CZ2003477A3 - Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů - Google Patents

Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů Download PDF

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Publication number
CZ2003477A3
CZ2003477A3 CZ2003477A CZ2003477A CZ2003477A3 CZ 2003477 A3 CZ2003477 A3 CZ 2003477A3 CZ 2003477 A CZ2003477 A CZ 2003477A CZ 2003477 A CZ2003477 A CZ 2003477A CZ 2003477 A3 CZ2003477 A3 CZ 2003477A3
Authority
CZ
Czechia
Prior art keywords
compound
formula
alkyl
hydrogen
pharmaceutically acceptable
Prior art date
Application number
CZ2003477A
Other languages
Czech (cs)
English (en)
Inventor
Michael Huai Gu Chen
Edward Mark Davis
Javier Magano
Thomas Norman Nanninga
Derick Dale Winkle
Original Assignee
Warner - Lambert Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner - Lambert Company Llc filed Critical Warner - Lambert Company Llc
Publication of CZ2003477A3 publication Critical patent/CZ2003477A3/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CZ2003477A 2000-08-25 2001-07-20 Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů CZ2003477A3 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25

Publications (1)

Publication Number Publication Date
CZ2003477A3 true CZ2003477A3 (cs) 2003-10-15

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2003477A CZ2003477A3 (cs) 2000-08-25 2001-07-20 Způsob přípravy N-aryl-anthranilových kyselin a jejich derivátů

Country Status (31)

Country Link
EP (1) EP1313694A1 (es)
JP (1) JP2004507518A (es)
KR (1) KR20030059115A (es)
CN (1) CN1458921A (es)
AP (1) AP2001002249A0 (es)
AR (1) AR032175A1 (es)
AU (1) AU2001277044A1 (es)
BG (1) BG107635A (es)
BR (1) BR0113520A (es)
CA (1) CA2420003A1 (es)
CZ (1) CZ2003477A3 (es)
DO (1) DOP2001000238A (es)
EA (1) EA200300187A1 (es)
GT (1) GT200100174A (es)
HN (1) HN2001000216A (es)
HU (1) HUP0300828A2 (es)
IL (1) IL154507A0 (es)
IS (1) IS6724A (es)
MA (1) MA26949A1 (es)
MX (1) MXPA03001654A (es)
NO (1) NO20030844L (es)
PA (1) PA8526501A1 (es)
PE (1) PE20020393A1 (es)
PL (1) PL360699A1 (es)
SK (1) SK2072003A3 (es)
SV (1) SV2002000601A (es)
TN (1) TNSN01127A1 (es)
UY (1) UY26908A1 (es)
WO (1) WO2002018319A1 (es)
YU (1) YU14303A (es)
ZA (1) ZA200301182B (es)

