CZ296130B6 - Ligand mpl - Google Patents

Ligand mpl Download PDF

Info

Publication number
CZ296130B6
CZ296130B6 CZ0192296A CZ192296A CZ296130B6 CZ 296130 B6 CZ296130 B6 CZ 296130B6 CZ 0192296 A CZ0192296 A CZ 0192296A CZ 192296 A CZ192296 A CZ 192296A CZ 296130 B6 CZ296130 B6 CZ 296130B6
Authority
CZ
Czechia
Prior art keywords
mpl ligand
mpl
ligand
sequence
cells
Prior art date
Application number
CZ0192296A
Other languages
Czech (cs)
English (en)
Other versions
CZ192296A3 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed filed Critical
Publication of CZ192296A3 publication Critical patent/CZ192296A3/cs
Publication of CZ296130B6 publication Critical patent/CZ296130B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Vehicle Body Suspensions (AREA)
  • Information Transfer Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CZ0192296A 1994-01-03 1994-12-28 Ligand mpl CZ296130B6 (cs)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand

Publications (2)

Publication Number Publication Date
CZ192296A3 CZ192296A3 (en) 1997-05-14
CZ296130B6 true CZ296130B6 (cs) 2006-01-11

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ0192296A CZ296130B6 (cs) 1994-01-03 1994-12-28 Ligand mpl

Country Status (28)

Country Link
EP (1) EP0738323A1 (fr)
JP (2) JPH09508262A (fr)
CN (1) CN1134539C (fr)
AU (1) AU704266B2 (fr)
BG (1) BG63639B1 (fr)
CA (1) CA2178482C (fr)
CZ (1) CZ296130B6 (fr)
DK (1) DK149194A (fr)
ES (1) ES2114786B1 (fr)
FI (1) FI121573B (fr)
FR (1) FR2714670B1 (fr)
GB (1) GB2285446B (fr)
HR (1) HRP941020A2 (fr)
HU (1) HUT75657A (fr)
IE (1) IE72517B1 (fr)
IL (1) IL112184A (fr)
IT (1) IT1283770B1 (fr)
LU (1) LU88573A1 (fr)
LV (1) LV11632B (fr)
NL (1) NL9500010A (fr)
NO (1) NO326903B1 (fr)
NZ (1) NZ278726A (fr)
PT (1) PT101627B (fr)
RO (1) RO117110B1 (fr)
SG (1) SG47030A1 (fr)
SI (1) SI9420079A (fr)
SK (1) SK282265B6 (fr)
WO (1) WO1995018858A1 (fr)

Families Citing this family (57)

