PE20120907A1 - Sal de clorhidrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-dihidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil)metilsulfamato - Google Patents
Sal de clorhidrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-dihidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil)metilsulfamatoInfo
- Publication number
- PE20120907A1 PE20120907A1 PE2011001962A PE2011001962A PE20120907A1 PE 20120907 A1 PE20120907 A1 PE 20120907A1 PE 2011001962 A PE2011001962 A PE 2011001962A PE 2011001962 A PE2011001962 A PE 2011001962A PE 20120907 A1 PE20120907 A1 PE 20120907A1
- Authority
- PE
- Peru
- Prior art keywords
- xrpd
- peaks
- presenting
- methylsulfamate
- pirrolo
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UNA SAL DE CLORHIDRATO DE ((1S,2S,4R)-4-{4-[(1S)-2,3-DIHIDRO-1H-INDEN-1-ILAMINO]-7H-PIRROLO[2,3-D]PIRIMIDIN-7-IL}-2-HIDROXICICLOPENTIL)METILSULFAMATO QUE COMPRENDE: (A) UNA FORMA 1 QUE SE CARACTERIZA POR PRESENTAR UN PATRON DE DIFRACCION DE POLVO DE RAYOS X (XRPD) CON PICOS EN ANGULOS 2THETA DE: 9.6º, 13.6º Y 19.1º O 9.6º, 13.6º, 14.5º, 19.1º Y 23.7º; (B) UNA FORMA 2 QUE SE CARACTERIZA POR PRESENTAR UN XRPD CON PICOS EN ANGULOS 2THETA DE: 8.7º, 18.2º Y 23.8º O 8.7º, 18.2º, 19.4º, 23.8º, 24.3º Y 27.5º; (C) UNA FORMA 3A QUE SE CARACTERIZA POR PRESENTAR UN XRPD CON PICOS EN ANGULOS 2THETA DE: 10.9º, 14.6º, 19.5º Y 24.0º O 10.9º, 14.6º, 16.9º, 19.5º, 24.0º Y 25.9º; (D) UNA FORMA 3B QUE SE CARACTERIZA POR PRESENTAR UN XRPD CON PICOS EN ANGULOS 2THETA DE: 10.8º, 16.9º, 23.7º Y 24.0º O 10.8º, 14.5º, 16.9º, 19.3º, 21.2º, 23.7º, 24.0º Y 28.8º; (E) UNA FORMA 3C QUE SE CARACTERIZA POR PRESENTAR UN XRPD CON PICOS EN ANGULOS 2THETA DE: 11.0º, 12.2º Y 24.4º; 11.0º, 12.2º, 14.9º, 19.8º, 24.0º Y 24.4º; (F) UNA FORMA 5 QUE SE CARACTERIZA POR PRESENTAR UN XRPD CON PICOS EN ANGULOS 2THETA DE: 16.7º Y 22.9º O 16.7º, 17.2º, 18.1º Y 22.9º; (G) UNA FORMA 7 QUE SE CARACTERIZA POR PRESENTAR UN XRPD CON PICOS EN ANGULOS 2THETA DE: 15.4º, 17.3º, 19.6º Y 22.5º O 10.0º, 15.4º, 16.6º, 17.3º, 18.0º, 18.3º, 19.6º, 22.0º Y 22.5º. DICHO COMPUESTO ES UN INHIBIDOR DE ENZIMA ACTIVANTE DE E1 UTIL EN EL TRATAMIENTO DEL CANCER
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21622109P | 2009-05-14 | 2009-05-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120907A1 true PE20120907A1 (es) | 2012-08-18 |
Family
ID=42396430
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016001604A PE20161222A1 (es) | 2009-05-14 | 2010-05-13 | Sal de clorhidrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-dihidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil)metilsulfamato |
PE2011001962A PE20120907A1 (es) | 2009-05-14 | 2010-05-13 | Sal de clorhidrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-dihidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil)metilsulfamato |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016001604A PE20161222A1 (es) | 2009-05-14 | 2010-05-13 | Sal de clorhidrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-dihidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil)metilsulfamato |
Country Status (18)
Country | Link |
---|---|
US (2) | US9187482B2 (es) |
EP (2) | EP2430026A1 (es) |
JP (3) | JP2012526808A (es) |
KR (2) | KR20120024715A (es) |
CN (2) | CN104016987A (es) |
AU (1) | AU2010248151B2 (es) |
BR (1) | BRPI1012142A2 (es) |
CA (1) | CA2761256C (es) |
IL (1) | IL216201A (es) |
MX (1) | MX2011012108A (es) |
NZ (2) | NZ621128A (es) |
PE (2) | PE20161222A1 (es) |
PH (1) | PH12015501925A1 (es) |
RU (1) | RU2562245C2 (es) |
SG (2) | SG10201402148SA (es) |
UA (1) | UA108986C2 (es) |
WO (1) | WO2010132110A1 (es) |
ZA (1) | ZA201108347B (es) |
Families Citing this family (17)
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US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
CN103483342B (zh) | 2007-08-02 | 2016-08-31 | 米伦纽姆医药公司 | 合成e1活化酶抑制剂的方法 |
BRPI1012142A2 (pt) | 2009-05-14 | 2016-03-29 | Millennium Pharm Inc | sal cloridrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-diidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil) metil sulfamato |
US20120115892A1 (en) * | 2010-11-05 | 2012-05-10 | Millennium Pharmaceuticals, Inc. | Administration of nedd8-activating enzyme inhibitor |
MY166889A (en) * | 2011-08-24 | 2018-07-24 | Millennium Pharm Inc | Inhibitors of nedd8-activating enzyme |
US8980850B2 (en) | 2011-11-03 | 2015-03-17 | Millennium Pharmaceuticals, Inc. | Administration of a NEDD8-activating enzyme inhibitor and hypomethylating agent |