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TWI338685B (en) 2002-03-13 2011-03-11 Array Biopharma Inc N3 alkylated benzimid azole derivatives as mek inhibitors
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
EP1682495A1 (en) 2003-10-21 2006-07-26 Warner-Lambert Company LLC Polymorphic form of n- (r)-2,3-dihydroxy-propoxy -3,4-d ifluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
WO2005051300A2 (en) 2003-11-19 2005-06-09 Array Biopharma Inc. Bicyclic inhibitors of mek and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
KR20110137838A (ko) 2003-11-21 2011-12-23 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제
UA89035C2 (ru) 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
RS52715B (en) 2005-04-13 2013-08-30 Astex Therapeutics Limited HYDROXYBENZAMIDE DERIVATIVES AND THEIR APPLICATIONS AS HSP90 INHIBITORS
ATE539064T1 (de) 2005-05-18 2012-01-15 Array Biopharma Inc Heterozyklische inhibitoren von mek und verwendungsverfahren damit
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
JP5268904B2 (ja) 2006-07-06 2013-08-21 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのシクロペンタ［ｄ］ピリミジン
ATE493418T1 (de) 2006-07-06 2011-01-15 Array Biopharma Inc Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren
SI2054418T1 (sl) 2006-07-06 2012-02-29 Array Biopharma Inc Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2081891A2 (en) 2006-10-12 2009-07-29 Astex Therapeutics Limited Pharmaceutical compounds having hsp90 inhibitory or modulating activity
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
EP2073802A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
JP5518478B2 (ja) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド 医薬化合物
MX2009014013A (es) 2007-07-05 2010-01-28 Array Biopharma Inc Pirimidil ciclopentanos como inhibidores de la proteina cinasa akt.
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
RU2486181C2 (ru) 2007-07-05 2013-06-27 Эррэй Биофарма Инк. Пиримидилциклопентаны как ингибиторы акт-протеинкиназ
MX2010007546A (es) 2008-01-09 2010-09-30 Array Biopharma Inc Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
JP5346345B2 (ja) 2008-01-09 2013-11-20 アレイ バイオファーマ、インコーポレイテッド Ａｋｔタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン類
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (zh) * 2009-07-29 2014-02-12 杭州民生药业有限公司 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途
WO2011101604A1 (fr) * 2010-02-19 2011-08-25 Centre National De La Recherche Scientifique Procede de preparation de composes chimiques d'interet par substitution nucleophile aromatique de derives d'acides carboxyliques aromatiques portant au moins un groupement electroattracteur
CN102958892A (zh) * 2010-02-19 2013-03-06 国家科学研究中心 通过芳香族亲核取代来制备目的化合物的方法
ES2688809T3 (es) 2011-04-01 2018-11-07 Genentech, Inc. Combinaciones de compuestos inhibidores de AKT y MEK para tratar el cáncer
ES2657750T3 (es) 2011-04-01 2018-03-06 Genentech, Inc. Combinación de compuesto inhibidor de AKT y vemurafenib para su uso en tratamientos terapéuticos
PL2909188T3 (pl) * 2012-10-12 2018-08-31 Exelixis, Inc. Nowy sposób wytwarzania związków do stosowania w leczeniu raka
CN112745237B (zh) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-芳基胺类化合物及其制备方法和应用

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US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
WO1998037881A1 (en) * 1997-02-28 1998-09-03 Warner Lambert Company Method of treating or preventing septic shock by administering a mek inhibitor
CN1163475C (zh) * 1997-07-01 2004-08-25 沃尼尔·朗伯公司 4-溴或4-碘苯基氨基苯氧肟酸衍生物及其作为mek抑制剂的用途
NZ501277A (en) * 1997-07-01 2002-12-20 Warner Lambert Co -2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
ES2235843T3 (es) * 1999-04-21 2005-07-16 Warner-Lambert Company Llc Metodo para la produccion de acidos 2-(n-fenilamino)benzoicos.

Also Published As

Publication number Publication date
KR20030059115A (ko) 2003-07-07
IL154507A0 (en) 2003-09-17
BR0113520A (pt) 2003-06-24
SK2072003A3 (en) 2004-01-08
AU2001277044A1 (en) 2002-03-13
CN1458921A (zh) 2003-11-26
GT200100174A (es) 2002-07-18
JP2004507518A (ja) 2004-03-11
PL360699A1 (en) 2004-09-20
HN2001000216A (es) 2002-05-22
HUP0300828A2 (hu) 2003-09-29
SV2002000601A (es) 2002-04-03
IS6724A (is) 2003-02-20
PA8526501A1 (es) 2002-07-30
AR032175A1 (es) 2003-10-29
PE20020393A1 (es) 2002-05-09
EA200300187A1 (ru) 2003-08-28
ZA200301182B (en) 2004-05-12
YU14303A (sh) 2006-08-17
UY26908A1 (es) 2001-11-30
DOP2001000238A (es) 2003-01-31
BG107635A (bg) 2004-09-30
WO2002018319A1 (en) 2002-03-07
AP2001002249A0 (en) 2001-09-30
MXPA03001654A (es) 2004-09-10
NO20030844D0 (no) 2003-02-24
TNSN01127A1 (en) 2005-11-10
NO20030844L (no) 2003-02-25
CA2420003A1 (en) 2002-03-07
MA26949A1 (fr) 2004-12-20
EP1313694A1 (en) 2003-05-28

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