CZ281669B6 - Nové dihydroisochinolinové deriváty - Google Patents

Nové dihydroisochinolinové deriváty Download PDF

Info

Publication number
CZ281669B6
CZ281669B6 CS913757A CS375791A CZ281669B6 CZ 281669 B6 CZ281669 B6 CZ 281669B6 CS 913757 A CS913757 A CS 913757A CS 375791 A CS375791 A CS 375791A CZ 281669 B6 CZ281669 B6 CZ 281669B6
Authority
CZ
Czechia
Prior art keywords
formula
acid addition
addition salt
dihydroisoquinoline
compounds
Prior art date
Application number
CS913757A
Other languages
Czech (cs)
English (en)
Inventor
Reto Dr. Naef
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CS375791A3 publication Critical patent/CS375791A3/cs
Publication of CZ281669B6 publication Critical patent/CZ281669B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
CS913757A 1990-12-13 1991-12-11 Nové dihydroisochinolinové deriváty CZ281669B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909027055A GB9027055D0 (en) 1990-12-13 1990-12-13 Organic compounds

Publications (2)

Publication Number Publication Date
CS375791A3 CS375791A3 (en) 1992-06-17
CZ281669B6 true CZ281669B6 (cs) 1996-12-11

Family

ID=10686945

Family Applications (1)

Application Number Title Priority Date Filing Date
CS913757A CZ281669B6 (cs) 1990-12-13 1991-12-11 Nové dihydroisochinolinové deriváty

Country Status (25)

Country Link
US (1) US5177085A (enExample)
EP (1) EP0490823B1 (enExample)
JP (1) JPH0764820B2 (enExample)
KR (1) KR920012040A (enExample)
AT (1) ATE145201T1 (enExample)
AU (1) AU643575B2 (enExample)
CA (1) CA2057524A1 (enExample)
CZ (1) CZ281669B6 (enExample)
DE (1) DE69123124T2 (enExample)
DK (1) DK0490823T3 (enExample)
ES (1) ES2093694T3 (enExample)
FI (1) FI915844A7 (enExample)
GB (1) GB9027055D0 (enExample)
GR (1) GR3022034T3 (enExample)
HU (1) HUT61729A (enExample)
IE (1) IE914325A1 (enExample)
IL (1) IL100328A (enExample)
MX (1) MX9102502A (enExample)
MY (1) MY129941A (enExample)
NZ (1) NZ240936A (enExample)
PL (1) PL168329B1 (enExample)
PT (1) PT99775B (enExample)
RU (1) RU2060992C1 (enExample)
TW (1) TW201736B (enExample)
ZA (1) ZA919858B (enExample)

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IT1302677B1 (it) 1998-10-15 2000-09-29 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
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PL200923B1 (pl) 1999-08-21 2009-02-27 Nycomed Gmbh Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu
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Also Published As

Publication number Publication date
FI915844L (fi) 1992-06-14
HU913760D0 (en) 1992-02-28
EP0490823B1 (en) 1996-11-13
JPH04275276A (ja) 1992-09-30
TW201736B (enExample) 1993-03-11
GB9027055D0 (en) 1991-02-06
ZA919858B (en) 1993-06-14
JPH0764820B2 (ja) 1995-07-12
CS375791A3 (en) 1992-06-17
DE69123124T2 (de) 1997-05-15
FI915844A0 (fi) 1991-12-11
IL100328A (en) 1995-12-08
FI915844A7 (fi) 1992-06-14
PL168329B1 (pl) 1996-02-29
ES2093694T3 (es) 1997-01-01
KR920012040A (ko) 1992-07-25
HUT61729A (en) 1993-03-01
US5177085A (en) 1993-01-05
MX9102502A (es) 1992-06-01
RU2060992C1 (ru) 1996-05-27
AU643575B2 (en) 1993-11-18
AU8898591A (en) 1992-06-18
PT99775B (pt) 1999-05-31
IL100328A0 (en) 1992-09-06
GR3022034T3 (en) 1997-03-31
PL292738A1 (en) 1992-12-14
MY129941A (en) 2007-05-31
ATE145201T1 (de) 1996-11-15
DE69123124D1 (de) 1996-12-19
PT99775A (pt) 1992-11-30
EP0490823A1 (en) 1992-06-17
IE914325A1 (en) 1992-06-17
DK0490823T3 (enExample) 1997-02-17
CA2057524A1 (en) 1992-06-14
NZ240936A (en) 1993-09-27

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