EP0283801A3
(en)
*
|
1987-03-27 |
1990-05-30 |
Abbott Laboratories |
Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
|
US5236899A
(en)
*
|
1987-11-16 |
1993-08-17 |
Merck & Co., Inc. |
6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
|
GB2222770B
(en)
*
|
1988-09-16 |
1992-07-29 |
Sandoz Ltd |
Pharmaceutical compositions containing cyclosporins
|
US6007840A
(en)
*
|
1988-09-16 |
1999-12-28 |
Novartis Ag |
Pharmaceutical compositions comprising cyclosporins
|
BE1003009A5
(fr)
*
|
1989-02-09 |
1991-10-22 |
Sandoz Sa |
Nouvelles compositions pharmaceutiques a base de cyclosporines.
|
US5540931A
(en)
*
|
1989-03-03 |
1996-07-30 |
Charles W. Hewitt |
Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
|
GB8916901D0
(en)
*
|
1989-07-24 |
1989-09-06 |
Sandoz Ltd |
Improvements in or relating to organic compounds
|
US5122511A
(en)
*
|
1990-02-27 |
1992-06-16 |
Merck & Co., Inc. |
Immunosuppressive cyclosporin analogs with modified amino acids at position-8
|
US6262022B1
(en)
|
1992-06-25 |
2001-07-17 |
Novartis Ag |
Pharmaceutical compositions containing cyclosporin as the active agent
|
GB9204466D0
(en)
*
|
1992-03-02 |
1992-04-15 |
Sandoz Ltd |
Improvements in or relating to organic compounds
|
GB9208712D0
(en)
*
|
1992-04-22 |
1992-06-10 |
Sandoz Ltd |
Pharmaceutical compositions containing cyclosporin derivates
|
SG45449A1
(en)
|
1992-05-13 |
1998-01-16 |
Sandoz Ltd |
Ophthalmic compositions
|
CZ278863B6
(en)
*
|
1992-09-07 |
1994-07-13 |
Galena |
Medicinal preparations with n-methylated cyclic undecapeptides
|
DK0589843T3
(da)
|
1992-09-25 |
2002-04-02 |
Novartis Ag |
Cyclosporinholdige farmaceutiske præparater
|
US20020099067A1
(en)
*
|
1993-07-08 |
2002-07-25 |
Ulrich Posanski |
Pharmaceutical compositions for sparingly soluble therapeutic agents
|
GB9318612D0
(en)
*
|
1993-09-08 |
1993-10-27 |
Sandoz Ltd |
An assay
|
US6187547B1
(en)
|
1993-09-08 |
2001-02-13 |
Novartis Ag |
Assay kit
|
US6334997B1
(en)
|
1994-03-25 |
2002-01-01 |
Isotechnika, Inc. |
Method of using deuterated calcium channel blockers
|
WO1995026325A2
(en)
*
|
1994-03-25 |
1995-10-05 |
Isotechnika Inc. |
Enhancement of the efficacy of drugs by deuteration
|
DE59510233D1
(de)
|
1994-11-03 |
2002-07-11 |
Novartis Ag |
Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
|
GR1002687B
(el)
*
|
1995-04-17 |
1997-05-06 |
Novartis Ag (Novartis Sa) (Novartis Inc.) |
Διαδικασια παραγωγης.
