DD142712A5 - Verfahren zur herstellung neuer mercaptoimidazolderivate - Google Patents

Verfahren zur herstellung neuer mercaptoimidazolderivate Download PDF

Info

Publication number
DD142712A5
DD142712A5 DD79212098A DD21209879A DD142712A5 DD 142712 A5 DD142712 A5 DD 142712A5 DD 79212098 A DD79212098 A DD 79212098A DD 21209879 A DD21209879 A DD 21209879A DD 142712 A5 DD142712 A5 DD 142712A5
Authority
DD
German Democratic Republic
Prior art keywords
phenyl
formula
pyridyl
acid addition
items
Prior art date
Application number
DD79212098A
Other languages
German (de)
English (en)
Inventor
Pier G Ferrini
Richard Goeschke
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DD142712A5 publication Critical patent/DD142712A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DD79212098A 1978-04-11 1979-04-09 Verfahren zur herstellung neuer mercaptoimidazolderivate DD142712A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU79412 1978-04-11

Publications (1)

Publication Number Publication Date
DD142712A5 true DD142712A5 (de) 1980-07-09

Family

ID=19728887

Family Applications (1)

Application Number Title Priority Date Filing Date
DD79212098A DD142712A5 (de) 1978-04-11 1979-04-09 Verfahren zur herstellung neuer mercaptoimidazolderivate

Country Status (24)

Country Link
US (3) US4461770A (xx)
EP (1) EP0004648B1 (xx)
JP (1) JPS54135769A (xx)
KR (2) KR820002314B1 (xx)
AT (1) AT376971B (xx)
AU (1) AU532402B2 (xx)
CS (1) CS220324B2 (xx)
CY (1) CY1302A (xx)
DD (1) DD142712A5 (xx)
DE (1) DE2963572D1 (xx)
DK (1) DK148879A (xx)
ES (5) ES8303355A1 (xx)
FI (1) FI65066C (xx)
GR (1) GR71193B (xx)
HK (1) HK87285A (xx)
HU (1) HU182018B (xx)
IL (1) IL57040A (xx)
MY (1) MY8600271A (xx)
NO (1) NO148926C (xx)
NZ (1) NZ190153A (xx)
PL (2) PL125882B1 (xx)
PT (1) PT69460A (xx)
SU (2) SU1259962A3 (xx)
ZA (1) ZA791702B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2823197A1 (de) * 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE2856909A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3025484A1 (de) * 1980-07-03 1982-02-04 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4686231A (en) * 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
US4780470A (en) * 1986-08-19 1988-10-25 Smithkline Beckman Corporation Inhibition of interleukin-1 by monocytes and/or macrophages
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
US5955480A (en) * 1996-11-20 1999-09-21 Merck & Co., Inc. Triaryl substituted imidazoles, compositions containing such compounds and methods of use
ES2202840T3 (es) * 1997-04-24 2004-04-01 Ortho-Mcneil Pharmaceutical, Inc. Imidazoles sustituidos utiles en el tratamiento de enfermedades inflamatorias.
KR20010014288A (ko) * 1997-06-30 2001-02-26 오르토-맥네일 파마슈티칼, 인코퍼레이티드 염증성 질환의 치료에 유용한 2-치환된 이미다졸
DE19842833B4 (de) * 1998-09-18 2005-04-14 Merckle Gmbh 2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung
DE10107683A1 (de) * 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10238045A1 (de) * 2002-08-20 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
US8134029B2 (en) * 2002-09-16 2012-03-13 Sunovion Pharmaceuticals Inc. Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine
EP1904066B1 (en) 2005-07-06 2018-05-23 Sunovion Pharmaceuticals Inc. COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS
ES2555315T3 (es) * 2006-03-31 2015-12-30 Sunovion Pharmaceuticals Inc. Preparación de amidas y aminas quirales
EP1894925A1 (en) * 2006-08-24 2008-03-05 Merckle Gmbh Imidazole compounds having an antiinflammatory effect

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981739A (en) * 1958-01-27 1961-04-25 Diamond Alkali Co Certain alpha-haloaldehyde addition products of ethylenethioureas and process
US3714179A (en) * 1970-09-08 1973-01-30 Searle & Co 1-alkyl-2-furfurylthioimidazoles and congeners
JPS5343958B2 (xx) * 1972-07-29 1978-11-24
SE428686B (sv) * 1975-08-11 1983-07-18 Du Pont Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler
US4159338A (en) * 1977-02-09 1979-06-26 E. I. Du Pont De Nemours And Company Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones
DK16778A (da) * 1977-02-09 1978-08-10 Du Pont Imidazolderivater deres anvendelser og fremstilling
LU77703A1 (de) * 1977-07-07 1979-03-26 Ciba Geigy Ag Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen
DE2823197A1 (de) * 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4308277A (en) * 1978-08-10 1981-12-29 Ciba-Geigy Corporation 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same
US4175127A (en) * 1978-09-27 1979-11-20 Smithkline Corporation Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles
DE2856909A1 (de) * 1978-12-28 1980-07-17 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate