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US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
WO1995021920A1 (fr) * 1994-02-14 1995-08-17 Zymogenetics, Inc. Proteine hematopoietique, produits et methodes pour la preparer
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
KR100203824B1 (ko) * 1994-03-31 1999-06-15 스티븐 엠. 오드리 거핵구 성장 및 분화를 자극하기 위한 조성물 및방법
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
US6254870B1 (en) 1995-02-03 2001-07-03 G. D. Searle & Co. Thrombopoietin: IL-3 fusion protein
AU691410B2 (en) * 1995-02-15 1998-05-14 Amgen, Inc. MPL ligand analogs
US5696250A (en) 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
PL188795B1 (pl) * 1995-06-07 2005-04-29 Glaxo Group Ltd Związek wiążący się z receptorem trombopoetyny, kompozycja farmaceutyczna i zastosowanie związku wiążącego się z receptorem trombopoetyny
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
AU728881B2 (en) * 1996-08-13 2001-01-18 Zymogenetics Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
WO1998052598A1 (fr) * 1997-05-21 1998-11-26 Genentech, Inc. Nouveau procede d'administration de thrombopoietine
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
JP3820105B2 (ja) 1998-10-23 2006-09-13 キリン−アムジエン・インコーポレーテツド Ｍｐ１受容体に結合し血小板生成活性を有する二量体トロンボポエチンペプチド模倣体
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
EP1994824A1 (fr) 2001-11-15 2008-11-26 Kirin Pharma Kabushiki Kaisha Animal non humain chimérique
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
US8067367B2 (en) 2002-09-18 2011-11-29 Janssen Pharmaceutica, N.V. Methods of increasing platelet and hematopoietic stem cell production
HUE032370T2 (en) 2003-08-28 2017-09-28 Janssen Pharmaceuticals Inc Peptides and compounds that bind to thrombopoietin receptors
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
WO2005116231A1 (fr) * 2004-05-18 2005-12-08 Intrexon Corporation Methodes pour assemblage de vecteurs dynamiques au moyen de plasmides vecteurs de clonage d'adn
EP1773400A2 (fr) 2004-07-08 2007-04-18 Amgen Inc. Peptides therapeutiques
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (fr) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited Molécule et chimères de cette molécule
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
EP2044197B8 (fr) 2006-07-24 2018-03-07 The University Of Queensland Procédé de production d'une population de cellules
TW200902708A (en) 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
MX2009012609A (es) 2007-05-22 2009-12-07 Amgen Inc Composiciones y metodos para producir proteinas de fusion bioactivas.
WO2010085086A2 (fr) 2009-01-20 2010-07-29 한올바이오파마 주식회사 Fragment polypeptidique de thrombopoïétine humaine modifié et son procédé de fabrication
WO2014089478A1 (fr) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Procédés d'analyse numérique pour troubles plaquettaires et supports lisibles par ordinateur et systèmes pour leur mise en œuvre
EP2934555B1 (fr) 2012-12-21 2021-09-22 Astellas Institute for Regenerative Medicine Procédés de production de plaquettes à partir de cellules souches pluripotentes
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
SG11201804902UA (en) * 2015-12-21 2018-07-30 Brainon Inc A composition for improving memory, learning ability, and cognitive ability
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
US20230212565A1 (en) * 2019-09-20 2023-07-06 Ractigen Therapeutics Nucleic acid molecule for treating thrombocytopenia and application thereof
CA3164986A1 (fr) 2019-12-20 2021-06-24 Instil Bio (Uk) Limited Dispositifs et procedes d'isolement de lymphocytes infiltrant les tumeurs et leurs utilisations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (fr) * 1989-04-19 1990-11-01 Cetus Corporation Proteines m-csf multifonctionnelles et codage de genes pour celles-ci
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
ES2160591T3 (es) * 1991-12-06 2001-11-16 Genentech Inc Celulas transformadas por convertasas prohormonales.
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
CA2178482C (fr) 2012-01-03
SG47030A1 (en) 1998-03-20
IL112184A (en) 2004-07-25
DK149194A (da) 1995-07-04
AU1514695A (en) 1995-08-01
CN1134539C (zh) 2004-01-14
LU88573A1 (de) 1995-06-01
ITTO950002A0 (it) 1995-01-02
LV11632B (en) 1997-04-20
ITTO950002A1 (it) 1995-07-03
NL9500010A (nl) 1995-08-01
HRP941020A2 (en) 1997-04-30
IT1283770B1 (it) 1998-04-30
CN1141061A (zh) 1997-01-22
NO326903B1 (no) 2009-03-16
SK282265B6 (sk) 2001-12-03
SI9420079A (en) 1997-02-28
HU9601805D0 (en) 1996-08-28
IE72517B1 (en) 1997-04-23
JPH09508262A (ja) 1997-08-26
FI962723A0 (fi) 1996-07-02
NO962783L (no) 1996-09-03
CA2178482A1 (fr) 1995-07-13
EP0738323A1 (fr) 1996-10-23
ES2114786A1 (es) 1998-06-01
PT101627B (pt) 1996-11-29
GB9425831D0 (en) 1995-02-22
JPH10113186A (ja) 1998-05-06
IE950002A1 (en) 1995-07-12
WO1995018858A1 (fr) 1995-07-13
GB2285446B (en) 1999-07-28
BG100693A (en) 1998-01-30
AU704266B2 (en) 1999-04-15
CZ192296A3 (en) 1997-05-14
SK87596A3 (en) 1997-11-05
PT101627A (pt) 1995-11-30
NZ278726A (en) 1998-06-26
BG63639B1 (bg) 2002-07-31
HUT75657A (en) 1997-05-28
RO117110B1 (ro) 2001-10-30
FR2714670B1 (fr) 1997-01-10
ES2114786B1 (es) 1999-01-01
LV11632A (lv) 1996-12-20
IL112184A0 (en) 1995-03-15
FI121573B (fi) 2011-01-14
FR2714670A1 (fr) 1995-07-07
GB2285446A (en) 1995-07-12
NO962783D0 (no) 1996-07-02
FI962723A (fi) 1996-09-03

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20141228