|
US6245805B1
(en)
|
1995-10-26 |
2001-06-12 |
Baker Norton Pharmaceuticals, Inc. |
Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
|
US6395770B1
(en)
*
|
1995-10-26 |
2002-05-28 |
Baker Norton Pharmaceuticals, Inc. |
Method and compositions for administering taxanes orally to human patients
|
DE19549852B4
(de)
|
1995-11-29 |
2009-06-04 |
Novartis Ag |
Cyclosporin enthaltende Präparate
|
GB9601120D0
(en)
|
1996-01-19 |
1996-03-20 |
Sandoz Ltd |
Organic compounds
|
EP0988046B1
(en)
|
1997-01-30 |
2004-09-15 |
Novartis AG |
Oil-free pharmaceutical compositions containing cyclosporin a
|
DE69832984T2
(de)
*
|
1997-10-08 |
2006-09-21 |
Isotechnika, Inc., Edmonton |
DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
|
US20030220234A1
(en)
*
|
1998-11-02 |
2003-11-27 |
Selvaraj Naicker |
Deuterated cyclosporine analogs and their use as immunodulating agents
|
US6657104B1
(en)
|
1997-10-16 |
2003-12-02 |
Texas Systems, University Of The Board Of The Regents |
Transgenic mouse model for cardiac hypertrophy and methods of use thereof
|
JP4350898B2
(ja)
|
1998-07-01 |
2009-10-21 |
デビオファーム・ソシエテ・アノニム |
活性の特徴が改善された新規のシクロスポリン
|
JP2002534370A
(ja)
|
1998-12-30 |
2002-10-15 |
デクセル リミテッド |
サイクロスポリンを送達するための分散可能な濃縮物
|
US6255280B1
(en)
*
|
1999-04-08 |
2001-07-03 |
University Of Kentucky Research Foundation |
Protection against traumatic brain injury
|
US7732404B2
(en)
|
1999-12-30 |
2010-06-08 |
Dexcel Ltd |
Pro-nanodispersion for the delivery of cyclosporin
|
US6784156B2
(en)
|
2001-03-05 |
2004-08-31 |
Enanta Pharmaceuticals, Inc. |
Cyclosporins for the treatment of respiratory diseases
|
GB0113663D0
(en)
*
|
2001-06-05 |
2001-07-25 |
Novartis Ag |
Use of organic compounds
|
US6809077B2
(en)
*
|
2001-10-12 |
2004-10-26 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogs for the treatment of autoimmune diseases
|
US20030087813A1
(en)
|
2001-10-12 |
2003-05-08 |
Or Yat Sun |
Cyclosporin analogs for the treatment of lung diseases
|
NZ531946A
(en)
|
2001-10-19 |
2005-09-30 |
Isotechnika Inc |
Preconcentrate formulations comprising cyclosporin analogue microemulsions that reduce adverse effects while maintaining high bioavailability
|
AU2007221839B2
(en)
*
|
2001-10-19 |
2011-05-12 |
Aurinia Pharmaceuticals Inc. |
Synthesis of cyclosporin analogs
|
MXPA04003624A
(es)
*
|
2001-10-19 |
2004-12-06 |
Isotechnika Inc |
Mezclas analogas de ciclosporina y su uso como agentes inmunolomoduladores.
|
PL210795B1
(pl)
*
|
2001-10-19 |
2012-03-30 |
Isotechnika Inc |
Sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (E), sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (Z), sposób stereoselektywnej syntezy izomeru (E) ISATX247, sposób stereoselektywnej syntezy izomeru (Z) ISATX247 i sposób wytwarzania mieszaniny izomerów ISATX247
|
US7012065B2
(en)
|
2003-02-07 |
2006-03-14 |
Enanta Pharmaceuticals, Inc. |
Cyclosporins for the treatment of immune disorders
|
AU2004222306A1
(en)
*
|
2003-03-17 |
2004-09-30 |
Albany Molecular Research, Inc. |
Novel cyclosporins
|
TW200505946A
(en)
*
|
2003-04-08 |
2005-02-16 |
Hoffmann La Roche |
Process for preparation of cyclosporin a analog
|
CN1960726A
(zh)
*
|
2004-04-08 |
2007-05-09 |
应用研究系统Ars股份公司 |
包含jnk抑制剂和环孢菌素的组合物
|
US20060014677A1
(en)
*
|
2004-07-19 |
2006-01-19 |
Isotechnika International Inc. |
Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
|
JP2008514702A
(ja)
*
|
2004-09-29 |
2008-05-08 |
エーエムアール テクノロジー インコーポレイテッド |
新規シクロスポリン類似体およびそれらの薬学的使用
|
JP2008514701A
(ja)
*
|
2004-09-29 |
2008-05-08 |
エーエムアール テクノロジー インコーポレイテッド |
シクロスポリンアルキン類似体およびそれらの薬学的使用
|
WO2006041631A2
(en)
*
|
2004-10-06 |
2006-04-20 |
Amr Technology, Inc. |
Novel cyclosporin alkynes and their utility as pharmaceutical agents
|
BRPI0517207A
(pt)
*
|
2004-12-17 |
2008-09-30 |
Isotechnika Inc |
composto isolado, metabólito isolado de ciclo {{(e)- e (z)- (2s,3r,4r)-3-hidróxi-4-metil-2-(metilamino)-6,8-nonadien oil}-l-2-aminobutiril-n-metil-glicil-n-metil-l-leucil-l-v alil-n-metil-l-leucil-l-alanil-d-alanil-n-metil-l-leucil- n-metil-l-leucil-n-metil-l-valil} (isa247) e os sais e solvatos farmaceuticamente aceitáveis dos mesmos, método de preparação de metabólitos de isa247 in vitro, método de produção de um metabólito hidroxilado de isa247, metabólito hidroxilado isolado de isa247, metabólito hidroxilado isolado, método de produção de um metabólito de epóxido de isa247 in vitro, metabólito isolado de epóxido de isa247, metabólito isolado de epóxido, método de produção de um metabólito de diol de isa247 in vitro, metabólito de diol isolado de isa247, metabólito de diol isolado, método de produção de um metabólito de diol de isa247, método de produção de um metabólito de diol de isa247 e composição farmacêutica
|
US7696165B2
(en)
*
|
2006-03-28 |
2010-04-13 |
Albany Molecular Research, Inc. |
Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
|
US7696166B2
(en)
*
|
2006-03-28 |
2010-04-13 |
Albany Molecular Research, Inc. |
Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
|
US20080206287A1
(en)
*
|
2006-09-18 |
2008-08-28 |
Reed John C |
Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands
|
MX2009007045A
(es)
*
|
2007-01-04 |
2009-10-07 |
Debiopharm Sa |
Ciclosporina no inmunosupresora para el tratamiento de distrofia muscular congenita de ullrich.
|
TW200932240A
(en)
|
2007-10-25 |
2009-08-01 |
Astellas Pharma Inc |
Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
|
CN102164948A
(zh)
*
|
2008-07-30 |
2011-08-24 |
伊索技术制药公司 |
非免疫抑制的环孢菌素类似分子
|
US8642536B2
(en)
|
2008-10-17 |
2014-02-04 |
Wisconsin Alumni Research Foundation |
Method of making biologically active alpha-beta peptides
|
US8536114B2
(en)
*
|
2008-12-31 |
2013-09-17 |
Scynexis, Inc. |
Macrocycles
|
WO2010088573A1
(en)
*
|
2009-01-30 |
2010-08-05 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogues for preventing or treating hepatitis c infection
|
US8481483B2
(en)
*
|
2009-02-19 |
2013-07-09 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogues
|
US8349312B2
(en)
*
|
2009-07-09 |
2013-01-08 |
Enanta Pharmaceuticals, Inc. |
Proline substituted cyclosporin analogues
|
US8685917B2
(en)
*
|
2009-07-09 |
2014-04-01 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogues
|
US8367053B2
(en)
*
|
2009-07-09 |
2013-02-05 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogues
|
