MX9102502A - Nuevos derivados de dihidro-isoquinolina y procedimiento para su preparacion. - Google Patents
Nuevos derivados de dihidro-isoquinolina y procedimiento para su preparacion.Info
- Publication number
- MX9102502A MX9102502A MX9102502A MX9102502A MX9102502A MX 9102502 A MX9102502 A MX 9102502A MX 9102502 A MX9102502 A MX 9102502A MX 9102502 A MX9102502 A MX 9102502A MX 9102502 A MX9102502 A MX 9102502A
- Authority
- MX
- Mexico
- Prior art keywords
- dihydro
- isoquinoline
- procedure
- preparation
- new derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909027055A GB9027055D0 (en) | 1990-12-13 | 1990-12-13 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9102502A true MX9102502A (es) | 1992-06-01 |
Family
ID=10686945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9102502A MX9102502A (es) | 1990-12-13 | 1991-12-11 | Nuevos derivados de dihidro-isoquinolina y procedimiento para su preparacion. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5177085A (enExample) |
| EP (1) | EP0490823B1 (enExample) |
| JP (1) | JPH0764820B2 (enExample) |
| KR (1) | KR920012040A (enExample) |
| AT (1) | ATE145201T1 (enExample) |
| AU (1) | AU643575B2 (enExample) |
| CA (1) | CA2057524A1 (enExample) |
| CZ (1) | CZ281669B6 (enExample) |
| DE (1) | DE69123124T2 (enExample) |
| DK (1) | DK0490823T3 (enExample) |
| ES (1) | ES2093694T3 (enExample) |
| FI (1) | FI915844A7 (enExample) |
| GB (1) | GB9027055D0 (enExample) |
| GR (1) | GR3022034T3 (enExample) |
| HU (1) | HUT61729A (enExample) |
| IE (1) | IE914325A1 (enExample) |
| IL (1) | IL100328A (enExample) |
| MX (1) | MX9102502A (enExample) |
| MY (1) | MY129941A (enExample) |
| NZ (1) | NZ240936A (enExample) |
| PL (1) | PL168329B1 (enExample) |
| PT (1) | PT99775B (enExample) |
| RU (1) | RU2060992C1 (enExample) |
| TW (1) | TW201736B (enExample) |
| ZA (1) | ZA919858B (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9212673D0 (en) * | 1992-06-15 | 1992-07-29 | Celltech Ltd | Chemical compounds |
| GB9222253D0 (en) * | 1992-10-23 | 1992-12-09 | Celltech Ltd | Chemical compounds |
| US5622977A (en) * | 1992-12-23 | 1997-04-22 | Celltech Therapeutics Limited | Tri-substituted (aryl or heteroaryl) derivatives and pharmaceutical compositions containing the same |
| GB9226830D0 (en) * | 1992-12-23 | 1993-02-17 | Celltech Ltd | Chemical compounds |
| GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9304920D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| GB9322828D0 (en) * | 1993-11-05 | 1993-12-22 | Sandoz Ltd | Organic compounds |
| EP0738268B1 (en) * | 1993-12-22 | 2004-03-03 | Celltech R&D Limited | Trisubstituted phenyl derivatives, processes for their preparation and their use as phosphodiesterase (type iv) inhibitors |
| GB9326173D0 (en) * | 1993-12-22 | 1994-02-23 | Celltech Ltd | Chemical compounds and process |
| US6245774B1 (en) | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| GB9412573D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412571D0 (en) | 1994-06-22 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| GB9412672D0 (en) * | 1994-06-23 | 1994-08-10 | Celltech Ltd | Chemical compounds |
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| RU2161967C2 (ru) * | 1994-08-18 | 2001-01-20 | Дзе Проктер Энд Гэмбл Компани | Соединения 7-(2-имидазолиниламино) хинолина, пригодные в качестве агонистов альфа-2-адренорецептора |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| ES2171191T3 (es) * | 1994-08-22 | 2002-09-01 | Mitsubishi Pharma Corp | Compuesto de benceno y uso medicinal del mismo. |
| US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| JP2001523213A (ja) * | 1994-12-13 | 2001-11-20 | ユーロ−セルティーク,エス.エイ. | 三置換チオキサンチン類 |
| US6268373B1 (en) * | 1995-06-07 | 2001-07-31 | Euro-Celtique S.A. | Trisubstituted thioxanthines |
| GB9523267D0 (en) * | 1995-11-14 | 1996-01-17 | Sandoz Ltd | Organic compounds |
| GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526245D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526243D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9526246D0 (en) * | 1995-12-21 | 1996-02-21 | Celltech Therapeutics Ltd | Chemical compounds |
| AU2593997A (en) * | 1996-03-21 | 1997-10-10 | Trustees Of Columbia University In The City Of New York, The | Craf1 (traf-3) isoforms and uses thereof |
| US6075016A (en) * | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| AU4674797A (en) * | 1996-10-22 | 1998-05-15 | Ortho Pharmaceutical Corporation | Phenylalaninol derivatives for the treatment of central nervous system disorders |
| GB9622363D0 (en) * | 1996-10-28 | 1997-01-08 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9625184D0 (en) * | 1996-12-04 | 1997-01-22 | Celltech Therapeutics Ltd | Chemical compounds |
| ID19155A (id) * | 1996-12-13 | 1998-06-18 | Tanabe Seiyaku Co | Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya |
| AU5330698A (en) | 1996-12-23 | 1998-07-17 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors |
| WO1998038168A1 (en) * | 1997-02-27 | 1998-09-03 | Tanabe Seiyaku Co., Ltd. | Isoquinolinone derivatives, process for preparing the same, and their use as phosphodiesterase inhibitors |
| GB9705361D0 (en) | 1997-03-14 | 1997-04-30 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
| HUP0002510A3 (en) * | 1997-07-25 | 2002-10-28 | Altana Pharma Ag | Tetrazole derivatives and pharmaceutical compositions containing them |
| AU9512298A (en) * | 1997-09-30 | 1999-04-23 | Molecular Design International, Inc. | Beta3-adrenoreceptor agonists, agonist compositions and methods of using |
| IT1296985B1 (it) | 1997-12-19 | 1999-08-03 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 |
| IT1302677B1 (it) * | 1998-10-15 | 2000-09-29 | Zambon Spa | Derivati benzazinici inibitori della fosfodiesterasi 4 |
| GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
| ATE320800T1 (de) | 1999-08-21 | 2006-04-15 | Altana Pharma Ag | Synergistische kombination von roflumilast und salmeterol |
| GB9924862D0 (en) * | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
| US6924292B2 (en) * | 2000-03-23 | 2005-08-02 | Takeda Chemical Industries, Ltd. | Furoisoquinoline derivatives, process for producing the same and use thereof |
| AU2002224835A1 (en) * | 2000-11-14 | 2002-05-27 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Dihydroisoquinolines as novel phosphodiesterase inhibitors |
| US6818651B2 (en) | 2000-11-14 | 2004-11-16 | Altana Pharma Ag | (Dihydro) isoquinoline derivatives as phosphodiesterase inhibitors |
| US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
| RU2330024C2 (ru) * | 2001-05-29 | 2008-07-27 | Шеринг Акциенгезельшафт | Ингибирующие cdk-киназы пиримидины, способ их получения и их применение в качестве лекарственных средств |
| WO2003059880A1 (en) | 2002-01-11 | 2003-07-24 | Sankyo Company, Limited | Amino alcohol derivative or phosphonic acid derivative and medicinal composition containing these |
| US7745180B2 (en) * | 2002-04-24 | 2010-06-29 | Hitachi Chemical Co., Ltd. | Device and method for high-throughput quantification of mRNA from whole blood |
| WO2004018465A2 (en) * | 2002-08-17 | 2004-03-04 | Altana Pharma Ag | Benzonaphthyridines with pde 3/4 inhibiting activity |
| AU2003253408A1 (en) * | 2002-08-17 | 2004-03-11 | Nycomed Gmbh | Novel phenanthridines |
| WO2004019945A1 (en) * | 2002-08-29 | 2004-03-11 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| ATE348616T1 (de) | 2002-08-29 | 2007-01-15 | Altana Pharma Ag | 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer |
| US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2006522151A (ja) | 2003-04-01 | 2006-09-28 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 不妊症におけるホスホジエステラーゼ阻害剤 |
