MA26949A1 - Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives. - Google Patents

Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives.

Info

Publication number
MA26949A1
MA26949A1 MA27069A MA27069A MA26949A1 MA 26949 A1 MA26949 A1 MA 26949A1 MA 27069 A MA27069 A MA 27069A MA 27069 A MA27069 A MA 27069A MA 26949 A1 MA26949 A1 MA 26949A1
Authority
MA
Morocco
Prior art keywords
preparation
derivatives
arylanthranilic
arylanthranilic acids
acids
Prior art date
Application number
MA27069A
Other languages
English (en)
Inventor
Michael Huai Gu Chen
Edward Mark Davis
Javier Magano
Thomas Norman Nanninga
Derick Dale Winkle
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of MA26949A1 publication Critical patent/MA26949A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)

Abstract

DEPOSANT Société dite : WARNER-LAMBERT COMPANY LLC REVENDICATION DE PRIORITES US 25 Août 2000 60/228,206 Voir en annexe le titre de l'invention et le texte de l'abrégé Procédé pour la préparation d'acides N-arylanthraniliques et de leurs dérivés La présente invention concerne un procédé pour la préparation d'acides N-arylanthraniliques et un procédé pour la préparation d'esters, amides et esters hydroxamiques N-arylanthraniliques.
MA27069A 2000-08-25 2003-03-14 Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives. MA26949A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25

Publications (1)

Publication Number Publication Date
MA26949A1 true MA26949A1 (fr) 2004-12-20

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27069A MA26949A1 (fr) 2000-08-25 2003-03-14 Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives.

Country Status (31)

