BRPI1012142A2 - sal cloridrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-diidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil) metil sulfamato - Google Patents
sal cloridrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-diidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil) metil sulfamatoInfo
- Publication number
- BRPI1012142A2 BRPI1012142A2 BRPI1012142A BRPI1012142A BRPI1012142A2 BR PI1012142 A2 BRPI1012142 A2 BR PI1012142A2 BR PI1012142 A BRPI1012142 A BR PI1012142A BR PI1012142 A BRPI1012142 A BR PI1012142A BR PI1012142 A2 BRPI1012142 A2 BR PI1012142A2
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxycyclopentyl
- inden
- ylamino
- pyrrolo
- pyrimidin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21622109P | 2009-05-14 | 2009-05-14 | |
PCT/US2010/001415 WO2010132110A1 (en) | 2009-05-14 | 2010-05-13 | Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI1012142A2 true BRPI1012142A2 (pt) | 2016-03-29 |
Family
ID=42396430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI1012142A BRPI1012142A2 (pt) | 2009-05-14 | 2010-05-13 | sal cloridrato de ((1s,2s,4r)-4-{4-[(1s)-2,3-diidro-1h-inden-1-ilamino]-7h-pirrolo[2,3-d]pirimidin-7-il}-2-hidroxiciclopentil) metil sulfamato |
Country Status (18)
Country | Link |
---|---|
US (2) | US9187482B2 (pt) |
EP (2) | EP3091020B1 (pt) |
JP (3) | JP2012526808A (pt) |
KR (2) | KR20120024715A (pt) |
CN (2) | CN104016987A (pt) |
AU (1) | AU2010248151B2 (pt) |
BR (1) | BRPI1012142A2 (pt) |
CA (1) | CA2761256C (pt) |
IL (1) | IL216201A (pt) |
MX (1) | MX2011012108A (pt) |
NZ (2) | NZ596470A (pt) |
PE (2) | PE20161222A1 (pt) |
PH (1) | PH12015501925A1 (pt) |
RU (1) | RU2562245C2 (pt) |
SG (2) | SG10201402148SA (pt) |
UA (1) | UA108986C2 (pt) |
WO (1) | WO2010132110A1 (pt) |
ZA (1) | ZA201108347B (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
ES2758027T3 (es) | 2007-08-02 | 2020-05-04 | Millennium Pharm Inc | Intermedios para la síntesis de inhibidores de enzimas activadoras de actividad E1 |
WO2010132110A1 (en) | 2009-05-14 | 2010-11-18 | Millennium Pharmaceuticals, Inc. | Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
JP2013541587A (ja) * | 2010-11-05 | 2013-11-14 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | Nedd8活性化酵素阻害剤の投与 |
BR112014004239A2 (pt) * | 2011-08-24 | 2017-03-21 | Millennium Pharm Inc | inibidores de enzima ativadora de nedd8 |
CA2854461C (en) | 2011-11-03 | 2021-01-19 | Millennium Pharmaceuticals, Inc. | Administration of nedd8-activating enzyme inhibitor and hypomethylating agent |
BR112014020365B1 (pt) * | 2012-02-17 | 2023-02-23 | Takeda Pharmaceutical Company Limited | Inibidores de pirazolopirimidinila de enzima de ativação de ubiquitina |
CN104684559A (zh) * | 2012-08-03 | 2015-06-03 | 米伦纽姆医药公司 | 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂 |
WO2014055543A2 (en) * | 2012-10-01 | 2014-04-10 | Millennium Pharmaceuticals, Inc. | Biomarkers and methods to predict response to inhibitors and uses thereof |
US20160074404A1 (en) | 2013-05-14 | 2016-03-17 | Millennium Pharmaceutcals, Inc. | Administration of nedd8-activating enzyme inhibitor and chemotherapeutic agents |
US9695154B2 (en) | 2013-07-02 | 2017-07-04 | Millennium Pharmaceuticals, Inc. | Heteroaryl inhibitors of sumo activating enzyme |
UY36198A (es) | 2014-07-01 | 2016-01-29 | Millennium Pharm Inc | Compuestos de heteroarilo útiles como inhibidores de enzima activadora de sumo |
CN106008394B (zh) * | 2016-05-23 | 2018-12-04 | 中国人民解放军第二军医大学 | 巯基苯并噻唑酰胺类化合物及其制备与作为药物的用途 |
