ATE543799T1 - Piperidinyl- und piperazinylmodulatoren von g- sekretase - Google Patents
Piperidinyl- und piperazinylmodulatoren von g- sekretaseInfo
- Publication number
- ATE543799T1 ATE543799T1 AT08839601T AT08839601T ATE543799T1 AT E543799 T1 ATE543799 T1 AT E543799T1 AT 08839601 T AT08839601 T AT 08839601T AT 08839601 T AT08839601 T AT 08839601T AT E543799 T1 ATE543799 T1 AT E543799T1
- Authority
- AT
- Austria
- Prior art keywords
- secretase
- piperazinyl
- piperidinyl
- modulators
- compounds
- Prior art date
Links
- -1 PIPERIDINYL Chemical class 0.000 title 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/38—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98118907P | 2007-10-19 | 2007-10-19 | |
| PCT/US2008/079905 WO2009052126A1 (en) | 2007-10-19 | 2008-10-15 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF γ-SECRETASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE543799T1 true ATE543799T1 (de) | 2012-02-15 |
Family
ID=40090456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08839601T ATE543799T1 (de) | 2007-10-19 | 2008-10-15 | Piperidinyl- und piperazinylmodulatoren von g- sekretase |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8252935B2 (de) |
| EP (1) | EP2212287B1 (de) |
| JP (1) | JP5439381B2 (de) |
| KR (1) | KR101569391B1 (de) |
| CN (1) | CN101903347B (de) |
| AT (1) | ATE543799T1 (de) |
| AU (1) | AU2008312612B2 (de) |
| BR (1) | BRPI0817433A2 (de) |
| CA (1) | CA2702837A1 (de) |
| CO (1) | CO6270359A2 (de) |
| CR (1) | CR11447A (de) |
| EA (1) | EA017119B1 (de) |
| ES (1) | ES2378594T3 (de) |
| IL (1) | IL205045A (de) |
| MX (1) | MX2010004309A (de) |
| NI (1) | NI201000064A (de) |
| NZ (1) | NZ584716A (de) |
| WO (1) | WO2009052126A1 (de) |
| ZA (1) | ZA201003519B (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010004309A (es) | 2007-10-19 | 2010-05-03 | Janssen Pharmaceutica Nv | Moduladores de piperidinil y piperazinil de gamma-secretasa. |
| AU2008312371B2 (en) | 2007-10-19 | 2013-06-20 | Janssen Pharmaceutica, N.V. | Amine linked modulators of gamma-secretase |
| EA019710B1 (ru) | 2007-10-19 | 2014-05-30 | Янссен Фармацевтика, Н.В. | ПРОИЗВОДНЫЕ 2-АРИЛ-4-МЕТИЛПЕНТАНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ γ-СЕКРЕТАЗЫ |
| EP2455370A1 (de) | 2009-07-17 | 2012-05-23 | Shionogi&Co., Ltd. | Pharmazeutisches produkt mit lactam- oder benzen-sulfonamid-verbindung |
| US20120129189A1 (en) * | 2009-07-17 | 2012-05-24 | Chulan Kwon | Methods of Controlling Cell Proliferation |
| US8586776B2 (en) | 2009-11-05 | 2013-11-19 | Fibrostatin, S.L. | GPBP inhibition using Q2 peptidomimetics |
| MX2021002087A (es) | 2018-09-03 | 2021-04-28 | Hoffmann La Roche | Derivados de heteroarilo biciclicos. |
| SG11202103340PA (en) | 2018-12-13 | 2021-04-29 | Hoffmann La Roche | 7-phenoxy-n-(3-azabicyclo[3.2.1]octan-8-yl)-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma-secretase modulators for the treatment of alzheimer's disease |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2212287A (en) * | 1938-09-13 | 1940-08-20 | William S Stateler | Milk bottle holder |
| BE790287A (fr) * | 1971-10-28 | 1973-04-19 | Delalande Sa | Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique |
| BE826017R (fr) | 1974-03-19 | 1975-08-26 | Acides pyrimidin-6yl acethydroxamiques, leur procede de preparation et leur application en therapeutique | |
| US4252951A (en) | 1979-10-09 | 1981-02-24 | Eli Lilly And Company | Isolation of syn-7-(2-amino-4-thiazolyl)-(methoxyimino)acetamido-3-acetoxymethyl-3-cephem-4-carboxylic acid |
| US5391817A (en) | 1993-12-21 | 1995-02-21 | Bristol-Myers Squibb | Biaryl phospholipase A2 inhibitors |
| US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| US5416187A (en) * | 1994-04-04 | 1995-05-16 | Eastman Chemical Company | Process for the preparation of phenol-functional polyester resins |
| CA2406383A1 (en) | 2000-04-13 | 2001-10-25 | Mayo Foundation For Medical Education And Research | A.beta.42 lowering agents |
| DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
| CN1950358A (zh) * | 2004-04-05 | 2007-04-18 | 先灵公司 | 新颖的γ分泌酶抑制剂 |
| WO2005110963A1 (en) | 2004-05-19 | 2005-11-24 | Cellzome Ag | (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy |
| DE602005020156D1 (de) * | 2004-06-30 | 2010-05-06 | Schering Corp | Substituierte n-arylsulfonylheterocyclische amine als gamma-sekretase-hemmer |
| WO2006004555A1 (en) | 2004-06-30 | 2006-01-12 | Paysetter Pte Ltd | System and method for facilitating transfer of physical money and/or credit |
| DE102004033876B4 (de) | 2004-07-13 | 2009-01-15 | Christoph Kaesbohrer | Dreidimensionales Struktursystem |
| GB0416508D0 (en) | 2004-07-23 | 2004-08-25 | Merck Sharp & Dohme | Therapeutic agents |
| EP1650183A1 (de) | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl)essigsäuren, ihre Derivate und Verwendung in der Therapie |
| WO2006088705A1 (en) * | 2005-02-14 | 2006-08-24 | Wyeth | Terphenyl guanidines as [beta symbol] -secretase inhibitors |
| PL1849762T3 (pl) | 2006-04-21 | 2009-12-31 | Cellzome Ltd | Podstawione kwasy bifenylo-karboksylowe i ich pochodne |
| PT1847524E (pt) | 2006-04-21 | 2009-12-18 | Cellzome Ltd | Derivados de terfenilo para o tratamento da doença de alzheimer |
| JP2009539881A (ja) * | 2006-06-09 | 2009-11-19 | アイコス コーポレイション | Ｄｐ−２アンタゴニストとしての置換フェニル酢酸 |
| ES2395083T3 (es) | 2007-10-17 | 2013-02-08 | Janssen Pharmaceutica, N.V. | Ácidos bifenilcarboxílicos y sus derivados |
| MX2010004309A (es) | 2007-10-19 | 2010-05-03 | Janssen Pharmaceutica Nv | Moduladores de piperidinil y piperazinil de gamma-secretasa. |
| AU2008312371B2 (en) | 2007-10-19 | 2013-06-20 | Janssen Pharmaceutica, N.V. | Amine linked modulators of gamma-secretase |
| CN101903334A (zh) | 2007-10-19 | 2010-12-01 | 詹森药业有限公司 | Gsm中间体 |
| EA019710B1 (ru) | 2007-10-19 | 2014-05-30 | Янссен Фармацевтика, Н.В. | ПРОИЗВОДНЫЕ 2-АРИЛ-4-МЕТИЛПЕНТАНОВОЙ КИСЛОТЫ В КАЧЕСТВЕ МОДУЛЯТОРОВ γ-СЕКРЕТАЗЫ |
| BRPI0817425A2 (pt) | 2007-10-19 | 2015-06-16 | Janssen Pharmaceutica Nv | Moduladores de gama-secretase ligados à amida |
| US7968725B2 (en) | 2008-07-22 | 2011-06-28 | Janssen Pharmaceutica N.V. | Pyridinyl modulators of γ-secretase |
-
2008
- 2008-10-15 MX MX2010004309A patent/MX2010004309A/es active IP Right Grant
- 2008-10-15 CA CA2702837A patent/CA2702837A1/en not_active Abandoned
- 2008-10-15 NZ NZ584716A patent/NZ584716A/en not_active IP Right Cessation
- 2008-10-15 EA EA201070495A patent/EA017119B1/ru not_active IP Right Cessation
- 2008-10-15 BR BRPI0817433-4A patent/BRPI0817433A2/pt not_active IP Right Cessation
- 2008-10-15 US US12/251,521 patent/US8252935B2/en not_active Expired - Fee Related
- 2008-10-15 EP EP08839601A patent/EP2212287B1/de active Active
- 2008-10-15 KR KR1020107010877A patent/KR101569391B1/ko not_active Expired - Fee Related
- 2008-10-15 AU AU2008312612A patent/AU2008312612B2/en not_active Ceased
- 2008-10-15 ES ES08839601T patent/ES2378594T3/es active Active
- 2008-10-15 AT AT08839601T patent/ATE543799T1/de active
- 2008-10-15 CN CN200880121603XA patent/CN101903347B/zh not_active Expired - Fee Related
- 2008-10-15 WO PCT/US2008/079905 patent/WO2009052126A1/en not_active Ceased
- 2008-10-15 JP JP2010530071A patent/JP5439381B2/ja not_active Expired - Fee Related
-
2010
- 2010-04-13 IL IL205045A patent/IL205045A/en not_active IP Right Cessation
- 2010-04-16 NI NI201000064A patent/NI201000064A/es unknown
- 2010-04-30 CO CO10051578A patent/CO6270359A2/es not_active Application Discontinuation
- 2010-05-18 ZA ZA2010/03519A patent/ZA201003519B/en unknown
- 2010-05-19 CR CR11447A patent/CR11447A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EA017119B1 (ru) | 2012-09-28 |
| ZA201003519B (en) | 2012-07-25 |
| JP5439381B2 (ja) | 2014-03-12 |
| CR11447A (es) | 2011-01-14 |
| MX2010004309A (es) | 2010-05-03 |
| JP2011500700A (ja) | 2011-01-06 |
| ES2378594T8 (es) | 2013-02-27 |
| US8252935B2 (en) | 2012-08-28 |
| AU2008312612A8 (en) | 2010-05-27 |
| EP2212287A1 (de) | 2010-08-04 |
| US20090105275A1 (en) | 2009-04-23 |
| EA201070495A1 (ru) | 2010-10-29 |
| KR20100083829A (ko) | 2010-07-22 |
| KR101569391B1 (ko) | 2015-11-16 |
| NZ584716A (en) | 2011-12-22 |
| AU2008312612A2 (en) | 2010-07-22 |
| WO2009052126A1 (en) | 2009-04-23 |
| BRPI0817433A2 (pt) | 2015-06-16 |
| AU2008312612B2 (en) | 2013-11-28 |
| ES2378594T3 (es) | 2012-04-16 |
| EP2212287B1 (de) | 2012-02-01 |
| NI201000064A (es) | 2010-09-13 |
| CA2702837A1 (en) | 2009-04-23 |
| IL205045A0 (en) | 2010-11-30 |
| CO6270359A2 (es) | 2011-04-20 |
| AU2008312612A1 (en) | 2009-04-23 |
| CN101903347A (zh) | 2010-12-01 |
| IL205045A (en) | 2015-08-31 |
| CN101903347B (zh) | 2013-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE543799T1 (de) | Piperidinyl- und piperazinylmodulatoren von g- sekretase | |
| CY1115789T1 (el) | 2,3-διυδροβενζο[1,4]διοξιν-2-υλομεθυλο παραγωγα ως αλφα2c ανταγωνιστες για χρηση στη θεραπευτικη αγωγη παθησεων του περιφερικου και του κεντρικου νευρικου συστηματος | |
| CY1112083T1 (el) | Υποκαθιστουμενα ν-φαινυλο-διπυρρολιδινο καρβοξαμιδια και η θεραπευτικη τους χρηση | |
| ATE534625T1 (de) | Substituierte n-phenyl-bipyrrolidinharnstoffe und deren therapeutische verwendung | |
| TW200736233A (en) | Cyclohexyl piperazinyl methanone derivatives | |
| CO6190616A2 (es) | Carboxamidas n-fenil-bipirrolidina sustituidas y su uso terapeutico | |
| ATE466854T1 (de) | 1h-indol-6-ylpiperazin-1-ylmethanonderivate zur verwendung als h3-rezeptormodulatoren | |
| ATE530525T1 (de) | Piperidine und verwandte verbindungen zur behandlung von demenz | |
| EA201070496A1 (ru) | УГЛЕРОД-СВЯЗАННЫЕ МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ | |
| EA201070494A1 (ru) | МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ С АМИДНЫМИ СВЯЗЯМИ | |
| DE602005015697D1 (de) | Te zur behandlung von alzheimer-krankheit | |
| EA201070497A1 (ru) | Промежуточные продукты мгс | |
| DE602005014632D1 (de) | Pyrrol- bzw. imidazolamide zur behandlung von obesitas | |
| UY32002A (es) | Piridinilo moduladores de gamma-secretasa | |
| EA201070498A1 (ru) | МОДУЛЯТОРЫ γ-СЕКРЕТАЗЫ С АМИДНЫМИ СВЯЗЯМИ | |
| EA200701813A1 (ru) | Новые амидозамещенные 6-фенилфенантридины | |
| ATE479691T1 (de) | 4,5,6,7-tetrahydrothienoä2,3-cüpyridine als h3- modulatoren | |
| EA200701815A1 (ru) | 6-гетероарил-1,2,3,4,4а,10в-гексагидрофенантридины в качестве pde-4 ингибиторов для лечения воспалительных заболеваний | |
| ATE502947T1 (de) | 4,5,6,7-tetrahydrothienoä3,2-cüpyridinderivate als h3-modulatoren | |
| DOP2004000982A (es) | Compuestos para el tratamiento de trastornos neurodegenerativos |