CA2420003A1 - Procede de fabrication d'acides n-aryle-anthraniliques et de leurs derives - Google Patents
Procede de fabrication d'acides n-aryle-anthraniliques et de leurs derives Download PDFInfo
- Publication number
- CA2420003A1 CA2420003A1 CA002420003A CA2420003A CA2420003A1 CA 2420003 A1 CA2420003 A1 CA 2420003A1 CA 002420003 A CA002420003 A CA 002420003A CA 2420003 A CA2420003 A CA 2420003A CA 2420003 A1 CA2420003 A1 CA 2420003A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- alkyl
- hydrogen
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
L'invention concerne un procédé de préparation d'acides N-arylanthraniliques, ainsi qu'un procédé de préparation d'esters N-aryle anthraniliques, d'amides N-aryle anthraniliques, et d'esters hydroxamiques N-aryle anthraniliques.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22820600P | 2000-08-25 | 2000-08-25 | |
US60/228,206 | 2000-08-25 | ||
PCT/US2001/022948 WO2002018319A1 (fr) | 2000-08-25 | 2001-07-20 | Procede de fabrication d'acides n-aryle-anthraniliques et de leurs derives |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2420003A1 true CA2420003A1 (fr) | 2002-03-07 |
Family
ID=22856235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002420003A Abandoned CA2420003A1 (fr) | 2000-08-25 | 2001-07-20 | Procede de fabrication d'acides n-aryle-anthraniliques et de leurs derives |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP1313694A1 (fr) |
JP (1) | JP2004507518A (fr) |
KR (1) | KR20030059115A (fr) |
CN (1) | CN1458921A (fr) |
AP (1) | AP2001002249A0 (fr) |
AR (1) | AR032175A1 (fr) |
AU (1) | AU2001277044A1 (fr) |
BG (1) | BG107635A (fr) |
BR (1) | BR0113520A (fr) |
CA (1) | CA2420003A1 (fr) |
CZ (1) | CZ2003477A3 (fr) |
DO (1) | DOP2001000238A (fr) |
EA (1) | EA200300187A1 (fr) |
GT (1) | GT200100174A (fr) |
HN (1) | HN2001000216A (fr) |
HU (1) | HUP0300828A2 (fr) |
IL (1) | IL154507A0 (fr) |
IS (1) | IS6724A (fr) |
MA (1) | MA26949A1 (fr) |
MX (1) | MXPA03001654A (fr) |
NO (1) | NO20030844L (fr) |
PA (1) | PA8526501A1 (fr) |
PE (1) | PE20020393A1 (fr) |
PL (1) | PL360699A1 (fr) |
SK (1) | SK2072003A3 (fr) |
SV (1) | SV2002000601A (fr) |
TN (1) | TNSN01127A1 (fr) |
UY (1) | UY26908A1 (fr) |
WO (1) | WO2002018319A1 (fr) |
YU (1) | YU14303A (fr) |
ZA (1) | ZA200301182B (fr) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
ES2335276T3 (es) | 2002-03-13 | 2010-03-24 | Array Biopharma, Inc. | Derivados de bencimidazol alquilado n3 como inhibidores de mek. |
US7538120B2 (en) | 2003-09-03 | 2009-05-26 | Array Biopharma Inc. | Method of treating inflammatory diseases |
US7144907B2 (en) | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
NZ546011A (en) | 2003-10-21 | 2009-09-25 | Warner Lambert Co | Polymorphic form of N-[(R)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide |
MXPA06005657A (es) | 2003-11-19 | 2006-08-23 | Array Biopharma Inc | Inhibidores heterociclicos de mek y metodos para usarlos. |
US7732616B2 (en) | 2003-11-19 | 2010-06-08 | Array Biopharma Inc. | Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof |
US7517994B2 (en) | 2003-11-19 | 2009-04-14 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
RU2006121990A (ru) | 2003-11-21 | 2007-12-27 | Эррэй Биофарма Инк. (Us) | Ингибиторы протеинкиназ акт |
UA89035C2 (ru) | 2003-12-03 | 2009-12-25 | Лео Фарма А/С | Эфиры гидроксамовых кислот и их фармацевтическое применение |