JP2020534331A (ja) | 2017-09-21 | 2020-11-26 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | ((1s,2s,4r)−4−{4−[(1s)−2,3−ジヒドロ−1h−インデン−1−イルアミノ]−7h−ピロロ[2,3−d]ピリミジン−7−イル}−2−ヒドロキシシクロペンチル)メチルスルファメートの共結晶形態、その製剤及び使用 |
JP2022521972A (ja) * | 2019-02-26 | 2022-04-13 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | アジュバントとして有用な化合物 |
KR20210115680A (ko) | 2020-03-16 | 2021-09-27 | 서희강 | 연설용 프롬프터 |
WO2022112951A1 (en) * | 2020-11-25 | 2022-06-02 | Takeda Pharmaceutical Company Limited | Solid state forms of hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo[2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3622561A (en) | 1969-08-18 | 1971-11-23 | Univ Utah | Nucleoside sugar esters of sulfamic acid and method for preparation of the same |
US4252951A (en) * | 1979-10-09 | 1981-02-24 | Eli Lilly And Company | Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid |
JPS62108897A (ja) | 1985-11-05 | 1987-05-20 | Rikagaku Kenkyusho | アスカマイシン誘導体及びその合成法並びに制癌剤 |
GB8813148D0 (en) | 1988-06-03 | 1988-07-06 | Glaxo Group Ltd | Chemical compounds |
GB8826205D0 (en) | 1988-11-09 | 1988-12-14 | Wellcome Found | Heterocyclic compounds |
US5763596A (en) | 1989-09-15 | 1998-06-09 | Metabasis Therapeutics, Inc. | C-4' modified adenosine kinase inhibitors |
US5721356A (en) | 1989-09-15 | 1998-02-24 | Gensia, Inc. | Orally active adenosine kinase inhibitors |
US5726302A (en) | 1989-09-15 | 1998-03-10 | Gensia Inc. | Water soluble adenosine kinase inhibitors |
US5674998A (en) | 1989-09-15 | 1997-10-07 | Gensia Inc. | C-4' modified adenosine kinase inhibitors |
US5864033A (en) | 1989-09-15 | 1999-01-26 | Metabasis Therapeutics, Inc. | Adenosine kinase inhibitors |
US5470898A (en) | 1993-06-30 | 1995-11-28 | Montell North America Inc. | Sorbitol derivatives as nucleators and clarifiers for polyolefins, and polyolefin compositions obtained therewith |
GB9325809D0 (en) | 1993-12-17 | 1994-02-23 | Zeneca Ltd | Herbicidal composition |
GB9325810D0 (en) | 1993-12-17 | 1994-02-23 | Zeneca Ltd | Herbicidal composition |
US6210917B1 (en) | 1993-12-29 | 2001-04-03 | The Regents Of The University Of California | Method for suppressing multiple drug resistance in cancer cells |
US5767097A (en) | 1996-01-23 | 1998-06-16 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes |
US5973161A (en) | 1996-03-18 | 1999-10-26 | The University Of North Carolina At Chapel Hill | Enantioselective synthesis of cyclopentenes |
US5824657A (en) | 1997-03-18 | 1998-10-20 | Cubist Pharmaceuticals, Inc. | Aminoacyl sulfamides for the treatment of hyperproliferative disorders |
US6734283B1 (en) | 1997-12-19 | 2004-05-11 | Millennium Pharmaceuticals, Inc. | Human proteins responsible for NEDD8 activation and conjugation |
JPH11228422A (ja) | 1998-02-16 | 1999-08-24 | Mitsubishi Chemical Corp | 抗マラリア剤 |
JPH11228446A (ja) | 1998-02-16 | 1999-08-24 | Mitsubishi Chemical Corp | 抗マラリア剤 |
PT1411954E (pt) | 2000-10-18 | 2011-03-16 | Pharmasset Inc | Nucleosídeos modificados para o tratamento de infecções virais e proliferação celular anormal |
EP1474147B1 (en) | 2001-12-07 | 2010-05-05 | Vertex Pharmaceuticals Incorporated | Pyrimidine-based compounds useful as gsk-3 inhibitors |
AU2003248708A1 (en) | 2002-06-17 | 2003-12-31 | Isis Pharmaceuticals, Inc. | Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation |
EP1651595A2 (en) | 2003-05-30 | 2006-05-03 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
US7338957B2 (en) | 2003-08-28 | 2008-03-04 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