SG10201606581RA (en) * | 2012-02-17 | 2016-09-29 | Millennium Pharm Inc | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
US9593121B2 (en) | 2012-08-03 | 2017-03-14 | Millennium Pharmaceuticals, Inc. | Indole substituted pyrrolopyrimidinyl inhibitors of Uba6 |
CA2886783A1 (en) | 2012-10-01 | 2014-04-10 | Millennium Pharmaceuticals, Inc. | Biomarkers and methods to predict response to inhibitors and uses thereof |
CN105407973A (zh) | 2013-05-14 | 2016-03-16 | 米伦纽姆医药公司 | Nedd8活化酶抑制剂及化学治疗剂的投与 |
EP3016934B1 (en) | 2013-07-02 | 2018-01-10 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
AU2015284135B2 (en) | 2014-07-01 | 2019-11-28 | Takeda Pharmaceutical Company Limited | Heteroaryl compounds useful as inhibitors of SUMO activating enzyme |
CN106008394B (zh) * | 2016-05-23 | 2018-12-04 | 中国人民解放军第二军医大学 | 巯基苯并噻唑酰胺类化合物及其制备与作为药物的用途 |
JP2020534331A (ja) | 2017-09-21 | 2020-11-26 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | ((1s,2s,4r)−4−{4−[(1s)−2,3−ジヒドロ−1h−インデン−1−イルアミノ]−7h−ピロロ[2,3−d]ピリミジン−7−イル}−2−ヒドロキシシクロペンチル)メチルスルファメートの共結晶形態、その製剤及び使用 |
JP2022521972A (ja) * | 2019-02-26 | 2022-04-13 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | アジュバントとして有用な化合物 |
KR20210115680A (ko) | 2020-03-16 | 2021-09-27 | 서희강 | 연설용 프롬프터 |
WO2022112951A1 (en) * | 2020-11-25 | 2022-06-02 | Takeda Pharmaceutical Company Limited | Solid state forms of hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
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CN103483342B (zh) * | 2007-08-02 | 2016-08-31 | 米伦纽姆医药公司 | 合成e1活化酶抑制剂的方法 |
BRPI1012142A2 (pt) | 2009-05-14 | 2016-03-29 | Millennium Pharm Inc | sal cloridrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-diidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil) metil sulfamato |
US8980850B2 (en) | 2011-11-03 | 2015-03-17 | Millennium Pharmaceuticals, Inc. | Administration of a NEDD8-activating enzyme inhibitor and hypomethylating agent |
CN105407973A (zh) | 2013-05-14 | 2016-03-16 | 米伦纽姆医药公司 | Nedd8活化酶抑制剂及化学治疗剂的投与 |
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2010
- 2010-05-13 BR BRPI1012142A patent/BRPI1012142A2/pt not_active IP Right Cessation
- 2010-05-13 KR KR1020117029162A patent/KR20120024715A/ko not_active Application Discontinuation
- 2010-05-13 PE PE2016001604A patent/PE20161222A1/es not_active Application Discontinuation
- 2010-05-13 MX MX2011012108A patent/MX2011012108A/es not_active Application Discontinuation
- 2010-05-13 CN CN201410200959.XA patent/CN104016987A/zh active Pending
- 2010-05-13 CN CN2010800213224A patent/CN102421780A/zh active Pending
- 2010-05-13 AU AU2010248151A patent/AU2010248151B2/en not_active Ceased
- 2010-05-13 EP EP10732492A patent/EP2430026A1/en not_active Withdrawn
- 2010-05-13 CA CA2761256A patent/CA2761256C/en not_active Expired - Fee Related
- 2010-05-13 SG SG10201402148SA patent/SG10201402148SA/en unknown
- 2010-05-13 NZ NZ621128A patent/NZ621128A/en not_active IP Right Cessation
- 2010-05-13 PE PE2011001962A patent/PE20120907A1/es not_active Application Discontinuation
- 2010-05-13 WO PCT/US2010/001415 patent/WO2010132110A1/en active Application Filing
- 2010-05-13 KR KR1020177024122A patent/KR20170102381A/ko not_active Application Discontinuation
- 2010-05-13 NZ NZ596470A patent/NZ596470A/en not_active IP Right Cessation
- 2010-05-13 EP EP16159438.7A patent/EP3091020B1/en active Active
- 2010-05-13 US US12/779,331 patent/US9187482B2/en not_active Expired - Fee Related
- 2010-05-13 RU RU2011150826/04A patent/RU2562245C2/ru not_active IP Right Cessation
- 2010-05-13 SG SG2011081957A patent/SG175929A1/en unknown
- 2010-05-13 UA UAA201114830A patent/UA108986C2/uk unknown
- 2010-05-13 JP JP2012510795A patent/JP2012526808A/ja not_active Withdrawn
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2011
- 2011-11-08 IL IL216201A patent/IL216201A/en not_active IP Right Cessation
- 2011-11-14 ZA ZA2011/08347A patent/ZA201108347B/en unknown
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2015
- 2015-01-16 JP JP2015006444A patent/JP2015096547A/ja not_active Withdrawn
- 2015-09-01 PH PH12015501925A patent/PH12015501925A1/en unknown
- 2015-10-09 US US14/879,151 patent/US10016427B2/en not_active Expired - Fee Related
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2017
- 2017-02-08 JP JP2017020911A patent/JP2017105816A/ja active Pending
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