WO2006109085A1 (fr) | 2005-04-13 | 2006-10-19 | Astex Therapeutics Limited | Derives d'hydroxybenzamide et leur utilisation comme inhibteurs de hsp90 |
CN101626767A (zh) | 2005-05-18 | 2010-01-13 | 阵列生物制药公司 | Mek的杂环抑制剂及其使用方法 |
US7754725B2 (en) | 2006-03-01 | 2010-07-13 | Astex Therapeutics Ltd. | Dihydroxyphenyl isoindolymethanones |
WO2008006039A1 (fr) | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Dihydrothiéno pyrimidines comme inhibiteurs de la protéine kinase akt |
WO2008006025A1 (fr) | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Dihydrofuro pyrimidines comme inhibiteurs de la protéine kinase akt |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
MY147628A (en) | 2006-07-06 | 2012-12-31 | Array Biopharma Inc | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
WO2008044045A1 (fr) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Combinaisons pharmaceutiques |
WO2008044029A1 (fr) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Combinaisons pharmaceutiques |
JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
EP2081891A2 (fr) | 2006-10-12 | 2009-07-29 | Astex Therapeutics Limited | COMPOSES PHARMACEUTIQUES AYANT UNE ACTIVITE INHIBITRICE OU MODULATRICE HSP90& xA; |
JP5628028B2 (ja) | 2007-07-05 | 2014-11-19 | アレイ バイオファーマ、インコーポレイテッド | Aktプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
BRPI0813993A2 (pt) | 2007-07-05 | 2015-06-16 | Array Biopharma Inc | Ciclopentanos de pirimidila como inibidores de proteína quinase akt |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
EP2240455B1 (fr) | 2008-01-09 | 2012-12-26 | Array Biopharma, Inc. | Pyrimidyl cyclopentane hydroxylé en tant qu'inhibiteur de protéine kinase akt |
BRPI0906798A2 (pt) | 2008-01-09 | 2015-07-14 | Array Biopharma Inc | Pirimidil ciclopentanos hidroxilados como inibidores de proteína quinase akt |
GB0806527D0 (en) | 2008-04-11 | 2008-05-14 | Astex Therapeutics Ltd | Pharmaceutical compounds |
CN101985428B (zh) * | 2009-07-29 | 2014-02-12 | 杭州民生药业有限公司 | 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途 |
US20120316337A1 (en) * | 2010-02-19 | 2012-12-13 | Universite Du Maine | Method for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group |
JP2013519715A (ja) * | 2010-02-19 | 2013-05-30 | センター ナショナル デ ラ リシェルシェ サイエンティフィック | 少なくとも1つの電子求引性基を有する芳香族カルボン酸誘導体の芳香族求核置換による目的の化学化合物の調製方法 |
JP6143739B2 (ja) | 2011-04-01 | 2017-06-07 | ジェネンテック, インコーポレイテッド | Akt阻害剤化合物及びベムラフェニブの組み合わせ、及び使用方法 |
PL2694073T3 (pl) | 2011-04-01 | 2019-06-28 | Genentech, Inc. | Kombinacje inhibitorów AKT i MEK do leczenia nowotworu |
CR20200237A (es) * | 2012-10-12 | 2020-07-26 | Exelixis Inc | Proceso novedoso para la elaboración de compuestos para su uso en el tratamiento del cáncer (diviisional 2015-0245) |
CN112745237B (zh) * | 2019-10-29 | 2023-06-20 | 中国科学院上海药物研究所 | 2-芳基胺类化合物及其制备方法和应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3138636A (en) * | 1960-06-23 | 1964-06-23 | Parke Davis & Co | Anthranilic acid derivatives |
AU5610398A (en) * | 1997-02-28 | 1998-09-18 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a mek inhibitor |
WO1999001421A1 (fr) * | 1997-07-01 | 1999-01-14 | Warner-Lambert Company | Derives d'acide benzoique 2-(4-bromo ou 4-iodo phenylamino) et utilisation de ces derniers en tant qu'inhibiteurs de mek |
CA2290506C (fr) * | 1997-07-01 | 2005-12-27 | Warner-Lambert Company | Derives d'acide benzhydroxamique phenylamino 4-bromo ou 4-iodo et utilisation de ces derniers en tant qu'inhibiteurs de mek |
