BR0316927A - Proteìna, métodos para produzir um derivado de ácido glutâmico oticamente ativo e para produzir uma proteìna tendo uma atividade de d-aminotransferase, dna, célula - Google Patents

Proteìna, métodos para produzir um derivado de ácido glutâmico oticamente ativo e para produzir uma proteìna tendo uma atividade de d-aminotransferase, dna, célula

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Publication number
BR0316927A
BR0316927A BR0316927-8A BR0316927A BR0316927A BR 0316927 A BR0316927 A BR 0316927A BR 0316927 A BR0316927 A BR 0316927A BR 0316927 A BR0316927 A BR 0316927A
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BR
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Prior art keywords
protein
producing
aminotransferase
dna
methods
Prior art date
Application number
BR0316927-8A
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English (en)
Inventor
Masakazu Sugiyama
Kunihiko Watanabe
Tatsuki Kashiwagi
Ei-Ichiro Suzuki
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Ajinomoto Kk
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Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BR0316927A publication Critical patent/BR0316927A/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROTEìNA, MéTODOS PARA PRODUZIR UM DERIVADO DE áCIDO GLUTâMICO OTICAMENTE ATIVO E PARA PRODUZIR UMA PROTEìNA TENDO UMA ATIVIDADE DE D-AMINOTRANSFERASE, DNA,CéLULA". Substituindo-se um resíduo de aminoácido pelo menos em uma posição que participe na formação eficiente de (2R, 4R)-monatina (posição 100, posições 180 a 183, posição 243 e posição 244) na seq³ência de aminoácido de D-aminotransferase do tipo selvagem representada pela SEQ ID NO: 2 na Listagem de Seq³ência, a D-aminotransferase pode ser mutada de modo que ela possa produzir eficientemente (2R, 4R)-monatina tendo uma doçura elevada a partir do ácido 4-(indol-3-ilmetil)-4-hidróxi-2-oxoglutárico.
BR0316927-8A 2002-12-09 2003-12-09 Proteìna, métodos para produzir um derivado de ácido glutâmico oticamente ativo e para produzir uma proteìna tendo uma atividade de d-aminotransferase, dna, célula BR0316927A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2002357043 2002-12-09
JP2003183290 2003-06-26
PCT/JP2003/015714 WO2004053125A1 (ja) 2002-12-09 2003-12-09 変異型ｄ−アミノトランスフェラーゼおよびこれを用いた光学活性グルタミン酸誘導体の製造方法

Publications (1)

Publication Number Publication Date
BR0316927A true BR0316927A (pt) 2005-10-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316927-8A BR0316927A (pt) 2002-12-09 2003-12-09 Proteìna, métodos para produzir um derivado de ácido glutâmico oticamente ativo e para produzir uma proteìna tendo uma atividade de d-aminotransferase, dna, célula

Country Status (9)

Country Link
US (3) US7402412B2 (pt)
EP (3) EP2557160A3 (pt)
JP (2) JP4544154B2 (pt)
KR (1) KR100723826B1 (pt)
CN (1) CN1723281B (pt)
AU (1) AU2003289264A1 (pt)
BR (1) BR0316927A (pt)
CA (1) CA2507225C (pt)
WO (1) WO2004053125A1 (pt)

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CA2507225A1 (en) 2004-06-24
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US20080193975A1 (en) 2008-08-14
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US8058034B2 (en) 2011-11-15
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US20060003411A1 (en) 2006-01-05
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