Also Published As

Publication number Publication date
ES8504738A1 (es) 1985-05-01
AU4599479A (en) 1979-10-18
GR71193B (xx) 1983-04-11
MY8600271A (en) 1986-12-31
ES8403877A1 (es) 1984-04-01
HU182018B (en) 1983-12-28
SU1259962A3 (ru) 1986-09-23
FI65066C (fi) 1984-03-12
NO791228L (no) 1979-10-12
ES528580A0 (es) 1985-05-01
ES528579A0 (es) 1985-05-01
IL57040A0 (en) 1979-07-25
IL57040A (en) 1984-08-31
AT376971B (de) 1985-01-25
US4461770A (en) 1984-07-24
NO148926C (no) 1984-01-11
KR820002315B1 (ko) 1982-12-17
PL125972B1 (en) 1983-06-30
ATA266179A (de) 1984-06-15
US4584310A (en) 1986-04-22
DK148879A (da) 1979-10-12
ES479490A0 (es) 1983-02-01
NO148926B (no) 1983-10-03
JPS6339594B2 (xx) 1988-08-05
ES8303355A1 (es) 1983-02-01
CS220324B2 (en) 1983-03-25
FI65066B (fi) 1983-11-30
EP0004648B1 (de) 1982-08-25
DE2963572D1 (en) 1982-10-21
US4608382A (en) 1986-08-26
ES528581A0 (es) 1985-05-16
ES8504737A1 (es) 1985-05-01
EP0004648A2 (de) 1979-10-17
SU991945A3 (ru) 1983-01-23
KR820002314B1 (ko) 1982-12-17
ES515766A0 (es) 1984-04-01
AU532402B2 (en) 1983-09-29
PL125882B1 (en) 1983-06-30
ES8505352A1 (es) 1985-05-16
ZA791702B (en) 1980-04-30
HK87285A (en) 1985-11-15
NZ190153A (en) 1981-05-15
EP0004648A3 (en) 1979-11-14
PT69460A (en) 1979-05-01
CY1302A (en) 1985-12-06
PL214745A1 (xx) 1980-06-16
JPS54135769A (en) 1979-10-22
FI791158A (fi) 1979-10-12

Similar Documents

Publication Publication Date Title
DD142712A5 (de) Verfahren zur herstellung neuer mercaptoimidazolderivate
DE69906554T2 (de) P38 inhibitoren
DE2655681A1 (de) Substituierte imidazo eckige klammer auf 1,2-a eckige klammer zu pyridine
DE2542329A1 (de) Verfahren zur herstellung von neuen 2,3-dihydro-1-benzothiepin-4-carbonsaeureamiden
DD145101A5 (de) Verfahren zur herstellung von inda yl-derivaten
DD145538A5 (de) Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen
EP0214479A2 (de) Benzimidazol-2-yl-pyridiniumverbindungen
DE3509333A1 (de) Substituierte benzimidazolderivate, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zubereitungen und ihre verwendung als magensaeuresekretionshemmer
DE2363511A1 (de) Pyrazol-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
EP0473963A1 (de) Neue Pyrrolobenzimidazole, Imidazobenzoxazinone und Imidazochinolone, Verfahren zu ihrer Herstellung und ihre Verwendung sowie die Verbindungen enthaltende Zubereitungen
AT374198B (de) Verfahren zur herstellung neuer 2-substituierter mercaptoimidazolderivate, ihrer n-oxyde und ihrer salze
DD145269A5 (de) Verfahren zur herstellung neuer thiosubstituierter diazacycloalkene
WO1992022536A1 (de) Bicyclisch substituierte vinylimidazole, -triazole und -tetrazole
EP0163842A1 (de) Tricyclische Imidazolderivate
AT375933B (de) Verfahren zur herstellung neuer 2-substituierter mercaptoimidazolderivate und ihrer salze
DE2805167A1 (de) Entzuendungshemmende imidazole, verfahren zu ihrer herstellung und sie entheltende arzneimittel
WO2000003978A2 (de) 2,5-substituierte benzolsulfonylharnstoffe und -thioharnstoffe, v,rfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
DE3124673A1 (de) Subsituierte 2-amino-pyridinderivate, verfahren zu ihrer herstellung, ihre verwendung in arzneimitteln, sowie deren herstellung
EP0124630A1 (de) Pyrimidin-Thioalkylpyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindung enthaltende Arzneimittel
DE1950990A1 (de) Verfahren zur Herstellung von neuen triazacyclischen Verbindungen
DD201788A5 (de) Verfahren zur herstellung neuer diaryl-imidazol-verbindungen
DE2428294A1 (de) Mercaptomethylpyridine und derivate derselben
DD234005A5 (de) Verfahren zur herstellung neuer 1,2,4-triazacycloalkadienderivate
DE2357277A1 (de) (1-alkyl-5-nitro-imidazolyl-2-alkyl)- pyridyl-verbindungen und verfahren zu ihrer herstellung
DD234006A5 (de) Verfahren zur herstellung neuer 3-mercapto-1,2,4-triazacycloalkadienderivate