| BRPI0415497A (pt) * | 2003-10-16 | 2006-12-26 | Hoffmann La Roche | composto processo para a sua preparação , composição farmacêutica que compreende o mesmo, utilização de um composto e método para o tratamento de diabetes do tipo ii |
| JP4728259B2 (ja) * | 2004-02-18 | 2011-07-20 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 効果的なホスホジエステラーゼ(pde)4インヒビターとしての新規のグアニジニル置換されたヒドロキシ−6−フェニルフェナントリジン |
| EP1733724A4 (en) | 2004-02-24 | 2010-07-07 | Sankyo Co | Aminoalcohol compound |
| MX341474B (es) | 2004-03-03 | 2016-08-19 | Takeda Gmbh | Nuevas hidroxi-6-heteroarilfenantridinas y su uso como inhibidores de la fosfodiesterasa tipo 4 ( pde4). |
| RU2281100C1 (ru) * | 2005-01-11 | 2006-08-10 | Общество с ограниченной ответственностью "Синтез-2000" | Спазмолитическое средство |
| PT1856093E (pt) | 2005-03-02 | 2010-02-08 | Nycomed Gmbh | Sal hcl de (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-etoxi- 8-metoxi-1,2,3,4,4a,10b-hexa-hidrofenantridin-2-ol |
| ES2559319T3 (es) | 2007-06-04 | 2016-02-11 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| DK2681236T3 (en) | 2011-03-01 | 2018-04-16 | Synergy Pharmaceuticals Inc | PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| WO2014197720A2 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| CN105979959B (zh) | 2013-08-09 | 2021-11-30 | 阿德利克斯公司 | 用于抑制磷酸盐转运的化合物和方法 |
| US10357486B2 (en) | 2013-08-16 | 2019-07-23 | Universiteit Maastricht | Treatment of cognitive impairment with PDE4 inhibitor |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1400425A (en) * | 1971-09-22 | 1975-07-16 | Rolland Sa A | Substituted 3-hydroxymethyl-isoquinolines and derivatives |
| CA1330560C (en) * | 1986-05-21 | 1994-07-05 | Maurits E. A. Vandewalle | Di- and tetrahydroisoquinoline derivatives |
| HU196758B (en) * | 1986-05-21 | 1989-01-30 | Gyogyszerkutato Intezet | Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them |
| GB8800397D0 (en) * | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds |
-
1990
- 1990-12-13 GB GB909027055A patent/GB9027055D0/en active Pending
-
1991
- 1991-12-02 HU HU913760A patent/HUT61729A/hu unknown
- 1991-12-09 DK DK91810954.7T patent/DK0490823T3/da active
- 1991-12-09 ES ES91810954T patent/ES2093694T3/es not_active Expired - Lifetime
- 1991-12-09 EP EP91810954A patent/EP0490823B1/en not_active Expired - Lifetime
- 1991-12-09 DE DE69123124T patent/DE69123124T2/de not_active Expired - Fee Related
- 1991-12-09 AT AT91810954T patent/ATE145201T1/de not_active IP Right Cessation
- 1991-12-10 MY MYPI91002283A patent/MY129941A/en unknown
- 1991-12-11 CZ CS913757A patent/CZ281669B6/cs unknown
- 1991-12-11 IL IL10032891A patent/IL100328A/en not_active IP Right Cessation
- 1991-12-11 AU AU88985/91A patent/AU643575B2/en not_active Ceased
- 1991-12-11 MX MX9102502A patent/MX9102502A/es unknown
- 1991-12-11 NZ NZ240936A patent/NZ240936A/xx unknown
- 1991-12-11 FI FI915844A patent/FI915844A7/fi not_active Application Discontinuation
- 1991-12-12 IE IE432591A patent/IE914325A1/en unknown
- 1991-12-12 JP JP3328665A patent/JPH0764820B2/ja not_active Expired - Lifetime
- 1991-12-12 PL PL91292738A patent/PL168329B1/pl unknown
- 1991-12-12 CA CA002057524A patent/CA2057524A1/en not_active Abandoned
- 1991-12-12 KR KR1019910022728A patent/KR920012040A/ko not_active Ceased
- 1991-12-12 US US07/805,662 patent/US5177085A/en not_active Expired - Fee Related
- 1991-12-12 PT PT99775A patent/PT99775B/pt not_active IP Right Cessation
- 1991-12-12 RU SU915010401A patent/RU2060992C1/ru active
- 1991-12-13 ZA ZA919858A patent/ZA919858B/xx unknown
- 1991-12-13 TW TW080109769A patent/TW201736B/zh active
-
1996
- 1996-12-13 GR GR960403459T patent/GR3022034T3/el unknown
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