Country Link
EP (1) EP1313694A1 (fr)
JP (1) JP2004507518A (fr)
KR (1) KR20030059115A (fr)
CN (1) CN1458921A (fr)
AP (1) AP2001002249A0 (fr)
AR (1) AR032175A1 (fr)
AU (1) AU2001277044A1 (fr)
BG (1) BG107635A (fr)
BR (1) BR0113520A (fr)
CA (1) CA2420003A1 (fr)
CZ (1) CZ2003477A3 (fr)
DO (1) DOP2001000238A (fr)
EA (1) EA200300187A1 (fr)
GT (1) GT200100174A (fr)
HN (1) HN2001000216A (fr)
HU (1) HUP0300828A2 (fr)
IL (1) IL154507A0 (fr)
IS (1) IS6724A (fr)
MA (1) MA26949A1 (fr)
MX (1) MXPA03001654A (fr)
NO (1) NO20030844L (fr)
PA (1) PA8526501A1 (fr)
PE (1) PE20020393A1 (fr)
PL (1) PL360699A1 (fr)
SK (1) SK2072003A3 (fr)
SV (1) SV2002000601A (fr)
TN (1) TNSN01127A1 (fr)
UY (1) UY26908A1 (fr)
WO (1) WO2002018319A1 (fr)
YU (1) YU14303A (fr)
ZA (1) ZA200301182B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3000810B1 (fr) 2002-03-13 2017-07-19 Array Biopharma, Inc. Dérivé de benzimidazole d'alkylat n3 en tant qu'inhibiteur de mek
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
RU2352558C2 (ru) 2003-10-21 2009-04-20 Уорнер-Ламберт Компани Ллс Полиморфная форма n-[(r)-2,3-дигидроксипропокси]-3,4-дифтор-2-(2-фтор-4 йодфениламино)бензамида
US7598383B2 (en) 2003-11-19 2009-10-06 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
KR101223914B1 (ko) 2003-11-21 2013-01-18 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제
UA89035C2 (ru) * 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
EP1877379B1 (fr) 2005-04-13 2013-01-16 Astex Therapeutics Limited Derives d'hydroxybenzamide et leur utilisation comme inhibteurs de hsp90
CN102942522A (zh) 2005-05-18 2013-02-27 阵列生物制药公司 Mek的杂环抑制剂及其使用方法
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
EP2049500B1 (fr) 2006-07-06 2011-09-07 Array Biopharma, Inc. Cyclopenta [d] pyrimidines utiles en tant qu'inhibiteurs de la protéine kinase akt
WO2008006025A1 (fr) 2006-07-06 2008-01-10 Array Biopharma Inc. Dihydrofuro pyrimidines comme inhibiteurs de la protéine kinase akt
JP5231411B2 (ja) 2006-07-06 2013-07-10 アレイ バイオファーマ、インコーポレイテッド Ａｋｔプロテインキナーゼ阻害剤としてのジヒドロチエノピリミジン
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2073807A1 (fr) 2006-10-12 2009-07-01 Astex Therapeutics Limited Combinaisons pharmaceutiques
WO2008044027A2 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Composés pharmaceutiques
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
EP2073804B1 (fr) 2006-10-12 2017-09-13 Astex Therapeutics Limited Composes amides d'acide benzoique substitues par un groupe hydroxyle pour son utilisation dans le traitement de la douleur
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
US8277807B2 (en) 2006-10-12 2012-10-02 Astex Therapeutics Limited Pharmaceutical combinations
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
SI2173723T1 (sl) 2007-07-05 2011-12-30 Array Biopharma Inc Pirimidil ciklopentani kot inhibitorji AKT-protein-kinaze
RU2486181C2 (ru) 2007-07-05 2013-06-27 Эррэй Биофарма Инк. Пиримидилциклопентаны как ингибиторы акт-протеинкиназ
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
KR101624753B1 (ko) 2008-01-09 2016-05-26 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 저해물질로서의 수산화된 피리미딜 시클로펜탄
ES2401685T3 (es) 2008-01-09 2013-04-23 Array Biopharma, Inc. Pirimidil ciclopentano hidroxilado como inhibidor de la proteína quinasa AKT
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (zh) * 2009-07-29 2014-02-12 杭州民生药业有限公司 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途
WO2011101599A1 (fr) * 2010-02-19 2011-08-25 Centre National De La Recherche Scientifique Procédé de préparation de composés chimiques d'intérêt par substitution nucléophile aromatique
CA2789373A1 (fr) * 2010-02-19 2011-08-25 Centre National De La Recherche Scientifique Processus de preparation de composes chimiques d'interet par substitution nucleophile aromatique de derives d'acides carboxyliques aromatiques soutenant au moins un groupe attirant les electrons
ES2620644T3 (es) 2011-04-01 2017-06-29 Genentech, Inc. Combinaciones de compuestos inhibidores de AKT y agentes quimioterapéuticos, y métodos de uso
MX2013011333A (es) 2011-04-01 2014-04-16 Genentech Inc Combinaciones de compuestos inhibidores de akt y mek, y metodos de uso.
MY186549A (en) * 2012-10-12 2021-07-26 Exelixis Inc Novel process for making compounds for use in the treatment of cancer
CN112745237B (zh) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-芳基胺类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
US6251943B1 (en) * 1997-02-28 2001-06-26 Warner-Lambert Company Method of treating or preventing septic shock by administering a MEK inhibitor
CA2290509A1 (fr) * 1997-07-01 1999-01-14 Warner-Lambert Company Derives d'acide benzoique 2-(4-bromo ou 4-iodo phenylamino) et utilisation de ces derniers en tant qu'inhibiteurs de mek
WO1999001426A1 (fr) * 1997-07-01 1999-01-14 Warner-Lambert Company Derives d'acide benzhydroxamique phenylamino 4-bromo ou 4-iodo et utilisation de ces derniers en tant qu'inhibiteurs de mek
CA2348236A1 (fr) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, et 4-arylthio diarylamines et leurs derives comme inhibiteurs selectifs de mek
KR20010108521A (ko) * 1999-04-21 2001-12-07 로즈 암스트롱, 크리스틴 에이. 트러트웨인 2-(ｎ-페닐아미노)벤조산의 제조 방법

Also Published As

Publication number Publication date
EP1313694A1 (fr) 2003-05-28
NO20030844D0 (no) 2003-02-24
ZA200301182B (en) 2004-05-12
CN1458921A (zh) 2003-11-26
PL360699A1 (en) 2004-09-20
PA8526501A1 (es) 2002-07-30
SK2072003A3 (en) 2004-01-08
WO2002018319A1 (fr) 2002-03-07
EA200300187A1 (ru) 2003-08-28
MXPA03001654A (es) 2004-09-10
DOP2001000238A (es) 2003-01-31
CZ2003477A3 (cs) 2003-10-15
JP2004507518A (ja) 2004-03-11
HN2001000216A (es) 2002-05-22
YU14303A (sh) 2006-08-17
SV2002000601A (es) 2002-04-03
GT200100174A (es) 2002-07-18
BR0113520A (pt) 2003-06-24
AU2001277044A1 (en) 2002-03-13
PE20020393A1 (es) 2002-05-09
CA2420003A1 (fr) 2002-03-07
BG107635A (bg) 2004-09-30
IS6724A (is) 2003-02-20
IL154507A0 (en) 2003-09-17
AP2001002249A0 (en) 2001-09-30
NO20030844L (no) 2003-02-25
KR20030059115A (ko) 2003-07-07
TNSN01127A1 (en) 2005-11-10
AR032175A1 (es) 2003-10-29
UY26908A1 (es) 2001-11-30
HUP0300828A2 (hu) 2003-09-29

Similar Documents

Publication Publication Date Title
MA26949A1 (fr) Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives.
PT1004578E (pt) Derivados hidroxamida do acido 5-oxo-pirrolidino-2-carboxilico
HUP0302230A3 (en) Polyarylcarboxamides useful as lipid lowering agents, process for producing them and pharmaceutical compositions containing them
MY151458A (en) Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
GR3036305T3 (en) Chiral methyl phenyl oxazolidinones
MA27182A1 (fr) Derives de thiazole et d'oxazole qui modulent l'activite de ppar.
FR2814174B1 (fr) Lubrifiants contenant des esters d'acides gras substitues par un groupe 5-tert-butyl-4-hydroxy-3-methylphenyle
MA27169A1 (fr) Metabolites de l'acide (3-{ [(4-tertiobutylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetique
GB2383041B (en) Process for the preparation of gabapentin
SI1274685T1 (sl) Derivat piridin-1-oksida in postopek njegove transformacije v farmacevtsko ucinkovite sestavine
DZ3041A1 (fr) Composition pharmaceutique nouvelle comprenant un inhibiteur de nos, et procédé pour sa préparation.
HUP9901260A3 (en) Optically active phenylpyrimidine derivative as analgesic agent, process for producing it, pharmaceutical composition containing it and its intermediate
DZ2948A1 (fr) Dérivé d'indole nouveau, procédé pour sa préparation et compositions pharmaceutiques le contenant.
DZ2607A1 (fr) Procédé pour la synthése de dérivés de quinoléine pharmaceutiquement actifs.
MXPA03008837A (es) Una composicion farmaceutica estable de pravastatina.
HK1046637A1 (en) Use of racemic alpha-lipoic acid in preparation pharmaceutical for treatment of migraine.
ES2076838T3 (es) Nuevo derivado de la isoindolinona, su preparacion y las composiciones farmaceuticas que le contienen.
ITTO20010028A0 (it) Metodo per aumentare l'attivita' antitumorale di una sostanza contenente amigdalina, composizione contenente una sostanza con contenuto aume
BR0016400A (pt) Processo para a preparação de sais de sódio de estatinas
WO2001054647A3 (fr) Composition pharmaceutique comprenant des transporteurs de produits a base de vitamine e, de papaine et d'hyaluronidase
DZ2932A1 (fr) Dérivés d'hygromycine a nouveaux, procédé pour le ur préparation et compositions pharmaceutiques lescontenant.
DE69629703D1 (de) Synthese von optisch reinen verbindungen als garft-inhibitoren und deren zwischenprodukte
WO2002039965A3 (fr) Composition pour l'ondulation permanente de la chevelure comprenant au moins un derive de l'acide formamidinesulfinique
HK1038768A1 (zh) 制備旋光的3-羥基吡咯烷衍生物的微生物法
ITMI20001660A0 (it) Processo per la sintesi del metil estere dell'acido l-metil-5-(4-metilbenzoli)-pirrol-2-acetico