KR830004314A - syn-7-(2-아미노-4-티아졸릴)-(메톡시이미노)아세트아미도-3-아세톡시메틸-3-세펨-4-카복실산의 분리방법 - Google Patents

syn-7-(2-아미노-4-티아졸릴)-(메톡시이미노)아세트아미도-3-아세톡시메틸-3-세펨-4-카복실산의 분리방법 Download PDF

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Publication number
KR830004314A
KR830004314A KR1019800003868A KR800003868A KR830004314A KR 830004314 A KR830004314 A KR 830004314A KR 1019800003868 A KR1019800003868 A KR 1019800003868A KR 800003868 A KR800003868 A KR 800003868A KR 830004314 A KR830004314 A KR 830004314A
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KR
South Korea
Prior art keywords
cepem
methoxyimino
acetoxymethyl
acetamido
thiazolyl
Prior art date
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KR1019800003868A
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English (en)
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KR840000866B1 (ko
Inventor
그린넬 잭슨 빌리
네찌히 가드너 돈나
Original Assignee
아서 알. 훼일
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 아서 알. 훼일, 일라이 릴리 앤드 캄파니 filed Critical 아서 알. 훼일
Publication of KR830004314A publication Critical patent/KR830004314A/ko
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Publication of KR840000866B1 publication Critical patent/KR840000866B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Abstract

내용 없음

Description

syn-7-(2-아미노-4-티아졸릴)-(메톡시이미노)아세트아미도-3-아세톡시메틸-3-세펨-4-카복실산의 분리방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. syn-7-[2-(2-아미노-4-티아졸릴)-2-메톡시이미노]-아세트아미도-3-아세톡시메틸-3-세펨-4-카복실산과 알리사이클 에테르를 pH2.0 내지 3.5범위의 수용성 매질중에서 반응시켜 이 세펨산과 알리사이클에테르의 고형 용매화물을 제조하는 방법.
  2. (1) syn-7-[2-(2-아미노-4-티아졸릴)-2-메톡시이미노]-아세트아미도-3-아세톡시메틸-3-세펨-4-카복실산의 농도가 0.07몰/ℓ내지 0.4몰/ℓ인 수용성 반응 혼합물에 테트라하이드로푸란, 1,4-디옥산, 1,3-디옥소란 또는 테트라하이드로피란 같은 알리사이클에테르를 수용성 반응 혼합물의 0.1부피 내지 2부피를 첨가하고 또
    (2) 혼합물의 pH를 2.2내지 3.2로 조정한 후, 화합물 A의 용매화물 침전이 형성될 때까지 혼합물을 방치한후 침전물을 분리하는 단계 또는 이의 역순단계로 진행하는 것을 특징으로하는 수용성 반응 혼합물로부터 syn-7-[2-(2-아미노-4-티아졸릴)-2-메톡시이미노]-아세트아미도-3-아세톡시메틸-3-세펨-4-카복실산을 분리하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800003868A 1979-10-09 1980-10-08 세팔로스포린 용매화물의 제조방법 KR840000866B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/082,822 US4252951A (en) 1979-10-09 1979-10-09 Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid
US82822 1979-10-09

Publications (2)

Publication Number Publication Date
KR830004314A true KR830004314A (ko) 1983-07-09
KR840000866B1 KR840000866B1 (ko) 1984-06-20

Family

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Family Applications (1)

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KR1019800003868A KR840000866B1 (ko) 1979-10-09 1980-10-08 세팔로스포린 용매화물의 제조방법

Country Status (27)

Country Link
US (1) US4252951A (ko)
EP (1) EP0027050B1 (ko)
JP (1) JPS5661388A (ko)
KR (1) KR840000866B1 (ko)
AT (1) AT369008B (ko)
AU (1) AU6306180A (ko)
BE (1) BE885569A (ko)
CA (1) CA1146539A (ko)
CH (1) CH647523A5 (ko)
CS (1) CS215142B2 (ko)
DD (1) DD153375A5 (ko)
DE (1) DE3065181D1 (ko)
DK (1) DK424680A (ko)
ES (1) ES495753A0 (ko)
FI (1) FI803200L (ko)
FR (1) FR2467211A1 (ko)
GB (1) GB2059966B (ko)
GR (1) GR70219B (ko)
HU (1) HU183230B (ko)
IE (1) IE50390B1 (ko)
IL (1) IL61227A (ko)
IT (1) IT1132926B (ko)
PH (1) PH15023A (ko)
PT (1) PT71886B (ko)
RO (1) RO80664B (ko)
YU (1) YU256480A (ko)
ZA (1) ZA806192B (ko)

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Also Published As

Publication number Publication date
JPS5661388A (en) 1981-05-26
KR840000866B1 (ko) 1984-06-20
RO80664A (ro) 1983-02-15
IL61227A (en) 1983-07-31
PT71886B (en) 1981-08-13
ES8201166A1 (es) 1981-12-01
EP0027050A1 (en) 1981-04-15
EP0027050B1 (en) 1983-10-05
IE50390B1 (en) 1986-04-16
DK424680A (da) 1981-04-10
PH15023A (en) 1982-05-13
CS215142B2 (en) 1982-07-30
IT8025200A0 (it) 1980-10-08
DE3065181D1 (en) 1983-11-10
GB2059966A (en) 1981-04-29
ATA498080A (de) 1982-04-15
HU183230B (en) 1984-04-28
AT369008B (de) 1982-11-25
ES495753A0 (es) 1981-12-01
FI803200L (fi) 1981-04-10
FR2467211B1 (ko) 1983-06-10
BE885569A (fr) 1981-04-08
CA1146539A (en) 1983-05-17
IL61227A0 (en) 1980-12-31
GR70219B (ko) 1982-08-31
IE802086L (en) 1981-04-09
GB2059966B (en) 1983-09-01
DD153375A5 (de) 1982-01-06
AU6306180A (en) 1981-04-16
IT1132926B (it) 1986-07-09
CH647523A5 (fr) 1985-01-31
YU256480A (en) 1983-02-28
PT71886A (en) 1980-11-01
RO80664B (ro) 1983-02-28
FR2467211A1 (fr) 1981-04-17
US4252951A (en) 1981-02-24
ZA806192B (en) 1982-05-26

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