ATE530525T1 - Piperidine und verwandte verbindungen zur behandlung von demenz - Google Patents
Piperidine und verwandte verbindungen zur behandlung von demenzInfo
- Publication number
- ATE530525T1 ATE530525T1 AT07733578T AT07733578T ATE530525T1 AT E530525 T1 ATE530525 T1 AT E530525T1 AT 07733578 T AT07733578 T AT 07733578T AT 07733578 T AT07733578 T AT 07733578T AT E530525 T1 ATE530525 T1 AT E530525T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- dementia
- piperidine
- related compounds
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- 206010012289 Dementia Diseases 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0606015.6A GB0606015D0 (en) | 2006-03-28 | 2006-03-28 | therapeutic agents |
| PCT/GB2007/050155 WO2007110667A1 (en) | 2006-03-28 | 2007-03-27 | Piperidines and related compounds for the treatment of dementia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE530525T1 true ATE530525T1 (de) | 2011-11-15 |
Family
ID=36384184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07733578T ATE530525T1 (de) | 2006-03-28 | 2007-03-27 | Piperidine und verwandte verbindungen zur behandlung von demenz |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8222418B2 (de) |
| EP (1) | EP2001848B1 (de) |
| JP (1) | JP2009531407A (de) |
| AT (1) | ATE530525T1 (de) |
| AU (1) | AU2007231164A1 (de) |
| CA (1) | CA2647290A1 (de) |
| GB (1) | GB0606015D0 (de) |
| WO (1) | WO2007110667A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2013171B1 (de) * | 2006-04-26 | 2013-05-15 | Merck Sharp & Dohme Limited | Piperidine und verwandte verbindungen zur behandlung von alzheimer-krankheit |
| AU2007342604A1 (en) | 2006-12-20 | 2008-07-17 | Merck Sharp & Dohme Corp. | Silylated piperidine derivatives |
| US8217064B2 (en) | 2007-12-20 | 2012-07-10 | Envivo Pharmaceuticals, Inc. | Tetrasubstituted benzenes |
| EP2378879A4 (de) | 2008-12-16 | 2012-06-06 | Merck Sharp & Dohme | Triazolderivate für die behandlung von morbus alzheimer |
| CN102249990B (zh) * | 2011-06-08 | 2013-06-12 | 上海玉函化工有限公司 | 一种6-三氟甲基烟醛的合成工艺 |
| WO2015109109A1 (en) | 2014-01-15 | 2015-07-23 | Forum Pharmaceuticals Inc. | Fused morpholinopyrimidines and methods of use thereof |
| WO2016201168A1 (en) | 2015-06-10 | 2016-12-15 | Forum Pharmceuticals Inc. | Oxadiazine compounds and methods of use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001257903A1 (en) | 2000-03-22 | 2001-10-03 | The General Hospital Corporation | Method for treatment of neurodegenerative diseases |
| ITMI20010985A1 (it) | 2001-05-15 | 2002-11-15 | Nicox Sa | Farmaci per il morbo di alzheimer |
| JP2005501817A (ja) | 2001-06-12 | 2005-01-20 | アクティブ パス ファーマシューティカルズ， インコーポレイテッド | β−アミロイド産生を調節する化合物、組成物および方法 |
| GB0423356D0 (en) | 2004-10-21 | 2004-11-24 | Merck Sharp & Dohme | Therapeutic agents |
-
2006
- 2006-03-28 GB GBGB0606015.6A patent/GB0606015D0/en not_active Ceased
-
2007
- 2007-03-27 CA CA002647290A patent/CA2647290A1/en not_active Abandoned
- 2007-03-27 WO PCT/GB2007/050155 patent/WO2007110667A1/en not_active Ceased
- 2007-03-27 AT AT07733578T patent/ATE530525T1/de not_active IP Right Cessation
- 2007-03-27 EP EP07733578A patent/EP2001848B1/de not_active Not-in-force
- 2007-03-27 AU AU2007231164A patent/AU2007231164A1/en not_active Abandoned
- 2007-03-27 JP JP2009502225A patent/JP2009531407A/ja not_active Withdrawn
- 2007-03-27 US US12/294,303 patent/US8222418B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007231164A1 (en) | 2007-10-04 |
| WO2007110667A1 (en) | 2007-10-04 |
| US20090239905A1 (en) | 2009-09-24 |
| EP2001848A1 (de) | 2008-12-17 |
| US8222418B2 (en) | 2012-07-17 |
| GB0606015D0 (en) | 2006-05-03 |
| EP2001848B1 (de) | 2011-10-26 |
| JP2009531407A (ja) | 2009-09-03 |
| CA2647290A1 (en) | 2007-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |