ATE529427T1 - Ä1h-indol-5-yl)-heteroaryloxyü-(1-aza-bicyclo- ä3.3.1ü-nonane als cholinergische liganden des n- achr zur behandlung psychotischer und neurodegenerativer leiden - Google Patents

Ä1h-indol-5-yl)-heteroaryloxyü-(1-aza-bicyclo- ä3.3.1ü-nonane als cholinergische liganden des n- achr zur behandlung psychotischer und neurodegenerativer leiden

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Publication number
ATE529427T1
ATE529427T1 AT06846986T AT06846986T ATE529427T1 AT E529427 T1 ATE529427 T1 AT E529427T1 AT 06846986 T AT06846986 T AT 06846986T AT 06846986 T AT06846986 T AT 06846986T AT E529427 T1 ATE529427 T1 AT E529427T1
Authority
AT
Austria
Prior art keywords
heteroaryloxyü
nonanes
achr
psychotic
indol
Prior art date
Application number
AT06846986T
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English (en)
Inventor
Dominik Feuerbach
Mathias Frederiksen
Konstanze Hurth
Bernard Roy
Beatrix Wagner
Original Assignee
Novartis Ag
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Application filed by Novartis Ag filed Critical Novartis Ag
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Publication of ATE529427T1 publication Critical patent/ATE529427T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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AT06846986T 2005-12-16 2006-12-14 Ä1h-indol-5-yl)-heteroaryloxyü-(1-aza-bicyclo- ä3.3.1ü-nonane als cholinergische liganden des n- achr zur behandlung psychotischer und neurodegenerativer leiden ATE529427T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0525672.2A GB0525672D0 (en) 2005-12-16 2005-12-16 Organic compounds
PCT/EP2006/012023 WO2007068476A1 (en) 2005-12-16 2006-12-14 [ (1h- indol- 5 -yl) -heteroaryloxy] - (1-aza-bicyclo [3.3.1] nonanes as cholinergic ligands of the n-achr for the treatment of psychotic and neurodegenrative disorders.

Publications (1)

Publication Number Publication Date
ATE529427T1 true ATE529427T1 (de) 2011-11-15

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ID=35736290

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AT06846986T ATE529427T1 (de) 2005-12-16 2006-12-14 Ä1h-indol-5-yl)-heteroaryloxyü-(1-aza-bicyclo- ä3.3.1ü-nonane als cholinergische liganden des n- achr zur behandlung psychotischer und neurodegenerativer leiden

Country Status (35)

Country Link
US (4) US7713976B2 (de)
EP (2) EP1966209B1 (de)
JP (1) JP5230441B2 (de)
KR (2) KR101174943B1 (de)
CN (1) CN101331132B (de)
AR (1) AR058348A1 (de)
AT (1) ATE529427T1 (de)
AU (1) AU2006326258B2 (de)
BR (1) BRPI0619888A2 (de)
CA (1) CA2631654C (de)
CR (1) CR10056A (de)
CY (1) CY1112708T1 (de)
DK (1) DK1966209T3 (de)
EC (1) ECSP088541A (de)
ES (1) ES2375847T3 (de)
GB (1) GB0525672D0 (de)
HK (1) HK1121444A1 (de)
HR (1) HRP20120030T1 (de)
IL (1) IL191841A (de)
JO (1) JO2734B1 (de)
MA (1) MA30027B1 (de)
MY (1) MY145627A (de)
NO (1) NO20082937L (de)
NZ (1) NZ569013A (de)
PE (1) PE20070750A1 (de)
PL (1) PL1966209T3 (de)
PT (1) PT1966209E (de)
RU (1) RU2471797C2 (de)
SA (1) SA06270445B1 (de)
SI (1) SI1966209T1 (de)
TN (1) TNSN08260A1 (de)
TW (1) TWI423965B (de)
UA (1) UA94725C2 (de)
WO (1) WO2007068476A1 (de)
ZA (1) ZA200804628B (de)

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GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) * 2005-10-21 2005-11-30 Novartis Ag Organic compounds
TWI403320B (zh) * 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
EP2959902A1 (de) * 2009-07-23 2015-12-30 Novartis AG Verwendung von azabicycloalkylderivaten zur behandlung oder vorbeugung von ataxie
TWI558398B (zh) 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
JP5734999B2 (ja) * 2009-12-17 2015-06-17 アッヴィ・インコーポレイテッド 神経変性および神経精神医学的障害の治療に有用な架橋アミン環縮合インドールおよびインドリン
MX2013008704A (es) 2011-01-27 2013-08-21 Novartis Ag Uso de activadores del receptor de acetil-colina nicotinico alfa-7.
US20140228398A1 (en) 2011-03-18 2014-08-14 Novartis Ag COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE
CA3083244C (en) 2011-10-20 2023-01-03 Novartis Ag Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
JP6114951B2 (ja) 2012-12-11 2017-04-19 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アクチベーターによる処置に対する応答性を予測するバイオマーカー
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
CN105263495B (zh) 2013-01-15 2019-05-14 诺华有限公司 α7烟碱型乙酰胆碱受体激动剂的应用
ES2865736T3 (es) 2013-01-15 2021-10-15 Novartis Ag Uso de agonistas del receptor de acetilcolina nicotínico alfa 7
EP2945626B1 (de) 2013-01-15 2018-09-12 Novartis AG Verwendung von alpha-7-nikotinrezeptor-agonisten zur behandlung von narkolepsie

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