４−カルボン酸（シン異性体）の新規結晶およびその製造方法
WO2004104010A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Crystalline form of cefdinir
US20050137182A1 (en) * 2003-06-02 2005-06-23 Ramesh Dandala Novel crystalline form of cefdinir
US20040242556A1 (en) * 2003-06-02 2004-12-02 Ramesh Dandala Novel crystalline form of cefdinir
WO2004111059A1 (en) * 2003-06-19 2004-12-23 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of a cephalosporin antibiotic
US20050059818A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Polymorph of a pharmaceutical
US20050059819A1 (en) * 2003-09-12 2005-03-17 Duerst Richard W. Cefdinir pyridine salt
US20050113355A1 (en) * 2003-09-12 2005-05-26 Duerst Richard W. Cefdinir pyridine salt
US20050131079A1 (en) * 2003-12-10 2005-06-16 Pujara Chetan P. Cefdinir oral suspension
US20080139528A1 (en) * 2003-12-10 2008-06-12 Pujara Chetan P Cefdinir oral suspension
US20060211676A1 (en) * 2004-03-16 2006-09-21 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060142261A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20050209211A1 (en) * 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20060142563A1 (en) * 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060069079A1 (en) * 2004-09-27 2006-03-30 Sever Nancy E Stable amorphous cefdinir
US20050245738A1 (en) * 2004-05-03 2005-11-03 Lupin Ltd Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof
WO2006018807A1 (en) * 2004-08-16 2006-02-23 Ranbaxy Laboratories Limited Crystalline forms of cefdinir
WO2006059753A1 (en) * 2004-11-30 2006-06-08 Astellas Pharma Inc. Novel oral pharmaceutical suspension of cefdinir crystal
GB2421024A (en) * 2004-12-07 2006-06-14 Sandoz Ag Cefdinir crystalline form C
WO2006117794A1 (en) * 2005-05-02 2006-11-09 Hetero Drugs Limited A novel crystalline form of cefdinir
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
JP2008524265A (ja) * 2005-10-31 2008-07-10 テバ ファーマシューティカル インダストリーズ リミティド セフジニルの製造方法
EP1828208A2 (en) * 2005-10-31 2007-09-05 Teva Pharmaceutical Industries Ltd Crystalline form of cefdinir cesium salt
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
ITMI20071628A1 (it) 2007-08-06 2007-11-05 Acs Dobfar Spa Sintesi di 3-alchenilcefalosporine e nuovi intermedi utili ad esse correlati
CN101481383B (zh) * 2008-12-31 2012-01-11 杭州奥默医药技术有限公司 头孢地尼酸式复盐化合物及制备方法
TR201000686A1 (tr) 2010-01-29 2011-08-22 B�Lg�� Mahmut Bakteriyel enfeksiyonların tedavisinde suda çözünebilir sefdinir ve klavulanik asit formülasyonları.@
EA028342B1 (ru) 2011-09-09 2017-11-30 Мерк Шарп И Доум Корп. Способы лечения пневмонии
CN102643293A (zh) * 2012-03-30 2012-08-22 石药集团中诺药业（石家庄）有限公司 头孢地尼三元复合物及其用于制备头孢地尼的方法
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
CN103012433B (zh) * 2012-12-13 2015-06-24 珠海保税区丽珠合成制药有限公司 头孢地尼晶型b的制备方法
AU2014227660B2 (en) 2013-03-15 2014-11-06 Merck Sharp & Dohme Llc Ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
CN103622933B (zh) * 2013-12-19 2015-04-08 石家庄市华新药业有限责任公司 一种头孢地尼胶囊及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8323034D0 (en) * 1983-08-26 1983-09-28 Fujisawo Pharmaceutical Co Ltd 7-substituted-3-vinyl-3-cephem compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030018536A (ko) * 2001-08-30 2003-03-06 임득수 유리제품의 표면처리방법

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AU2099888A (en) 1989-02-23
ES2072856T3 (es) 1995-08-01
EP0304019A3 (en) 1990-12-27
HK18496A (en) 1996-02-09
AU617347B2 (en) 1991-11-28
ATE123221T1 (de) 1995-06-15
DE3853901D1 (de) 1995-07-06
EP0304019A2 (en) 1989-02-22
KR970008126B1 (ko) 1997-05-21
ZA885709B (en) 1989-04-26
CA1297096C (en) 1992-03-10
US4935507A (en) 1990-06-19
EP0304019B1 (en) 1995-05-31
IE882411L (en) 1989-02-19
IE67348B1 (en) 1996-03-20
DE3853901T2 (de) 1995-10-12

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