DE102009037551A1
(de)
|
2009-08-17 |
2011-02-24 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Cyclosporinderivate
|
US8623814B2
(en)
*
|
2010-02-23 |
2014-01-07 |
Enanta Pharmaceuticals, Inc. |
Antiviral agents
|
WO2011141891A1
(en)
|
2010-05-12 |
2011-11-17 |
Debio Recherche Pharmaceutique S.A. |
Use of cycloundecadepsipeptide compounds
|
SG191069A1
(en)
|
2010-12-15 |
2013-07-31 |
Isotechnika Pharma Inc |
Cyclosporine analogue molecules modified at amino acid 1 and 3
|
WO2012145427A1
(en)
|
2011-04-18 |
2012-10-26 |
The Trustees Of Columbia University In The City Of New York |
Methods to treat cancer using cyclosporine and cyclosporine derivatives
|
WO2014049540A2
(en)
|
2012-09-29 |
2014-04-03 |
Novartis Ag |
Cyclic peptides and use as medicines
|
US8906853B2
(en)
|
2012-11-28 |
2014-12-09 |
Enanta Pharmaceuticals, Inc. |
[N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
|
AU2014311346A1
(en)
|
2013-08-26 |
2016-03-17 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogues for preventing or treating hepatitis C
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
AU2015229103C9
(en)
|
2014-03-14 |
2020-11-26 |
Immutep S.A.S |
Antibody molecules to LAG-3 and uses thereof
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
TWI716362B
(zh)
|
2014-10-14 |
2021-01-21 |
瑞士商諾華公司 |
針對pd-l1之抗體分子及其用途
|
WO2016073480A1
(en)
|
2014-11-03 |
2016-05-12 |
Enanta Pharmaceuticals, Inc. |
Novel cyclosporin analogues for preventing or treating hepatitis c infection
|
US20170340733A1
(en)
|
2014-12-19 |
2017-11-30 |
Novartis Ag |
Combination therapies
|
JP6692826B2
(ja)
|
2015-03-10 |
2020-05-13 |
アドゥロ バイオテック,インク. |
「インターフェロン遺伝子刺激因子」依存性シグナル伝達の活性化のための組成物及び方法
|
US20180222982A1
(en)
|
2015-07-29 |
2018-08-09 |
Novartis Ag |
Combination therapies comprising antibody molecules to pd-1
|
EP3316902A1
(en)
|
2015-07-29 |
2018-05-09 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
LT3317301T
(lt)
|
2015-07-29 |
2021-07-26 |
Novartis Ag |
Kombinuotos terapijos, apimančios antikūno molekules prieš lag-3
|
CA2996064C
(en)
|
2015-08-18 |
2024-02-13 |
Novation Pharmaceuticals Inc. |
Benzopyran derivatives and uses thereof
|
JP2019500893A
(ja)
|
2015-11-03 |
2019-01-17 |
ヤンセン バイオテツク,インコーポレーテツド |
Pd−1及びtim−3に特異的に結合する抗体及びそれらの使用
|
US20180371093A1
(en)
|
2015-12-17 |
2018-12-27 |
Novartis Ag |
Antibody molecules to pd-1 and uses thereof
|
US11098077B2
(en)
|
2016-07-05 |
2021-08-24 |
Chinook Therapeutics, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
UY37695A
(es)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
|
CN110785187B
(zh)
|
2017-06-22 |
2024-04-05 |
诺华股份有限公司 |
针对cd73的抗体分子及其用途
|
EP3642240A1
(en)
|
2017-06-22 |
2020-04-29 |
Novartis AG |
Antibody molecules to cd73 and uses thereof
|
TW202015726A
(zh)
|
2018-05-30 |
2020-05-01 |
瑞士商諾華公司 |
Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法
|
WO2019232244A2
(en)
|
2018-05-31 |
2019-12-05 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
JP2022548881A
(ja)
|
2019-09-18 |
2022-11-22 |
ノバルティス アーゲー |
Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法
|
CN114208781B
(zh)
*
|
2022-01-20 |
2022-12-20 |
河南农业大学 |
一种抑制草地贪夜蛾龄期的方法及其应用
|