CA2348236A1 (fr) * | 1999-01-13 | 2000-07-20 | Stephen Douglas Barrett | 4-arylamino, 4-aryloxy, et 4-arylthio diarylamines et leurs derives comme inhibiteurs selectifs de mek |
DE60017109T2 (de) * | 1999-04-21 | 2006-01-12 | Warner-Lambert Co. Llc | Verfahren zur herstellung von 2-(n-phenylalmino)benzoesäure |
-
2001
- 2001-07-20 SK SK207-2003A patent/SK2072003A3/sk unknown
- 2001-07-20 AU AU2001277044A patent/AU2001277044A1/en not_active Abandoned
- 2001-07-20 IL IL15450701A patent/IL154507A0/xx unknown
- 2001-07-20 WO PCT/US2001/022948 patent/WO2002018319A1/fr not_active Application Discontinuation
- 2001-07-20 CZ CZ2003477A patent/CZ2003477A3/cs unknown
- 2001-07-20 JP JP2002523437A patent/JP2004507518A/ja active Pending
- 2001-07-20 PL PL36069901A patent/PL360699A1/xx unknown
- 2001-07-20 CA CA002420003A patent/CA2420003A1/fr not_active Abandoned
- 2001-07-20 AP APAP/P/2001/002249A patent/AP2001002249A0/en unknown
- 2001-07-20 KR KR10-2003-7002675A patent/KR20030059115A/ko not_active Application Discontinuation
- 2001-07-20 YU YU14303A patent/YU14303A/sh unknown
- 2001-07-20 HU HU0300828A patent/HUP0300828A2/hu unknown
- 2001-07-20 EA EA200300187A patent/EA200300187A1/ru unknown
- 2001-07-20 MX MXPA03001654A patent/MXPA03001654A/es unknown
- 2001-07-20 CN CN01815869A patent/CN1458921A/zh active Pending
- 2001-07-20 EP EP01954824A patent/EP1313694A1/fr not_active Withdrawn
- 2001-07-20 BR BR0113520-1A patent/BR0113520A/pt not_active Application Discontinuation
- 2001-08-15 SV SV2001000601A patent/SV2002000601A/es not_active Application Discontinuation
- 2001-08-22 TN TNTNSN01127A patent/TNSN01127A1/en unknown
- 2001-08-23 PA PA20018526501A patent/PA8526501A1/es unknown
- 2001-08-24 GT GT200100174A patent/GT200100174A/es unknown
- 2001-08-24 AR ARP010104047A patent/AR032175A1/es unknown
- 2001-08-24 UY UY26908A patent/UY26908A1/es not_active Application Discontinuation
- 2001-08-24 PE PE2001000853A patent/PE20020393A1/es not_active Application Discontinuation
- 2001-08-24 DO DO2001000238A patent/DOP2001000238A/es unknown
- 2001-09-26 HN HN2001000216A patent/HN2001000216A/es unknown
-
2003
- 2003-02-12 ZA ZA200301182A patent/ZA200301182B/en unknown
- 2003-02-20 IS IS6724A patent/IS6724A/is unknown
- 2003-02-24 NO NO20030844A patent/NO20030844L/no not_active Application Discontinuation
- 2003-03-13 BG BG107635A patent/BG107635A/bg unknown
- 2003-03-14 MA MA27069A patent/MA26949A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
IS6724A (is) | 2003-02-20 |
TNSN01127A1 (en) | 2005-11-10 |
GT200100174A (es) | 2002-07-18 |
YU14303A (sh) | 2006-08-17 |
BG107635A (bg) | 2004-09-30 |
NO20030844D0 (no) | 2003-02-24 |
PA8526501A1 (es) | 2002-07-30 |
UY26908A1 (es) | 2001-11-30 |
ZA200301182B (en) | 2004-05-12 |
PL360699A1 (en) | 2004-09-20 |
AU2001277044A1 (en) | 2002-03-13 |
IL154507A0 (en) | 2003-09-17 |
AR032175A1 (es) | 2003-10-29 |
KR20030059115A (ko) | 2003-07-07 |
JP2004507518A (ja) | 2004-03-11 |
SK2072003A3 (en) | 2004-01-08 |
BR0113520A (pt) | 2003-06-24 |
SV2002000601A (es) | 2002-04-03 |
MXPA03001654A (es) | 2004-09-10 |
EP1313694A1 (fr) | 2003-05-28 |
HN2001000216A (es) | 2002-05-22 |
CN1458921A (zh) | 2003-11-26 |
WO2002018319A1 (fr) | 2002-03-07 |
NO20030844L (no) | 2003-02-25 |
DOP2001000238A (es) | 2003-01-31 |
PE20020393A1 (es) | 2002-05-09 |
EA200300187A1 (ru) | 2003-08-28 |
HUP0300828A2 (hu) | 2003-09-29 |
AP2001002249A0 (en) | 2001-09-30 |
MA26949A1 (fr) | 2004-12-20 |
CZ2003477A3 (cs) | 2003-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |