PT87745A - Process for the preparation of pharmaceutical compounds containing cyclosporins - Google Patents

Process for the preparation of pharmaceutical compounds containing cyclosporins

Info

Publication number
PT87745A
PT87745A PT87745A PT8774588A PT87745A PT 87745 A PT87745 A PT 87745A PT 87745 A PT87745 A PT 87745A PT 8774588 A PT8774588 A PT 8774588A PT 87745 A PT87745 A PT 87745A
Authority
PT
Portugal
Prior art keywords
residue
mebmt
cyclosporins
dihydro
preparation
Prior art date
Application number
PT87745A
Other languages
English (en)
Other versions
PT87745B (pt
Inventor
Pietro Bollinger
Johann Jakob Boelsterli
Jean Francois Borel
Manfred Krieger
Trevor Glyn Payne
Rene P Traber
Roland Wenger
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878714125A external-priority patent/GB8714125D0/en
Priority claimed from GB878714115A external-priority patent/GB8714115D0/en
Priority claimed from GB878714093A external-priority patent/GB8714093D0/en
Priority claimed from GB878714119A external-priority patent/GB8714119D0/en
Priority claimed from GB878714100A external-priority patent/GB8714100D0/en
Priority claimed from GB878714098A external-priority patent/GB8714098D0/en
Priority claimed from GB878714118A external-priority patent/GB8714118D0/en
Priority claimed from GB878714090A external-priority patent/GB8714090D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of PT87745A publication Critical patent/PT87745A/pt
Publication of PT87745B publication Critical patent/PT87745B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT87745A 1987-06-17 1988-06-16 Processo para a preparacao de composicoes farmaceuticas contendo ciclosporinas PT87745B (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB878714125A GB8714125D0 (en) 1987-06-17 1987-06-17 Organic compounds
GB878714115A GB8714115D0 (en) 1987-06-17 1987-06-17 Organic compounds
GB878714093A GB8714093D0 (en) 1987-06-17 1987-06-17 Organic compounds
GB878714119A GB8714119D0 (en) 1987-06-17 1987-06-17 Organic compounds
GB878714100A GB8714100D0 (en) 1987-06-17 1987-06-17 Organic compounds
GB878714098A GB8714098D0 (en) 1987-06-17 1987-06-17 Organic compounds
GB878714118A GB8714118D0 (en) 1987-06-17 1987-06-17 Organic compounds
GB878714090A GB8714090D0 (en) 1987-06-17 1987-06-17 Organic compounds

Publications (2)

Publication Number Publication Date
PT87745A true PT87745A (pt) 1988-07-01
PT87745B PT87745B (pt) 1992-10-30

Family

ID=27571252

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87745A PT87745B (pt) 1987-06-17 1988-06-16 Processo para a preparacao de composicoes farmaceuticas contendo ciclosporinas

Country Status (21)

Country Link
US (1) US5525590A (pt)
EP (1) EP0296122B1 (pt)
JP (2) JPH0832724B2 (pt)
KR (1) KR970010927B1 (pt)
AT (1) ATE95193T1 (pt)
AU (1) AU614086B2 (pt)
CA (1) CA1338728C (pt)
CY (1) CY1939A (pt)
CZ (1) CZ411791A3 (pt)
DE (1) DE3884470T2 (pt)
DK (1) DK173873B1 (pt)
ES (1) ES2059558T3 (pt)
HK (1) HK152796A (pt)
HU (1) HU211678A9 (pt)
IE (1) IE62482B1 (pt)
IL (1) IL86751A (pt)
MY (1) MY103582A (pt)
NZ (1) NZ225041A (pt)
PT (1) PT87745B (pt)
SA (1) SA97170746A (pt)
SK (1) SK411791A3 (pt)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0283801A3 (en) * 1987-03-27 1990-05-30 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GB2230440B (en) * 1989-02-09 1993-05-19 Sandoz Ltd Novel cyclosporin galenic forms
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
GB8916901D0 (en) * 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
GB9204466D0 (en) * 1992-03-02 1992-04-15 Sandoz Ltd Improvements in or relating to organic compounds
GB9208712D0 (en) * 1992-04-22 1992-06-10 Sandoz Ltd Pharmaceutical compositions containing cyclosporin derivates
DK0642332T3 (da) * 1992-05-13 1997-06-16 Sandoz Ltd Ophthalmiske præparater indeholdende cyclosporin
CZ278863B6 (en) * 1992-09-07 1994-07-13 Galena Medicinal preparations with n-methylated cyclic undecapeptides
DK0589843T3 (da) 1992-09-25 2002-04-02 Novartis Ag Cyclosporinholdige farmaceutiske præparater
US20020099067A1 (en) * 1993-07-08 2002-07-25 Ulrich Posanski Pharmaceutical compositions for sparingly soluble therapeutic agents
US6187547B1 (en) 1993-09-08 2001-02-13 Novartis Ag Assay kit
GB9318612D0 (en) * 1993-09-08 1993-10-27 Sandoz Ltd An assay
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
CN1087725C (zh) * 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
CA2231404C (en) 1994-11-03 2009-02-17 Arzneimittelwerk Dresden Gmbh Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
GR1002687B (el) * 1995-04-17 1997-05-06 Novartis Ag (Novartis Sa) (Novartis Inc.) Διαδικασια παραγωγης.
US6245805B1 (en) 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
US6395770B1 (en) * 1995-10-26 2002-05-28 Baker Norton Pharmaceuticals, Inc. Method and compositions for administering taxanes orally to human patients
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
GB9601120D0 (en) 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds
GB2355195B (en) 1997-01-30 2001-09-12 Novartis Ag Oil-free pharmaceutical compositions containing cyclosporin A
DE69832984T2 (de) * 1997-10-08 2006-09-21 Isotechnika, Inc., Edmonton DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US6673768B1 (en) 1997-10-16 2004-01-06 Board Of Regents, The University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)
ES2255275T3 (es) 1998-07-01 2006-06-16 Debiopharm S.A. Nueva ciclosporina con perfil de actividad mejorado.
DK1154759T3 (da) 1998-12-30 2008-12-08 Dexcel Ltd Dispergerbart koncentrat til indgift af cyclosporin
US6255280B1 (en) * 1999-04-08 2001-07-03 University Of Kentucky Research Foundation Protection against traumatic brain injury
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6784156B2 (en) 2001-03-05 2004-08-31 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of respiratory diseases
GB0113663D0 (en) * 2001-06-05 2001-07-25 Novartis Ag Use of organic compounds
US20030087813A1 (en) * 2001-10-12 2003-05-08 Or Yat Sun Cyclosporin analogs for the treatment of lung diseases
US6809077B2 (en) * 2001-10-12 2004-10-26 Enanta Pharmaceuticals, Inc. Cyclosporin analogs for the treatment of autoimmune diseases
ES2266564T3 (es) * 2001-10-19 2007-03-01 Isotechnika Inc. Sintesis de analogos de cicloporinas.
CA2461730C (en) * 2001-10-19 2012-05-15 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
AU2007221839B2 (en) * 2001-10-19 2011-05-12 Aurinia Pharmaceuticals Inc. Synthesis of cyclosporin analogs
NZ531945A (en) * 2001-10-19 2006-01-27 Isotechnika Inc Cyclosporine analogue mixtures and their use as immunomodulating agents
US7012065B2 (en) 2003-02-07 2006-03-14 Enanta Pharmaceuticals, Inc. Cyclosporins for the treatment of immune disorders
JP2006524232A (ja) * 2003-03-17 2006-10-26 アルバニー モレキュラー リサーチ インコーポレーティッド 新規サイクロスポリン
TW200505946A (en) * 2003-04-08 2005-02-16 Hoffmann La Roche Process for preparation of cyclosporin a analog
CN1960726A (zh) * 2004-04-08 2007-05-09 应用研究系统Ars股份公司 包含jnk抑制剂和环孢菌素的组合物
US20060014677A1 (en) * 2004-07-19 2006-01-19 Isotechnika International Inc. Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
JP2008514701A (ja) * 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
US7511013B2 (en) * 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
JP2008515886A (ja) * 2004-10-06 2008-05-15 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
MX2007007262A (es) * 2004-12-17 2007-10-19 Isotechnika Inc Metabolitos de analogos de ciclosporina.
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US20080206287A1 (en) * 2006-09-18 2008-08-28 Reed John C Use of cyclosporin A to sensitize resistant cancer cells to death receptor ligands
BRPI0806265A2 (pt) * 2007-01-04 2011-09-06 Debiopharm Sa ciclosporina não-imunossupressora para tratamento de distrofia muscular congênita de ullrich
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
CN102164948A (zh) * 2008-07-30 2011-08-24 伊索技术制药公司 非免疫抑制的环孢菌素类似分子
JP6265583B2 (ja) 2008-10-17 2018-01-24 ウィスコンシン アルムニ リサーチ ファンデイション 生理活性アルファベータペプチドを作製する方法
JP5780969B2 (ja) * 2008-12-31 2015-09-16 サイネクシス，インコーポレーテッド シクロスポリンａの誘導体
NZ594755A (en) * 2009-01-30 2013-12-20 Enanta Pharm Inc Cyclosporin analogues for preventing or treating hepatitis c infection
US8481483B2 (en) * 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) * 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8367053B2 (en) * 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
DE102009037551A1 (de) 2009-08-17 2011-02-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cyclosporinderivate
US8623814B2 (en) * 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
WO2011141891A1 (en) 2010-05-12 2011-11-17 Debio Recherche Pharmaceutique S.A. Use of cycloundecadepsipeptide compounds
WO2012079172A1 (en) 2010-12-15 2012-06-21 Isotechnika Pharma Inc. Cyclosporine analogue molecules modified at amino acid 1 and 3
WO2012145426A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
JP2015532277A (ja) 2012-09-29 2015-11-09 ノバルティス アーゲー 環状ペプチドおよび医薬としてのその使用
US8906853B2 (en) 2012-11-28 2014-12-09 Enanta Pharmaceuticals, Inc. [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
SG11201601274QA (en) 2013-08-26 2016-03-30 Enanta Pharm Inc Cyclosporin analogues for preventing or treating hepatitis c
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
BR122024001145A2 (pt) 2014-03-14 2024-02-27 Novartis Ag Molécula de anticorpo isolada capaz de se ligar a lag-3, seu método de produção, composição farmacêutica, ácidos nucleicos, vetor de expressão, método para detecção de lag-3 em uma amostra biológica, e uso das referidas molécula de anticorpo e composição
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
ES2952717T3 (es) 2014-10-14 2023-11-03 Novartis Ag Moléculas de anticuerpos contra PD-L1 y usos de las mismas
US9669095B2 (en) 2014-11-03 2017-06-06 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection
US20170340733A1 (en) 2014-12-19 2017-11-30 Novartis Ag Combination therapies
MX2017011597A (es) 2015-03-10 2018-05-11 Aduro Biotech Inc Composiciones y metodos para activar la señalizacion dependiente del "estimulador del gen de interferon".
EP3317301B1 (en) 2015-07-29 2021-04-07 Novartis AG Combination therapies comprising antibody molecules to lag-3
WO2017019896A1 (en) 2015-07-29 2017-02-02 Novartis Ag Combination therapies comprising antibody molecules to pd-1
EP3316902A1 (en) 2015-07-29 2018-05-09 Novartis AG Combination therapies comprising antibody molecules to tim-3
US11576892B2 (en) 2015-08-18 2023-02-14 Novation Pharmaceuticals Inc. Benzopyran derivatives and uses thereof
WO2017079112A1 (en) 2015-11-03 2017-05-11 Janssen Biotech, Inc. Antibodies specifically binding pd-1 and their uses
US20180371093A1 (en) 2015-12-17 2018-12-27 Novartis Ag Antibody molecules to pd-1 and uses thereof
EP3507367A4 (en) 2016-07-05 2020-03-25 Aduro BioTech, Inc. CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
US11312783B2 (en) 2017-06-22 2022-04-26 Novartis Ag Antibody molecules to CD73 and uses thereof
EP3642240A1 (en) 2017-06-22 2020-04-29 Novartis AG Antibody molecules to cd73 and uses thereof
UY38247A (es) 2018-05-30 2019-12-31 Novartis Ag Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
US20210214459A1 (en) 2018-05-31 2021-07-15 Novartis Ag Antibody molecules to cd73 and uses thereof
EP4031578A1 (en) 2019-09-18 2022-07-27 Novartis AG Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
CN114208781B (zh) * 2022-01-20 2022-12-20 河南农业大学 一种抑制草地贪夜蛾龄期的方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210581A (en) * 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
CH614931A5 (pt) * 1975-11-04 1979-12-28 Sandoz Ag
DE3167014D1 (en) * 1980-02-14 1984-12-13 Sandoz Ag A method for the total synthesis of cyclosporins and novel cyclosporins
GB8407618D0 (en) * 1984-03-23 1984-05-02 Sandoz Ltd Organic compounds
CH667274A5 (de) * 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"

Also Published As

Publication number Publication date
DE3884470D1 (de) 1993-11-04
NZ225041A (en) 1991-03-26
DE3884470T2 (de) 1994-03-10
IE62482B1 (en) 1995-02-08
CZ411791A3 (en) 1993-02-17
CA1338728C (en) 1996-11-19
DK326588A (da) 1988-12-18
DK326588D0 (da) 1988-06-15
IL86751A (en) 1994-02-27
EP0296122A2 (en) 1988-12-21
CY1939A (en) 1997-05-16
KR970010927B1 (ko) 1997-07-02
HK152796A (en) 1996-08-16
PT87745B (pt) 1992-10-30
MY103582A (en) 1993-08-28
IE881807L (en) 1988-12-17
ATE95193T1 (de) 1993-10-15
JP2772372B2 (ja) 1998-07-02
US5525590A (en) 1996-06-11
AU1767988A (en) 1988-12-22
JPH0832724B2 (ja) 1996-03-29
SA97170746A (ar) 2005-12-03
EP0296122B1 (en) 1993-09-29
IL86751A0 (en) 1988-11-30
JPH0848696A (ja) 1996-02-20
EP0296122A3 (en) 1990-06-20
HU211678A9 (en) 1995-12-28
DK173873B1 (da) 2002-01-21
AU614086B2 (en) 1991-08-22
KR890000519A (ko) 1989-03-15
ES2059558T3 (es) 1994-11-16
JPS6445396A (en) 1989-02-17
SK411791A3 (en) 1995-07-11

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920401

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