WO2005037845A1 (en) | 2003-10-17 | 2005-04-28 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors |
JP2007530445A (ja) | 2004-03-30 | 2007-11-01 | 大正製薬株式会社 | ピリミジン誘導体及びその使用に関連する治療方法 |
EP1758873A1 (en) | 2004-06-22 | 2007-03-07 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
JP5048520B2 (ja) | 2005-02-04 | 2012-10-17 | ミレニアム ファーマシューティカルズ, インコーポレイテッド | E1活性化酵素の阻害剤 |
EP2402334B1 (en) | 2006-02-02 | 2016-06-29 | Millennium Pharmaceuticals, Inc. | Inhibitors of E1 Activating Enzymes |
MY157177A (en) | 2006-08-08 | 2016-05-13 | Millennium Pharm Inc | Heteroaryl compounds useful as inhibitors of e1 activating enzymes |
ES2758027T3 (es) * | 2007-08-02 | 2020-05-04 | Millennium Pharm Inc | Intermedios para la síntesis de inhibidores de enzimas activadoras de actividad E1 |
WO2010132110A1 (en) | 2009-05-14 | 2010-11-18 | Millennium Pharmaceuticals, Inc. | Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
CA2854461C (en) | 2011-11-03 | 2021-01-19 | Millennium Pharmaceuticals, Inc. | Administration of nedd8-activating enzyme inhibitor and hypomethylating agent |
US20160074404A1 (en) | 2013-05-14 | 2016-03-17 | Millennium Pharmaceutcals, Inc. | Administration of nedd8-activating enzyme inhibitor and chemotherapeutic agents |
-
2010
- 2010-05-13 WO PCT/US2010/001415 patent/WO2010132110A1/en active Application Filing
- 2010-05-13 BR BRPI1012142A patent/BRPI1012142A2/pt not_active IP Right Cessation
- 2010-05-13 EP EP16159438.7A patent/EP3091020B1/en active Active
- 2010-05-13 MX MX2011012108A patent/MX2011012108A/es not_active Application Discontinuation
- 2010-05-13 NZ NZ596470A patent/NZ596470A/en not_active IP Right Cessation
- 2010-05-13 CN CN201410200959.XA patent/CN104016987A/zh active Pending
- 2010-05-13 NZ NZ621128A patent/NZ621128A/en not_active IP Right Cessation
- 2010-05-13 KR KR1020117029162A patent/KR20120024715A/ko not_active Application Discontinuation
- 2010-05-13 PE PE2016001604A patent/PE20161222A1/es not_active Application Discontinuation
- 2010-05-13 CA CA2761256A patent/CA2761256C/en not_active Expired - Fee Related
- 2010-05-13 UA UAA201114830A patent/UA108986C2/uk unknown
- 2010-05-13 SG SG10201402148SA patent/SG10201402148SA/en unknown
- 2010-05-13 CN CN2010800213224A patent/CN102421780A/zh active Pending
- 2010-05-13 AU AU2010248151A patent/AU2010248151B2/en not_active Ceased
- 2010-05-13 PE PE2011001962A patent/PE20120907A1/es not_active Application Discontinuation
- 2010-05-13 KR KR1020177024122A patent/KR20170102381A/ko not_active Application Discontinuation
- 2010-05-13 RU RU2011150826/04A patent/RU2562245C2/ru not_active IP Right Cessation
- 2010-05-13 JP JP2012510795A patent/JP2012526808A/ja not_active Withdrawn
- 2010-05-13 SG SG2011081957A patent/SG175929A1/en unknown
- 2010-05-13 EP EP10732492A patent/EP2430026A1/en not_active Withdrawn
- 2010-05-13 US US12/779,331 patent/US9187482B2/en not_active Expired - Fee Related
-
2011
- 2011-11-08 IL IL216201A patent/IL216201A/en not_active IP Right Cessation
- 2011-11-14 ZA ZA2011/08347A patent/ZA201108347B/en unknown
-
2015
- 2015-01-16 JP JP2015006444A patent/JP2015096547A/ja not_active Withdrawn
- 2015-09-01 PH PH12015501925A patent/PH12015501925A1/en unknown
- 2015-10-09 US US14/879,151 patent/US10016427B2/en not_active Expired - Fee Related
-
2017
- 2017-02-08 JP JP2017020911A patent/JP2017105816A/ja active Pending
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Legal Events
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2514 DE 12-03-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |