BR0113520A - Processo de preparação de ácidos n-aril-antranìlicos e seus derivados - Google Patents

Processo de preparação de ácidos n-aril-antranìlicos e seus derivados

Info

Publication number
BR0113520A
BR0113520A BR0113520-1A BR0113520A BR0113520A BR 0113520 A BR0113520 A BR 0113520A BR 0113520 A BR0113520 A BR 0113520A BR 0113520 A BR0113520 A BR 0113520A
Authority
BR
Brazil
Prior art keywords
preparation
derivatives
anthranilic acids
aryl anthranilic
aryl
Prior art date
Application number
BR0113520-1A
Other languages
English (en)
Inventor
Michael Huai Gu Chen
Edward Mark Davis
Javier Magano
Thomas Norman Nanninga
Derick Dale Winkle
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0113520A publication Critical patent/BR0113520A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Abstract

"PROCESSO DE PREPARAçãO DE áCIDOS NARIL-ANTRANìLICOS E SEUS DERIVADOS". A presente invenção refere-se a um processo para a preparação de ácidos N-arilantranílicos, e a um processo para a preparação de ésteres, amidas e ésteres hidroxâmicos N-arilantranílicos.
BR0113520-1A 2000-08-25 2001-07-20 Processo de preparação de ácidos n-aril-antranìlicos e seus derivados BR0113520A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25
PCT/US2001/022948 WO2002018319A1 (en) 2000-08-25 2001-07-20 Process for making n-aryl-anthranilic acids and their derivatives

Publications (1)

Publication Number Publication Date
BR0113520A true BR0113520A (pt) 2003-06-24

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113520-1A BR0113520A (pt) 2000-08-25 2001-07-20 Processo de preparação de ácidos n-aril-antranìlicos e seus derivados

Country Status (31)

Country Link
EP (1) EP1313694A1 (pt)
JP (1) JP2004507518A (pt)
KR (1) KR20030059115A (pt)
CN (1) CN1458921A (pt)
AP (1) AP2001002249A0 (pt)
AR (1) AR032175A1 (pt)
AU (1) AU2001277044A1 (pt)
BG (1) BG107635A (pt)
BR (1) BR0113520A (pt)
CA (1) CA2420003A1 (pt)
CZ (1) CZ2003477A3 (pt)
DO (1) DOP2001000238A (pt)
EA (1) EA200300187A1 (pt)
GT (1) GT200100174A (pt)
HN (1) HN2001000216A (pt)
HU (1) HUP0300828A2 (pt)
IL (1) IL154507A0 (pt)
IS (1) IS6724A (pt)
MA (1) MA26949A1 (pt)
MX (1) MXPA03001654A (pt)
NO (1) NO20030844L (pt)
PA (1) PA8526501A1 (pt)
PE (1) PE20020393A1 (pt)
PL (1) PL360699A1 (pt)
SK (1) SK2072003A3 (pt)
SV (1) SV2002000601A (pt)
TN (1) TNSN01127A1 (pt)
UY (1) UY26908A1 (pt)
WO (1) WO2002018319A1 (pt)
YU (1) YU14303A (pt)
ZA (1) ZA200301182B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
EP2130536B1 (en) 2002-03-13 2013-05-08 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as mek inhibitors
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
AU2004283148A1 (en) 2003-10-21 2005-05-06 Warner-Lambert Company Llc Polymorphic form of N-[(R)-2,3-Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
BRPI0416692A (pt) 2003-11-19 2007-01-30 Array Biopharma Inc inibidores heterocìclicos de mek e métodos de emprego destes
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
EP1684694A2 (en) 2003-11-21 2006-08-02 Array Biopharma, Inc. Akt protein kinase inhibitors
UA89035C2 (ru) * 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
AU2006235735C1 (en) 2005-04-13 2013-10-31 Astex Therapeutics Limited Hydroxybenzamide derivatives and their use as inhibitors of Hsp90
BRPI0610139A2 (pt) 2005-05-18 2010-06-01 Array Biopharma Inc inibidores heterocìclicos de mek e métodos de uso dos mesmos
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
US8003651B2 (en) 2006-07-06 2011-08-23 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
ATE532789T1 (de) 2006-07-06 2011-11-15 Array Biopharma Inc Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
EP2049546B1 (en) 2006-07-06 2010-12-29 Array Biopharma, Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
JP5721949B2 (ja) 2006-10-12 2015-05-20 アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ 複合薬剤
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
JP5518478B2 (ja) 2006-10-12 2014-06-11 アステックス、セラピューティックス、リミテッド 医薬化合物
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US8779132B2 (en) 2006-10-12 2014-07-15 Astex Therapeutics Limited Pharmaceutical compounds
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CA2692502C (en) 2007-07-05 2016-03-01 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
WO2009006569A1 (en) 2007-07-05 2009-01-08 Array Biopharma Inc. Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
EP2247578B1 (en) 2008-01-09 2013-05-22 Array Biopharma, Inc. Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
NZ586720A (en) 2008-01-09 2012-11-30 Array Biopharma Inc Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (zh) * 2009-07-29 2014-02-12 杭州民生药业有限公司 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途
EP2536682A1 (fr) * 2010-02-19 2012-12-26 Centre National De La Recherche Scientifique Procede de preparation de composes chimiques d'interet par substitution nucleophile aromatique de derives d'acides carboxyliques aromatiques portant au moins un groupement electroattracteur
CA2789361A1 (en) * 2010-02-19 2011-08-25 Jacques Mortier Method for preparing chemical compounds of interest by aromatic nucleophilic substitution
AU2012236166A1 (en) 2011-04-01 2013-11-14 Genentech, Inc. Combinations of AKT inhibitor compounds and chemotherapeutic agents, and methods of use
ES2688809T3 (es) 2011-04-01 2018-11-07 Genentech, Inc. Combinaciones de compuestos inhibidores de AKT y MEK para tratar el cáncer
AU2013328929B2 (en) * 2012-10-12 2018-01-04 Exelixis, Inc. Novel process for making compounds for use in the treatment of cancer
CN112745237B (zh) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-芳基胺类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
US6251943B1 (en) * 1997-02-28 2001-06-26 Warner-Lambert Company Method of treating or preventing septic shock by administering a MEK inhibitor
EP0993437B1 (en) * 1997-07-01 2006-11-08 Warner-Lambert Company Llc 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as mek inhibitors
DE69826662T2 (de) * 1997-07-01 2005-02-17 Warner-Lambert Co. Llc 4-brom or 4-iod-phenylamino-benzhydroxamsäurederivate und ihre anwendung als mek-inhibitoren
CA2348236A1 (en) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
ATE286015T1 (de) * 1999-04-21 2005-01-15 Warner Lambert Co Verfahren zur herstellung von 2-(n- phenylalmino)benzoesäure

Also Published As

Publication number Publication date
AU2001277044A1 (en) 2002-03-13
NO20030844D0 (no) 2003-02-24
MA26949A1 (fr) 2004-12-20
IS6724A (is) 2003-02-20
AR032175A1 (es) 2003-10-29
JP2004507518A (ja) 2004-03-11
MXPA03001654A (es) 2004-09-10
PA8526501A1 (es) 2002-07-30
KR20030059115A (ko) 2003-07-07
CA2420003A1 (en) 2002-03-07
HN2001000216A (es) 2002-05-22
IL154507A0 (en) 2003-09-17
PE20020393A1 (es) 2002-05-09
YU14303A (sh) 2006-08-17
CZ2003477A3 (cs) 2003-10-15
SV2002000601A (es) 2002-04-03
BG107635A (bg) 2004-09-30
SK2072003A3 (en) 2004-01-08
PL360699A1 (en) 2004-09-20
AP2001002249A0 (en) 2001-09-30
UY26908A1 (es) 2001-11-30
WO2002018319A1 (en) 2002-03-07
GT200100174A (es) 2002-07-18
TNSN01127A1 (en) 2005-11-10
ZA200301182B (en) 2004-05-12
HUP0300828A2 (hu) 2003-09-29
NO20030844L (no) 2003-02-25
EP1313694A1 (en) 2003-05-28
CN1458921A (zh) 2003-11-26
DOP2001000238A (es) 2003-01-31
EA200300187A1 (ru) 2003-08-28

Similar Documents

Publication Publication Date Title
BR0113520A (pt) Processo de preparação de ácidos n-aril-antranìlicos e seus derivados
BR0115482A (pt) Composição de sacralose melhorada e processo para sua preparação
BR9500052A (pt) Mutante de gênero escherichia e processo para produção de ácido L-glutâmico por fermentação
EA200100524A1 (ru) Амиды антраниловой кислоты и их применение в качестве лекарственных средств
BR0307529A (pt) Derivados de n-fenil-2-pirimidina-amina
BR9811827A (pt) Preparações de aerossol aquosas contendo macromoléculas biologicamente ativas e processo para a produção de aerossóis correspondentes
HUP0104709A2 (hu) Eritropoietin vagy eritropoietrinszármazékok alkalmazása agyi iszkémiák kezelésére használható gyógyszer előállítására
IL154470A0 (en) Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders
BR9911887A (pt) Método para o tratamento da insÈnia
BRPI9814894A (pt) processo para a preparação de ácidos 8-metóxi-quinolonocarboxílicos.
BR0211063A (pt) Sais de derivados anticonvulsivantes
IT1319234B1 (it) Processo di preparazione di gabapentina.
BR0213561B1 (pt) processo para a preparaÇço de amidas de Ácido 2-halopiridincarboxÍlico.
BR0316400A (pt) agentes branqueadores fluorescentes anfotéricos
BR9812085A (pt) "método para a sìntese de derivados de quinolina"
BR0208999A (pt) Processo para a preparação de ácido de cefpodoxima
BR0113650A (pt) N-(3,5-dicloro-2-metoxifenil)-4-metóxi-3-piperazina-1-il a-benzenossulfonamida
BRPI0409235A (pt) processo para a produção de sal de amÈnio do ácido 2-hidróxi-4-metiltiobutìrico
BR0016941A (pt) Derivados de aminometil-fenil-ciclohexanona
BR0208504A (pt) Composição farmacêutica estável de pravastatina
BR0209842A (pt) Processo para a preparação de imipenem
BR0015404A (pt) Compostos relacionados com ácido 15-hidroxieicosatetraenóico e métodos de uso
BR0009277A (pt) Processo de preparação de ácido propiÈnico de 3s-3-amino-3-arila e derivados deste
DE60029979D1 (de) LIPOSOMZUSAMMENSETZUNG VON 6,9-BIS-i(2-AMINOETHYL)-AMINOöBENZOiGöISOQUINOLIN-5,10-DIONE-DIMALEAT
AU6843498A (en) Process for the preparation of n-(3-hydroxy-succinyl)-amino acid derivatives

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]